controlling mirna regulation in disease
Báo cáo y học: " Vgf is a novel biomarker associated with muscle weakness in amyotrophic lateral sclerosis (ALS), with a potential role in disease pathogenesis"
... tissue staining intensities influ-enced the measured values. Average value density measurements from individual Vgf immunoreactive dorsal spinal cord neurons, reflecting immunostaining intensity, ... C-terminal epitope of Vgf. Unoccupied binding sites on the plates were blocked by incubation with casein. Samples and standards were applied in duplicate and incubated overnight at 4°C. Following ... in the serum, in the CSF, and in spinal cord motorneurons may be a biological diagnostic index for ALS. It remains to be directly tested whether restoring Vgf expression in spinal cord motor...
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Cell Cycle Regulation in Mammalian Germ Cells
... Connexin 43 These intracellular signaling molecules in their absence cause Juneja et al. 1999impaired folliculogenesis resulting in a germ cell deficiencywithin the gonads.Gja4/Cx37 Connexin 37 Intracellular ... absence of which results in vestigialelement binding protein ovaries with immature oocytes arrested at the pachytene stage.Dazla Dazla protein (Deleted in RNA binding protein that affects translational ... Chaperone protein involved in protein folding, Dix et al. 199670 kDa protein 2 (HSP70-2) leads to spermatogenic arrest at metaphase stage in knockouts.Cell Cycle Regulation in Mammalian Germ...
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Tài liệu Reading Our Lips: The History of Lipstick Regulation in Western Seats ... doc
... low in England during the nineteenth century, focusing only on lipstick in England could generate a most misleadingimage of lipstick’s global status. For example, during the same period in China, ... Members, 16 Law & Ineq. J. 661 (1998) (pointing out that: “a Marine recruit trainingmanual used after the Gulf War stated that female recruits would be given ‘instruction in hair care, techniques ... well as the continued complaining of religious writers,makes clear that lipstick remained at least relatively in use by females and entirely free from regulation oflaw.37 In Spain around 500...
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Tài liệu Emotion Regulation in Couples and Families ppt
... domain playsan important role in maintaining good interpersonal relationships.Managing EmotionsBefore we discuss findings supporting the importance of managing emo-tions in ... areregulated intrapersonally (within individuals) than interpersonally (betweenindividuals). Investigators are only beginning to propose and test dyadicmodels specifying how the emotion regulation ... emotions, ranging from listening to musicto drinking caffeinated beverages to withdrawing from social interaction.Parkinson and Totterdell (1999) classified various emotion regulation...
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Tài liệu Báo cáo khoa học: "WORD AND OBJECT IN DISEASE DESCRIPTIONS" doc
... TICK FRDM SKIN; APPLICA- TIONS TO SKIN OF TURPENTINE, IODINE, R~'TONE; REMOVAL OF TICK BY INSERTION OF NEEDLE BETWEEN MOUTH PARTS; ASPIRIN FOR PAIN; ANTIBIOTIC TREATMENT IN- ~-~CTIVE. ... in CMIT, in order of increasing 'enT.ropy' The enl=ropy is given in P.he first column; ,':he ent.ries in ~h~ nezt ii columns are ~he percent of occurrences in the 11 disease ... correspond to the disease categories represented in CMIT. This is done by assign- ing terms which occur predominantly in one category to a single vocabulary and then sorting by entropy. Tables...
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Báo cáo khoa học: Subcellular compartmentalization of FADD as a new level of regulation in death receptor signaling pdf
... against CD3 (1 lgÆmL)1, UCHT1;BD Pharmingen, Franklin Lakes, NJ, USA) and CD28(5 lgÆmL)1, CD28.2; BD Pharmingen), and maintained in RPMI-1640 standard medium containing recombinanthuman interleukin-2 ... domain of INP54p was cloned into the modi-fied pEGFP-C1 (Clontech, Mountain View, CA, USA)vector following the C-terminus of GFP. The first 10 aminoacids of Fyn were engineered in frame N-terminal ... Kiessling S, Sansom OJ, Millar CB,Maddison K, Bird A, Clarke AR & Frisch SM (2003)Fas-associated death domain protein interacts withmethyl-CpG binding domain protein 4: a potential linkbetween...
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Báo cáo khoa học: Isolation of a putative peroxidase, a target for factors controlling foot-formation in the coelenterate hydra docx
... arrow pointsat peroxidase containing cells lying in theectoderm of the foot. The diaminobenzidine-stained granules are localized mainly in theapical part of the foot mucous cells asindicated ... the arrow in (B). (C,D) Higherpower electron micrographs, which show (C)the diaminobenzidine-stained granules in thefoot mucous cells (fm), and granules withoutdiaminobenzidine-staining as a ... S.,Hikichi, K., Nitta, K. & Kawano, K. (2000) Chitin-binding pro-teins in invertebrates and plants comprise a common chitin-binding structural motif. J. Biol. Chem. 275, 17929–17932.38....
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Rural and Micro Finance Regulation in Ghana: Implications for Development and Performance of the Industry ppt
... conditions. Innovative microfinance institutions have had substantial success in making financial services accessible to the poor in many parts of the world, and microfinance is increasingly provided ... Ethiopia was a leader in Africa in moving to treat MFIs as financial intermediaries, it has only gradually moved toward promoting financial self-suffic iency. The interest rate was initially fixed ... Union Law. • The informal financial system covers a range of activities known as susu, including individual savings collectors, rotating savings and credit associations, and savings and credit...
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Báo cáo khoa học: Gene regulation by tetracyclines Constraints of resistance regulation in bacteria shape TetR for application in eukaryotes Christian Berens and Wolfgang Hillen pptx
... and screening systems in E.coli [104,105] and in S. cerevisiae [88] have lead to aprofound understanding of how DNA binding, inducerbinding and dimerization function in TetR. This informa-tion ... the inducer-binding and dimerization domain is in dark gray, activation domains areblack boxes, and the silencing domain is stippled. The conformational change leading to the loss of DNA-binding ... disorders. In a conditional model of Hunting-ton’s disease, mice expressing a mutated huntingtinfragment in the brain demonstrated that its continuoussupply was needed to maintain the characteristic...
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Báo cáo khoa học: "Controlling Lexical Substitution in Computer Text Generation" docx
... appears to he describing two windows, because there is no device indicating that the window of the second sentence is the same as the window of tile first sentence. If in tact the speaker me:mr ... goal is to dislinguL",h new information from old. ,so that the listener can tully undemtand what fs being said. [1} The room has a large window, The room has a window facing east. {1} ... Computational Theory of Definite Anaphora Comprehension in English Discourse Tech. Rep. AI-TR 537, MI r, Cambridge, 1979. 384 Controlling Lexical Substitution in Computer Text Generation...
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Better Regulation In Europe Better Regulation In Europe - Austria 2010 pptx
... responsibility. Binding guidelines for all federal ministries and the Länder relating to the negotiation, transposition and infringement phases have been in place since 2003. In 2003, the Ministry of ... co-ordination of rule-making is weak in Austria, with regulations being autonomously conceived within each responsible ministry. As a result forward planning policies vary from ministry to ministry. ... existing IT systems in the preparation of regulation including a clear link between public consultation and the drafting process. Develop a single consultation portal for use by all ministries...
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Báo cáo khoa học: Death-associated protein kinase (DAPK) and signal transduction: regulation in cancer ppt
... byactivating DAPK activity [40]. Indeed, bosutinib, aninvestigational Src kinase inhibitor, has been shown toinhibit the migration and invasion of breast cancercells [48]. In addition, dasatinib, ... are now being tested in combination therapies[47].Tyrosine kinase inhibitors are widely and success-fully used in the treatment of cancer, and in thecontext of this review, may inhibit tumour ... revealed that DAPK protein was inactive, sug-gesting that the kinase activity of DAPK was inacti-vated in cancer cells [38]. Our own studies assessingprotein expression of DAPK in freshly isolated...
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Báo cáo khoa học: Impact of cyclic hypoxia on HIF-1a regulation in endothelial cells – new insights for anti-tumor treatments doc
... gain in endothelial cell survival, therebymirroring the effects of a PI3K ⁄ Akt inhibitor. However, combination ofboth drugs resulted in a net reduction in HIF-1a and a dramatic in decrease in ... alterations occurring during thereoxygenation periods. These observations also indicate the potential ofcombining Akt-targeting drugs with anti-angiogenic drugs, in particularthose interfering with ... dependency of the COX-2 inductionwas shown using echinomycin, a pharmacologicalhypoxia-responsive element-interfering drug [27], whichcompletely prevented the increase in COX-2 transcriptabundance...
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transcriptional regulation in eukaryotes
... immunoglobulin heavy-chain proteinIL-2, interleukin-2IL-12, interleukin-12Inr, initiator elementsint, integraseIPTG, isopropyl-β-D-thiogalactosideIRE, iron-responsive elementIRP, iron-regulating ... different affinities for core promoters (e.g., TBP binding to consensus and non-consensus TATAs; TFIIB binding to a consensus vs. a degenerate BRE; TFIID binding to anInr-containing vs. Inr-less ... Thegypsy insulator binds the suppressor of hairy wing (su[Hw]) proteins (in one case theinsulator comprises 12 su[Hw] binding sites). Unlike BEAF32, mutations in su(Hw) inac-tivate insulator activity.Most...
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- the discovery that micrornas mirnas are synthesized as hairpincontaining precursors and share many features has stimulated the development of several computational approaches for identifying new mirna genes in various animal species
- especially in developed countries chronic diseases disproportionately affect the older segment of the population
- the regulation of cdx1 expression in the intestinal metaplasia is poorly understood
- microrna regulation in disease
- microrna expression in disease
- altered microrna regulation in huntingtons disease models
- microrna regulation in cardiovascular disease
- overlaps in the financial sector regulation in kenya
- structure of financial sector regulation in kenya
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