central nervous system atypical teratoid rhabdoid tumors role of insulin like growth factor i receptor
Báo cáo hóa học: " The emerging role of insulin-like growth factor 1 receptor (IGF1r) in gastrointestinal stromal tumors (GISTs)" pdf
... Lollini PL, Nanni P, Picci P, Scotlandi K: Inhibition of insulin- like growth factor I receptor increases the antitumor activity of doxorubicin and vincristine against Ewing’s sarcoma cells Clin ... Scotlandi K, Benini S, Nanni P, Lollini PL, Nicoletti G, Landuzzi L, Serra M, Manara MC, Picci P, Baldini N: Blockage of insulin- like growth factor- I receptor inhibits the growth of Ewing’s sarcoma in ... Osteosarcoma Etiology Study Group: Analysis of genes critical for growth regulation identifies Insulin- like Growth Factor Receptor variations with possible functional significance as risk factors for...
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báo cáo hóa học: " Neuroprotective response after photodynamic therapy: Role of vascular endothelial growth factor" pot
... production of VEGF might be influenced by a decrease in bioactivity of RPE cells This is consistent with previous data showing a trend toward reduced density of the choriocapillaris, which is positively ... VEGF inhibition immediately after PDT promotes photoreceptor cell apoptosis Influence of VEGF inhibition on Akt and BAX We next analyzed the influence of VEGF inhibition on Akt activation in PDT-treated ... influences of inhibiting VEGF expression after PDT were not observed outside the irradiated area, which indicates that this level of VEGF inhibition is not cytotoxic for non-irradiated and non-stressed...
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Báo cáo y học: " Protective role of vascular endothelial growth factor in endotoxin-induced acute lung injury in mice" potx
... ALI/ARDS Apoptosis of endothelial and epithelial cells, which is induced by a variety of stimuli, contributes to the impairment of the barrier function of pulmonary endothelium and epithelium ... microscopic observations were conducted by single investigator in a blinded fashion TUNEL staining of the lung section TUNEL staining was performed with MEBSTAIN II Apoptosis kit (Medical&Biological ... endothelial cell differentiation, angiogenesis, and the maintenance of existing vessels [1-4] VEGF is involved in the pathogenesis of rheumatoid arthritis, diabetic retinopathy, and tumor growth, ...
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The role of hydrogen sulfide in the central nervous system implications in the treatment of alzheimers disease
... peroxynitrite-mediated tyrosine nitration and inactivation of alpha1-antiproteinase inhibiting peroxynitrite-induced cytotoxicity, intracellular protein nitration and protein oxidation in human ... institutionalization of patients An additional impact of AD is on the day to day activity of patients (activities of daily living) These symptoms result in adverse effects of quality of life, impact on caregiver ... II TABLE OF CONTENTS III SUMMARY VII LIST OF TABLES X LIST OF FIGURES XI LIST OF ABBREVEATIONS XII LIST OF PUBLICATIONS XIV Introduction...
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Role of central nervous system ceramides and free radicals in a mouse model of orofacial pain
... peroxide XIII Abbreviations IASP International association for the study of pain IC50 median inhibition concentration ICV intracerebroventricular iNOS inducible nitric oxide synthase IP intraperitoneal ... capable of interacting with a multiplicity of targets In addition, sphingolipid metabolites generated in cells are capable of modifying the activity of a number of proteins, including receptors, ion ... XVI Chapter I Introduction Chapter I INTRODUCTION Chapter I Introduction General introduction of pain 1.1 History of pain study and pain definitions Pain is defined by the International Association...
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Cancer of the Brain and Other Central Nervous System doc
... younger individuals with the same diagnosis, which would negatively affect their survival Though competing risk information was unavailable for this analysis, performing relative survival analysis ... 25 Cancer of the Brain and Nervous System SEER Stage of Disease Primary Site SEER classifies invasive stage of disease into categories: localized, regional, distant and unstaged Survival decreased ... sufficient information to assign stage The American Joint Committee on Cancer (AJCC) TNM staging system, 5th Edition, (14) is also used Primary Site Classification For brain cancers, primary site of...
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Báo cáo khoa học: Planarian peptidylglycine-hydroxylating monooxygenase, a neuropeptide processing enzyme, colocalizes with cytochrome b561 along the central nervous system pptx
... bodies (G) In situ hybridization of a horizontal section of eye with antisense PHM probe (brown) (H) Immunohistochemical staining with anti-arrestin (green) was superimposed on nuclei-staining ... project their microvilli into the inside of the cup, as indicated by immunohistochemical staining with antiplanarian arrestin (green) (Fig 7H,J) Planarian PHM was expressed only in the photoreceptor ... locations are indicated in Fig 2, as underlining with broken lines) with planarian head cDNA library mixture as a template These two primers had a BglII and a HindIII restriction site, respectively The...
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báo cáo hóa học: " Temporal expression and cellular origin of CC chemokine receptors CCR1, CCR2 and CCR5 in the central nervous system: insight into mechanisms of MOG-induced EAE" pptx
... identified those cells as infiltrating macrophages or amoeboid microglia Our findings confirm previous studies describing the expression of CCR2 and its ligand CCL2 within inflamed brain lesions ... CNS elicit microglial activation [63] Microglia may display different activity states under different pathological conditions [66] Microglial activation is generally associated with a change in ... pathogenesis of MS is the reliable identification of phagocytes capable of degrading myelin Since infiltration of leukocytes including monocyte-derived macrophages into the CNS is a key step in the...
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Section III - Drugs Acting on the Central Nervous System docx
... postoperative period This finding led to clinical trials of prophylactic, perioperative administration of -adrenergic receptor antagonists in high-risk patients Preoperative and postoperative administration ... anatomical divisions provide a superficial classification of the distribution of brain functions Cerebral Cortex The two cerebral hemispheres constitute the largest division of the brain Regions of ... are synergistic with sedative-hypnotic agents and inhalational agents, including nitrous oxide The ability of opioids to block painful stimuli, accompanied by intrinsic hemodynamic stability, has...
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Báo cáo sinh học: "The long term effects of chemotherapy on the central nervous system" docx
... been considered ‘standard’ therapy (craniospinal radiation) by first delaying and then, in subsequent trials, eliminating radiation in certain ‘good risk’ children by using a regimen of prolonged ... greatest risk factor for radiation-induced cognitive decline is young age at the time of treatment Cranial irradiation can be so devastating to the brains of young children (under three to five years) ... first identifying risk factors for radiation-induced cognitive decline and then modifying treatments to reduce neurotoxicity [7] Two of the most important of the risk factors are high dose and...
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Báo cáo sinh học: "Systemic 5-fluorouracil treatment causes a syndrome of delayed myelin destruction in the central nervous system" doc
... described [79] In vitro toxicity and viability assay In vitro toxicity studies involved microscopic analysis of staining with the 3,(4,5-dimethylthiazol-2-yl) 2,5-diphenyltetrazoliumbromide (MTT) ... transmission electron microscope was used to examine and digitally capture images using a MegaView III digital camera (Soft Imaging) Additional data files An additional data file is available with ... (d) or high-dose bolus administration (e) yielded similar results, with vulnerability of O-2A/OPCs and non-dividing oligodendrocytes to 5-FU exceeding the vulnerability of rapidly dividing cancer...
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Báo cáo sinh học: "How chemotherapy damages the central nervous system Christina A Meyers" ppsx
... toxicity), the different agents under study, and the specific animal or preclinical model that was utilized Clinical studies The studies of Noble and colleagues [9,10] will directly affect clinical ... which subsided 56 days after injection They found a more persistent suppression of proliferation in regions of the brain where proliferation is essential to normal function (the subventricular zone, ... Journal of Biology 2008, Volume 7, Article 11 Meyers and nondividing oligodendrocytes were vulnerable, suggesting that 5-FU neurotoxicity was not limited to dividing cells This toxicity was observed...
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Báo cáo khoa học: "Immunohistochemical study of constitutive neuronal and inducible nitric oxide synthase in the central nervous system of goat with natural listeriosis" potx
... caprine brains with natural listeriosis A: Brain of a goat with listeriosis showing meningoencephalitis H-E staining, X66 B: Many dot-type bacteria (arrows) with immunoreactivity to anti-Listeria ... antisera were observed in inflammatory microabscesses Counterstained with hematoxylin Magnification: ×132 C: Immunohistochemical staining of inducible NOS in the caprine brain with natural listeriosis ... microns, and stained with hematoxylin and eosin by routine histopathologic techniques Brainstem sections of paraffin-embedded tissues from animals with characteristic histopathologic lesions of...
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báo cáo khoa học: "Isolated angiitis of the central nervous system with tumor-like lesion, mimicking brain malignant glioma: a case report and review of the literature" pdf
... Beijing Tiantan Hospital, Capital Medical University, Beijing 100050, China 2Department of Neuroradiology, Beijing Tiantan Hospital, Capital Medical University, Beijing 100050, China Department of ... individualized to make a differential diagnosis [3,14,17] IACNS may clinically mimic encephalitis, multiple sclerosis, acute disseminated encephalomyelitis, myelinoclastic diffuse sclerosis, cerebral infarction, ... reversible perivascular inflammation causing blood-brain barrier disruption and injury of surrounding white matter, might likely be specific for vasculitis Unfortunately, this did not show up in...
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Báo cáo khoa học: " Experimental concepts for toxicity prevention and tissue restoration after central nervous system irradiation" ppt
... CNS in vivo by systemic administration of amifostine appears possible However, additional studies are warranted to investigate the protective effect with differing regimens of administration, ... radiation-induced Schematic concept of the time course of radiation-induced reactions in cancer patients treated with ionizing radiation via portals exposing some part of the central nervous system ... body of research on radiation-induced CNS toxicity is still necessary, one can envision a scenario with individually tailored strategies where patients with comorbidity resulting in impaired...
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Báo cáo y học: "Cerebrospinal fluid neopterin: an informative biomarker of central nervous system immune activation in HIV-1 infection" ppt
... specificity of 93% and likelihood ration of 9.8, while for ADC 1-4 the sensitivity of 66%, specificity again 93% and the likelihood ratio is 8.9 Thus, measuring the CSF neopterin has diagnostic ... neopterin, particularly in the case of CMV encephalitis which may also be difficult to distinguish by neuroimaging and non-focal clinical findings, emphasizing the importance of CSF CMV PCR in this ... pathologically Since none of these patients exhibited clinical or radiographic immune reconstitution inflammatory syndrome (IRIS), it will be of interest in the future to examine whether neopterin...
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Báo cáo y học: "The impact of therapy for childhood acute lymphoblastic leukaemia on intelligence quotients; results of the risk-stratified randomized central nervous system treatment trial MRC UKALL XI" ppsx
... also highlight that mean IQ values may mask significant individual declines in IQ as discussed below The finding of similar outcomes in males and females is reassuring Initial reports of inferior ... of possible risk-factors Candidates include; inherent genetic susceptibility, drug toxicity, time out of full-time education or particular vulnerability of certain individuals to the impact of ... main study questions but this design makes it impossible to track the unfolding of impairments in individual patients over time The large numbers of participants, balanced randomisation and inclusion...
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Báo cáo y học: " Primary central nervous system lymphoma presenting as a pure third ventricular lesion: a case report" pps
... postoperatively showing a hematoma in the surgery field with no indications of hydrocephalus In this case, the pre-operative diagnosis based on the findings of an initial MRI incorrectly indicated ... occur with exceptional localization Thus, for proper diagnosis, it is important to differentiate between other possible third ventricle lesions that may mimic the radiological appearance of such ... tumor regression that is often associated with clinical improvement [13] The neuro-imaging response can be dramatic, sometimes showing complete remission of contrast-enhancing abnormalities Most...
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báo cáo khoa học: "In vivo observation of gold nanoparticles in the central nervous system of Blaberus discoidalis" potx
... changes in noise and vibration in the building Although proteins not break into ions, introducing charged particles into the nervous system causes an imbalance in the signal transmission that links ... provided a range of emitted signal due to the variations in size during nanoparticle fabrication and possible agglomeration Figure Hyperspectral imaging of NP solution and treated nervous system ... that of the Spectroscopic analysis The hyperspectral imaging system from CitoViva was used to identify the location of the nAuNPs particles in the tested roach This imaging system identified the...
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Báo cáo y học: "Possible gabapentin and ketamine interaction causing prolonged central nervous system depression during post-operative recovery following cervical laminoplasty: a case report" potx
... deltoids, biceps and triceps, 4/5 in his bilateral wrist extensors, 4/5 in his right finger abductors, 3/5 in his left finger abductors, 4/5 in his bilateral finger flexors, and +/5 in his bilateral ... interaction of these drugs, one must further investigate the bioavailability of these drugs Gabapentin elimination half-life is five to seven hours, while the ketamine metabolite half-life is two ... Gabapentin is eliminated from the systemic circulation by renal excretion Ketamine is metabolized in the liver and excreted by the kidneys [17,18] After parenteral administration of ketamine, high...
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