... Centrally acting cholinolytics and the choice behaviour oftherat A M Van der Poel (Leiden, The Netherlands) Centralcholinergicmechanismsinthethermoregulationofthe ... specific labelling of ACh inthe pools after infiltration of labelled choline into the cerebral cortex (Chakrin and Whittaker, 1969) constitutes proof that the pools exist in vivo The binding of ACh ... on the origin of Lholine inthe brain oftherat Biochem G J., 122,741-750 BARKER, A., DOWDALL, J., ESSMAN, B AND WHITTAKER, P (1970) The compartmentation L M W V of acetylcholine in cholinergic...
... selectivity ofthe palytoxin-induced pore Assuming that palytoxin might induce cation-permeable pores inthe apical membrane, the Isc evoked by the toxin should consist of an in ux of Na+, the prevalent ... we were interested in investigating the interactions ofthe toxin with the H+/K+-ATPase from rat colon The experiments were carried out in an Ussing chamber, which, compared to the single-cell ... paradigm, has the advantage of allowing one to asses at any time ofthe measurement either the apical or the basolateral surfaces ofthe epithelial cell membrane Administration of palytoxin on the apical...
... limited number of cytokines that inhibit the adhesiveness, growth and migration of cancer cells The most intriguing finding ofthe present study was that the function of MDA-7 in prostate cancer ... sec which resulted in complete death ofthe cells over the electrode The migration of healthy cells from the edge ofthe wounding to the wounding space was tracked Similar to the changes seen with ... is linked to the invasiveness of prostate cancer cells [12] and participates inthe regulation ofthe interactions between prostate cancer cells and endothelial cells, the later involving the...
... limited number of cytokines that inhibit the adhesiveness, growth and migration of cancer cells The most intriguing finding ofthe present study was that the function of MDA-7 in prostate cancer ... sec which resulted in complete death ofthe cells over the electrode The migration of healthy cells from the edge ofthe wounding to the wounding space was tracked Similar to the changes seen with ... is linked to the invasiveness of prostate cancer cells [12] and participates inthe regulation ofthe interactions between prostate cancer cells and endothelial cells, the later involving the...
... complement-mediated injury [18] DAF and MCP act at the level ofthe C3 convertase In contrast, CD59 inhibits the terminal pathway of complement activation, preventing the incorporation of C9 into the MAC ... anti-inflammatory action of statins in RA The combined effects of DAF, at the level of C3 and C5 convertases, and of CD59 inhibiting the terminal attack complex has the potential to exert antiinflammatory ... respectively Furthermore, the failure of squalene to influence the response suggested that the mechanism underlying the actions ofthe statins was cholesterol independent Although the effect of statins on...
... plexus ofthe enteric nervous system inthe stomach Taurinergic neurons inthe muscle layer ofthe gastrointestinal (GI) tract might be involved in motility ofthe GI tract and the function of endocrine ... taurine-containing cells intherat stomach is confirmed, as indicated by CSAD- and taurine-positive cells We found the presence of taurine-containing cells and taurine-induced acid secretion in ... magnification ofthe area in (A) showing taurine-positive processes inthe antrum (E) A higher magnification ofthe area in (B) showing taurinepositive processes inthe body Taurine-immunoreactive...
... explaining the purpose ofthe study to the prospective respondent General 33 instructions on completing the questionnaire and the importance of completing all questions were included The covering ... days in one week, there is a reminding email The respondents are instructed during the administration ofthe questionnaires by the researcher to mark the most suitable answer b) Research instruments: ... object to another, it is a measure ofthe 19 employees‟ willingness to remain with a firm inthe future It often reflects the employees‟ belief inthe mission and goals ofthe firm, willingness to...
... prevalence of smoking between male living spouses of women who died of any cause and those spouses of women who died of some other causes other than smoking related causes The prevalence of smoking ... http://www.medsci.org Int J Med Sci 2009, for rural male spouses indicating the relative risk analyses will not exaggerate the hazard of tobacco The third issue involves the validity of smoking data obtained ... uncertain ofthe age when smoking began A validity study in Shanghai was conducted where the surviving spouse was the informant and both husband and wife had reported their smoking habits in the...
... Effect of KNO3 Spraying on yield and yield Component of rice on Alluvial Soie in Nam Dinh- Spring Rice – 2009 ( Quinal/ha) Number of paricals/m2 Number of grain/pan 1A 1B 12 LS DO5 % of umfiiied ... DO5 Number of grain/pan % of umfiiied grain 1000 grain weight(g) Grain yield Tab 6: Effect of KNO3 Spraying on rice yield on degraded Soie in Bac Giang 2009 ( Quinal/ha) Treat Spring Rice Summer ... umfiiied grain 1000 grain weight(g) Grain yield Tab 5: Effect of KNO3 Spraying on yield and yield Component of rice on Alluvial Soie in Nam Dinh- Summer rice – 2009 ( Quinal/ha) Number of paricals/m2...
... difficulty in understanding these concepts, which may have resulted in inconsistent responses We found inconsistencies in 12.2% ofthe sample, indicating the difficulties in communicating the information ... among the study sites, but the data from the pilot project were not The following is an outline ofthe questionnaire: the first page was an informed consent form to participate inthe study The ... influence in their life Nine point seven percent ofthe participants were classified into the group with "high religiosity" There were no Muslim, Hindu or Buddhist participants The majority of...
... located inthe middle ofthe specimen (Fig 4a) The Cr(VI) profile for kaolin as shown in Fig 5a indicates that the majority ofthe chromium was present inthe form of Cr(VI) and this chromium migrated ... Based on the actual mass ofthe soil used in electrokinetic cell and the concentrations measured inthe contaminated soil prior to electrokinetic testing b NDsnot detected in both soils Initially, ... inthe glacial till As a result of this, the electro-osmotic flow in contaminated kaolin is higher than that observed inthe contaminated glacial till The potable water initially introduced into...
... located inthe middle ofthe specimen (Fig 4a) The Cr(VI) profile for kaolin as shown in Fig 5a indicates that the majority ofthe chromium was present inthe form of Cr(VI) and this chromium migrated ... Based on the actual mass ofthe soil used in electrokinetic cell and the concentrations measured inthe contaminated soil prior to electrokinetic testing b NDsnot detected in both soils Initially, ... inthe glacial till As a result of this, the electro-osmotic flow in contaminated kaolin is higher than that observed inthe contaminated glacial till The potable water initially introduced into...
... located inthe middle ofthe specimen (Fig 4a) The Cr(VI) profile for kaolin as shown in Fig 5a indicates that the majority ofthe chromium was present inthe form of Cr(VI) and this chromium migrated ... Based on the actual mass ofthe soil used in electrokinetic cell and the concentrations measured inthe contaminated soil prior to electrokinetic testing b NDsnot detected in both soils Initially, ... inthe glacial till As a result of this, the electro-osmotic flow in contaminated kaolin is higher than that observed inthe contaminated glacial till The potable water initially introduced into...
... inthe baseline health status reached minimal clinical significance, and may have influenced the changes in health status However, except for the baseline score ofthe Symptoms inthe SGRQ, the ... effect ofthe exacerbations on the health status deterioration inthe Fatigue and Mastery ofthe CRQ and the Symptoms ofthe SGRQ These results support our hypothesis that subjects experiencing ... total score ofthe CRQ Following the baseline scores, the frequency of exacerbations significantly accounted for the changes inthe Mastery ofthe CRQ (R2 = 0.03) and the Symptoms ofthe SGRQ (R2...
... inthe baseline health status reached minimal clinical significance, and may have influenced the changes in health status However, except for the baseline score ofthe Symptoms inthe SGRQ, the ... effect ofthe exacerbations on the health status deterioration inthe Fatigue and Mastery ofthe CRQ and the Symptoms ofthe SGRQ These results support our hypothesis that subjects experiencing ... total score ofthe CRQ Following the baseline scores, the frequency of exacerbations significantly accounted for the changes inthe Mastery ofthe CRQ (R2 = 0.03) and the Symptoms ofthe SGRQ (R2...
... heads) in seminiferous tubules H & E stain, ×50 and multiple layering ofthe tubular endothelium, degeneration of germ cells, and the formation of many multinucleated giant cells in atrophied seminiferous ... manner Most ofthe rats inthe treatment groups showed some evidence of morphological changes inthe testicular histology when compared with the vehicle control group (Fig 5) All rats inthe control ... isolated from the vehicle control rat (A) and the acrylamide (60 mg/kg/day)treated rat (B) Thickening and multiple layering ofthe tubular endothelium (arrow), and the formation of many multinucleated...
... targets of anti-TNF-α activity in RA, and may provide an insight into a new and interesting mechanism of action of anti-TNF-α mAbs inthe control of inflammatory arthritis Competing interests The ... in ml polystyrene vials with × 10-5 mol/l lucigenin in a final volume of 700 µl The vials were placed inthe Luminometer 1251 (LKB Wallace, Turku, Finland) inthe dark and allowed to equilibrate ... buffer containing FITC-conjugated goat anti-mouse IgG in a saturating concentration and incubated for 30 at 4°C The cells were then washed twice in PBS and resuspended in 0.5 ml of ice-cold 2%...
... peptide (AP9) on the invasive ability ofthe co-culture cells (a) The haematoxylin and eosin staining results ofthe cells lower surface filters show that the cells had invaded through the filter and ... showed positive expression of TIMP-1 inthe lining and the sublining layers The expression of CD147 correlated significantly with that of MMP-1 (p < 0.05), but the expression of CD147 and MMP-1 did ... metalloproteinase-1 (RA MMP-1), tissue inhibitor of metalloproteinases-1 (RA TIMP-1) and blank contrast (RA blank) inthe lining and sublining layers in RA synovium (× 400) The bottom two images show the...
... the role of CYC inthe care of these patients In our meta-analysis, two ofthe three greatest mean differences ofthe FVC after 12 months of therapy were achieved in observational studies using ... [12,13] The oral or intravenous administration routes of CYC did not influence the mean difference ofthe FVC or the DLCO after 12 months of therapy, and CYC treatment did not alter the risk of adverse ... within the range of those reported inthe literature altered the results Adverse events We evaluated the relative risk of having adverse events inthe CYC group compared with the control groups in...
... of long-term administration of αTOL in spinal cord reperfusion injury against high oxidative stress induced by ischemia; and to investigate the role of α-TOL inthe inhibition of COX-2 activity, ... responses ofthe spinal cord in IRI but also its clinical neurological impacts [14] Interruption of aortic blood flow in IRI may not only induce spinal cord injury, but also induce injury ofthe heart, ... competing interests Authors' contributions MMD participated inthe design ofthe study, performing ofthe experiments and helping draft the manuscript OAM participated inthe performing the experiment...