cell cycle regulation transcription factors
cell cycle regulation - Ebook USA ( biotechnology)
... TransductionofDNADamageSignals 744 Regulation of Downstream Cellular Processes . . . . . . . . 764.1 RegulationoftheCellCycle 774.2 RegulationofDNAReplicationForks 784.3 RegulationofDNARepair 794.4 RegulationofTelomeres ... restriction point of the cell cycle. Cell Cycle 1:103–110Buchkovich K, Duffy LA, Harlow E (1989) The retinoblastoma protein is phosphorylatedduring specific phases of the cell cycle. Cell 58:1097–1105Burdon ... Division of the cell cycle into temporally ordered, discrete steps implied different proteins regu-late specific cell cycle transitions (Hartwell 1974). If so, then factors advancing cell cycle progression...
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Cell Cycle Regulation in Mammalian Germ Cells
... female Cell Cycle Regulation in Mammalian Germ Cells 347Table 1 (continued)Gene Protein Name Effect on germ cell development Refs.B. Transcriptional and Translational Factors Ahch Dax1 A transcriptional ... Probl Cell Differ (42)P. Kaldis: Cell Cycle Regulation DOI 10.1007/003/Published online: 20 December 2005© Springer-Verlag Berlin Heidelberg 2005 Cell Cycle Regulation in Mammalian Germ CellsChanganamkandath ... mediating cell cycle regulators, growth factors andintracellular communication pathways for germ cell development.5Cytoplasmic and Apoptotic Factors During gametogenesis, apoptosis of germ cells...
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The Retinoblastoma Gene Family in Cell Cycle Regulation and Suppression of Tumorigenesis
... critical regulator of most cell cycle responses. While each single pocket protein can mediate cell cycle arrest upon cell- cell contact, pRb is the critical mediator of cell cycle arrestupon growth ... roles in controlling cell cycle exit upon growth-inhibiting signals. Only ablation of all pocket proteins fullyalleviated a cell cycle arrest upon serum withdrawal, cell- cell contact inhi-bition, ... pro-teins at these specific stages of the cell cycle. 4.4pRb Family Mediated Regulation of E2F by Cellular LocalizationAnother level of control of the E2F transcriptional activity is added by the...
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Tài liệu Báo cáo khoa học: The central role of CDE/CHR promoter elements in the regulation of cell cycle-dependent gene transcription pdf
... p53. Cell cycle arrest can be medi-ated by p53 downregulating the transcription of central cell cycle regulators such as cyclin B, Cks1, Cdc2 and Cdc25C.CDE ⁄ CHR-dependent cell cycle- gene transcription ... RegulatedDuring the Cell Cycle by a CDE ⁄ CHR TandemElement and is Downregulated by p53 but not by p63or p73. Cell Cycle 6, 853–862.37 Yoshida K (2005) Cell- cycle- dependent regulation ofthe ... found to play only a limited role in cell cycle- dependent transcription [4]. Later, this finding on theCDE was confirmed and the major cell cycle- depen-dent regulation was attributed to a novel...
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Tài liệu Báo cáo khoa học: Identification and characterization of the transcription factors involved in T-cell development, t-bet, stat6 and foxp3, within the zebrafish, Danio rerio docx
... andhuman T-cells, B-cells, myeloid cells, monocytic cellsand fibroblasts, but not neuronal cells or embryonicstem cells, express STAT6, indicating that this gene isexpressed in haematopoietic cells ... effector cell populations exist,Th1, Th2 and Th17, characterized by their cytokinerepertoire and how they regulate B -cell and T -cell Keywordsadaptive immunity; fish immunology; T-cells; transcription ... relationshipbetween the expression of these transcription factors and the cytokine genes known to be produced by dif-ferent T -cell subtypes in mammals. These transcription factors, together with many of...
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Tài liệu Báo cáo khoa học: Roles of AP-2 transcription factors in the regulation of cartilage and skeletal development doc
... and several molecular factors are known to influence the events of this enchondral ossification, especially transcription factors. Members of the AP-2 family of transcription factors play important ... M, Schorle H & BuettnerR (2000) Regulatory roles of AP-2 transcription factors in vertebrate development, apoptosis and cell- cycle con-trol. Gene 260, 1–12.46 Pfisterer P, Ehlermann J, Hegen ... binds the promoter of the survivalgene bcl-2 and regulates its transcription in epithelialcells through transcription factor AP-2. Mol Cell Biol22, 7877–7888.44 McPherson LA, Loktev AV & Weigel...
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Báo cáo y học: "BRCA1 May Modulate Neuronal Cell Cycle Re-Entry in Alzheimer Disease"
... tangles contain the antigenic profile of many cell cycle markers, re-flecting a re-entry into the cell cycle by affected neurons. However, while such a cell cycle re-entry phenotype is an early and ... suppression of the cell cycle and cell survival instead of apoptosis and their presence may be a neuroprotective factor to prolong the life of the cell after re-entry into the cell cycle, pro-tecting ... dividing neuronal cells during development, and is present in smaller amounts in fully differentiated cells [13]. BRCA1 is known to regulate transcription, regulate cell cycle progression,...
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Báo cáo y học: "Cell Cycle Arrest by a Natural Product via G2/M Checkpoint"
... of cell cycle arrest and apoptosis. We have investigated its effects on cell cycle regulation using a gastric cancer cell line, AGS. The effects of CKBM on cell proliferation, cell cycle regulation ... cell line. CKBM is found to inhibit cell proliferation through the induction of apoptosis and G2/M cell cycle arrest. To further elucidate the mechanism of CKBM on apoptosis and G2/M cell cycle ... AGS cells were seeded in a 6-well plate at a density of 1.2 x 106 cells/well. After 2, 4 or 6 hr of CKBM treatment at a concentration of 5, 10 or 15 % v/v, cells were trypsinized. Then cells...
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Modeling Cell Cycle Control and Cancer with pRB Tumor Suppressor
... Nature 343:665–669Modeling Cell Cycle Control and Cancer with pRB Tumor Suppressor 231 cycle, and strongly suggested that deregulation of the mechanisms controlling cell cycle progression could ... coordinate cell cycle exit with the induction of differentiationthat confers upon pRB its tumor suppressor function.230 L. Yamasaki2The Universality of the Cell Cycle The discovery of the cell cycle ... progression.Results Probl Cell Differ (42)P. Kaldis: Cell Cycle Regulation DOI 10.1007/b136682/Published online: 1 September 2005© Springer-Verlag Berlin Heidelberg 2005Modeling Cell Cycle Control and...
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MouseModels of Cell Cycle Regulators - New Paradigms
... mammalswithin certain cell types such as trophoblast giant cells of the placenta andmegakaryocytes, but it can also be observed in cells due to a defect in the cell cycle regulation of these cells. For ... principal cell cycle inhibitor in β cells, as it accumu-latesinthenucleusofβ cells from obese mice, inhibiting compensatory β cell expansion (Uchida et al. 2005).Mouse Models of Cell Cycle Regulators: ... one round of cell division, every cell in metazoans hasto decide whether it will re-enter the cell cycle, exit the cell cycle and en-ter a quiescence state, and every quiescent cell has to similarly...
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Senescence and Cell Cycle Control
... RA (1995) The role of Rb in cell cycle control. Prog Cell Cycle Res 1:9–19Senescence and Cell Cycle Control 259eliminates telomere-mediated signaling, allowing cells to undergo transform-ation ... ofretinoblastoma gene function is sufficient for cell cycle re-entry. Nature 424:223–228Serrano M, Hannon GJ, Beach D (1993) A new regulatory motif in cell- cycle controlcausing specific inhibition of ... and cell mortality. Cell 85:27–37Serrano M, Lin AW, McCurrach ME, Beach D, Lowe SW (1997) Oncogenic ras provokespremature cell senescence associated with accumulation of p53 and p16INK4a .Cell 88:593–602Sharpless...
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The ubiquitin-proteasome pathway in cell cycle control
... a transcription factor that is activated in response tovariety of cellular stresses, evokes a number of responses ranging from cell cycle arrest to programmed cell death, depending on the cell ... Probl Cell Differ (42)P. Kaldis: Cell Cycle Regulation DOI 10.1007/b136681/Published online: 6 July 2005© Springer-Verlag Berlin Heidelberg 2005The ubiquitin-proteasome pathway in cell cycle ... from studies on the early embryonic cell cycles ofTable 1 Cell cycle targets of the anaphase promoting complexSubstrate Organism Specificity factor Cell cycle functionSecurin S. cerevisiae...
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Tài liệu Báo cáo khoa học: Protein kinase CK2 activates the atypical Rio1p kinase and promotes its cell-cycle phase-dependent degradation in yeast pdf
... phase of the cell- division cycle. Therefore, we tested,using light microscopy and after DAPI staining, whetherthe slow growth yields a cell- cycle phenotype. Cells ofthe logarithmically ... asynchronouscells. To test whether phosphorylated Rio1p is, in fact,degraded at a certain stage of the cell- division cycle, whereas the unphosphorylated form is not, we per-formed cell- cycle arrest ... observeda cell- cycle phenotype with this mutant. Cytologicalapproaches investigating cell- cycle stages reveal thatthis mutant yeast strain accumulates G1cells, whereasthe number of S phase cells...
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Tài liệu Báo cáo khoa học: Molecular aspects of rheumatoid arthritis: role of transcription factors ppt
... pathological roles in RA.Other transcription factors Other transcription factors implicated in the patho-genesis of RA are the signal transducer and activatorof transcription (STAT) family of ... remarks Transcription factors play critical roles in the functionof immune effector cells, including cytokine ⁄ chemokineexpression and also in the control of synovial cell apop-tosis. These cells ... SAA in RA joints binds to RAGE on synovial cells and acti-vates the NF-jB signaling pathway in these cells.H. Okamoto et al. Role of transcription factors FEBS Journal 275 (2008) 4463–4470 ª...
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Tài liệu Báo cáo khoa học: Characterization of the promoter for the mouse a3 integrin gene Involvement of the Ets-family of transcription factors in the promoter activity doc
... integrin gene in these cells isregulated by the Ets-family of transcription factors. Keywords: integrin; gene promoter; luciferase assay;Ets -transcription factor; gastric carcinoma cell. The a3b1integrin(VLA-3) ... receptorthat mediates both cell- extracellular matrix and cell cell interactions. It has been suggested that this integrin is apromiscuous receptor for a variety of extracellular matrixproteins ... recently reported that these transcription factors regulated the expression of the aV integrin in mousemelanoma cells [54] and the a5 integrin in human gliomacells [55]. These factors have also been...
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