caspases bcl 2 family proteinsand other components of the death machinery their role in the regulation of the immune response
Báo cáo y học: "Conservation and divergence of gene families encoding components of innate immune response systems in zebrafish" pdf
... indicates independent duplication events in the pufferfish and zebrafish lineage The other set of genes that reliably group together are those encoding IL20R1, IL20R2, and IL -22 binding protein (IL22BP), ... and the three genes encoding the D200-containing proteins thrombopoietin and titin were eliminated from further analysis Gene predictions were available for eight of the remaining 12 genes Of the ... Structure of the amino-termini of the new zebrafish NLR proteins Structure of the amino-termini of the new zebrafish NLR proteins ClustalW alignment of the set of 70 predicted NLR proteins was...
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Báo cáo khoa học: Pituitary adenylate cyclase-activating polypeptide attenuates streptozotocin-induced apoptotic death of RIN-m5F cells through regulation of Bcl-2 family protein mRNA expression pdf
... features of apoptosis include the activation of one or more cysteine proteases of the caspase family [23 ] To examine the possible involvement of caspase-3 in the STZ-induced cell death in RIN-m5F ... down -regulation of Bcl- XL mRNA, they promoted expression of Bcl- 2 mRNA significantly According to these novel findings, the regulation of Bcl- 2, Noxa and Bax expression would be involved in the ... Pattou F (20 02) 1 ,25 -dihydroxyvitamin D3 protects RINm5F and human islet cells against cytokine-induced apoptosis: implication of the antiapoptotic protein A20 Endocrinology 143, 4809–4819 22 Konarkowska...
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Báo cáo khoa học: The proapoptotic member of the Bcl-2 family Bcl-2 / E1B-19K-interacting protein 3 is a mediator of caspase-independent neuronal death in excitotoxicity pot
... proapoptotic member of the Bcl- 2 family However, unlike in other members of the Bcl- 2 family, the BH3 domain of BNIP3 is not required for its death- inducing activity Our results showing that full-length, ... protein synthesis, we evaluated the effectiveness of the RNA synthesis inhibitor actinomycin D (1 lgÆmL)1) in preventing excitatory neuronal cell death As shown in Fig 4A, addition of actinomycin D ... Quantification of the western blot bands revealed a nine-fold increase of BNIP3 in KA-injected striatum There was a 3.5-fold increase in CL striatum of the injected animal as compared with striatum of uninjected...
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Báo cáo y học: "Coaggregation of Fc RI with Fc RIIB Inhibits Degranulation but Not Induction of Bcl-2 Family Members A1 and Bim in Mast Cells" ppsx
... Not Affect the Induction of A1 Apoptosis is regulated by members of the Bcl- 2 family A1, one of the antiapoptotic Bcl- 2 family members, is described as being important for the survival of mast cells ... apoptosis in mast cells.19 Antiapoptotic members of the Bcl- 2 family are needed for cell survival One of the murine prosurvival Bcl- 2 family members is A1, which plays a prominent role in preventing ... Foxo3a, which in its unphosphorylated state is located in the nucleus and acts as a transcription factor for Bim Bim is a proapoptotic protein of the Bcl- 2 family, involved in the regulation of mast-cell...
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Báo cáo khoa học: " AT-101, a small molecule inhibitor of anti-apoptotic Bcl-2 family members, activates the SAPK/JNK pathway and enhances radiation-induced apoptosis" pdf
... important role in the cytotoxic effects of AT-101 Proteins of the Bcl- 2 family mediate mitochondrial permeability and are therefore the key regulators of the intrinsic apoptotic pathways [36] Bcl- 2 proteins ... Bcl- 2 proteins contain regions of amino acid sequence similarity, known as Bcl2 homology (BH) domains The family consists of the anti-apoptotic Bcl- 2 group (such as Bcl- 2, Bcl- XL, Mcl-1), the pro-apoptotic ... Thus, the anti-apoptotic function of Bcl- XL /Bcl- 2 is largely attributed to their ability to interact with pro-apoptotic members of the Bcl- 2 family through the hydrophobic BH3 binding α helix, thereby...
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Báo cáo y học: "A poxvirus Bcl-2-like gene family involved in regulation of host immune response: sequence similarity and evolutionary history" pptx
... enhanced immune response in vivo (manuscript in preparation), indicating that this protein may also be involved in the regulation of the host immune response An early study revealed N2 location in the ... alpha-helix in Bcl- 2- like proteins Interestingly, this region corresponds to the Page of 12 dimerization interface in A 52, which differentiates from K7 in that it cannot bind DDX3 Like A 52, K7 binds the ... observed in N1, K7, B15 and A 52 structures and it can be predicted in other proteins from their sequences In N1 protein residues projecting outwards from alphahelix include Asp 22, Lys25, Lys26 and...
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Báo cáo khoa học: " Differential protection by wildtype vs. organelle-specific Bcl-2 suggests a combined requirement of both the ER and mitochondria in ceramide-mediated caspase-independent programmed cell death" docx
... construct Bcl- 2 cb5 (Fig 2A, B) contains the 35 amino acid insertion sequence of the ER-specific isoform of rat hepatic cytochrome b5, directing Bcl- 2 to the cytosolic face of the ER In addition, ... Oncology 20 09, 4:41 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 He S, Wang L, Miao L, Wang T, Du F, Zhao L, Wang X: Receptor interacting protein kinase-3 determines cellular necrotic response ... mitochondria and the ER, Bcl- 2 ActA targeted to mitochondria, Bcl- 2 cb5 expressed at the ER, and Bcl- 2 ΔTM localized in the cytosol The Bcl- 2 homology domains BH1-BH4 are indicated together with the transmembrane...
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báo cáo khoa học: " Expression of Ets-1, Ang-2 and maspin in ovarian cancer and their role in tumor angiogenesis" pps
... MJ: The paradoxical expression of maspin in ovarian carcinoma Clin Cancer Res 20 02, 8 :29 24 -29 32 doi:10.1186/1756-9966-30-31 Cite this article as: Lin et al.: Expression of Ets-1, Ang -2 and maspin ... 94:769-773 10 Yuan HT, Khankin EV, Karumanchi SA, Parikh SM: Angiopoietin is a partial agonist/antagonist of tie2 signaling in the endothelium Mol cell Biol 20 09, 29 :20 11 -20 22 11 Tse V, Xu L, Yung ... proteins in different parts of tissue samples Its major disadvantage is that it is impossible to show that the staining corresponds with the protein of interest as in the case of immunoblotting...
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Báo cáo y học: "hytol-based novel adjuvants in vaccine formulation: 2. assessment of efficacy in the induction of protective immune responses to lethal bacterial infections in mice" ppsx
... Efficacy of adjuvants in sustaining antibody response induced Efficacy of adjuvants in sustaining antibody response induced BALB/c mice in groups of or more were immunized at day 0, 10, 20 with ... Y, Nakane A: Interleukin-4 and interleukin10 are involved in host resistance to Staphylococcus aureus infection through regulation of gamma interferon Infect Immun 20 00, 68(5) :24 24 -24 30 Takano ... [6,7] Therefore, vaccines that interact with both components of the immune system have the ability to induce effective prophylaxis against a variety of infectious diseases In bacterial infection,...
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Mechanisms and functions of lymphangiogenesis in regulating the immune response and inflammation resolution 2
... VEGF-A expression was mainly confined to the subcapsular region of the LN The heparin-binding carboxyl-domain of the predominant VEGF-A isoform, VEGF164 may bound the molecule to the extracellular ... to further confirm and extend the role of neutrophils in driving lymphangiogenesis in a disease model of inflammation We choose to examine this in a chronic skin inflammation, in a model of cutaneous ... al., 20 09; Kubota et al., 20 09; Maruyama et al., 20 05; Yao et al., 20 10) and LNs draining the inflamed sites (Kataru et al., 20 09) DCs have been linked to the induction of lymphangiogenesis in...
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Báo cáo hóa học: " Elicitation of protective immune responses using a bivalent H5N1 VLP vaccine" pot
... 1/Clade rHA 4096 20 48 1 024 5 12 256 128 64 32 16 HAI (GMT; Log2) HAI (GMT; Log2) Clade VLP d In /0 VN /0 /0 ui nh A W S/ 05 /0 * In d VN /0 /0 ui nh 4096 20 48 1 024 5 12 256 128 64 32 16 A In d W S/ 05 ... vaccine expressing hemagglutinin-C3d fusion proteins Vaccine 20 03, 21 :9 02- 914 Couch R: Seasonal inactivated influenza virus vaccine Vaccine 20 08 in press Bright RA, Ross TM, Subbarao K, Robinson ... Impact of glycosylation on the immunogenicity of a DNA-based influenza H5 HA vaccine Virology 20 03, 308 :27 0 -27 8 15 18 19 20 21 22 23 24 Ross TM, Xu Y, Bright RA, Robinson HL: C3d enhancement of antibodies...
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Báo cáo hóa học: " Promotion of allergic immune responses by intranasally-administrated nanosilica particles in mice" pot
... allergic immune responses, indicating the immune- activating potential of nanomaterials [ 12, 13] However, the role of the different physical characteristics of nanomaterials in the production of allergic ... probes for targeting of T-lymphocytes Int J Nanomedicine 20 07, 2: 227 -23 3 Kagan VE, Bayir H, Shvedova AA: Nanomedicine and nanotoxicology: two sides of the same coin Nanomedicine 20 05, 1:313-316 ... binding was minimized by incubating the plates with 4% blocking solution (Block Ace; Antigen-specific cytokine responses were evaluated by culturing the splenocytes (5 × 106 cells/well) in the...
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PHYTOCHEMICALS – A GLOBAL PERSPECTIVE OF THEIR ROLE IN NUTRITION AND HEALTH potx
... identification of an authentic drug, in excluding the adulterants and in maintaining the quality and consistency of the drug HPLC fingerprinting includes recording of the chromatograms, retention time of individual ... Perspective of Their Role in Nutrition and Health pink or violet colour in the base layer indicates the presence of anthraquinones in the plant sample (Sarker & Nahar, 20 07) Salinos poramide Luteolin ... alkaloids in clinical use include the analgesics morphine and codeine, the muscle relaxant (+)-tubocurarine, the antibiotics sanguinafine and berberine, the anticancer agent vinblastine, the antiarrythmic...
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study on the immune response of orange spotted grouper (epinephelus coioides hamilton, 1822) cultured in khanh hoa province to bacteria vibrio parahaemolyticus
... virulence of the bacteria was determined by lethal dose 50% following the procedure according to Reed and Muench (1938) 2. 2 .2 The effect of oral administration β-glucan on non-specific immune responses ... Neutrophil 21 .5 2. 8a Monocyte 18.7± 8.0a 4 .2 ± 0.4 G1000 b 5.3 ± 0.4 23 .6± 4.4ab G2000 c 27 .9 ± 1.9b 6.0 ± 0.5c 27 .1 ± 3.3b 26 .4 ± 3.7ab 26 .5 ± 5.4ab 27 .6 ± 2. 5b Eosinophil 4.9 ± 2. 4a 5 .2 ± 1.3a ... acceptable environment in farming areas 2 Aims and contents of research 2. 1 Aims of research Study the immune response of orange-spotted grouper to Vibrio parahaemolyticus 2. 2 Contents of research ...
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Báo cáo khoa học: " Enhancement of protective immune responses by oral vaccination with Saccharomyces cerevisiae expressing recombinant Actinobacillus pleuropneumoniae ApxIA or ApxIIA in mice" pptx
... noninvasive in the gut in comparison to other biodegradable vehicles [2, 30] The yeast may also stimulate the host mucosal immune system by interacting with intestinal epithelial cells in the ... observed a large increase in antigen-specific IgA antibodies and the number of IgA-secreting cells in the intestine and lung Based on the findings of other reports [7,8,34], these results strongly ... groups remained unchanged (Fig 3B) Changes in IgA-secreting cells in the lung and intestine The number of IgA-secreting cells in the lung and intes- Fig Specific-IgA antibody responses to Actinobacillus...
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báo cáo khoa học: "A Review of Metallothionein Isoforms and their Role in Pathophysiology" ppsx
... to insulin Zinc can replace insulin in mammalian cells cultured in serum-free media [18] The actions of zinc are intracellular because zinc increases the phosphorylation state of the insulin ... beginning of training, showed a poorer rate of learning during the training period In addition, the MT-1/MT -2- null mice showed significantly less choice of accuracy than the parental strain [15] ... supplementation in both diabetic laboratory animals and in humans The above findings indicate that differences in the cellular availability of zinc in both insulin producing b-cells and in insulin target...
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Báo cáo y học: "Application of in vivo microscopy: evaluating the immune response in living animals" pps
... mobility in lymph nodes of living animals breathing either room air or 95% O2/5% CO2 In contrast, manipulations involved in the intravital approach including the trauma associated with anesthesia ... allow the tracking of specific cell types such as endogenous DCs in the steady state [18] The ideal goal, of course, is to image single immune cells within their undisturbed environment in an intact ... particularly between 24 and 72 hours after transfer [18] These data are in line with other published reports describing a random DC ‘crawling’ with average speeds of 2. 7 to 6.6 mm/min [23 ,25 ,37,38] At...
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Báo cáo y học: " Characterisation of the immune response to type I collagen in scleroderma" pps
... Arthritis Research & Therapy Vol No Warrington et al Cell line cytokine profile We were interested in comparing the Th1 and Th2 cytokine secretion profile of CI-specific cell lines Cell lines generated ... play a role in modulating the homeostasis of extracellular matrix in SSc Indeed, TNF-α prevents the transforming growth factor-β-induced upregulation of α -2( I) collagen and tissue inhibitor of metalloproteinases ... detected interferon (IFN)-γ staining but no interleukin (IL)-4 staining Multiplex cytokine assay was used to analyse the cytokine profile of three T-cell line supernatants (b) An excess of Th1...
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Báo cáo y học: "Dynamic activation of bone morphogenetic protein signaling in collagen-induced arthritis supports their role in joint homeostasis and disease" ppsx
... 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 in rheumatic diseases Best Pract Res Clin Rheumatol 20 06, 20 : 829 -848 Lories RJ, Luyten FP: Bone morphogenetic protein signaling in joint homeostasis ... magnified in BMP2 stainings Arrows indicate BMP2-positive cells in synovium Bars = 20 0 μm (a, c, e, g) and 25 μm (b, d, f, h) their in vitro data, they concluded that a decrease in the cartilage ... mg of CII) was injected intradermally at the base of the tail At day 21 after immunization, mice received an intraperitoneal booster injection of 100 μL of CII (2 mg/mL) At day 25 , the onset of...
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Báo cáo y học: "Modulation of humoral immune response to oral BCG vaccination by Mycobacterium bovis BCG Moreau Rio de Janeiro (RDJ) in healthy adults" ppsx
... tuberculo- Page of (page number not for citation purposes) Journal of Immune Based Therapies and Vaccines 20 06, 4:4 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 sis: delay in dissemination and ... vaccination results in a greater number of individuals capable of responding to skin testing, but the durability of this response varies between individuals and the diameter of induration diminishes ... of altering the immune response to the cellular arm (Th1), critical for protection against infection, without failing to stimulate the humoral immune response (Th2) necessary for control of the...
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