... Environmental Auditing in 1992, the Working Group on Programme Evaluation in 1992, the Working Group on Privatization in 1993, and the Working Group on the Audit ofInternational Institutions in 2001, ... highest inthe system of standards, contains the founding principles of government auditing. Specifically it includes the Lima Declaration adopted at the 9th INCOSAI in 1977, because the Lima ... the relationship between documents defining the principles of government auditing and those defining more detailed auditing procedures is unclear. Thus, INTOSAI is now considering integrating...
... existing on the aesthetic value assigned (aswell as their frequency of use).2. Determine therole that the restorative capacity of a place (in terms ofthe ART) may exercise in itsaesthetic ... place themselves on the otherside ofthe aesthetic spectrum and name, in theiropinion, the three ‘‘most unattractive’’ places in the city. These places were assessed with the samevariables as the ... representativeness of each ofthe categories established inthe list of the most attractive and unattractive places in the city (those inthe first place), from the percentage of responses in each category.The...
... Schematic representation ofthe roles ofthe FadD proteins encoded by the DIM + PGL locus inthe biosynthesis of DIMs and relatedcompounds in Mycobacterium tuberculosis. Theroleofthe activation enzymes ... [16,18].To examine the involvement of FadD29 inthe bio-synthesis of DIMs and PGLs, we took advantage of the existence inthe laboratory of an M. tuberculo-sis H37Rv recombinant strain, harboring an ... progress in our knowledge ofthe bio-synthesis of DIMs and PGLs, thein vivo functions of these FadD proteins in this pathway remain to beestablished and ⁄ or completed. For instance, the involvement...
... comprehensive overview ofthe rise, role and status of these private product safety standards inthe legal regulation of integrating markets. Ininternational and regional trade law as in European and ... increasingly replacing their regulationswith private standards. This is a book about the interrelationships between law and standards in the regulation of integrating markets. It deals with the interactionbetween ... for a “World (Internal) Law”? Legal Developments in a Changing International System’ (2002) 9 Ind J Glob Leg S 401, 402 ( In short, international law is inthe process of trans-forming, at least...
... 60m in depth. The deepest area (70m) is inthe Andaman Sea at the northern tip of the Straits, while the shallowest is at the One Fathom Bank inthe south. The current predominantly flows in ... establishment of artificial reefs with the hope of creating a new breeding ground for marine fishes. A study by Zainuddin and Razak (2000) and recent evidence on the increase in marine landings on the ... governing the use of wetlands and mining are still inadequate due to the absence of clear guidelines, standards or benchmarks for sustainable utilization ofthe resource. 2.4.2 Living Marine...
... appearsstronger in G2⁄ M than in G1[44]. This contradictsrepression through a complex in G1and in vivo foot-printing results inthe original definition ofthe sites[10]. Taken together, the sites in ... Dimethyl sulfate footprint-ing ofthe CDE inthe presence of SV40 large T indi-cated a loss of protein occupation on this site in vivo[79].Elevated expression of cyclin A, cyclin B, Cdc25Cand Cdc2 ... functional mapping ofthe cyclinB1 promoter did not yield the class II CHR as the sitethrough which Lin-9 exerts its control [94]. In anotherreport, depletion of Lin-9, Lin-37, Lin-52 or Lin-54 byRNAi...
... TGF-aD152 (lacking the lasteight amino acids ofthe ICD) compared to the TGF-aD158 construct lacking only the last two valine resi-dues, suggesting a role for an internal motif in the interaction ... identified the EWV614motif in MT5-MMP ICD as comprising animportant sequence for the interaction with the PDZproteins: Mint-3, AMPA binding protein and gluta-mate receptor interacting protein (GRIP). ... lane 4), therefore confirming the interaction of these two proteins previously observed biochemically[37] or using a yeast two-hybrid assay [39]. Interestingly, in the M2H system, the interaction...
... folding ofthe mutant. The lowerintensity may arise from partitioning ofthe proteininto an aggregated state. The effect of copper binding on the secondary struc-ture was determined using CD in ... human cystatins.Further support for the premise that the C-terminuscould be the copper binding domain comes from stud-ies ofthe P79S mutant, which differs from the copperbinding forms of stefin ... important inthe brain, there-fore theroleof copper binding or loss of its bindingcould be related to specific cerebellar function(s) of stefin B [18], which remains to be seen by more in vivostudies.Stefin...
... demonstrates the important roleof GALA in the degradation of both linear andL-arabinose-substitutedgalactan side chains of pectin. This is in agreement with aprevious study in which the synergy of ... under the control ofthe xylanolytic activator protein [32,41]. The increase in expression levels of galA inthe CREA mutant,indicates that at least one ofthe detected putative CREAbinding sites ... synergy of enzymes degrading the pectin side chains was studied [34]. GALA had a positiveeffect on the activity ofthe other enzymes involved in the degradation of these side chains.DISCUSSIONA....
... of GSK3 (using Li or SB-415286)appears to be sufficient for inducing activation of GS in muscle and fat cells, and that inhibition ofthe kinasepotentiates insulin action in muscle of insulin-resistant ... (1994) The inhibition of glycogensynthase kinase-3 by insulin or IGF-1 inthe rat skeletal muscle cellline L6 by wortmannin, but not rapamycin: evidence that wort-mannin blocks activation ofthe ... phosphatidylinositol3-kinase, p70, S6 kinase and glycogen synthase kinase-3 activity in L6 muscle cells: evidence for the involvement ofthe mammaliantarget of rapamycin (mTOR) pathway in the L-leucine-inducedup-regulation...
... 20 lL ofthe enzyme/inhibitor mixture to 180 lLofsubstrate (4NPGlc), incubating for 30 min at 37 °C, andmeasuring the rel ease of 4NP.Protein assays and protein sequencingTotal protein in crude ... rate of 1 mLámin)1 .The following gradients were used: incubations containingarbutin or salicin as substrate; 100% C initial, i ncreasingD t o 2 0% (10 min), 50% ( 15 min), 100% (5 min), held ... oleuropein (olives). The fourth general property of enzymes involved in transformation of xenobiotics isincreased enzyme levels inthe presence of xenobioticsubstrates, i.e. inducibility. Cloning the...
... likelythat the increased rate of 13C label incorporation into the C6position of glycogen inthe ADM group is indicative of activated 6-phosphofructo-1-kinase, which can lead toincreased13C labeling ... labeling at the triose level. Such a mechanismcan lead to increases in labeling of glycogen C6 even in the presence of decreased activity ofthe indirect pathway,provided that the increase in glycolytic ... achieved inthe intactliver in vivo. The importance ofthe detection of labelincorporation into glycogen C6 while infusing [1-13C]glu-cose can be appreciated from the fact that this labelingpattern...