bioinformatics search of atox1 consensus sequences and response elements in the promoter of genes involved in dna damage response and antioxidant defense
Role of poly (ADP ribose) polymerase 1 and copper homeostasis factor, antioxidant protein 1 in the maintenance of genomic integrity
... significantly upregulated upon DNA damage in ATOX1 deficient cells 132 3.3.9 ATOX1 consensus sequences present in some genes involved in DNA damage response and antioxidant defense .133 Chapter ... sequences and response elements in the promoter of genes involved in DNA damage response and antioxidant defense viii List of Figures • Figure 1: Telomere structure • Figure 2: The telomeric end replication ... cellular necrosis and leakage of copper into the plasma and deposition of copper in extra hepatic tissues, including the limbus of the cornea and the basal ganglia of the brain (Culotta, 2001)...
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Tài liệu Báo cáo khoa học: Functional hierarchy of plasminogen kringles 1 and 4 in fibrinolysis and plasmin-induced cell detachment and apoptosis docx
... Lysine ⁄ fibrin binding sites of kringles modeled after the structure of kringle of prothrombin Proteins 3, 85–96 20 Thorsen S (1975) Differences in the binding to fibrin of native plasminogen and ... was further explored by measuring the effect of the mAbs on the interaction of purified plasmin and Lys-Pg with fibrin and cells The binding of Lys-Pg was partially inhibited by both 34D3 and A10.2 ... effects of intact mAbs, including the reproduction of 3390 similar results with their Fab fragments and the absence of effect on plasminogen binding and activation in the presence of the unrelated...
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Tài liệu Báo cáo Y học: Binding of gelsolin domain 2 to actin An actin interface distinct from that of gelsolin domain 1 and from ADF/cofilin pptx
... gelsolin S2 sequences (and homologue S2 equivalents) within residues 197–226 (including the long helix of the domain) and within residues 161 – 172 (including the A strand and the AB loop in S2) in ... and 347–365 interacted significantly with the gelsolin fragment The activities of overlapping peptides within the C-terminal of actin towards Fig Determination of actin sequences involved in the ... that S2 binds actin with a similar interface as S1 in addition to binding around the DNAse1 binding site in subdomain of actin The Puius model is attractive in that proposing two actinbinding sites...
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An Equilibrium Model of Rare-Event Premia and Its Implication for Option Smirks potx
... over P b instead of P finds the jump-magnitude aspect of the model unreliable, while having full faith in the jump-timing aspect of the model Finally, by letting a ¼ and b ¼ 0, we reduce the set ... uncertainty averse in the sense of Knight (1921) and Ellsberg (1961), then the uncertainty about rare events will eventually find its way into financial prices in the form of a premium To formally investigate ... show that the pricing kernel is indeed of the form in Equation (E.27) Let J be the indirect utility function, which is a function of the state variables including the wealth process W and other state...
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Báo cáo Y học: Structural and serological relatedness of the O-antigens of Proteus penneri 1 and 4 from a novel Proteus serogroup O72 pptx
... attachment of other, minor O-acetyl groups were not determined Judging from the ratio of integral intensities of the signals for the O-acetyl and N-acetyl groups in the 1H NMR spectrum, the total ... assigned on the basis of the H6/C6 correlations, which were observed in the H-detected 1H,13C HMQC spectrum The spin system of Glc was distinguished from those of Gal and GalNAc on the basis of the 3JH,H ... con®guration of the Gal residue [19] Signi®cant low-®eld displacements of the signals for C6 of Glc, C3 and C4 of Gal, and C3 of GalNAcI to d 66.8, 81.3, 77.1, and 81.6 in the 13C NMR spectrum of the...
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Báo cáo khoa học: Inhibitors of protein phosphatase 1 and 2A decrease the level of tubulin carboxypeptidase activity associated with microtubules pptx
... were incubated in vitro, and carboxypeptidase activity was inferred from the increase of the reaction product, detyrosinated tubulin (Glu-tubulin), as a function of incubation time The slope of the ... microtubules, and continued the culture of intact cells The amount of Glu-tubulin in cells was measured as a function of time in culture following addition of taxol The amount of Glu-tubulin was directly ... integrated intensity of the corresponding immunostaining with the aid of the METAMORPH IMAGING SYSTEM (Version 4.6r5) For a determined field, the value of integrated intensity of Glu-microtubules...
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báo cáo hóa học:" Gene and microRNA analysis of neutrophils from patients with polycythemia vera and essential thrombocytosis: down-regulation of micro RNA-1 and -133a" pot
... is indicated by the bar and is expressed as -1 times the log of the p value The line represents the ratio of the number of genes in a given pathway that meet the cutoff criteria divided by the ... sights into the molecular changes in ET and PV PV and ET neutrophils were characterized by the down-regulation of miR-1 and miR-133a and changes in the expression of many genes involved in inflammation ... V617F and the development of MPD [1,9] Further characterization of the molecular changes in MPD neutrophils could lead to a better understanding of the development of these diseases and their clinical...
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Báo cáo toán học: "Graphs Associated with Codes of Covering Radius 1 and Minimum Distance 2" ppsx
... Method Let Gα be the subgraph of G containing all the vertices of G but only the edges of colour α We are only interested in the structure of colours within the graph; permuting colours will ... characteristics of the OQW-graphs, and can use them in the search for Kq (n, R, d) and Aq (n, R, d) BR (C), the ball of radius R around a code is the union of balls of radius R around the codewords ... corresponds to equivalence in codes: permutation of the rows, the columns and the symbols in L corresponds to permuting the symbols in each of the positions in C; permutation on the set {row, column,...
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Báo cáo khoa học: "Consequences of an excess Al and a deficiency in Ca and Mg for stomatal functioning and net carbon assimilation of beech leaves" ppt
... specific inhibitor of inward K channels in the plasmalemma of the guard cells [33], and may have limited K influx However, the reduction in gw was not significantly higher than in –CaMg plants, and the ... K+ fluxes between the guard cells and the epidermal cells On the other hand, such investigation gives no information about Ca2+ and Al3+ concentrations in the apoplast or in the cytosol 2.4 Statistical ... s-1) Aluminium, stomata and photosynthesis in beech of both chl a and chl b concentrations was recorded in the leaves of +Al, –CaMg and +Al–CaMg plants to about 40% of the control values The ratio...
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Báo cáo y học: "Thymic function and T cell parameters in a natural human experimental model of seasonal infectious diseases and nutritional burden" potx
... dilutions of standards containing telomeric DNA of known concentration were prepared by doubling dilution Sample DNA and standard were then placed in 0.2 μl tubes and heated at 95°C for minutes, and then ... conducive to the propagation of infections We predict that the exposure of both the mothers and their fetuses during pregnancy, and of their babies after birth, to deprivation and infectious burden ... hungry/high infection or harvest/low infection season for each of the 24 TCRVb types is determined by expressing the sum of the fluorescence intensities of each TCRVb type as a percentage of the total of...
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báo cáo khoa học: " FCR (Fludarabine, Cyclophosphamide, Rituximab) regimen followed by 90yttrium ibritumomab tiuxetan consolidation for the treatment of relapsed grades 1 and 2 follicular lymphoma: a report of 9 cases" pot
... utilized in the majority of patients during FCR treatment, and in all of them after 90 Y-RIT Despite the high incidence of grade or neutropenia there were no patients requiring hospitalization for infection ... combination therapy [3]; even if in our two patients there is no proof that this conversion was due to RIT and not to a late response to FCR In the FIT study close to 17% of the patients in the ... of 60-75 and earlier in first relapse; further studies will help to clarify the best strategy for incorporating RIT into the treatment algorithm of these patients Abbreviations FCR: fludarabine...
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Báo cáo y học: "An exploration of how clinician attitudes and beliefs influence the implementation of lifestyle risk factor management in primary healthcare: a grounded theory study" pot
... extensive use of participant quotes, and discussing coding frameworks and preliminary theoretical ideas with two other members of the research team (MH and LK) for the purpose of gaining other perspectives ... including community nurses, and registered and licensed practical nurses in USA and Finland, have also reported the importance of clinician beliefs and attitudes, mirroring the findings in general ... role, influencing 'if and when' clinicians address lifestyle issues, the amount of time they are willing to invest, and the scope of their practice (type of risk factors addressed and frequency in...
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Báo cáo y học: " Molecular characterization of genome segments 1 and 3 encoding two capsid proteins of Antheraea mylitta cytoplasmic polyhedrosis virus" pps
... directly interacting with viral RNA indicating the role of capsid in RNA packaging, replication and transcription [17] Therefore, understanding the assembly of capsid not only provides insight into in ... kDa protein remains associated with it and plays an important role in maturation of virus particles by maintaining the stability and integrity of the capsid protein Since the stability of native ... work and contributed to the writing of the manuscript All authors read and approved the final version of the manuscript Competing interests The authors declare that they have no competing interests...
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Báo cáo y học: "Transcriptional regulation of matrix metalloproteinase-1 and collagen 1A2 explains the anti-fibrotic effect exerted by proteasome inhibition in human dermal fibroblasts" docx
... results in a specific increase in binding of cJun to the most proximal AP-1 site of the MMP-1 promoter We next investigated whether binding of c-Jun to the MMP-1 promoter in the presence of bortezomib ... transcription of the MMP-1 gene depends on enhanced binding of c-Jun to the most proximal AP-1 binding site of the MMP-1 promoter On the other hand, we have shown that inhibition of SP1 binding to the promoter ... (ORFs) of the MMP-1 or COL1A2 genes (Figure 6a, b) In conclusion, the effect of PI dominates the influence of TGF-β in controlling the binding of both SP1 to COL1A2 and c-Jun to MMP-1 Discussion The...
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Báo cáo y học: "Heliox improves pulmonary mechanics in a pediatric porcine model of induced severe bronchospasm and independent lung mechanical ventilation" pdf
... of asthma and the variability of disease between patients and their response to therapy makes the study of a single agent during acute, severe bronchospasm difficult to extrapolate to the clinical ... assistance and support in completing this project References Barach A: The use of helium in the treatment of asthma and obstructive lesions in the larynx and trachea Ann Int Med 1935, 9:739–765 ... variability in lung response to methacholine challenge and inability to accurately discriminate between the effect of a lower density gas on the resistance generated by the endotracheal tube, large and...
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Báo cáo y học: " A mechanistic model of infection: why duration and intensity of contacts should be included in models of disease spread" ppt
... may then affect the model behaviour in various ways (e.g., altering the shape of the epidemic curves or changing the predictions of the effectiveness of intervention measures) In particular, the ... justified The average dose of infectious material that is ingested by an individual is a linear function of the duration and intensity of the contact with an infectious individual Research has ... duration and contact intensity are interrelated, thereby allowing an interpretation of how the consideration of the contact intensity might alter the findings presented in Figures 1ad and Figure shows...
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Báo cáo y học: "A continuum mathematical model of endothelial layer maintenance and senescence" ppsx
... correlation of the aging of the organism to the aging of the EC wall The aim of the present paper is to develop a continuum mathematical model of the EC layer, incorporating maintenance and damaging ... that, indeed, platelets may be involved in the recruitment of EPCs as well as in the stimulation of proliferation and migration of non-senescent ECs surrounding the wound Since the clotting process ... model to study the rates of filling up holes in the endothelia of persons of different ages We start with the spatial profile of the holes defined by Eq (10); this profile is plotted in Figure h(x,...
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The roles of histone deacetylases 1 and 2 in hepatocellular carcinoma
... affecting the binding of transcription factors and methyl-binding proteins The hypermethylation at the promoter results in the silencing of numerous tumor-suppressor genes as well as other cancer-associated ... distinct functions of HDAC1 and and they will be discussed in subsequent sections 1.8.2 Structure The HDAC1 and proteins contain several domains The largest and most important of these is the ... understanding the role of a protein in the development and progression of cancer is to compare its expression in the tumor to that in the normal tissue To establish the clinical significance of HDAC1...
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Báo cáo y học: "Patients'''' recollections of experiences in the intensive care unit may affect their quality of life" doc
... aware of their condition until late in their ICU stay and some of them only after their discharge to the ward However, during their ICU stay they continue to have an emotional life, in a mixture of ... stress in our patients This can be explained by the traditionally strong family ties in the Portuguese culture Pain came in fourth place in the ranking of stressors This finding, together with the ... advised for the search of neuropsychological consequences in critical patients and contributed to the final interpretation of these consequences on the final manuscript CD undertook the statistical...
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Tìm thêm: hệ việt nam nhật bản và sức hấp dẫn của tiếng nhật tại việt nam xác định các mục tiêu của chương trình khảo sát các chuẩn giảng dạy tiếng nhật từ góc độ lí thuyết và thực tiễn khảo sát chương trình đào tạo của các đơn vị đào tạo tại nhật bản điều tra với đối tượng sinh viên học tiếng nhật không chuyên ngữ1 khảo sát thực tế giảng dạy tiếng nhật không chuyên ngữ tại việt nam khảo sát các chương trình đào tạo theo những bộ giáo trình tiêu biểu nội dung cụ thể cho từng kĩ năng ở từng cấp độ xác định mức độ đáp ứng về văn hoá và chuyên môn trong ct phát huy những thành tựu công nghệ mới nhất được áp dụng vào công tác dạy và học ngoại ngữ mở máy động cơ lồng sóc mở máy động cơ rôto dây quấn đặc tuyến hiệu suất h fi p2 đặc tuyến tốc độ rôto n fi p2 đặc tuyến dòng điện stato i1 fi p2 động cơ điện không đồng bộ một pha sự cần thiết phải đầu tư xây dựng nhà máy thông tin liên lạc và các dịch vụ phần 3 giới thiệu nguyên liệu chỉ tiêu chất lượng theo chất lượng phẩm chất sản phẩm khô từ gạo của bộ y tế năm 2008