benefits and when their value can be measured reliably where the value must be estimated the use of reasonable estimates should not diminish the reliability of the value the following in particular should be noted
... inhibitors ofthe HIV reverse transcriptase and protease Depending on the HIV disease stage andthe level of HIV viral control over time, theuseof HAART results in an increase inthe number of CD4+ ... repertoire followingthe treatment of this chronic infection [34] The increase in CD4+ T-cell counts coincides with the decrease in several ofthe AIDS-defining illnesses arising from opportunistic infections ... Screening and treatment options for CIN and cancer are well established and consequently the incidence of cervical cancer in HIV-positive women has not increased followingthe implementation of...
... theValueofthe Target Company Thevalueofthe target company is calculated by multiplying the ratio obtained in (3) by the weight ofthe company to be valued obtained when applying (1) The ... with the principle the more the better”, the inverse of both the criteria included inthe group of inputs andthe default rate is calculated 160 European Journal of Economics, Finance And Administrative ... c ij wj of each ofthe criteria, the weighting ofthe different companies is (2) where xi is the weighting ofthe company i , wj is the weight ofthe criteria j , c ij is thevalueofthe criteria...
... online correctness testing Moreover, online fault injection and load testing require a performance- and reliability- isolated subset ofthe production service to be used, because ofthe threat they ... software In theory both of these factors should tend to decrease the failure rate of backend software, and indeed Online, the one site that used off -the- shelf back-end software, was also the site ... issue because the remote mirroring still ensured the existence of one backup copy ofthe data One night, the disk holding the primary copy ofthe problem tracking database failed, leaving the backup...
... change their credits, the amounts claimed on their original returns shouldbethe best estimate oftheir expectations For taxpayers that know they may be stretching the rules with some ofthe expenses ... expenses they are trying to claim as QREs, their post-exam credit amounts may be better estimatesoftheir expectations In other cases, given the lack of clarity in certain aspects ofthe definitions ... taxpayer cannot use all of its credit inthe current tax year or carry it back to use against last year’s taxes, then the net present valueofthe benefit is reduced according to thefollowing formula:...
... language The test interface gave them the labels andthe definitions ofthe 16 attitudes (in the native language ofthe listeners) No listener expressed any difficulty in understanding the concepts of ... syllable (F0_final_slope, Int_Final_slope) andthe slope of whole sentence (i.e., the mean valueofthe last syllable minus the mean valueofthe first syllable: F0_slope, Int_slope) For the syllabic ... either Vietnamese, French listeners or both of them may be explained by the assumption that such kinds of attitudes cannot be distinguished satisfactorily from others on the basis of audio information...
... placing a single soybean leaflet inthe 1I assimilation chamber ofthe LI6200 and allowing the leaflet to remove C0 until the compensation point was reached Assimilation rate, conductance and internal ... compensation point and correct each assimilation measurement as the chamber C0 mole fraction declines Both corrected and uncorrected data canbe stored Chamber leaks canbe modeled by thefollowing expression: ... temperature increases can often be held to under 2-3°C The data of Brooks and Farquhar (1985) on spinach indicate that a 2°C temperature increase at 30°C would cause a 7% increase inthe photorespiratory...
... narrowing score over thefollowing year (for example, a relative increase of 6.4% inthe joint space narrowing score during the next year caused by a one standard deviation increase inthe C2C value ... are Page of (page number not for citation purposes) necessary to better determine the clinical valueofthe biomarkers used in our investigation In these studies the predictive ability of biomarkers ... was 0.98, indicating excellent agreement [4] The total radiographic damage score is the sum ofthe joint space narrowing andthe erosion scores of both hands and feet, ranging between and 448 (a...
... to CRT, and thus canbe used as a predictor ofthe clinical effectiveness of CRT for advanced rectal cancer For the cases with low TIL, other anti-cancer drugs may be useful instead of 5Fu based ... were obtained at 3-17 days before the start of CRT, and serial-step sections ofthe biopsy samples were cut with μm width, fixed in 10% formalin solution, then embedded in paraffin, stained with ... tumors in clinical settings, the detailed mechanisms ofthe antitumor effects have not been fully elucidated Since the first report in 1979 [11], it has been proposed that tumor shrinkage is not...
... Expression of ICAM-1, MCP1, TNF-a, and tissue factor increased inthe I+G group compared with the control group (Figure 8A) Interestingly, increased expression of MCP-1 and ICAM-1 were also notedinthe ... These results indicate that statin treatment significantly enhanced the expression of eNOS and phosphorylation of Akt, and that the therapeutic effect of statin in ameliorating the thrombus formation ... respectively Note that the formation of a large mural thrombus in I+G heart (E and F) Obvious fibrosis near the endocardium was notedinthe I+G heart (F), but notinthe iron only group (E) (G and H)...
... monitoring of outcomes is becoming increasingly feasible in health care, and with it the hope of early detection of problems andthe ability to tell whether interventions are having their desired effect ... assessment of [a risk adjustment] tool calibration as ofthe clinical process of care Where a change is signaled, either the model fit or the clinical milieu may have changed.’ Real-time monitoring of ... control as practiced in industrial settings is conceived of as having three parts [5], monitoring the process, identifying the reasons for deviations inthe process and taking corrective action...
... professionals can withstand the temptation to intervene when they are faced with the patient who wishes not to be resuscitated Rather than perceiving that they are doing nothing, something has indeed been ... specifying an outline ofthe patient’s goals and objectives; or it could be left in place, detailing an exhaustive list ofthe procedures and Page of (page number not for citation purposes) interventions ... physician taking over the care of a new patient; they will err on the side of treating aggressively unless certain that they should otherwise Moreover, there are significant discrepancies between...
... professionals can withstand the temptation to intervene when they are faced with the patient who wishes not to be resuscitated Rather than perceiving that they are doing nothing, something has indeed been ... specifying an outline ofthe patient’s goals and objectives; or it could be left in place, detailing an exhaustive list ofthe procedures and Page of (page number not for citation purposes) interventions ... physician taking over the care of a new patient; they will err on the side of treating aggressively unless certain that they should otherwise Moreover, there are significant discrepancies between...
... their relationships with intensivists The main wishes of GPs concerning their patient's ICU stay were to be informed of patient ICU admission, preferably by a phone call, and to be involved in ... collaboration between intensivists and GPs, the present study aimed at assessing the opinions of GPs about their relationships with intensivists Page ofand two epidemiologists (TM and PFP)) and was ... date of degree certification, onset of professional activity, working area, population of working city, and distance between their office andthe nearest university hospital ICU In addition, information...
... each other Clifford: Now I’m the one who’s not understanding Mink: What I mean is that Greg is always complaining that chemists can t understand one another because the physical chemists speak ... important area of biology and end with a list of some ofthe major outstanding problems in that area and what sort of things would help get them solved That way, people from other disciplines who might ... I think that Greg’s forgotten something very important He’s forgotten that inthe age of genomics, when biology is becoming more quantitative and depending more and more on new techniques and...
... has been proposed that the glypicans in lipophorins may promote the formation of ligand-receptor complexes inthe target cells [6] In addition to their localization on the cell membrane andinthe ... environment, glypicans can also be found inthe cytoplasm In particular, there have been several studies reporting the presence of GPC3 inthe cytoplasm of liver cancer cells [34,35] Whether cytoplasmic ... glypicans can bind to Wnts and to Frizzleds [16,18,22,36], and that transfection of glypicans increases the Wnt-binding capacity ofthe transfected cells [22] Inthe case of Hhs, it has been...
... molybdate-binding domains (MOP) The functions of these chimeric molybdatebinding proteins, andthe mechanism of Mo-sensing by DNAbinding ModE domains inthe Desulfovibrio species, are not clear ... is involved in indirect regulation by forming inactive heterodimers with two other FUR proteins Scanning the genomes with the FUR-box profile of E coli did not result in identification of candidate ... Genes ofthe first part ofthe pathway, involved inthe corrin ring synthesis are shown as yellow arrows, the genes required for the attachment ofthe aminopropanol arm and assembly ofthe nucleotide...
... comparisons.14 The set of indicators does not include thebenefitsof increased electricity supply This is not because they are unimportant—they are—but because demand, including for rural electrification, ... energy sources are not working, e.g., whenthe sun is not shining for solar power, andwhenthe wind is not blowing for wind power Description ofthe Scenarios Unsurprisingly, under the energy efficiency ... tripling of demand inthe GMS, there is a perception that the demand forecasts within each country inthe GMS are overestimated and are often incompatible with those of other countries within the...