... 052. ApproachtothePatient with a Skin Disorder (Part 1) Harrison's Internal Medicine > Chapter 52. ApproachtothePatientwith a Skin Disorder APPROACH TOTHEPATIENTWITH ... assume that the erosion is the primary lesion andthe redness and scale are secondary, while the correct interpretation would be that thepatient has a pruritic eczematous dermatitis with erosions ... Fig. 52-3) andto formulate a differential diagnosis (Table 52-4). For instance, the finding of scaling papules (present in patients with psoriasis or atopic dermatitis) places thepatient in...
... elicits the desire to scratch. Pruritus is often the predominant symptom of inflammatory skin diseases (e.g., atopic dermatitis, allergic contact dermatitis); it is also commonly associated with ... Table 52-3 Common Dermatologic Terms A schematic representation of several common primary skin lesions (see Table 52-1). Chapter 052. ApproachtothePatient with a Skin Disorder (Part ... epidermal atrophy). Scar: A change in the skin secondary to trauma or inflammation. Sites may be erythematous, hypopigmented, or hyperpigmented depending on their age or character. Sites on hair-bearing...
... MD; with permission.)[newpage] APPROACH TOTHE PATIENT: SKIN DISORDER In examining the skin it is usually advisable to assess thepatient before taking an extensive history. This way, the ... highly with diagnosis (Fig. 52-6). For example, a hospitalized patientwith a generalized erythematous exanthem is more likely to have a drug eruption than is a patientwith a similar rash limited ... important individual skin lesions and make it possible to assess the distribution of the eruption accurately. The Chapter 052. ApproachtothePatient with a Skin Disorder (Part 4) Figure...
... is characterized by small and large erythematous papules and plaques with overlying adherent silvery scale. Figure 52-8 Chapter 052. ApproachtothePatient with a Skin Disorder (Part...
... lesions with a generalized arrangement are common and suggest a systemic etiology. Figure 52-9 Erythema multiforme. This eruption is characterized by multiple erythematous plaques with ... represents a hypersensitivity reaction to drugs (e.g., sulfonylamides) or infections (e.g., HSV). (Courtesy of the Yale Resident's Slide Collection; with permission.) Figure 52-10 ...
... against the surface of the skin and rotated with downward pressure until it penetrates tothe subcutaneous tissue. The circular biopsy is then lifted with forceps, andthe bottom is cut with iris ... of systems 9. Family history (particularly relevant for patients with melanoma, atopy, psoriasis, or acne) 10. Social, sexual, or travel history as relevant tothepatient DIAGNOSTIC TECHNIQUES ... gently with a no. 15 scalpel blade, andthe removed scale is collected on a glass microscope slide then treated with 1 to 2 drops of a solution of 10–20% KOH. KOH dissolves keratin and allows...
... in their published work and were not able to overcome the emerging division of labor between religious and theological studies, on the one hand, andthe anthropology of religion, on the other ... E” The two approaches tothe study of “religious experience,” which I will refer to as the sui generis model andthe ascription model, are summa-rized in table 1.1. They differ over whether there ... which the religiousness of the experience is understood to be inherent (sui generis) in the experience itself andthe other in which it is viewed as ascribed to it. I will opt for the latter approach...
... will thenbe possible to identify the appetite or attitude to that type of risk, together withthe capacity of the organisation to withstand that risk. Finally, the organisation can determine the ... need to understand the risks being taken when seeking to achieve objectives and attain the desired level ofreward. Organisations need to understand the overall level of risk embedded within theirprocesses ... responses. The objective is to achievemaximum sustainable value from all the activitiesof the organisation. Risk management enhances the understanding of the potential upside and downside of the factors...
... of these cytochromes have been proposed to be ter-minal Fe(III) and Mn(IV) reductases, although their role in the reductionof other metals is less well understood. To obtain more insight into ... anaerobicgrowth on either of the electron acceptors U(VI) and Se(VI) is due tothe decaheme cytochromes c notrecognizing either of these electron acceptors, weprobed the relative affinities via ... involved in the reduction of either Fe(III) or Mn(IV) in MR-1 isthought to be composed of cytochromes and a qui-none, located in both the cytoplasmic membrane(CymA and menaquinone) andthe outer...
... substrate client protein [the latterprobably as a complex with Hsc70 and Ydj1(Hsp40)]. ATPbinding tothe Hsp90 N-terminal domains in the Hsp90dimer then causes these N-domains to associate [32]. ... change may also be the signalfor Hsc70, Ydj1 and Sti(Hop) to be displaced from the complex and for other cochaperone proteins, includingSba1(p23), to bind so as to produce the later multiproteincomplexes ... streaked onto plates containing GA and RD. This revealed the Dpdr5 mutant to be hypersensitive to both drugs andthe Dsnq2 mutant to be slightly sensitive to RD (Fig. 4B). Pdr5p is a broad-specificity...