applications of pharmacokinetic pharmacodynamic models for the development of antimicrobial agents
Báo cáo y học: " Risk factors for the development of nosocomial pneumonia and mortality on intensive care units: application of competing risks models" ppt
... procedures, the Institutional Board on the Ethics of Clinical Studies waived the need for informed consent Further details on the setting of the study are described elsewhere [9,10] Analysis of risk ... the ICU Overall, in 214 of the 1,876 admissions (11.4%) the patient died in the ICU More details of risk factors and outcomes are shown in Table Analysis of risk factors for the acquisition of ... risk of dying (model 2) However, these patients stay longer in the ICU There are two possible explanations for this: firstly, there is an effect independent of whether they acquire NP during their...
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SOME SOLUTIONS FOR THE DEVELOPMENT OF CONSUMER LENDING AT TECHCOMBANK HOANG QUOC VIET
... Step 3: The director of the branch will responsible for approving the loan application form or not if the value of the loan does not exceed 500 million In case of an exceed, the director of the branch ... expanded the scope and form of lending to customers The orientation of the branch: expanding, strengthening and improving the operational efficiency of the office agency To attract more customers, the ... actually the major activity of the bank Therefore, continuing research and offering solutions would bring enormous significance for both theoretical and practical aspects for the diversification of the...
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The importance of project management in small- and medium-sized enterprises (SMEs) for the development of new products through E-collaboration docx
... to h The participants were given an explanation regarding the purpose of the feedback, the purpose of the conceptual model, some background of the research that lead to the development of the ... (either for the company or for the customer) It includes all activities from the development of an idea or a concept for a product, to the realization of the product during the production stage and ... product development New product development (NPD) is a business process for developing new products for a company, whether it is an upgrade of an existing product or a new concept (either for the...
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novel semiconductor materials for the development of
... CHEMFET of BIOFET In all of these devices, the surface potential developed at the surface of the semiconductor is based on the direct interaction of the ligand with the exposed atoms of the semiconductor, ... maturation with the commercialization of these pH sensors in the mid-80’s, while they were the platform for the development of other ion-selective FETs and bio-FETs up to date When SiO2 , or other metal ... used for the oxidation of ferrocyanide, or the reduction of methyl viologen, and the simultaneous spectroscopic monitoring of the products through the disc In the same year, the construction of...
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Báo cáo khoa học: "Multilingual Multiplatform Architecture for the development of Natural Language Voice Services" ppt
... conversation or for the most part of it) These two knowledges inform the rest of the modules about the situation of the conversation and which one is the goal expressed by the user Then, the Dialogue ... are responsible (among other factors) for the behaviour of the system during the dialogue The Describer also defines different "squeletons" for the rest of the modules of the application, and this ... system, related to the dialogue management The rest of the configurable modules are adjusted to the design of the different services using the Fast Environment Generation of Speech Applications (SQUEL...
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solutions for the development of bank marketing towards individual customers in vietnam prosperity joint stock commercial bank vpbank
... in the development of a bank The proper attention to these customers will bring considerable income and steady growth for banks, particularly for a bank with the goal of "becoming one of the ... needs of its customers, create the specific image of the products and services to stimulate customers’ demand This is also the basis for customer to distinguish the banks from the others Then the ... relationships and the impact of organic influence each other directly Therefore, to understand market needs to be closely linked with the activities of the bank will make the market of banking operations...
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báo cáo hóa học: " TLR3 signaling is either protective or pathogenic for the development of Theiler''''s virus-induced demyelinating disease depending on the time of viral infection" docx
... infiltrated the CNS of the TLR3KO-B6 mice were similar to those of the B6 mice at dpi (Fig 1B) However, the levels of these cells in the CNS of TLR3KO-B6 mice were significantly higher than those of control ... mechanisms for the increase are unknown, elevated levels of cytokines in the CNS of mice with high viral loads favoring the generation of FoxP3+ CD4+ T cells may contribute to the increase of the regulatory ... PKR [16, 24] Therefore, the relative role of TLR3-mediated signaling in the development of TMEV-induced demyelinating disease remains to be determined In particular, the induction of strong type...
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Báo cáo hóa học: " Combination of Polymer Technology and Carbon Nanotube Array for the Development of an Effective Drug Delivery System at Cellular Leve" pptx
... 3) where C2 is the protein in the bulk, C10 is the concentration inside the gel, S and V1 are, respectively, the surface and the volume of film, V2 is the volume of the bulk, h is the massive exchange ... 24 h, there is a spread of the number of differentiated cells, being about 85% of the total cells In the second day, the number increased up to 90% and, in the third day, about 96% of the cells ... is the protein concentration on the surface of the film and finally ks is the desorption rate constant Substituting known values and by fitting the experimental data with the mathematical model of...
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Báo cáo toán học: "Conjectured Combinatorial Models for the Hilbert Series of Generalized Diagonal Harmonics Modules" docx
... is the number of cells strictly left of c in the diagram of λ (3) The leg of c, denoted l(c), is the number of cells strictly below c in the diagram of λ (4) The coleg of c, denoted l (c), is the ... invalid in the other.) This lemma, together with the discussion preceding it, completes the proof of formula (18) We leave to the reader the task of showing that this formula reduces to formula ... journal of combinatorics 11 (2004), #R68 c Figure 1: Diagram of a partition (1) The arm of c, denoted a(c), is the number of cells strictly right of c in the diagram of λ (2) The coarm of c, denoted...
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Báo cáo sinh học: "On the relevance of three genetic models for the description of genetic variance in small populations undergoing selection" docx
... the simulation The analytical models of Verrier et al [14] and Chevalet [3] will then be described, each corresponding to a different choice of hypotheses for the algebraic formalization of the ... used for the MC simulations 4.1 Effect of number of loci Table I presents the values of RV[30] provided by the three models when ] [30 decreasing the number of loci L (with multiallelic loci in the ... that under the hypothesis of a very large number of independent identical loci, the oligogenic model and the Gaussian theory agree closely These first results validate the use of the ’full-finite’...
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Báo cáo y học: "Improving benchmarking by using an explicit framework for the development of composite indicators: an example using pediatric quality of care" docx
... threaten the external validity of the composite indicator Prevention metrics Much of the job of pediatric health professionals is to prevent illness or illness exacerbation Therefore, metrics of primary ... addition to the quality improvement toolbox, their development is complex, and the editorial choices required of developers may significantly influence performance ratings [14] Therefore, development ... not imply replacing the measurement of individual metrics of quality Rather, composites merely summarize the information contained in the individual metrics and make that information more digestible...
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báo cáo khoa học: " Exploiting EST databases for the development and characterization of EST-SSR markers in castor bean (Ricinus communis L.)" pptx
... knowledge, there has been no report of development of EST-SSR markers in castor bean to date Therefore, we report our work on EST-SSRs derived from castor bean ESTs in the National Centre of Bioinformatics ... a minimum of 10, 5, 4, 4, 4, and subunits, respectively The results of the MISA run were transferred to a Microsoft Excel worksheet for further analyses To localize the distribution of SSRs on ... and distribution The non-redundant EST sequences provided a more accurate representation of the densities of SSR motifs in the transcribed portions of the genome [20,32] Based on the 18,928 non-redundant...
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báo cáo khoa học: " Synthetic lethality: a framework for the development of wiser cancer therapeutics" docx
... selectivity [2,9] Exploiting synthetic lethal interactions to treat cancer cells is therefore very attractive insofar as it provides a concep tual framework for the development of drugs that will kill ... screens, are based on the downregulation of the abundance of a particular protein The biological consequences of down regulating a protein target need not phenocopy the effects of a small organic ... that target For example, the phenotypes of downregulating an enzyme might reflect the loss of its catalytic activity, loss of a scaffolding function, or perhaps both Moreover, the loss of catalytic...
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báo cáo khoa học: " Improving benchmarking by using an explicit framework for the development of composite indicators: an example using pediatric quality of care" potx
... threaten the external validity of the composite indicator Prevention metrics Much of the job of pediatric health professionals is to prevent illness or illness exacerbation Therefore, metrics of primary ... addition to the quality improvement toolbox, their development is complex, and the editorial choices required of developers may significantly influence performance ratings [14] Therefore, development ... not imply replacing the measurement of individual metrics of quality Rather, composites merely summarize the information contained in the individual metrics and make that information more digestible...
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Báo cáo y học: " Study protocol for the development of a European measure of best practice for people with long term mental health problems in institutional care (DEMoBinc)" pptx
... markers of recovery tests whether it can deliver a proxy-measure of the service users' experiences of care and the institution's promotion of their human rights and recovery The ability of the toolkit ... framework in the development of the toolkit since it incorporates these issues and offers a model for services that is relevant across different countries The Recovery Page of (page number not for citation ... stages of development Attention to the human rights of service users in these institutions is imperative since their mental health problems may impact on their capacity to make informed choices for...
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Báo cáo y học: " The utilization of humanized mouse models for the study of human retroviral infections" docx
... system development over the past 30 years The bottom half of the timeline denotes the emergence of key humanized mouse models The top half of the timeline denotes the application of the models ... model Here, we focus on the development of each of these models for the study of human retroviral infection, i.e., with HIV-1 and HTLV-1 The comparison of all of these models in historical context, ... Comparison of animal models for the study of retroviral infection The identification of HIV-1 as the causative agent of AIDS was followed only a year later by the recruitment of chimpanzees for the...
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Báo cáo y học: "Molecular control of HIV-1 postintegration latency: implications for the development of new therapeutic strategies" ppsx
... reactivated in 60% of the patients tested (25 out of 42 patients) [302] These results constitute a proof -of- concept for the co-administration of (at least) two different categories of therapeutically ... Nucleotide (nt1) is the start of U3 in the 5'LTR The transcription start site corresponds to the junction of U3 and R (C) Schematic representation of the nucleosomal organization of the HIV-1 genome ... In the next parts of this review, we draw the current portrait of the epigenetic control of HIV-1 transcription and we underline the potential of some new pharmacological agents to address the...
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Báo cáo y học: " Construction of doxycyline-dependent mini-HIV-1 variants for the development of a virotherapy against leukemias" pps
... remain for the development of therapeutic viruses based on the human pathogen HIV-1 One of the major concerns is the high mutation and recombination rate of HIV-1 that allows the generation of escape ... explanation for the improved replication of the mini-HIV-rtTAs is provided by inspection of the sizes of these viral genomes The RNA genome of the wild-type HIV-1 LAI isolate is 9,229 nt, but the HIV-rtTA ... MA) for the kind gift of the set of NL4-3 deletion constructs We thank Nienke Westerink for the preparations of PBMC, Stef Heynen for performing the CA-p24 Elisa experiments, and Atze Das for...
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Báo cáo y học: "Could increased axial wall stress be responsible for the development of atheroma in the proximal segment of myocardial bridges?" pot
... and Appendix) The force F1 is due to the pressure pushing in the entrance cone of the bridge; F2 is the force generated by the drag of the blood in the tunneled segment; F3 is due to the pressure ... surfaces of the constriction and expansion cones, and in the throat of the stenosis We consider only the axial components of these forces When flow is zero, the two forces pushing in the cones ... Because of the pressure drop across the stenosis the axial force exerted on the inner surface of the constriction cone (F1) is greater than the force exerted on the expansion cone (F3) Furthermore,...
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Báo cáo y học: " Prognostic models for the early care of trauma patients: a systematic review" pot
... accuracy of prognostic models for the early care of trauma patients Conclusions This systematic review located and appraised the quality of five prognostic models for the early care of trauma ... care of trauma patients The majority of models were developed in cohorts of trauma patients from the 80’s All except one of the models were developed in populations from high-income countries The ... approach was the MGAP The CRAMS study neither described the process of predictor identification nor the numerical weight assignments The PSS and the T-RTS aimed to simplify existing models and...
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