1 in drawing the normal stresses we could have made use of the fact that sxx is tensile and hence pulls the surface outward sz
Báo cáo y học: "The evolution of HIV-1 reverse transcriptase in route to acquisition of Q151M multi-drug resistance is complex and involves mutations in multiple domains" ppt
... L 210 V90 NNRTI E138 Y1 81 V100 F87 V SF 20 I A100 I100 I A100 I100 M230 L I100 A100 I100 A100 I100 Y70 H2 21 N348 N100 10 0 T69 Y100 10 0 I100 I3 L94 I 31 L100 A33 V97 T48 S100 S68 K102 G100 R 61 N100 ... d4T IC50, μM 30 90I 13 8A 18 1I 13 8A 18 1I 221Y 17 -RT 62V 69N 75I 18 4V C 31L 13 5T 202I D 17 -Cn-Rh 13 8A 18 1I 221Y 37-RT 62V 69N 75I 15 1M 18 4V 210 F 517 I W 4- T R 4- T P 17 ol 17 RT -P 37 ol 37 RT ... prevalent in patients who develop resistance through the Q151M pathway and that they could be playing an important role in the acquisition of the Q151M MDR Mbisa et al Retrovirology 2 011 , 8: 31 http://www.retrovirology.com/content/8 /1/ 31...
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simpson - what we could have done with the money; 50 ways to spend the trillion dollars we've spent on iraq (2008)
... provinces we could start buying them up and not even notice that we ve dipped into our trillion-dollar kitty The province of Prince Edward Island, for example We could buy every house in the province, ... this: if they ever swing too far to the left, we ll evict them All of them After all, we re the landlord for every person in the province We ll just post a notice on the bridge to the island that ... that tells them they have to leave by the end of the month Now, since we ve got $993 ,11 7,698, 014 left to spend, there’s a state in northern Mexico I’ve had my eye on, and a nice island in the Mediterranean—Malta,...
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báo cáo khoa học: "The use of some nanoemulsions based on aqueous propolis and lycopene extract in the skin’s protective mechanisms against UVA radiation" pps
... methyl bands shielding or to the dissolution of certain groups during the process of obtaining the nanoemulsion In the case of the bands group in the range of 11 50 -12 50 cm -1, characteristic of ester ... stretching), an increase in the intensity of the bands is observed, which is reflected in the decrease of its transmittance from 96% to 56% This is also explained by the increasing of the quantity of ... leads (in propolis) to the disappearance of intense bands at 750 -12 80 cm -1, assigned to ring vibrations: 12 35 -12 80 cm -1, 810 -905 cm -1 and 805-875 cm -1 and can be attributed to characteristic methyl...
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Programmatic update Use of Antiretroviral Drugs for Treating Pregnant Women and Preventing HIV Infection in Infants pptx
... than the cost of Option A (depending on regimen and assuming the provision of both ART and prophylaxis) However, by the end of 2 011 , this differential had diminished to two times higher The annual ... appropriately, in reducing the risk of infant infections for women with CD4 counts >350 cells/ mm3 Because of the difference in the prophylaxis options, it is sometimes not well understood that Options A and ... Treatment 2.0 Initiative to simplify and optimize the use of ARVs and standardize the first-line treatment regimen (8,9); •• reassuring data on the safety of efavirenz in pregnancy (10 ); and •• the decreasing...
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SUMMARY OF DOCTORATE THESIS RESEARCH ON OVERALL MANAGEMENT AND TECHNICAL SOLUTIONS FOR SURFACE COAL MINE RECLAMATION IN HON GAI CAM PHA REGION
... mining industry 10 Host university: Department of Surface Mining, Faculty of Mining, Hanoi University of Mining and Geology 11 Acknowledgements: During studying, researching and conducting the ... friends and family help me during the time of studying and researching the thesis 5 CHAPTER I OVERVIEW OF SURFACE COAL MINING RECLAMATION (SCMR) IN THE WORLD AND IN VIETNAM 1. 1 SCMR activities in the ... to isolate pit mining with neighborhoods (referred to HG2 area): including mining sites, the landfill of Nui Beo coal mine and a part of mining site and landfill of Southwest of Ha Tu coal mine...
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Báo cáo y học: "PKC and PKA Phosphorylation Affect the Subcellular Localization of Claudin-1 in Melanoma Cells"
... compromised skin integrity, and this has been shown to correlate to the lack of claudin -1 and also to the loss of p63 (15 ) Further, we have previously shown that increasing claudin -1 expression increases ... opens up the possibility that Wnt signaling is involved in claudin -1 expression and localization 99 Indeed, a study shows that increasing β-catenin increases the expression of claudin -1 in colorectal ... in an almost complete exclusion of claudin -1 from the nucleus (Figure 1B) This implies that active PKC may exist in the nucleus of melanoma cells, and the presence of active PKC isoforms in the...
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Tài liệu Báo cáo khoa học: Down-regulation of heme oxygenase-2 is associated with the increased expression of heme oxygenase-1 in human cell lines docx
... 0. 01) (B and D) Western blot analysis of HO -1 and HO-2 proteins The intensity representing HO -1 or HO-2 protein was normalized with respect to the intensity of the b-actin signal The ratio of ... lines with low HO -1 expression, K562, Jurkat, and H146, were maintained in suspension culture (Fig 1) , although HO -1 is expressed in two other cell lines, YN -1 and KG1, that were also maintained ... treatment with interferon-c [14 ,15 ] or desferrioxamine, an iron chelator [12 ] Likewise, the expression of HO-2 is decreased in the placental tissues of abnormal pregnancies [16 ,17 ] and in cultured...
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Recommendations for Use of Antiretroviral Drugs in Pregnant HIV-1-Infected Women for Maternal Health and Interventions to Reduce Perinatal HIV Transmission in the United States pdf
... 076) clinical trial that administration of zidovudine to pregnant women and their infants could reduce risk of perinatal transmission by nearly 70% .1 Following the results of PACTG 076, in the United ... to administer maternal antepartum and intrapartum therapy and only infant prophylaxis may be an option In the absence of maternal therapy, the standard infant prophylaxis regimen of weeks of zidovudine ... decreasing residual risk of perinatal transmission ,16 , 17 but that does not completely eliminate the risk of perinatal transmission .17 In addition, reports are mixed on the possible effects of combination...
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Báo cáo khoa học: Death inducer obliterator protein 1 in the context of DNA regulation Sequence analyses of distant homologues point to a novel functional role docx
... processes; this signature is missing in DIDO1 and SPP1 The absence of the CXXC signature distinguishes SPP1 from the CGBP family (Figs 1, and S1); otherwise, the fungal sequences could well constitute ... were preliminary, they indicated the involvement of this gene in cell division This is consistent with our observations, that the DIDO1 gene shares two domains with CGBP and SPP1, both proteins ... homologues The presence of a TFS2M domain is also indicative of a possible function for the DIDO1 long isoform (Figs and S2) It is the second domain of the elongation factor, TFSII [15 ], that stimulates...
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Báo cáo khoa học: Esculentin-1b(1–18) – a membrane-active antimicrobial peptide that synergizes with antibiotics and modifies the expression level of a limited number of proteins in Escherichia coli doc
... A and B are the MICs of drug A and drug B in the combination, MICA and MICB are the MICs of drug A and drug B alone, FICA and FICB are the FICs of drug A and drug B and n is the number of wells ... time-kill kinetics of erythromycin, we can assume that the synergistic activity between the two compounds is the result of increased access of erythromycin to its intracellular target, because of increased ... subphase, and the increment in surface pressure of the LPS film upon intercalation of the peptide dissolved in the subphase was monitored for the next 37 The difference between the initial surface...
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Báo cáo khoa học: Calpain 1–titin interactions concentrate calpain 1 in the Z-band edges and in the N2-line region within the skeletal myofibril doc
... according to these and previous results [20, 21] , titin appears to be a calpain carrier that concentrates calpain and in the N1- and N2-line region The presence of calpain in the vicinity of these ... calpain and T150 in the presence of calcium or in its absence (inset) The binding of increased amounts of T150 in the presence of mM CaCl2 or mM EGTA (inset) to immobilized calpain was determined ... calpain [29], situated near the Z-band and the N2-line [22] Hence, besides the Z–N1 region, the N2-line sector might constitute another binding region for calpain in the I-band The analysis of...
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Báo cáo khoa học: Dynamic reorganization of the motor domain of myosin subfragment 1 in different nucleotide states docx
... domain and actin binding domain was suppressed, which reected the stiffening of the converter region between the nucleotide-binding site and the lightchain-binding domain The transition to this ... V is the volume of the rotating unit, g is the viscosity and s is the lifetime of the uorophore The apparent limiting anisotropy (r0app) was determined from the y-intercept of linear ts to the ... of the positional distribution of Cys707 is narrow in the absence of nucleotides [49], which suggests that the rigidity of the actin binding region is maintained during the interaction of S1 with...
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Báo cáo khoa học: The role of residues R97 and Y331 in modulating the pH optimum of an insect b-glycosidase of family 1 pdf
... explain the DpKa of E187 in the Y331F mutant, because in the R97K and R97M mutants the same increment in the pKa of E399 did not change signicantly the pKa of E187 This suggests that in the Y331F ... ring in that complex [10 ,12 ] Nevertheless, it is not possible to assume that the same is occurring in the mutant R97M, because there is no data on the interactions between the substrate and the ... arginine residue Finally, another aspect of the R97 and Y3 31 inuence on catalysis that must be taken into account is the modulation of the ionization state of the catalytic glutamates Indeed, the...
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Báo cáo khoa học: A steady-state competition model describes the modulating effects of thrombomodulin on thrombin inhibition by plasminogen activator inhibitor-1 in the absence and presence of vitronectin ppt
... suggests that the binding between thrombin and TM, involving the VR1 loop of thrombin, is affected in the substitution variant Indeed, the rate of protein C activation by thrombin-VR1tPA, which is ... by PAI -1/ VN in the pathogenesis of vascular disease [16 ,17 ] Together, the presence of PAI -1, VN and TM in the vessel wall, including the unique property of thrombin to inactivate PAI -1, suggests ... as well as by TM [22,29,30] However, as demonstrated in this study, binding of TM does sterically hinder PAI -1 binding to thrombin (–VR1tPA) Therefore, the binding of PAI -1 to thrombin either involves...
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Báo cáo khoa học: Tumor suppressor p16INK4a: Downregulation of galectin-3, an endogenous competitor of the pro-anoikis effector galectin-1, in a pancreatic carcinoma model pptx
... connection between p16INK4a and Gal -1 [9], the question arises as to whether the in uence of p16INK4a is restricted to this family member The following four lines of evidence direct the focus of attention ... rate by run-off assays B p16INK4a negatively affects Gal-3 mRNA availability 10 0 10 0 0 10 0 C 10 1 10 2 10 3 10 4 10 0 10 1 10 2 10 3 10 4 Fig p16INK4a restitution inhibits Gal-3 expression (A) Western blot ... Gal-3 binding (log fluorescence) 80 40 Counts 12 0 C 10 0 10 1 10 2 Gal -1 binding (log fluorescence) Fig Gal-3 inhibits Gal -1- stimulated anoikis and Gal -1 binding (A) Determination of Gal -1- stimulated...
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Báo cáo khoa học: Adaptation to G93Asuperoxide dismutase 1 in a motor neuron cell line model of amyotrophic lateral sclerosis The role of glutathione doc
... activity in ALS [12 ,13 ], suggesting that normal handling of GSH may be altered However, GSH binding sites in the spinal cord and GSH levels in cerebrospinal fluid were high in SALS patients [14 ,15 ], ... penicillin and 10 0 lgÆmL )1 streptomycin) WT-NSC and G93A-NSC cell lines were maintained in the presence of 0.5 mgÆmL )1 G 418 The cell Samples of the conditional cell lines were thawed (time 0) and ... cell lines might result from increased synthesis This may be because of an upregulation of the expression of GCL We used western blotting to analyse the expression of the GCL subunits GCLC and...
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Báo cáo khoa học: Downregulation of protease-activated receptor-1 in human lung fibroblasts is specifically mediated by the prostaglandin E2 receptor EP2 through cAMP elevation and protein kinase A pot
... expression of PAR -1 in other cell lines expressing this receptor We used the human astrocytoma cell line 13 21N1 and the human alveolar epithelial cell line A549 In 13 21N1 cells, mithramycin A reduced the ... shown [19 ] We tested the involvement of Sp1 and AP-2 transcription factors in PAR -1 expression and the possible in uence of PGE2 on their activity For the analysis of Sp1 involvement, we used its ... downregulation of PAR -1 gene expression However, ongoing protein synthesis is required for maintaining the level of PAR -1 on the cell surface Counts Fig Involvement of PKA and Epac in PGE2-induced downregulation...
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Báo cáo khoa học: Dual expression of mouse and rat VRL-1 in the dorsal root ganglion derived cell line F-11 and biochemical analysis of VRL-1 after heterologous expression pptx
... the F -11 cells not only express the rat VRL -1, but also the mouse VRL -1 and that the mouse variant is derived from the F -11 parental cell line N18TG2 This finding is of interest when VRL -1 is functionally ... alignment of the open reading frames of rat VRL -1 (Acc No AF12 911 3) and mouse VRL -1 (Acc No NM_ 011 706) Rat and mouse VRL -1 cDNA share a homology of 92% The ORF length of rat VRL -1 is 2286 bp whereas the ... faster migrating band to the N18TG2 control In case of C the PCR product from rat brain appeared lower than that of F -11 and N18TG2 Ó FEBS 2003 Co-expression of mouse and rat VRL -1 in F -11 cells...
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báo cáo hóa học:" Epigenetic control of the ubiquitin carboxyl terminal hydrolase 1 in renal cell carcinoma" doc
... rather linked to the methylation of the UCHL1 promoter DNA This is further supported by the fact that a correlation between the methylation status of the CpG islet in the UCHL1 promoter DNA and the ... induction at the mRNA level ranges from 1. 1 - 1. 4 fold in the RCC cell line MZ1851RC (unmethylated UCHL1 promoter DNA) to 11 - 13 fold in the RCC cell line MZ1851LN (strong methylated UCHL1 promoter ... no UCHL1 protein, whereas 9/ 17 express high levels of UCHL1 mRNA and protein (Table 1; [ 21] ) Based on this screening we tested whether the lack of UCHL1 expression in RCC cell lines could be...
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Tìm thêm: hệ việt nam nhật bản và sức hấp dẫn của tiếng nhật tại việt nam xác định các nguyên tắc biên soạn khảo sát các chuẩn giảng dạy tiếng nhật từ góc độ lí thuyết và thực tiễn khảo sát chương trình đào tạo của các đơn vị đào tạo tại nhật bản tiến hành xây dựng chương trình đào tạo dành cho đối tượng không chuyên ngữ tại việt nam điều tra với đối tượng sinh viên học tiếng nhật không chuyên ngữ1 khảo sát thực tế giảng dạy tiếng nhật không chuyên ngữ tại việt nam khảo sát các chương trình đào tạo theo những bộ giáo trình tiêu biểu nội dung cụ thể cho từng kĩ năng ở từng cấp độ mở máy động cơ rôto dây quấn các đặc tính của động cơ điện không đồng bộ đặc tuyến hiệu suất h fi p2 đặc tuyến mômen quay m fi p2 đặc tuyến tốc độ rôto n fi p2 động cơ điện không đồng bộ một pha thông tin liên lạc và các dịch vụ phần 3 giới thiệu nguyên liệu từ bảng 3 1 ta thấy ngoài hai thành phần chủ yếu và chiếm tỷ lệ cao nhất là tinh bột và cacbonhydrat trong hạt gạo tẻ còn chứa đường cellulose hemicellulose chỉ tiêu chất lượng theo chất lượng phẩm chất sản phẩm khô từ gạo của bộ y tế năm 2008 chỉ tiêu chất lượng 9 tr 25