03 keratinocytes innate immunity and allergic contact dermatitis opportunities for the development of in vitro assays to predict the sensitizing potential of chemicals
Báo cáo khoa học: "Post-thaw development of in vitro produced buffalo embryos cryopreserved by cytoskeletal stabilization and vitrification" pps
... irreparable damage to cytoskeletal components An intact cytoskeleton is essential for cytokinesis and karyokinesis; irreversibly disruption of the cytoskeleton will abrogate the mitotic cell cycle, ... disappeared The straw was held at the sealed end and shaken to mix the columns The embryos were expelled into a 30-mm diameter Petri o dish and maintained at 24 C for To remove cyto-b, the embryos ... embryos The rest of the straw was then slowly immersed into the liquid nitrogen within 30 sec In the vitrified control group, the embryos were vitrified without the inclusion of microfilament...
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Báo cáo khoa học: "No Peri- and Postnatal Effects on Calves Born After Transfer of in Vitro Produced Embryos Vitrified by the Open Pulled Straw (OPS) Method" ppsx
... immersing the end of the straw containing the blastocysts into 1.2 ml of holding medium containing 0.25 M sucrose After min, the blastocysts were transferred into 1.2 ml of holding medium containing ... transferred into another drop containing apActa vet scand vol 44 no 1-2, 2 003 90 H Jacobsen et al proximately to µl solution Loading of the blastocysts into the straw was performed using the capillary ... simply touching the to µl droplet, containing the blastocysts with the narrow end of the pulled straw This end was then immediately submerged into liquid nitrogen Warming was performed by immersing...
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Báo cáo y học: "Between adaptive and innate immunity: TLR4-mediated perforin production by CD28null T-helper cells in ankylosing spondylitis" pptx
... cells In vitro assays were performed to test the effect of TNF-α on the expression of PRRs Incubation of PBMCs with TNF-α for 24 hours increased the expression of TLR4 and TLR2, but not of CD14 ... TLR4 and depends on CD14 Additional work has to be carried out to explain the downstream mechanisms of action and the clinical implications of these findings Competing interests The 'Verein zur ... are shown as box plots with the lines within the boxes representing the median, the boxes representing the 25th–75th percentiles and the lines outside the boxes including all values except mavericks...
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Báo cáo y học: " Innate immunity and monocyte-macrophage activation in atherosclerosis" pot
... CASPASE INFLAMMASOME cytosol Figure The interaction between innate signalling, through TLRs, and inflammasome signalling in the transcription and translation of the pro-inflammatory cytokine IL1 ... lupus erythematosus [7,8] The expanding knowledge base regarding inflammation in atherosclerosis has resulted in a keen interest in targeted therapeutics and functional imaging tools for the high-risk ... modification and, ultimately the secretion of IL1 protein Therefore, a connection between TLR and inflammasome pathways in the innate inflammatory process in atherosclerosis is alluded to ASC, apoptosis-associated...
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Báo cáo y học: " Innate immunity and monocyte-macrophage activation in atherosclerosis" potx
... CASPASE INFLAMMASOME cytosol Figure The interaction between innate signalling, through TLRs, and inflammasome signalling in the transcription and translation of the pro-inflammatory cytokine IL1 ... lupus erythematosus [7,8] The expanding knowledge base regarding inflammation in atherosclerosis has resulted in a keen interest in targeted therapeutics and functional imaging tools for the high-risk ... modification and, ultimately the secretion of IL1 protein Therefore, a connection between TLR and inflammasome pathways in the innate inflammatory process in atherosclerosis is alluded to ASC, apoptosis-associated...
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Báo cáo y học: "Maternal allergic contact dermatitis causes increased asthma risk in offspring" pdf
... infiltration in the lung samples of the offspring of TDItreated mothers (TDI offspring, Fig 4C) compared to offspring of DNCB- and vehicle-treated mothers (DNCB offspring and vehicle offspring; Fig 4B and ... compared to DNCB offspring and vehicle offspring (Fig 4F, p < 0.05) The cytokine profile in the BAL of the TDI offspring showed Th2 skewing, with significantly increased IL-4, IL-5, and Page of (page ... offspring tested in the protocol summarized in Fig The offspring of wild type mothers treated with TDI (WT+TDI offspring) and the offspring of IL-4KO mothers treated with TDI (IL-4KO+TDI offspring)...
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Báo cáo y học: " Innate immunity against HIV: a priority target for HIV prevention research" ppt
... components of innate immunity in protection or pathogenesis in HIV infection and of how the activation of innate responses is stimulated and regulated, together with the knowledge gaps and priorities for ... sites The opposing roles of pDCs in restricting and potentiating initial virus replication and the factors that govern which of these activities predominate, including the role of HIV signaling ... more sustained increase in IL-18 accompanied by elevations in multiple other pro-inflammatory cytokines/ chemokines, and a late-peaking increase in IL-10 [71] The initial pattern of cytokine elevations...
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Adult adversity - do early environment and genotype create lasting vulnerabilities for adult social adversity in psychosis
... found to influence the course and outcome of psychotic disorders, with a number of studies showing associations with higher levels of symptomatology and increased relapse rates (Bebbington et ... environmental and the genetic risk factors developed the disorder because of their coparticipation In a further study, the mechanism of gene–environment interaction was investigated using a more direct indicator ... indicator of genetic liability at the level of the person, rather than at the level of the family (Spauwen et al., 2006b) In a sample of 3000 young adolescents from the Early Developmental Stages of...
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Tài liệu Infrastructure Protection and Security Service Integration Design for the Next Generation WAN Edge v2.0 pptx
... snooping of the commands or passwords of administrators – Access control of SNMP, SSH, and other protocols used to monitor the devices – Disabling of known potentially hazardous services and interface ... routing information and may lead to network disruption or enabling an intruder to gain more access to the network than the solution administrator intended To overcome this, for all routing protocols ... uses EIGRP and OSPF), configure a key and enable the hashing option in that dynamic routing protocol The following commands are used for authentication and hashing of the routing protocol (OSPF)...
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Tài liệu Carrots, Sticks, and Promises: A Conceptual Framework for the Management of Public Health and Social Issue Behaviors docx
... up their bingeing habits during their junior and senior years The manager's goals here are to minimize the number of freshmen who begin to binge drink and to maximize the number of juniors and ... if the target cannot discern the reward in doing so Dickson (1992) discusses the invisible hand of competition that constrains the self-interest of the firm and forces the firm to serve the interests ... the proffered choice In general, the presence of a reinforcer is incentive (marketing), whereas the withholding of a reinforcer or the onset of a punishment is coercive (backed by the force of law)...
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Tài liệu AUDIT REPORT, CONSOLIDATED ANNUAL FINANCIAL STATEMENTS, AND CONSOLIDATED MANAGEMENT REPORT ALL FOR THE YEAR ENDED DECEMBER 31, 2011 pptx
... companies agreed to strengthen and deepen their strategic cooperation in certain business areas, and committed to investing the equivalent of 500 million US dollars in ordinary shares of the other party.Telefónica ... board of directors of the investee, its participation in decision-making processes, interchange of managerial personnel and access to technical information .The carrying amount of investments in ... reflect the fair value of the financial liability settled; and (iii) the difference between the carrying amount of the extinguished financial liability and the initial value of the equity instrument...
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Alternative Futures and Army Force Planning - Implications for the Future Force Era pdf
... attempted to help the Army deal with the task of long-term force planning by using the tool of alternative futures analysis Rather than positing a single point estimate of the 2025 future and trying to ... extent, there is already an increase in the power of nonstate actors going on in the world—this is being heavily driven by the information revolution and the rise of the Internet However, the current ... power The mechanism used to convert the development variables into alternative futures was to vary the slopes of the trend lines in each of the five according to their impact upon U.S national interest...
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The importance of project management in small- and medium-sized enterprises (SMEs) for the development of new products through E-collaboration docx
... a beginning and an ending, and project management has corresponding initiating and closing processes The middle, or work of the project, is managed by planning, executing, and monitoring and controlling ... According to these definitions and the importance of SMEs in manufacturing industries in this research, the author chose these types of companies Strengths and weakness characteristics of SMEs in ... realization of the product during the production stage and its introduction into a market place (Hohenegger et al., 2007) SMEs need to develop their products for competing in the market, and then they...
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Báo cáo khoa học: NMR and molecular dynamics studies of an autoimmune myelin basic protein peptide and its antagonist Structural implications for the MHC II (I-Au)–peptide complex from docking calculations ppt
... speculate therefore that an extension of the MBP(74–85) epitope in the N-terminus could increase the binding and affinity for I-Au because of occupation of the P1 pocket Recent thermodynamic and kinetic ... studies of the binding of TCRs to peptide–MHC ligands suggested that the low affinity of the TCR–peptide–MHC complex is a consequence not of insufficient contacts at the interface but, rather, of the ... point for position P9 of the MBP peptide-binding grooves Interestingly, truncation of the C-terminus of the MBP(86–105) peptide to P9 Thr greatly diminished binding, whereas truncation to P10...
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Báo cáo khoa học: "Computing and Evaluating Syntactic Complexity Features for Automated Scoring of Spontaneous Non-Native Speech" pot
... were used for the training of the boundary detectors, they were removed afterwards from the annotated data sets to obtain a trandivided by the length of the reference To obtain WER in percent, ... Lu’s tool contributed of the initial CB features and of the initial PT features, and we computed the remaining CB and PT features using Perl scripts, the Stanford Parser, and Tregex Table lists the ... resulting in 52 aggregated files in each test set Accordingly, we averaged the response scores of a single speaker to obtain the total speaker score to be used later in scoring model training and...
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Financial Frictions and Total Factor Productivity: Accounting for the Real Effects of Financial Crises pot
... Mt t (8) using the value of final goods, the sum of all value added and the total income in the economy respectively The last term in equation (8) is the income of the intermediary in the current ... Mexico and linked it to this process of structural transformation of the economy, together with a decline in the cost in foreign borrowing due to financial liberalization The Baseline Model In this ... explore the role of financial frictions in exacerbating existing inefficiencies and explaining the drop in TFP There is ample micro evidence that financial constraints and the increase in the cost of...
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UP AND AWAY: A resource book for English language support in primary schools pptx
... think could/should be explained For parents: • Encourage parents to speak to their children in the mother tongue, and to all the things they would normally – reading stories, talking about the ... regard to the education of their children and to encourage them to support the on-going education of their families What can the school if there is evidence of corporal punishment in the home? In ... continue to speak to children in the mother tongue Children need to develop their L1 in order to maintain contact with the extended family and home culture Parental involvement is critical for...
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Báo cáo khoa học: NovelN,N¢-diacyl-1,3-diaminopropyl-2-carbamoyl bivalent cationic lipids for gene delivery – synthesis,in vitro transfection activity, and physicochemical characterization docx
... vesicles Lipids of the 1,3lb series were synthesized with the intent of enhancing the transport of exogenous genetic material into cells in vitro, and their design eliminates the need for additional ... Fig In vitro transfection activity of cationic lipids in the absence of helper lipid(s) (A) and in the presence of DOPE (B) or DOPE and cholesterol (C), as measured in a murine skin cell line ... fluorescence (% of max.) pKa studies well separated from one another, precluding inuences of the hydrophobic anchors of the derivatives with respect to the number of carbon atoms and double bonds in the...
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CHICKEN GENETIC RESOURCES USED IN SMALLHOLDER PRODUCTION SYSTEMS AND OPPORTUNITIES FOR THEIR DEVELOPMENT pdf
... make an offspring test An offspring test involves producing a number of offspring from each breeding candidate and placing them in an infected environment The rate of mortality due to infectious ... a system, the growth pattern of the Mia would minimize the use of feed to meet the maintenance requirements of the birds India In India, the Kadaknath breed of the Jhabua District of Madhya Pradesh ... infectious diseases in the offspring groups is a direct measure of breeding value for disease resistance in the parents, and can be used to inform the selection of birds for breeding The second approach...
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www.it-ebooks.info .PHP & MySQL FOR ® Web Development ALL-IN-ONE DESK REFERENCE DUMmIES ‰ by Janet Valade with Tricia Ballad and Bill Ballad www.it-ebooks.info .www.it-ebooks.info .PHP & MySQL FOR ® Web Development ALL-IN-ONE DESK REFERENCE DU ppt
... the URL 517 Making Information Available to All Pages in the Web Site 522 Storing information in cookies 522 Saving and retrieving information in cookies .523 Setting the expiration ... Processing Information from the Form .490 Checking for empty fields 491 Checking the format of the information 497 Giving users a choice with multiple submit buttons . 503 Creating ... Using forms 512 Relocating users with an HTTP header 513 Passing Information from One Page to the Next 515 Passing information in a form 516 Adding information to the...
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