... course and reliability role of uCysC in the critically ill Key Messages • In the ICU, urinary cystatin C is diagnostic of acute kidney injury • In the ICU, urinary cystatin C is independently ... normally distributed, median (interquartile range) AKI, acute kidney injury on admission to intensive care; uCysC, urinary cystatin C; uCr, urinary creatinine; pCysC, plasma cystatin C; pCr, plasma ... independently diagnostic of sepsis • In the ICU, urinary cystatin C predicts AKI in the presence of sepsis • In the ICU, urinary cystatin C predicts death • In the ICU, AKI biomarker studies should exclude...