reactive oxygen and nitrogen species oxidative and nitrosative stress and their role in the pathogenesis of acute kidney injury

Báo cáo y học: "Glomerular matrix metalloproteinases and their regulators in the pathogenesis of lupus nephritis" pdf

Ngày tải lên : 09/08/2014, 13:22

... diseases of the glomerulus, the results of studies of the involvement of MMP activity in other renal pathologies should provide valuable guidance in elucidating the role of these enzymes in lupus ... this review The gelatinases cleave a number of substrates, including native forms of collagens I, IV, V, VII, X and XI, elastin, laminin, fibronectin, myelin and the core protein of proteoglycans ... metalloproteinase by direct interaction between the two proteins within the nucleus [31] The concept of TIMP-1 translocating into the nucleus remains controversial [32,33], and the functions of TIMP in...

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Tài liệu Báo cáo khoa học: High affinity copper binding by stefin B (cystatin B) and its role in the inhibition of amyloid fibrillation docx

Ngày tải lên : 19/02/2014, 06:20

... partitioning of the protein into an aggregated state The effect of copper binding on the secondary structure was determined using CD in the far UV To prepare proteins without Cu2+, part of each protein ... understanding what causes the loss of appropriate metal binding might be crucial for the understanding of the role of amyloidogenic proteins in a number of neurodegenerative disorders Copper binds ... copper binding could still allow domain swapping to occur It is of interest that a N-terminally truncated prion protein, lacking the copper binding domain is capable of domain swapping and forms...

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Báo cáo khoa học: Characterization of Trypanosoma brucei PEX14 and its role in the import of glycosomal matrix proteins pptx

Ngày tải lên : 23/03/2014, 17:21

... mislocalization of all three enzymes in these cells clearly shows the involvement of PEX14 in the targeting of PTS-1, PTS-2 and I-PTS proteins to the glycosome To further analyse the effect of the destruction ... with a binding constant Kd of 2.75 lM, and that the amino-terminal domains of the two peroxins were responsible for this interaction The role of TbPEX14 in glycosome biogenesis received further ... N-terminal domain of the polypeptide of each of these organisms is followed by a stretch of hydrophobic amino acids that is presumably involved in the protein’s anchoring to the membrane Also in...

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Báo cáo y học: "Downstream molecular pathways of FLT3 in the pathogenesis of acute myeloid leukemia: biology and therapeutic implications" pps

Ngày tải lên : 10/08/2014, 21:23

... tyrosine kinase, and results in the phosphorylation of these proteins [38] These actions affect the activation of further downstream PI3K/protein kinase B (Akt) and mitogenactivated protein kinase ... [69-82] The compounds currently in development are heterocyclic compounds containing components that structurally mimic the purine ring of adenosine and become inserted into the ATP-binding site of ... effects of ATO and MEK inhibition, as well as ATO and FLT3 inhibition, on FLT3-ITD cells [101] The combination of ATO and AG1296, an FLT3 inhibitor, profoundly inhibited the growth and induced...

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Báo cáo y học: " Th2 cytokines and asthma Interleukin-4: its role in the pathogenesis of asthma, and targeting it for asthma treatment with interleukin-4 receptor antagonists" pot

Ngày tải lên : 12/08/2014, 18:20

... involves its interaction with receptors consisting of a heterodimer of high-affinity IL-4Rα and either the common γ chain or the IL-13 receptor α chain Binding of IL-4 results in the tyrosine phosphorylation ... phosphorylation of signal transduction molecules including motifs similar to those involved in insulin signaling, the insulin receptor substrate (IRS)-1, IRS2 and signal transducer and activator of transcription ... high-affinity α chain (IL-4Rα) and a second chain that can be either the common γ chain or the α chain of the IL-13 receptor (IL-13Rα) [23] The common γ chain is found in multiple cytokine receptors...

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Báo cáo y học: " Serum Interleukin-6 and interleukin-8 are early biomarkers of acute kidney injury and predict prolonged mechanical ventilation in children undergoing cardiac surgery: a case-control study" pps

Ngày tải lên : 13/08/2014, 16:21

... potential role as a therapeutic target in AKI Modulation of these cytokines may reduce the degree of kidney injury itself, as well as the deleterious effects of kidney injury on other end organs, including ... sepsis and acute lung injury In those studies, the timing of the underlying AKI insult was less clear because of the underlying severity of illness of study subjects IL-6 was elevated between and ... occurred by the time serum creatinine increases Second, the pathogenesis of AKI in humans is complex and involves the endothelial and epithelial cell compartments, as well as inflammatory cells Finally,...

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Substance p regulates chemokine production in leukocytes implications in the pathogenesis of acute pancreatitis and associated lung injury

Ngày tải lên : 11/09/2015, 09:09

... hyperstimulation and CP96,345 administration, implies their differential roles in the pathogenesis of the disease The importance of chemokines (MCP-1, MIP-1α, RANTES, and MIP-2) in the pathogenesis of acute ... mediator in acute pancreatitis and associated lung injury The interaction between SP and other inflammatory molecules including tachykinins, neurokinin receptors, adhesion molecules and hydrogen ... objective of the present study is to elucidate the mechanism of proinflammatory actions of SP in the pathogenesis of acute pancreatitis and associated lung injury, particularly pertaining to its interaction...

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Báo cáo y học: " Oxygen-regulated transcription factors and their role in pulmonary disease" pptx

Ngày tải lên : 12/08/2014, 18:20

... direct the expression of a lacZ gene in the heart, kidney, and lung, but not the liver, of transgenic mice subjected to hypoxia or ischemia [3] The basis for the tissue-specific induction of NF-IL6 ... concentration of 6% (reduced from the 21% O2 in room air), EGR-1 and tissue factor expression are induced in the lung and marked vascular deposition of fibrin is observed, whereas none of these responses ... resulting in the accumulation of HIF-1α, which dimerizes with HIF-1β The heterodimer recognizes the core binding-site sequence 5′-RCGTG-3′ (R, purine) found within the hypoxia response element of...

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Báo cáo y học: "Nitrogen washout/washin, helium dilution and computed tomography in the assessment of end expiratory lung volume" docx

Ngày tải lên : 13/08/2014, 11:23

... obtained decreasing the FiO2 (r2 = 0.84, p < 0.0001) (b) The Bland-Altman plot of the EELV measurement obtained increasing the FiO 2and the EELV obtained decreasing the FiO2 The x axis shows the ... increasing the FiO2 as a function of the Accuracy of the nitrogen washin/washout technique EELV obtained decreasing FiO2 The EELV obtained increasing the FiO2 was -56 + 1.0078 multiplied by the ... (b) The Bland-Altman plot of the EELV measured with the CT scan and the EELV measured with the Engstrom Carestation The x axis shows the mean of the two measurement and the the y axis shows the...

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Characteristics of Leachate from Citrus Groves and their Changes in the Collecting Reservoirs in Matsuyama, Japan

Ngày tải lên : 05/09/2013, 10:17

... the middle parts of the grove from points Sampling points St.1 and St.2 are in the same stream, and sampling point St.3 is in the other stream The two streams flow together to be one stream and ... and periphery of the Seto Inland Sea The location of the research area and the distribution of the citrus groves in Matsuyama region are shown in Fig Matsuyama is situated in Shikoku Island in ... sea level The water in the stream is the leachate from the grove and it flows into a collecting reservoir at the foot of the hill The surface area of the reservoir is about 7300 m2 and the average...

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Tài liệu Báo cáo khoa học: Golgi reassembly stacking protein 55 interacts with membrane-type (MT) 1-matrix metalloprotease (MMP) and furin and plays a role in the activation of the MT1-MMP zymogen pdf

Ngày tải lên : 18/02/2014, 04:20

... increase the amount of complex containing MT1MMP and furin, and the expression of a catalytically inactive dominant negative furin construct affected the processing of pro-MT1-MMP Taken together, these ... sequence for the interaction with the PDZ proteins: Mint-3, AMPA binding protein and glutamate receptor interacting protein (GRIP) It would therefore be interesting to determine whether this motif ... the nature of the GRASP55 binding site in the MT1-MMP ICD pACT plasmids driving the expression of MT1-MMP ICDs containing single-, double- and triple-point mutations were generated (Fig 4A) and...

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Tài liệu Báo cáo khoa học: The small heat shock proteins and their role in human disease pptx

Ngày tải lên : 19/02/2014, 18:20

... identiﬁed, and the role of ATP-dependent chaperones in substrate release and refolding revealed sHSPs operate in the front lines of cell defense, protecting proteins during stress and providing opportunities ... changes, and these are outlined below and described in the text of the review In addition, changes in the amounts of sHSPs, unaccompanied by a structural change in the protein per se, are observed in ... avb3 integrin, a protein missing in normal melanocytes but often manufactured during the invasive phase [141] Hsp27 over expression in melanoma cells prevents E-cadherin loss, and synthesis of the...

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Tài liệu Báo cáo khoa học: Inorganic pyrophosphatase in the roundworm Ascaris and its role in the development and molting process of the larval stage parasites doc

Ngày tải lên : 20/02/2014, 11:20

... concerning the kinetics and properties of the enzyme More strikingly, we show a novel role of the PPase enzyme in the development and molting process of A suum larvae in vitro constructed in UniZap ... immunohistochemical staining), and that the inhibition of PPasecatalyzed PPi hydrolysis by these inhibitors, is likely to prevent the synthesis of the new cuticle from the hypodermis and/ or ecdysis of the old ... presence of increasing concentrations of inhibitors for 10 days, and the number of molting larvae was determined Molting was manifested by shedding of the L3 cuticle Results Identiﬁcation of cDNA...

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Tài liệu Báo cáo Y học: The b-1,4-endogalactanase A gene from Aspergillus niger is speciﬁcally induced on arabinose and galacturonic acid and plays an important role in the degradation of pectic hairy regions pdf

Ngày tải lên : 21/02/2014, 01:21

... stranded sequence was determined for a region of this construct containing galA and some of the ﬂanking regions, resulting in the genomic sequence of A niger galA The presence of one putative intron ... control of the xylanolytic activator protein [32,41] The increase in expression levels of galA in the CREA mutant, indicates that at least one of the detected putative CREA binding sites in the promoter ... proteins The three arabinogalactans were incubated with GALA for 15 min, 30 min, h and 20 h to determine the substrate speciﬁcity of the enzyme The degradation of the polymer Ó FEBS 2002 and subsequent...

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Báo cáo khoa học: Roles of the SH2 and SH3 domains in the regulation of neuronal Src kinase functions pptx

Ngày tải lên : 06/03/2014, 01:20

... application of SH2 domain binding peptides, which results in blocking of the binding of the SH2 domain to the substrate and thereby preventing interaction of the substrate with the kinase domain For ... C-terminus Kinase domain and C-terminus SH3 domain and C-terminus SH2 domain and C-terminus SH3, SH2 domain and C-terminus N-terminal, SH3, SH2 domain and C-terminus N-terminal, SH3, SH2, kinase ... tyrosine kinase, the SH2 and SH3 domains are redistributed from their auto-inhibitory positions at the back site of the kinase domain, adopting an extended conformation and stimulating the catalytic...

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AN ACCOUNT OF TIMBUCTOO AND HOUSA, TERRITORIES IN THE INTERIOR OF Africa docx

Ngày tải lên : 06/03/2014, 03:21

... and if no person of the royal line be the object of their choice, they may elect one of their own body The members of the council are appointed by the king; he chooses them for their wisdom and ... goods brought in by the gate of the Nile, (which is the gate of the Negroes,) pay a tax: another part of the revenue is two per cent, in kind on the produce of the land; but the people of Barbary ... buried in a winding-sheet and a coffin: the relations mourn over their graves, and pronounce a panegyric on the dead The men and women mix in society, and visit together with the same freedom as in...

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Báo cáo khoa học: Relationship between functional activity and protein stability in the presence of all classes of stabilizing osmolytes ppt

Ngày tải lên : 07/03/2014, 00:20

... in the presence of these amino acids and amino acid derivatives, and values of DGD°, measured in triplicate, are given in Table The effect of polyols on the kinetic parameters (Km and kcat) of ... efﬁciency in the presence of this group of osmolytes Interestingly, there is a linear relationship between DDGD° and Dlog(kcat ⁄ Km) in the presence of methylamines and sugar However, the slopes of the ... (a) the main driving force for the folding is the unfavourable interaction between the osmolyte and the peptide backbone, and (b) the total contribution of side chains to the stability of the...

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Báo cáo Y học: Inhibition of the SERCA Ca21 pumps by curcumin Curcumin putatively stabilizes the interaction between the nucleotide-binding and phosphorylation domains in the absence of ATP pot

Ngày tải lên : 08/03/2014, 23:20

... ATP into contact in the absence of ATP, curcumin is then able to bind to the ATPase (possibly at the hinge region) locking the two domains together and therefore precluding ATP binding (i.e inhibiting ... concentrations of curcumin (25 mM ) the Km for the catalytic site is also possibly increased In order to further assess the possibility of curcumin affecting the interaction of ATP binding to the ATPase, ... about mM Reversing the order of addition to the ATPase (i.e curcumin then ATP) had a similar effect on the extent of ATP binding, i.e in both cases, the amount of ATP binding to the ATPase was...

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corporate social responsibility strategies for sustainable development for small and medium enterprises in the village of bac ninh province, vietnam

Ngày tải lên : 13/03/2014, 14:20

... represents a unique Kinh Bac region (Northern of Vietnam) The businesses in the village have been promoting their intellectual inheritance of the essence of his father left, forming the well-known ... Development of production and business activities of small and medium enterprises in the village of Bac Ninh is the problem important and strategic in their careers to promote modernization of the province ... clarify the strength of the enterprise, the weaknesses of the business 21 The specific target for analysing of the inside and outside factorsin the enterprises from which we form strategic business...

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Postal Savings and the Provision of Financial Services: Policy Issues and Asian Experiences in the Use of the Postal Infrastructure for Savings Mobilization pdf

Ngày tải lên : 15/03/2014, 09:20

... Postal savings for the people The introduction of savings accounts at post offices followed the rise of the savings bank movement in Scotland and thrift movements elsewhere in the beginning of the ... of home Internet and telephone banking services in place of postal counter services in Finland and other countries invite further scrutiny Although Internet usage in Finland is 43 per cent, the ... network In 1987, in addition to the post offices, it had 50 branch offices in 33 cities and towns, 13 of them in the Helsinki area alone Following Finland’s commercial banking crisis in the early...

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