Báo cáo y học: "Large-scale 13C-flux analysis reveals mechanistic principles of metabolic network robustness to null mutations in yeast" pptx
Báo cáo y học: "Large-scale 13C-flux analysis reveals mechanistic principles of metabolic network robustness to null mutations in yeast" pptx
... (Figure 5). Inactivation of themitochondrial pyruvate dehydrogenase complex in the pda1mutant was bypassed by the import of cytosolic acetyl-CoAinto the mitochondria. Inactivation of the oxidative ... ratio analysis The recorded MS spectra include the distribution of mass iso-topomers in 1-5 fragments of alanine, aspartate, glutamate,glycine, isoleucine, leucine, phenylalanine, proline, serine,threonine, ... 25% to genetic robustness bycarbon flux rerouting. This leaves redundancy as the major,and modularity the minor, cause [50] of metabolic network robustness to single-gene deletions during growth...
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Báo cáo y học: "Global transcriptome analysis reveals circadian regulation of key pathways in plant growth and development" potx
... cir-cadian rhythm of resistance to extreme temperatures andchanges in fatty acid composition in cotton seedlings. PlantPhysiol 1993, 101:31-36.81. Foyer CH, Noctor G: Oxygen processing in photosynthesis:regulation ... circadianphases of peak transcript abundance of ethylene signalingand ethylene responsive genes. Interestingly, two key ethyl-ene signaling components, namely EIN3 (ETHYLENEINSENSITVE 3) and EIL1 (EIN3-LIKE ... peaks early in thesubjective day, with a phase similar to that of genes involved in the light-harvesting reactions of photosynthesis (Figure8b). It may be that clock regulation of photosynthetic...
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Báo cáo y học: "Comparative sequence analysis reveals an intricate network among REST, CREB and miRNA in mediating neuronal gene expression" pptx
... binding affinity of a site to REST withoutrequiring strict matching of each base to the NRSE consen-sus. To reduce false positives, we rely on comparativesequence analysis to identify only ... (3'UTRs) of the messages. Many of the characterizedmiRNAs are involved in developmental regulation, includingthe timing and neuronal asymmetry in worm; growth controland apoptosis in fly; brain ... olfactory epitheliumSkeletal muscleSmall intestineTongueTestisSpleenBonemarrowThyroidRetinaEmbryo day 10.5Vomeralnasal organBonELarge intestineMammary gland (lact)EpidermisBlastocystsHeartEmbryo...
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Báo cáo Y học: Synthesis, conformational analysis and biological activity of cyclic analogs of the octadecaneuropeptide ODN Design of a potent endozepine antagonist pot
... that the potency of cyclo128OP was increased by afactor of three and its efficacy by a factor of 1.4 compared to its linear counterpart in eliciting [Ca21]irise in rat astrocytes.As the ... amide proton frequency. Two glycine-typeremote peaks were clearly observed instead of one expected,suggesting the existence of two spectroscopically distinctmolecular conformers. Analysis of other ... polyphosphoinositideturnover in cultured rat astrocytes.MATERIALS AND METHODSMaterialsAll amino-acid residues, preloaded 4-hydroxymethyl-phenoxymethyl-copolystyrene-1%-divinylbenzene resin[Fmoc-Lys(Boc)-HMP],...
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Báo cáo Y học: GPI-microdomains (membrane rafts) and signaling of the multi-chain interleukin-2 receptor in human lymphoma/leukemia T cell lines doc
... Simons, K. (1999) Clusters of glycolipid andglycosylphosphatidyl-inositol-anchored proteins in lymphoid cells:accumulation of actin regulated by local tyrosine phosphorylation.Eur. J. Immunol. ... stimulated tyrosine-phosphorylation of STATsIL-2 induced tyrosine phosphorylation of STAT3 (andSTAT5) was followed by flow cytometry as described previ-ously for STAT1 [32]. Brie y, cells with ... consequences in T cells. First, rafts may concentrate the a chains (CD25) in the vicinity of signaling IL-2R b and ccchains, forming acommon signaling platform in the membrane, beforecytokine stimulation....
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Báo cáo Y học: A new conceptual framework for enzyme catalysis Hydrogen tunneling coupled to enzyme dynamics in flavoprotein and quinoprotein enzymes docx
... thisunderstanding is gained, H-tunneling can then be used asa tool for (a) increasing the catalytic efficiency of enzymes in the biotechnology industry (by enhancing the coupling of dynamics to the ... nss4@le.ac.ukAbbreviations:TST,transitionstatetheory;TTQ,tryptophantrypto-phylquinone; MADH, methylamine dehydrogenase; AADH, aroma-tic amine dehydrogenase; TMADH, trimethylamine dehydrogenase;TSOX, heterotetrameric sarcosine dehydrogenase; ... the tryptophan tryptophyl-quinone (TTQ)-dependent amine oxidases methylaminedehydrogenase (MADH) and aromatic amine dehydroge-nase (AADH), and also the flavoenzymes trimethylaminedehydrogenase...
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Báo cáo y học: "Advanced glycation end-product (AGE)-damaged IgG and IgM autoantibodies to IgG-AGE in patients with early synovitis." ppt
... is induced by AGE,can contribute to the inflammatory cycle by the induction of proinflammatory cytokines, via the nuclear factor-κBpathway [21]. No studies have yet examined RAGEexpression in ... Nε-(car-boxymethly)lysine (50 mg/ml) inhibited the binding of poly-clonal anti-IgG-AGE antibodies to IgG-AGE by 40% butdid not inhibit RF binding to IgG. Lysine at the same con-centration did not inhibit ... basis of having peripheral joint synovitis and not axialdisease, the presence of ‘inflammatory spinal pain’, whenpresent, was insufficient as the only major EuropeanSpondlyarthropathy Study Group...
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Báo cáo y học: "Women, men, and rheumatoid arthritis: analyses of disease activity, disease characteristics, and treatments in the QUEST-RA Study" ppsx
... VanderbiltUniversity, Nashville, TN; Yusuf Yazici, NYU Hospital for JointDiseases, New York, NY; Martin Bergman, Taylor Hospital,Ridley Park, PA; Christopher Swearingen, Medical University of South Carolina, ... Maria Majdan, Medical Uni-versity of Lublin, Lublin; Wojciech Romanowski, Poznan Rheu-matology Center in Srem, Srem; Witold Tlustochowicz,Military Institute of Medicine, Warsaw; Danuta Kapolka, ... Charleston, SC; Study Center: TuulikkiSokka, Jyväskylä Central Hospital, Jyväskylä, Medcare Oy,Äänekoski, Finland; Hannu Kautiainen, Medcare Oy, Ääneko-ski, Finland; Theodore Pincus, New York...
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Báo cáo y học: "Risk factors associated with the loss of cartilage volume on weight-bearing areas in knee osteoarthritis patients assessed by quantitative magnetic resonance imaging: a longitudinal study" pot
... contributed to study design,acquisition of data, analysis and interpretation of data, and sta-tistical analysis. M-JB and FA contributed to acquisition of dataand to analysis and interpretation of ... evidence of OA of the affected knee on a radio-graph obtained within 6 months of the outset of the study.Finally, patients had to have a minimum joint space width(JSW) of the medial compartment of ... Moreo-ver, the trend toward correlation with joint stiffness is a newand most interesting finding, as there is, to date, very littleinformation of this kind originating from longitudinal studies.However,...
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Báo cáo y học: "Women, men, and rheumatoid arthritis: analyses of disease activity, disease characteristics, and treatments in the QUEST-RA Study" potx
... 40620 Jyväskylä, Finland6Gazi University, Department of Physical Medicine and Rehabilitation, Division of Rheumatology, 06530 Ankara, Turkey7Rheumatology Department, Institute of Rheumatology ... VanderbiltUniversity, Nashville, TN; Yusuf Yazici, NYU Hospital for JointDiseases, New York, NY; Martin Bergman, Taylor Hospital,Ridley Park, PA; Christopher Swearingen, Medical University of South Carolina, ... Department of Internal Medicine and Clinical Immunology, Euroclinic of Athens, Athanasiadou 9, 11521, Athens, Greece14Department of Internal Medicine and Clinical Immunology, Euroclinic of Athens,...
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