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Báo cáo y học: "Recent developments in the immunobiology of rheumatoid arthritis" potx

Báo cáo y học:

Báo cáo y học: "Recent developments in the immunobiology of rheumatoid arthritis" potx

... Beer Y: Interleukin-17 enhances tumor necro-sis factor alpha-induced synthesis of interleukins 1,6, and 8 in skin and synovial fibroblasts: a possible role as a ‘fine-tuningcytokine’ in inflammation ... anti-IL-15 therapy in RA patients [29].T helper 17 cellsThere is increasing evidence that IL-17 plays a role in the immunopathology of RA. This proinflammatory cytokine isproduced by T helper ... anti-CD20 antibody[2], and the increased interest in the role of autoantibodies in RA. In addition to producing antibodies, proinflammatorycytokines and chemokines, B cells efficiently act as antigen-presenting...
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Báo cáo y học: "Somatic mutations in the mitochondria of rheumatoid arthritis synoviocytes" ppt

... fibroblast lines. YM participated in the molecular genetic studies and analysis. EK procured the sam-ples and helped in the analysis of data. GW participated in the design of the study, analysis of data, ... earlybacterial infection in the joint. Somatic mutations in mitochondrial peptides displayed by MHCs may be recognizedas non-self, furthering the destructive immune infiltration of the RA joint. ... derived from the amino terminus of mtND1 [14]. These findings provide evi-dence that antigenic peptides of human mtND1 may be dis-played and recognized by the immune system.To test the hypothesis...
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Báo cáo y học: " Gene therapy in animal models of rheumatoid arthritis: are we ready for the patients" pdf

... in the inflamed joint or in the lymph nodes via clearance of vectors or transgenes to the lymphatic system. In RA patients the draining lymphnodes of inflamed foot joints had higher levels of proinflammatory ... around the fact that the rheumatoid factors in RApatients may form immune complexes with the immunoglobulin domain of the tgAAC94 fusion protein,thereby inactivating the therapeutic protein in the ... of proinflammatory and anti-inflammatory cytokines thanfound in serum; furthermore, the levels reflected diseaseactivity [105]. Spillover of cytokines or inhibitors to the draining lymphatic system...
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Báo cáo y học: " Recent developments in podiatric prescribing in the UK and Australia" ppt

... indication of the extent to which the Department of Health now considers the prescribing of medicines by allied health professionals to be a safe andeffective use of resources in answer to the ... podiatry profession (approximately 1/3 of the podiatric profession in Australia) was recently granted anextension of scope of practice to include prescription of restricted medicines. The Victorian ... view themselves as excluded fromthese roles, and must also consider the contribution thatthey can make to ensuring the provision of healthcare fitfor purpose in the 21st century.Clearly, the...
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Báo cáo y học: "Recent developments in anti-rheumatic drugs in pediatrics: treatment of juvenile idiopathic arthritis" pptx

... of the Fcportion of the human immunoglobulin molecule combinedwith the extracellular portion of the cytotoxic T-lymphocyte-associated antigen 4 [26]. The drug binds tightly to the B7domain ... well-designedtrials, the attributability of these findings remains unclear and the ultimate long-term safety profile of anakinra needs to bedetermined. In this vein, a phase II/III double-blind,randomized, ... targeting TNFα are being usedcurrently in the treatment of JIA.EtanerceptEtanercept (Enbrel) is a fusion protein consisting of the extracellular domain of the TNFα receptor combined with the Fc...
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Báo cáo y học: "Special considerations in the treatment of patients with bipolar disorder and medical co-morbidities"

... purposes) of portacaval shunting, thereby decreasing first passmetabolism; decrease in quantities and affinity of plasmaproteins, thereby increasing free-drug levels; increase in volume of distribution ... and lamotrigine. The triad of hypersensi-tivity includes fever, rash and internal organ involvementwith onset of symptoms within 1 to 8 weeks of exposure. The frequency of the syndrome is estimated ... [57].Recognizing early symptoms of hepatic toxicity and dis-continuing treatment are important in optimizing recov-ery. Early symptoms of hepatic toxicity include apathy,malaise, fever, diminished...
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Báo cáo Y học: Expression pattern in the antennae of a newly isolated lepidopteran Gq protein a subunit cDNA potx

Báo cáo Y học: Expression pattern in the antennae of a newly isolated lepidopteran Gq protein a subunit cDNA potx

... be the start of the proteincoding domain. Sequence analysis of the 3¢ end cDNArevealed that there is a polyadenylation signal upstream of the poly(A).Analysis of the primary structure of M. ... 2002Recently, the a subunit of a G protein of the Gq familyhas been immunolocalized in olfactory sensilla preparations of the silkmoth Antherea pernyi [23]. Using immunocytol-ogy, the authors ... samecharacteristics, the molecular cloning of the correspondingcDNA to get the total amino-acid sequence of the protein,and the expression pattern of the corresponding mRNAas a first step to clarify the role of...
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Báo cáo y học: "Psychosocial aspects in the management of arthritis pain" pot

... of leisure in maintaining or restoring psychological well-being in the presence of arthritis pain warrants furtherstudy.Psychosocial approaches to managingarthritis painSearch strategy The ... [16]compared the psychosocial functioning and coping of mothers with chronic pain (including mothers with arthritis) tomothers without pain, with regard to their ratings of parentingefficacy. There ... Acomparison of conventional pain coping skills training andpain coping skills training with a maintenance training com-ponent: A daily diary analysis of short- and long-term treat-ment effects. J Pain...
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Báo cáo y học: " Immune mechanisms in the pathogenesis of idiopathic inflammatory myopathies" doc

... concerning the role of T lymphocytes, B lymphocytes, dendritic cells, andother antigen-presenting cells (APCs) in the pathophysiology of IIMs.T lymphocytesT lymphocyte functionT lymphocytes ... demonstrated the presence of differentiated B lymphocytes in the form of CD138+plasmacells predominantly in the endomysium of muscle tissue of patients with polymyositis and inclusion-body myositis ... plasmacytoid DCs wasfound in comparison with the amount of myeloid DCs [48]. The importance of the plasmacytoid DCs in activating the typeI interferon system in dermatomyositis was suggested by...
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Báo cáo y học: "Current approaches in the treatment of arthritic pain" pps

... capsaicin is in accord with increasedexcitability of spinal neurons in this condition [5]. Clinically,this leads to enhanced pain perception at the site of injury, aswell as to the development of ... goals for the management of both OA and RAinclude the prevention or amelioration of joint damage, the prevention of loss of function, and the reduction of pain [8,9]. In the absence of complete ... concept of a fixed immutable pain system thatfaithfully transmits information from a site of injury to paincentres within the brain. Although this is largely true afteracute injury, it is...
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