recent achievements in the field of lignin genetic engineering
plant biotechnology and transgenic plants - kirsi-marja oksman-caldentey , wolfgang h. barz
... of vinblastine are marketed, namely vindesine and vinorelbine Vindesine is prepared from vinblastine by formation of the hydrazide of 16-deacetylvinblastine (with hydrazine) and reduction of the ... Vincristine is used for the treatment of acute leukemia and in combination chemotherapy, and vinblastine is indicated in the treatment of Hodgkin's disease (2) Two semisynthetic derivatives of ... (scopolamine) (2) H Vinblastine and Vincristine Vinblastine and vincristine are binary indole alkaloids isolated from the aerial parts of the Madagascan periwinkle (Catharanthus roseus G Don syn Vinca...
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Báo cáo y học: " Low NO bioavailability in CCl4 cirrhotic rat livers might result from low NO synthesis combined with decreased superoxide dismutase activity allowing superoxide-mediated NO breakdown: A comparison of two portal hypertensive rat models wit
... identified as important endothelin-1 synthesising cells An increased endothelin-1 synthesis together with changes in endothelin-A and B receptor density may be implicated in haemodynamic deteriorations ... Results Western blots of eNOS, iNOS and nNOS The eNOS was the only NOS isoform detected in livers of all groups The amount of eNOS protein in liver homogenates was similar in normal and PPVL rats ... important than eNOS protein amounts, is the understanding of eNOS enzymatic activity [18] The eNOS activity is inhibited by protein-protein interaction of caveolin-1 with eNOS in hepatic [7,12] and...
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Báo cáo khoa học: Engineering and characterization of human manganese superoxide dismutase mutants with high activity and low product inhibition potx
... some of the catalytic activity lost by the imposition of the Q143A substitution These mutations are subsequently kinetically characterized separately and in combination in the context of the parental ... This may, at least in part, be due to a loss of the interaction between the side chains of Asn73 and Gln143 The X-ray crystal structure of hMnSOD shows that the side chain amide ˚ of Asn73 is near ... structures of the various mutants may further enhance our understanding of the structural ⁄ mechanistic contribution of the various mutations, and current efforts are focused in this direction The engineering...
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Báo cáo Y học: ER–resident chaperone interactions with recombinant antibodies in transgenic plants potx
... with the model of BiP binding transiently in the ER to Ig chains during protein folding and processing The immunoblot results matched those found by Northern blot, in that most BiP protein was ... plants for producing a variety of mammalian proteins Protein translocation and folding in the ER can be one of the rate limiting steps in protein secretion, and the presence of protein chaperones ... studied the involvement of BiP and calreticulin in the folding and assembly of recombinant immunoglobulin heavy and light chains in transgenic plants that express the assembled form of an IgG...
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Báo cáo hóa học: " A predominance of R5-like HIV genotypes in vaginal secretions is associated with elevated plasma HIV-1 RNA levels and the absence of anti-retroviral therapy" docx
... more than half of the women in this shedding cohort, demonstrating that vaginal HIV shedding occurs in a number of women taking ART ART use was associated with the presence of predominantly X4-like ... [9,13], the low levels of HIV detected in many of the samples only allowed the analysis of the predominant genotypes in genital secretions Despite this, and the inherent limitations of PCR amplification ... coordination of the study and facilitated the collection of clinical samples NL processed clinical samples and conducted PCR and viral load analyses AA participated in the coordination of the...
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Báo cáo y học: "A simple hepatic cyst with elevated serum and cyst fluid CA19-9 levels: a case report" pps
... the diagnosis of an infected hepatic cyst 400 mg of minocycline hydrochloride was dissolved in 50 ml of saline, and this minocycline solution was injected into the cyst using the drainage catheter ... with increased flow of necrotic cyst wall cells after the minocycline instillation, suggesting that CA19-9 may originate from the hepatic cyst wall cells Inflammation, including infection and the ... after and week after intracystic instillation of minocycline hydrochloride After intracystic instillation, necrotic cells in the cyst were drained, and the cyst totally col- Page of (page number not...
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Tài liệu Báo cáo khoa học: Crystal structure of the cambialistic superoxide dismutase from Aeropyrum pernix K1 – insights into the enzyme mechanism and stability pdf
... to the Mn or Fe ions incorporated into the enzyme as it accumulated in the E coli cells Indeed, the activity of the apo-enzyme was significantly lower than the metal-containing enzyme Metal cofactors ... tetramer in solution Each monomer had an independent metal-binding site at the interface of the two domains, which consists of four side chains: two (His31 and His79) from the N-terminal domain and ... difference in the stability of the proteins in organic solvents Indeed, although the stabilities of the two SODs were indistinguishable in aqueous solution, ApeSOD was more stable than TthSOD in a...
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Tài liệu Design of Feedback Control Systems for Stable Plants with Saturating Actuators ppt
... 4.3: Singular values of the plant in the academic example #1 Figure 4.3 shows the singular values of the open loop plant Notice the effect of the two resonant zeros of the plant in the singular ... of control directions at the input of the saturation U'l, U'2, U" 1, U"2 and at the output of the saturation u', u" Since the saturations can alter the direction of the control signals, and in ... with integrators is used in a closed loop system and the phenomenon of reset-windup appears During the time of saturation of the actuators, the error is continuously integrated even though the...
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Tài liệu Báo cáo khoa học: The solution structure of reduced dimeric copper zinc superoxide dismutase doc
... protein: at the interface between the two subunits (mainly in loop IV and b 8), in the odd loops and at the corresponding end of the b barrel, and in the even loops [52–56] Some of the residues involved ... H-bonds involving ring hydrogens of His43 are important in linking the loop III to the b barrel and the active site The presence of these H-bonds is consistent with the NMR observation of two HN ring ... still maintaining the disulfide bond, Arg143 is further from copper than in the wild-type protein but closer than in the copper-free SOD in the complex In the present solution structure of wild-type...
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Báo cáo khoa học: A superoxide dismutase–human hemoglobin fusion protein showing enhanced antioxidative properties pptx
... geometry of the protein and, possibly, also water shielding Oxidation of the heme to the met form (Fe3+) increases the probability of heme loss as the fifth coordination bond to the proximal histidine ... SOD, probably owing to locking of the SOD in the tetrameric form during conjugation The genetic fusion of Hb and SOD does not seem to perturb the globin structure noticeably, as both the O2 and CO ... the loss rate of Hb was almost three times lower (0.069 ± 0.008 min)1) Although the b-chains not take part directly in the fusion, the effect is more profound here, suggesting that the b-chains...
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Báo cáo khoa học: Betulinic acid-mediated inhibitory effect on hepatitis B virus by suppression of manganese superoxide dismutase expression pot
... reports on the role of cAMP-response element-binding protein (CREB) in SOD2 expression [17,18] CREB binds via its basic leucine zipper domain as a dimer to cAMP response elements containing the consensus ... phosphorylation of CREB at Ser133 [19] Ser133 phosphorylation of CREB, in turn, promotes recruitment of the coactivator paralogs CREB-binding protein and p300 via a kinase-inducible domain in CREB, ... 42% On the other hand, overexpression of CREB in the presence of BetA increased the CREB level 1.7-fold, but did not increase the pCREB level, whereas knockdown of CREB (siCREB) decreased the levels...
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TRANSGENIC PLANTS docx
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