... accessibility of the side-chain of His210 (Fig. 3C). When the accessibility of the side-chain of His210 increased, the electrostatic interaction betweenHis210 and Asp113 weakened due to the increasing ... p interaction in thepacking of the adenine ring in protein structures. Advan. ProteinChem. 39, 125–189.20. Brandl, M., Weiss, M.S., Jabs, A.S., ¸ hnel,J.&Hilgenfeld,R.(2001) C–H p-interaction ... profile of API shown in Fig. 2.Ion strength dependence of the pH-activity curve of APIThe pH-activity profiles depending on NaCl concentrationwere determined as part of the investigation into theshielding...