Báo cáo khoa học: Control of nuclear receptor function by local chromatin structure doc

... (2007) Identiﬁca-tion and analysis of functional elements in 1% of thehuman genome by the ENCODE pilot project. Nature447, 799–816. Nuclear receptor regulation by chromatin M. Wiench et al.2228 ... al. Nuclear receptor regulation by chromatin FEBS Journal 278 (2011) 2211–2230 Journal compilation ª 2011 FEBS. No claim to original US government works 2229MINIREVIEW Control of nuclear receptor ... differentialexpression of receptors (and receptors’ isoforms) andother co-factors, metabolism of ligands, and expression of selective modulators [17,18]. In addition, chromatin structure can play...

Tài liệu Báo cáo khoa học: Control of the coagulation system by serpins Getting by with a little help from glycosaminoglycans pptx

... 4842–4851 ª 2005 FEBS 4851R. N. Pike et al. Control of the coagulation system by serpinsMINIREVIEW Control of the coagulation system by serpinsGetting by with a little help from glycosaminoglycansRobert ... examine the basic elements of the structure and function of the serpins involved in con-trolling the central coagulation enzyme, thrombin, andtheir control by GAGs. Control over other enzymes,such ... circulation by the action of receptors whichspeciﬁcally recognize the inhibited conformation of theserpin (reviewed in [4]).The structure and mechanism of serpins is highlyamenable to control...

Báo cáo khoa học: Control of mammalian gene expression by amino acids, especially glutamine potx

... presence of aminoacid(s) resulted in inhibition of the DNA binding of the involved transcription factors. By contrast, thepresence of amino acid may also result in stimulation of the DNA binding of ... promotethe changes in the chromatin structure required toenhance transcription of amino acid-regulated genes.The mechanism(s) of detection of amino acid limita-tion by the ARR pathway relies ... Cloning of ratasparagine synthetase and speciﬁcity of the aminoacid-dependent control of its mRNA content. BiochemJ 304, 745–750.86 Huang Q, Lau SS & Monks TJ (1999) Induction of gad 153 by...

Báo cáo khoa học: Suppression of urokinase receptor expression by bikunin is associated with inhibition of upstream targets of extracellular signal-regulated kinase-dependent cascade pptx

... and uPAR possibly through suppression of upstreamtargets of ERK. Thus, one of the functions of bikunin is theregulation of uPA synthesis and uPA binding by modulat-ing uPAR. It is most likely ... Y. & Terao,T. (2001) Structure and function analysis of urinary trypsininhibitor (UTI): identiﬁcation of binding domains and signalingproperty of UTI by analysis of truncated proteins. Biochim.Biophys. ... FEBS 2002 Suppression of uPAR by bikunin (Eur. J. Biochem. 269) 3957Suppression of urokinase receptor expression by bikuninis associated with inhibition of upstream targets of extracellularsignal-regulated...

Tài liệu Báo cáo khoa học: Regulation of cathepsin B activity by 2A2 monoclonal antibody docx

... thepresence of various concentrations of 2A2 mAb. Thebinding of 2A2 mAb was followed by native gel elec-trophoresis. Increasing the concentration of 2A2 mAbat a ﬁxed molar ratio of cathepsin ... &Bjork I (2000) Cystatin inhibition of cathepsin Brequires dislocation of the proteinase occluding loop.Demonstration by release of loop anchoring throughmutation of His110. FEBS Lett 487, 156–160.40 ... Faculty of Pharmacy, University of Ljubljana, Slovenia2 Department of Biotechnology, Jozef Stefan Institute, Ljubljana, Slovenia3 Department of Biology, Biotechnical Faculty, University of Ljubljana,...

Báo cáo khoa học: Colocalization of insulin receptor and insulin receptor substrate-1 to caveolae in primary human adipocytes Cholesterol depletion blocks insulin signalling for metabolic and mitogenic control doc

... the insulin receptor indicatescolocalization (as demonstrated by the yellow colour) of IRS1 with both caveolin and the insulin receptor. To further examine a caveolar localization of IRS1 wenext ... [27].Insulin receptor signalling in caveolaeWe next examined the functional status of caveolae-localized receptors. After incubating cells with a submax-imal concentration of insulin the ... 6C) of the insulin receptor was not affected by this level of prior cholesterol depletion, nor was the totaltyrosine phosphorylation of IRS1 affected (Fig. 6D). Amore detailed examination of...

Báo cáo khoa học: Assembly of nuclear DNA-encoded subunits into mitochondrial complex IV, and their preferential integration into supercomplex forms in patient mitochondria doc

... terminal enzyme of the mitochondrial respiratory chain.In humans, biogenesis of complex IV involves the coordinated assembly of 13 subunits encoded by both mitochondrial and nuclear genomes. ... membrane [2]. The subunits of complex IV encoded by nuclear DNA (nDNA) do notharbor enzymatic activity but function in the structuralintegrity, regulation and dimerization of the enzyme.For example, ... assembly of the holoenzyme.ResultsIn vitro import and assembly of nDNA-encodedcomplex IV subunitsThe assembly of a number of nDNA-encoded com-plex IV subunits was investigated by importing...

Báo cáo khoa học: Control of transforming growth factor b signal transduction by small GTPases pot

... ATGFβRecyclingRecyclingABCFig. 1. Control of TGFb and activin ⁄ nodal receptor trafficking by small GTPases. (A) The role of Rab5 and Rab11 in TGFb receptor endocyto-sis and recycling. The cycling of Rab5 between ... motility. Rab7 localizesto the late endocytic compartment and controls thetrafficking of late endosomes [61]. Therefore, conver-sion of Rab5 to Rab7 controls the progression of cargo from the ... Which endocytic routes aretaken by TGFb receptor complexes and what is thecontribution of each pathway to the final signal? Of the five emerging transport routes, internalization of TGFb receptors...

Báo cáo khoa học: Modulation of glucocorticoid receptor-interacting protein 1 (GRIP1) transactivation and co-activation activities through its C-terminal repression and self-association domains pptx

... mechanisms control- ling the functional activities of GRIP1. They extendour understanding of the importance of the structuralstatus of GRIP1 in modulating NR functions.ResultsAutoregulation of GRIP1 ... activities and nuclear receptor co-activator functions.AbbreviationsACTR, activator for thyroid hormone and retinoid receptors; AD, activation domain; AF, activation function; AR, androgen receptor; ... vector]12302 461232x2x0.3x0.3x4.5xHDAC1.mycHDAC1.mycWB by α-mycWB by α-mycWB by α-mycWB by α-mycIP by α-HA IP by α-HA Input (5%)Input (5%)HAHA.GRIP15-1462GRIP15-1121HA.HA.GRIP1563-1121HA.GRIP1563-1462HA.GRIP11122-1462HA.GRIP15-765HDAC1.mycHAHA.GRIP1GRIP15-14625-1121HA.HA.GRIP1HA.GRIP1HA.GRIP1HA.GRIP1HDAC1.myc563-1121563-14621122-14625-765++...

Báo cáo khoa học: Pleiotropy of leptin receptor signalling is deﬁned by distinct roles of the intracellular tyrosines docx

... cDNA of LEPRb,phosphorylation of STAT1, STAT3, STAT5 and theERK kinases was induced by leptin. The weakresponse of STAT5 to leptin compared to that elicited by GH can be partially explained by ... C-terminal of the phosphotyrosine are important for binding of SH2 domains [55a]. Equivalent results have beenobtained by mutational analysis of the STAT bindingmotif of the IL-9 receptor TyrLeuProGln(367–370),which ... Hekerman et al. Pleiotropic leptin receptor signallingFEBS Journal 272 (2005) 109–119 ª 2004 FEBS 119Pleiotropy of leptin receptor signalling is deﬁned by distinct roles of the intracellular tyrosinesPaul...

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