Báo cáo khoa học: "Speech Communication in the Wild" pdf

Tài liệu Báo cáo khoa học: Nuclear receptors in the mosquito Aedes aegypti Annotation, hormonal regulation and expression proﬁling ppt

... recovered,only the longest amino acid sequences that included the DNA binding, hinge and ligand-binding domainswere used for this analysis, except for the Knirps fam-ily members that lack the LBD. In D. ... vitellogenic femalemosquitoes. They isolated several clones that codefor a single protein. Interestingly, during the initialprocess of identifying the NR family members in the A. aegypti genome, we ... were incubatedfor 30 min in culture medium without hormone, followedby a 6 h incubation in the presence or absence of the hormone (10)6m 20E). To test the effect of the proteinsynthesis inhibitor...

Tài liệu Báo cáo khoa học: Electrostatic contacts in the activator protein-1 coiled coil enhance stability predominantly by decreasing the unfolding rate docx

... interpretation in distinguish-ing interacting from noninteracting proteins. OneFig. 1. Schematics of library designs. The helical wheel diagram looks down the axis from the N-terminus to the C-terminus. ... focused on small molecule inhibitors, but the potential of using peptides as the starting point in the generation of therapeutics is now a growing area[18,19]. Peptides harbour the potential for chemicaland ... thisoverall value into its component kinetic steps. The ﬁndings of this study are therefore of interest to the protein design ﬁeld in general, but also inform uponhow to fast track the design of...

Tài liệu Báo cáo khoa học: Final steps in the catabolism of nicotine Deamination versus demethylation of c-N-methylaminobutyrate doc

... lead to the complete mineraliza-tion of the pyrrolidine ring of nicotine, which afteroxidation by 6-hydroxy-l-nicotine oxidase, is cleavedoff from the pyridine ring of nicotine in the form ... enzymesinvolved in nicotine catabolism will have applicationsnot only in the bioremediation of nicotine waste, butalso in the supply of nicotine derivatives as startingmaterials for the synthesis ... expect them also to be expressed in a nicotine-dependent manner. In order to investigate this, weanalyzed the transcription of these genes in the pres-ence and absence of nicotine in the growth...

Tài liệu Báo cáo khoa học: Isochore structures in the chicken genome ppt

... computing the G + Ccontent in sliding windows moving along the genome.Fig. 4. The negative cumulative GC proﬁlefor GGA12 marked with the segmentationpoints obtained. The bottom ﬁve plots show the ... all the seg-ments obtained at t0¼ 100 without the constraint of the minimumlength in the draft genome sequence of chicken. (A) The length dis-tribution of all the obtained segments. The ... versa, indicating a mosaic structure of the chromosomes. A jump in the Àz0ncurve indicates an increase of the G + C con-tent; whereas a drop down in the Àz0ncurve indicates a decrease of the...

Tài liệu Báo cáo khoa học: Oxidative stress in the hippocampus after pilocarpineinduced status epilepticus in Wistar rats doc

... in epileptic patients [27]. Other mechanisms maybe associated with the increase in ROS levels in the epilepsy model as well as in neurodegenerationobserved in epileptic humans [18,28].During ... ﬁndings show that pilocarpine induces SE,which can produce alterations in superoxide dismutaseand catalase activities in different areas, thereby pro-tecting the brain from neuronal damage induced ... only changes during the initiation of seizures [14]. When studying this epi-lepsy model, we found increased catalase activity in the hippocampus, indicating that this enzyme, in association with...

Tài liệu Báo cáo khoa học: Proton transfer in the oxidative half-reaction of pentaerythritol tetranitrate reductase Structure of the reduced enzyme-progesterone complex and the roles of residues Tyr186, His181 and His184 pdf

... productive binding of steroid substrates: in the ﬁrst, a (small) sub population of enzyme bindsdirectly the steroid in the reactive conformation, with the remainder of the enzyme binding the unreactiveconformation. ... unusual in havingtwo histidine residues (rather than the His-Asn pairseen in OYE, MR and some of the other memberproteins; Fig. 1B) in the active site for ligand andsubstrate binding. For ... role in the binding of phenolic compounds in the active site [3,26]. Likewise, in MR the counter-part residues His186 and Asn189 form key interactionswith reducing nicotinamide coenzyme and the...

Tài liệu Báo cáo khoa học: Proteasome involvement in the degradation of the Gq family of Ga subunits pptx

... lCiÆmL)1[3H]inositol for 24 h in inositol-free mediumcontaining 10% (v ⁄ v) dialyzed fetal bovine serum. Cellswere then washed and incubated in NaCl ⁄ Picontaining20 mm Li+with the agonist ... RGS domain in the amino-terminus of Gprotein-coupled receptor kinase 2 inhibits Gq-mediatedsignaling. Int J Mol Med 5, 335–340.20 Chen CA & Manning DR (2001) Regulation of G pro-teins by ... degradation of the phosphoinositidaseC-linked guanine-nucleotide-binding protein Gqalpha ⁄ G11 alpha following activation of the human M1muscarinic acetylcholine receptor expressed in CHOcells....

Tài liệu Báo cáo khoa học: Inorganic pyrophosphatase in the roundworm Ascaris and its role in the development and molting process of the larval stage parasites doc

... determined by incubating the diluted recombin-ant proteins in the standard reaction mixture in the presenceof increasing concentrations of PPi(0.05–0.5 mM)at55°C.Data were fit to the appropriate ... rate was then calculated.Larval molting inhibition assayTo confirm whether the native PPase enzyme is involved in the molting process, we examined the effects of two PPasespecific inhibitors, ... helminth parasite including the roundwormAscaris. To address this, we describe here the cloning,sequencing and heterologous expression in E. coli of a geneencoding PPase of A. suum. The amino...

Tài liệu Báo cáo khoa học: "Multimodal Generation in the COMIC Dialogue System" docx

... used in bathroom sales situa-tions to help clients redesign their rooms. The inputto the system includes speech, handwriting, and pengestures; the output combines synthesised speech, atalking ... control of the underlying applica-tion. Figure 1 shows screen shots of the COMICinterface.There are four main phases in the demonstra-tor. First, the user specifies the shape of theirown bathroom, ... speech synthesiser to finalise the schedules for the other modalities, the synthesiserfirst prepares and stores the waveform for its inputtext; the sound is then played at a later time, when the fission...

Tài liệu Báo cáo khoa học: Adaptive changes in the expression of nuclear and mitochondrial encoded subunits of cytochrome c oxidase and the catalytic activity during hypoxia pptx

... lgÆmL)1penicillin/streptomycin. The myocyteswere induced to differentiate into myoblasts by replacing the medium at confluence with a fresh medium containing 2%(v/v) fetal bovine serum. These myoblasts ... during hypoxia. In the absence of differential regulation of a specific nucleargene coding for the subunits of CytOX, changes in the microenvironment of the cell may induce alterations in the catalytic ... though the catalytic efficiencyof the enzyme (TN for cytochrome c oxidase) remainednearly the same. Increased glycolytic flux and alterations in the kinetic characteristics of the CytOX might be the...

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