... thatexpression of miR-27 resulted in blockade of expression of PPARc andC ⁄ EBPa, the two master regulators of adipogenesis. Importantly, expression of miR-27 was increased in fat tissue of obese ... role of miR-27 in the regulation of adipogenesisQun Lin1, Zhanguo Gao2, Rodolfo M. Alarcon1, Jianping Ye2and Zhong Yun11 Department of Therapeutic Radiology, Yale University School of ... regulation of miR-27 expression. Ourdata suggest that the miR-27 gene family is potentiallyan important class of negative regulators of adipogene-sis and may play a role in the regulation of adiposefunctions...