Báo cáo khoa học: Novel aspects of calmodulin target recognition and activation pptx

... 2003REVIEW ARTICLE Novel aspects of calmodulin target recognition and activation Stefan W. Vetter1 and Estelle Leclerc21Department of Molecular Biology and 2Department of Immunology, The ... thegrowing collection of the structural motifs recognizable byCaM.Ca2+activated K+-channelA radically novel target binding mode and possibly a novel mode of target protein activation through ... mechanisms of CaM target recognition and activation than structures of complexes with short peptides. With thisin mind we can look forward to up-coming structures of CaM in complex with full length targets...

Tài liệu Báo cáo khoa học: Novel aspects of heat shock factors: DNA recognition, chromatin modulation and gene expression ppt

... in thelevels of HSF1 and MTA1 (a component of the NuRDcomplex containing HDAC1 and HDAC2) proteins and to binding of HSF1 to MTA1 [78]. The complexis recruited to the promoters of estrogen-responsivegenes ... the nucleus and binds to and regulatesbasal expression via HSEs of target genes [26].Deletion of the HSF gene is lethal to cells, even atphysiological temperatures. The genes targeted byHSF ... shockresponses, respectively [30]. Phosphorylation of HSF,regulated by heat and oxidative stress, is involved inthe activation and inactivation of the transactivatingability [26]. Interestingly,...

Báo cáo khoa học: Functional aspects of the solution structure and dynamics of PAF – a highly-stable antifungal protein from Penicillium chrysogenum pdf

... surface potential of AFP (left) and PAF (right) structures representing the orientation of the side chain lysine resi-dues. Lys9, Lys35 and Lys38 of PAF and Lys9, Lys32 and Arg35 of AFP are the ... chains.The hydrophobic strand b4 is located between Cys43 and Asp46 and, as a central strand of sheet 2, partici-pates in an extensive hydrogen bonding network withboth strand b1 and b5 contributing ... University of Debrecen, Hungary2 Institute of Chemistry, Eo¨tvo¨s Lora´nd University, Budapest, Hungary3 Department of Inorganic and Analytical Chemistry, Centre of Arts, Humanities and Sciences,...

Báo cáo khoa học: "Joint Inference of Named Entity Recognition and Normalization for Tweets" doc

... consisting of entities and theirvariations.6 Conclusions and Future workWe study the task of NEN for tweets, a new genre of texts that are short and prone to noise. Two chal-lenges of this task ... set consists of 12,245 randomly sampled tweetswithin ﬁve days.526by recognition errors. Another challenge of NENis the dearth of information in a single tweet, dueto the short and noise-prone ... tmtodenote the mthtweet ,tim and yimto denote the ithword of of tm and its BILOU label, respectively, and fimto denote the factor related to yi−1m and yim. Next,for each word...

Tài liệu Báo cáo khoa học: Molecular aspects of rheumatoid arthritis: chemokines in the joints of patients pdf

... joints of the hands and feet. Theinflammatory process is characterized by infiltration of inflammatory cellsinto the joints, leading to proliferation of synoviocytes and destruction of cartilage and ... against the development of RA [61].The gene copy number variations of CCL3-like 1(CCL3L1), a nonallelic isoform of CCL3 encoded bydifferent genes and a potent ligand for CCR1 and CCR5, influenced ... Increasedexpression of MIP-3a ⁄ CCL20 and CCR6 has also beenconfirmed in tissue biopsies from RA subchondralbone [27].Our group recently found that the mRNA exp-ression of MCP-4 ⁄ CCL13 (a ligand of CCR2 and CCR3),...

Tài liệu Báo cáo khoa học: Molecular aspects of rheumatoid arthritis: role of environmental factors pdf

... 0.5–1% of the popu-lation and causes progressive joint destruction thatleads to the restriction of activities of daily living and deterioration of quality of life. Although the patho-genesis of ... 0.5–1% of the population. RA causes progressive joint destructionthat leads to the restriction of activities of daily living and deterioration of quality of life. Although the pathogenesis of RA ... extensivelystudied previously. Understanding of how these factors contribute to thedevelopment of RA may lead to the better understanding of pathogenesis of RA.AbbreviationsAhR, aryl hydrocarbone...

Tài liệu Báo cáo khoa học: Molecular aspects of rheumatoid arthritis: role of transcription factors ppt

... TNF-a,CD40 ligand and Fas ligand, etc. (Fig. 3). Ligand bind-ing of various receptors results in the activation of phospholipase C (PLC), the release of inositol 1,4,5-tri-phosphate (IP3), and a ... dose-dependent man-ner in the presence of PPAR-c ligands and a PPAR-aligand, fenoﬁbrate. Neither PPAR-a nor PPAR-cligands inhibit basal level expression of these cyto-kines, and these compounds are not ... We tested the effect of PPAR-a and PPAR-cligands in vivo on the progression and severity of adju-vant-induced arthritis in female Lewis rats and foundthat pioglitazone and fenoﬁbrate suppressed...

Báo cáo khoa học: Novel repressor of the human FMR1 gene ) identiﬁcation ¨ of p56 human (GCC)n-binding protein as a Kruppel-like transcription factor ZF5 ppt

... inter-actions, and a nuclear localization signal [25,26]. TheDNA-binding domain of ZF5 consists of the third and forth Zn-fingers [28]. Cyclic amplification and selection of targets (CAST) assays ... oligo(dT)primer and reverse transcriptase (Invitrogen) to make thefirst cDNA strand. Two pairs of primers, which amplifyoverlapping 5¢- and 3¢-parts of ZF5 cDNA, were designedusing Primer software ... designedusing Primer software developed by V. Prutkovsky and O. Sokur of the Institute of Influenza, Ministry of Health of the Russian Federation. The first pair of primers(5¢-GGCCTTCAAGGCATTAAG-3¢,5¢-AAACAAATGGCCTGTCCG-3¢)...

Báo cáo khoa học: Novel a-conotoxins from Conus spurius and the a-conotoxin EI share high-afﬁnity potentiation and low-afﬁnity inhibition of nicotinic acetylcholine receptors doc

... unambiguously deﬁned 12 and 13 resi-dues, respectively. Low glutamine signals at positions12 and 15 of SrIA and at position 15 of SrIBFig. 1. Puriﬁcation of SrIA and SrIB. (A)Fractionation of the crude ... aminoacid sequence determination and cloning of the cDNAencoding two novel peptides, SrIA and SrIB, found inthe venom of Conus spurius. The pattern and the spa-cing of their cysteines indicate ... a4b2, and ganglionic, a3b4) and muscle(a1b1cd) subtypes of nAChR. Unexpectedly, peptidesSrIA and SrIB were active on both central and muscletypes of the nAChR, which constitutes a novel...

Báo cáo khoa học: Novel isoenzyme of 2-oxoglutarate dehydrogenase is identiﬁed in brain, but not in heart potx

... peptides.Processing of the spectra was performed by the use of dataanalysis software package and biotools software fromBruker. A peptide mass tolerance of ± 2 Da, a fragmentmass tolerance of ± 1 Da and one ... components of the 2-oxoglutarate and pyruvate dehydrogenasecomplexes were ascribed to the major protein bands of our preparation as follows: E1o (band 1), E2p (band 2),E3 (band 3), E2o and the ... prepara-tion of the complex from heart. Expression of the novel OGDHL component of OGDHC in brain is in accordwith the isolation of OGDHL cDNA from brain tissue[31–33], whereas earlier cloning of the...

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