Báo cáo khoa học: Sequences, geographic variations and molecular phylogeny of venom phospholipases and threeﬁnger toxins of eastern India Bungarus fasciatus and kinetic analyses of its Pro31 phospholipases A2 docx

... FEBS 525 Sequences, geographic variations and molecular phylogeny of venom phospholipases and threeﬁnger toxins of eastern India Bungarus fasciatus and kinetic analyses of its Pro31 phospholipases ... receptors of an alpha-neurotoxin isolated from venom of the banded krait (Bungarus fasciatus) . Toxicon 24, 713–719.10 Liu CS & Lo TB (1994) Chemical studies of Bungarus fasciatus venom. J ... of isoforms for PLA and 3FTx from thepooled Bf venom were high, but the intraspecies orthe geographic variations of this venom species havenot been explored.Intra-species variations of venom...

Báo cáo khoa học: Sequences downstream of the transcription initiation site are important for proper initiation and regulation of mouse ribonucleotide reductase R2 gene transcription ppt

... mouseribonucleotidereductase is composed of two subunits, proteins R1 and R2.Both subunitsare required for enzymeactivity and itcould bereasonable to assume that the expression of the R1 and R2mRNAs should be ... initiation and regulation of mouse ribonucleotidereductase R2 gene transcriptionIrina Kotova, Anna L. Chabes*, Sergei Lobov, Lars Thelander and Stefan Bjo¨ rklundDepartment of Medical Biochemistry and ... promoters. Genes Dev. 10, 711–724.15. Thelander, M. & Thelander, L. (1989) Molecular cloning and expression of the functional gene encoding the M2 subunit of mouse ribonucleotide reductase: a...

Báo cáo khoa học: Sequences and structural organization of phospholipase A2 genes from Vipera aspis aspis, V. aspis zinnikeri and Vipera berus berus venom Identiﬁcation of the origin of a new viper population based on ammodytin I1 heterogeneity docx

... thegenes encoding the PLA2s present in the venoms of allthe venomous snake species of France. On the basis of its venom PLA2 characteristics and, particularly, sequenceanalysis of the ammodytin I1 ... ampliﬁca-tion of the ammodytin L gene.Table 2. Characteristics of the venom PLA2 genes of V. a. as pi s, V. a. zinnikeri,neurotoxicV. a. aspis and V. b. berus. The PLA2 content of V. am. ammodytes venom ... in theother PLA2 genes (Table 3). The ammodytoxin C, ammo-dytins I1 and I2 and ammodytin L genes of V. am. ammo-dytes, the VP7 and VP8 genes of V. palaestinae,andthePLA2 genes of Crotalinae...

Tài liệu Báo cáo khoa học: Mixed lineage leukemia: roles in gene expression, hormone signaling and mRNA processing docx

... evidenced by lowlevels of Hoxa1 , higher levels of Hoxa3 and Hoxa5 and the complete absence of Hoxa2, Hoxa4 and Hoxa6 expression [28]. These studies also demon-strated that Hoxa7 and Hoxa9 are required ... that mutation of Taspase 1 resultsin the downregulation of cyclin E, A and B, and upreg-ulation of p16 (an S-phase inhibitor). MLL1 binds tothe promoters of cyclin E1 and E2 and there is amarked ... Rbbp5 and Ash2, results from our laboratorydemonstrate that knockdown of CGBP abolishes therecruitment of MLL1 into the promoter of its targetHOXA7 gene, affecting H3K4 trimethylation and HOXA7...

Tài liệu Báo cáo khoa học: A knowledge-based potential function predicts the speciﬁcity and relative binding energy of RNA-binding proteins ppt

... twoatoms (i,j), of types ti and tj, and Nobs(dij,ti,tj) represents thenumber of atoms of types ti and tjobserved in the structuretraining set, separated by a distance of at least ... examples of binding-sequencediscrimination, the native sequences of the RRM1 of Sex-lethal protein (1B7F_1) and KH1 domain of Poly C-binding protein-2 were both ranked ﬁrst out of 256 sequences, ... structure.Some RRM and KH domains in complex with singlestrand DNA (PDB codes: 2UP1, 1WTB, 1X0F, 1ZZI and 1ZZJ) were also included in the test set because recognition of single stranded RNA and DNA are...

Tài liệu Báo cáo khoa học: What MAN1 does to the Smads TGFb/BMP signaling and the nuclear envelope Luiza Bengtsson pdf

... of SANE and xMAN1 in the NCBI gene database are identical(gi|56849616 and gi|29335751, respectively) and areorthologous to human MAN1.The C-terminus of human MAN1 interacted withSmads 2 and ... organiza-tion, cell development and differentiation, nuclearanchoring and migration, and apoptosis (reviewed in[1,2]). Mutations in several of the integral membraneproteins of the inner nuclear membrane ... emerin and MAN1 bind the transcriptionalrepressors germ cell-less (GCL) and Bcl-2-associatedtranscription factor (Btf) [7,8]. In addition, loss of emerin leads to up-regulation of expression of...

Tài liệu Báo cáo khoa học: 1,5-Diamino-2-pentyne is both a substrate and inactivator of plant copper amine oxidases ppt

... the presence of a triple bond (d 74.3 and 82.7 p.p.m) and aliphatic carbon atoms (signals of d 20–40 p.p.m), consis-tent with presence of an unoxidized DAPY moiety.The theoretical molecular mass ... Sayre51Department of Biochemistry,2Laboratory of Growth Regulators, and 3Department of Analytical Chemistry, Faculty of Science,Palacky´University, Olomouc, Czech Republic;4Department of Analytical ... exact molecular mass (177.14 Da) and molecular formula (C10H15N3). Electrospray ionization- and MALDI-MS/MS analyses yielded fragment mass patternsconsistent with the structure of a dihydropyridine...

Tài liệu Báo cáo khoa học: The SCO2299 gene from Streptomyces coelicolor A3(2) encodes a bifunctional enzyme consisting of an RNase H domain and an acid phosphatase domain pdf

... RNase H and acid phosphataseactivities of the full length SCO2299 protein depend on its N-terminal and C-terminal domains, respectively. The physiological functions of theSCO2299 gene and the ... bifunctional enzyme consisting of an RNaseH domain and an APase domain. The RNase H and APase activities of the full length SCO2299 proteindepend on its N-terminal RNase H domain and C-ter-minal APase ... Rv2228c (orMT2287) of Mycobacterium tuberculosis;Mle, ML1637 of Mycobacterium leprae;Mav, MAP1980c of Mycobacterium avium;Nfa, nfa16400 of Nocardia farcinica, and Tfu,Tfus02000308 of Thermobiﬁda...

Tài liệu Báo cáo khoa học: Nop53p, an essential nucleolar protein that interacts with Nop17p and Nip7p, is required for pre-rRNA processing in Saccharomyces cerevisiae pdf

... interaction between Nop53p and the exosome subunits and between Nop53p and snoRNP proteins of box C ⁄ D (Nop1p, Nop56p,Nop58p and Snu13p) and of box H ⁄ ACA (Cbf1p,Nop10p, Gar1p and Nhp2p), although ... accumulation of the 27S and 7Spre-rRNAs and depletion of the mature 25S and 5.8S mature rRNAs.Nop53p did not interact with any of the exosome subunits in the yeast two-hybrid system, but its depletion ... enzymes and snoRNPs(small nucleolar ribonucleoproteins). The precursor of three of the four eukaryotic mature rRNAs containsthe rRNA sequences ﬂanked by two internal (ITS1 and ITS2 ) and two...

Tài liệu Báo cáo khoa học: Efﬁcient RNA ligation by reverse-joined hairpin ribozymes and engineering of twin ribozymes consisting of conventional and reverse-joined hairpin ribozyme units ppt

... construction of twin ribozymes. Eventhough HPTWRJ is not as efﬁcient as its tandem-conﬁgured relative [16], its successful construction and the demonstration of its functionality supports the idea of ... structure of the reverse-joined ribozyme unit fortwin ribozyme design consists of two domains joinedby a single-stranded linker of eight adenosine residues and binds the 3¢-terminal part of its substrate ... min)1atequimolar concentrations of ribozyme and substrate(according to conditions used for sequence exchangereaction, see below).Design of a twin ribozyme and kinetic analysisAs a result of the studies described...

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