Báo cáo khoa học: Bridging the gap between in silico and cell-based analysis of the nuclear factor-jB signaling pathway by in vitro studies of IKK2 ppt

Tài liệu Báo cáo khoa học: a-Defensins increase lung ﬁbroblast proliferation and collagen synthesis via the b-catenin signaling pathway doc

... proliferation and collagen synthesisinvolve the b-catenin signaling pathway. Inhibition of b-catenin signaling pathway usingquercetin blocked the a-defensin-inducedincrease in collagen release ... signaling pathway. We then studied the role of the b-catenin signaling pathway in a-defensin-induced increases in the proliferation and collagen syn-thesis of lung ﬁbroblasts using quercetin. ... inhibi-tion of the b-catenin signaling pathway by quercetinprevented increases in lung ﬁbroblast proliferation and collagen synthesis induced by a-defensin-1 and a-de-fensin-2. Furthermore, by using...

Báo cáo khoa học: "A Graphical Interface for MT Evaluation and Error Analysis" doc

... categories of the words in the sentence and dis-play the information they contain. Figure 2 and 3show, respectively, several annotation levels of the sentences in the example and the constituency ... using the Jaccard coefﬁcient. First, the sets of all lexical items that are found in the ref-erence and the candidate sentences are considered.Then, Olis computed as the cardinality of their ... their in- tersection divided by the cardinality of their union. The example in Table 1 shows the counts used to cal-culate Ol between the reference and two candidatetranslations (boldface and...

Tài liệu Báo cáo khoa học: "Bridging the Gap Between Underspeciﬁcation Formalisms: Minimal Recursion Semantics as Dominance Constraints" docx

... present the first provablyefficient algorithm to enumerate the read-ings of MRS structures, by translatingthem into normal dominance constraints.1 Introduction In the past few years there has ... areconnected by a hypernormal path in the graph of the restricted constraint Φ|V−{X1}, and there exists no Zsuch that X ∗Z in Φ. The requirement of hypernormal connections in islands replaces the ... satisfies the following conditions.N1 (a) each variable of ϕ occurs at most once in the labeling literals of ϕ.(b) each variable of ϕ occurs at least once in the labeling literals of ϕ.N2 for distinct...

Tài liệu Báo cáo khoa học: "Bridging the Gap Between Underspecification Formalisms: Hole Semantics as Dominance Constraints" ppt

... sit-uated in a solution of the solved form. They caneither dominate each other in either direction, orthey can be disjoint. But if they are disjoint, wealso know the lowest node that dominates themboth, ... holes in all connectingchains in yo. Then the constraint yo A • A (p0 ischain-connected.2 The original grammar accounts for scope island con-straints by means of additional dominance ... not the root of the entire tree denotes the child of anotherroot, i.e. denotes the same node as a hole. We ob-tain an admissible plugging by mapping each holeh to the label P(h ) in the...

Báo cáo khoa học: Bridging the gap between in silico and cell-based analysis of the nuclear factor-jB signaling pathway by in vitro studies of IKK2 ppt

... FEBS Bridging the gap between in silico and cell-based analysis of the nuclear factor-jB signaling pathway by in vitro studies of IKK2 Adaoha E. C. Ihekwaba1,4, Stephen J. Wilkinson1, Dominic ... absence of the SC-514 inhibitor. (D, E) Timecourse plot of nuclear NF-jB from in vitro and in silico analysis of the data. The plot shows nuclear NF-jB oscillation in the original model and in the ... for binding GST-IjBa in the presence and absence of ATP, and the value of a indicates whether the binding of one substrate (ATP) affects the afﬁnity of the enzymefor the other substrate (GST-IjB...

Tài liệu Báo cáo khoa học: Speciﬁc interaction between the classical swine fever virus NS5B protein and the viral genome pdf

... (EMSA) and R dRpassays, and examined the in uence of d ifferent cis-actingelements on binding of NS5B protein and RNA synthesis in vitro. Materials and methodsExpression and puriﬁcation of NS5B ... tobinding of the CSFV NS5B protein. The minus-strand3¢ UTR with deletion of the 21 nucleotide fragment at the terminal did not interact with the N S5B protein at all.Characterization of the cis-acting ... –RNA0 in the presence of increasing amounts of c ompetitor, the unlabeled –RNA0also demonstrated an interaction between CSFV NS5Bprotein and the –RNA0 (results not shown).Mapping of the NS5B-binding...

Tài liệu Báo cáo khoa học: Evidence for interactions between domains of TatA and TatB from mutagenesis of the TatABC subunits of the twin-arginine translocase docx

... couldparticipate in proton translocation or, in the case of E103, in the binding of the twin-arginine motif in the signal peptide. The absence of any translocationdefects leads us to conclude that these ... 2275Evidence for interactions between domains of TatA and TatB from mutagenesis of the TatABC subunits of the twin-arginine translocaseClaire M. L. Barrett and Colin RobinsonDepartment of Biological ... synthesis with cleavable, N-ter-minal signal peptides that almost invariably contain anessential twin-arginine motif in the N-terminal domain[9,10]. They then interact with a translocon in the inner...

Tài liệu Báo cáo khoa học: Long-distance interactions between enhancers and promoters The case of the Abd-B domain of the Drosophila bithorax complex pdf

... removal of which shifts the ratio between the strength (indica-ted by the thickness of the curved arrows) of the cis and transinteractions in favor of the latter. An increase in the trans inter-action ... pairing between these sequences within the BX-C plays a role in restricting the extent of loop-ing-out domains.Tethering elementsDeletion analysis of the Abd-B gene strongly suggests the existence ... the effects of the neighboring chromatin (e.g. heterochro-matinization) if the reporter is ﬂanked by two of them. The apparent function of the boundaries within BX-Cis to separate neighboring...

Tài liệu Báo cáo khoa học: "STRING-TREE CORRESPONDENCE GRAMMAR: A DECLARATIVE GRAMMAR FORMALISM FOR DEFINING THE CORRESPONDENCE BETWEEN STRINGS OF TERMS AND TREE STRUCTURES" pdf

... representation is defined as a mapping between elements of the set of substrings of the string and elements of the set of subtrees of the tree : such a relation is called a string- tree correspondence. ... string of terms, and finally the correspondence which is a mapping (given by the arrows ~ ~>) defined between substrings of STRING and subtrees of TREE (a more formal notation using indices ... to the above, an STCG rule thus defines a correspondence between a set of strings of terms on one hand and a set of trees on the other (by means of a linear sequence of sets of trees). The...

Tài liệu Báo cáo khoa học: A novel coupled enzyme assay reveals an enzyme responsible for the deamination of a chemically unstable intermediate in the metabolic pathway of 4-amino-3-hydroxybenzoic acid inBordetellasp. strain 10d doc

... enzyme The activity of the enzyme present in the crude extract of strain 10d that used 2 -amino-5-carboxymuconic 6-semi-aldehyde as substrate was measured by monitoring the increase in the absorbance ... of the puriﬁed enzyme at 266 nm. The typicalprotein absorption p eak of 2 80 nm shifts to 265 nm if the protein contains a ﬂavin-type cofac tor [28]. We failed toidentify the cofactor of the ... released ammonia. The coupled enzymeassay revealed the mechanism of the deamination reaction and the subsequent metabolism, including the deaminationstep. The product formed from 4-amino-3-hydroxybenzoicacid...

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