Báo cáo khoa học: Protein-misfolding diseases and chaperone-based therapeutic approaches pdf

Báo cáo khoa học: "Paragraph-, word-, and coherence-based approaches to sentence ranking: A comparison of algorithm and human performance" ppt

... experiment to three different approaches to sentence ranking: A simple paragraph-based approach intended as a baseline, two word-based approaches, and two coherence-based approaches. In the paragraph-based ... Paragraph-, word-, and coherence-based approaches to sentence ranking: A comparison of algorithm and human performance Florian WOLF Massachusetts Institute ... 7 (very important). The approaches we evaluated are a simple paragraph-based approach that serves as a baseline, two word-based algorithms, and two coherence-based approaches 1. We furthermore...

Báo cáo khoa học: "Robust Generic and Query-based Summarisation" pdf

... extraction approach and the deep, un-derstand and generate approach (Mani, 2000).Sentence extraction methods are quite robust, butsentence extracts suffer from lack of cohesion and coherence. Methods ... informationextraction or text understanding and that use thekey information to produce a new text, lead tohigh-quality summarisation (Paice and Jones,1993; Saggion and Lapalme, 2002) but sufferfrom ... research and are made available asa library of Java classes and configuration file (i.e.creole in GATE terminology):•Corpus statistics: token statistics including to-ken frequency and lemma...

Báo cáo khoa học: "Bootstrapping Events and Relations from Text" pdf

... Given a set of exam-ples and an un-annotated text corpus, the BEAR system (Bootstrapping Events And Relations) will automatically learn how to recognize and understand descriptions of complex ... (Thelen and Riloff, 2002) generated new syntac-tic patterns by exploiting the context of known seeds for learning semantic categories. In Snowball (Agichtein and Gravano, 2000 ) and Yangarber’s ... et al. 2000) and its extension, e.g., the chain model (Sudo, et al. 2001) and other related variants (Riloff, 1996) all of which lack the expressive power to accurately recognize and represent...

Tài liệu Báo cáo khoa học: ER stress and diseases docx

... nucleus and cytoplasm, and c-Abl activated by adeath signal induces phosphorylation and activation ofpro-apoptotic JNK and SAPK. Interestingly, c-Abl isalso located on the ER surface, and translocates ... under-standing conformational diseases. I will review hottopics such as ERAD, regulated intramembrane pro-teolysis (RIP) and cytoplasmic splicing, and brieﬂysummarize the ER stress-related diseases. ER ... induces theexpression of BiP and CHOP, activates JNK2 and caspase-12, and causes the apoptosis of neurons [219].These ﬁndings suggest a strong correlation betweenER stress and GM1 gangliosidosis.Bipolar...

Tài liệu Báo cáo khoa học: Afﬁnity and kinetics of proprotein convertase subtilisin ⁄ kexin type 9 binding to low-density lipoprotein receptors on HepG2 cells docx

... time courses and effects of unlabeled ligands and low pH on the dissociation rates of [125I]TC-PCSK9 (A) and [125I]TC-PCSK9-D374Y (B) from HepG2 cells. Binding to equilibrium and removal of ... HepG2 cells (70 000, 140 000 and 280 000) were seeded in 12-well plates and incubated eitherfor 48 h in complete growth medium or for 24 h in com-plete growth medium, and then for 26 h in 3% LPDS-con-taining ... NaCl ⁄ Picontaining0.1 mm CaCl2 and 0.5% BSA, and three times with 1 mLof wash buffer without BSA. The cells were solubilized in0.5 mL of 0.2 m NaOH, and transferred to counting tubesfollowing...

Tài liệu Báo cáo khoa học: a-enolase: a promising therapeutic and diagnostic tumor target ppt

... 917–924.133 Fernandez Madrid F (2005) Autoantibodies in breastcancer sera: candidate biomarkers and reporters oftumorigenesis. Cancer Lett 230, 187–198.a-enolase in tumor diagnosis and therapy ... ARTICLEa-enolase: a promising therapeutic and diagnostic tumortargetMichela Capello, Sammy Ferri-Borgogno, Paola Cappello and Francesco NovelliDepartment of Medicine and Experimental Oncology, ... were found in both leu-kemia and lung cancer and one serine in both tumoral and normal pancreas.ENOA in tumor cells is subjected to more acetyla-tion, methylation and phoshorylation than in normaltissues,...

Tài liệu Báo cáo khoa học: Membrane targeting and pore formation by the type III secretion system translocon pdf

... PcrH and IpgC are shown in yellow, green and magenta, respec-tively. The peptides located within the concave regions of PcrH and IpgC, corresponding to sections of the N-termini of PopD and IpaB, ... levels (i.e. 38% forPseudomonas PopD and Yersinia YopD; 29% for Shi-gella IpaC and Salmonella SipC). Indeed, sections ofIpaC and SipC (as well as YopD and PopD) are inter-changeable without ... membrane and increasing Salmonella invasionefﬁciency [62]. It is of note that both IpaC and SipCare essential for Shigella and Salmonella uptake bymacrophages in the early steps of invasion, and...

Tài liệu Báo cáo khoa học: Identiﬁcation and characterization of the transcription factors involved in T-cell development, t-bet, stat6 and foxp3, within the zebraﬁsh, Danio rerio docx

... t-bet, stat6 and foxp3 were also determined and found to be very simi-lar to their human homologues. Both the human and zebrafish T-bet and Foxp3 genes contained the samenumber of exons and introns. ... beenseen within a wide variety of tissues and cells in theGinbuna crucian carp [27] and, in mammals, in thelung tissue of mouse and spleen and thymus of human and mouse [11,37]. Foxp3 is also highly ... zebrafish t-bet, stat6 and foxp3expression was also investigated, and indicated thatthese molecules are biologically relevant to bony fishimmune responses and, in particular, Th and Tregcellresponses....

Tài liệu Báo cáo khoa học: Pronounced adipogenesis and increased insulin sensitivity caused by overproduction of prostaglandin D2 in vivo pptx

... family, and is also called GSTS1[17]. On the other hand, L-PGDS has been puriﬁedfrom rat brain [18], and is expressed in brain, heart, and male genital organs, as well as in adipocytes and omen-tal ... liver and WAT. Parafﬁnsections of liver and WAT from WT and TGmice (S55) were stained with antibodyagainst human H-PGDS. Bars: 100 lm.(D) PGDS activity in liver of WT and S41,S55 and S66 ... H-PGDS,hematopoietic prostaglandin D synthase; IBMX, 3-isobutyl-1-methylxanthine; L-PGDS, lipocalin-type prostaglandin D synthase; LPL,lipoprotein lipase; PG, prostaglandin; PGDS, prostaglandin D synthase;...

Tài liệu Báo cáo khoa học: Neuropeptide Y and osteoblast differentiation – the balance between the neuro-osteogenic network and local control ppt

... and ubiquitin C-terminal hydrolase (speciﬁc markers forneural and neuroendocrine tissues) were found in ratlong bones at embryonic day 15, in the diaphyseal and metaphyseal perichondrium, and ... adrenergic and cholinergic in nature, and originate from paravertebral sympathetic ganglia[16]. Experimental nerve deletion and immunohisto-chemistry analysis have shown that both myelinated and unmyelinated ... thatvary in their binding proﬁles and in their distributionin the central nervous system and periphery. Y1, Y2 and Y5 are the best characterized NPY receptors, and the majority of NPY functions...

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