... reversed the hypoxia-dependent downregulation of FXR. As shownin the top panel of Fig. 6A, the amount of FXR pro-tein under hypoxia was 27% of the value of the ‘norm-oxia’ control, and the treatment ... functional, neither of themlowered the FXR protein expression level (Fig. 3C).Furthermore, when FXR mRNA levels were examined,none of the HIF-a isoforms could mimic the effect of hypoxia, whereas ... mem-brane of hepatocytes, and secrete bile acids from the hepatocytes into the bile canaliculi [13]. Bile, containingbile acids, phospholipids, cholesterol, and proteins, isthen stored in the gall...