viral safety evaluation of biotechnology products derived from cell lines of human or animal origin
Safety Evaluation Of Certain Food Additives potx
... country, territory, city or area or of its authorities, or concerning the delimitation of its frontiers or boundaries Dotted lines on maps represent approximate border lines for which there may not ... country, territory, city or area or its authorities, or concerning the delimitation of its frontiers or boundaries The mention of specific companies or of certain manufacturers’ products does ... The mention of specific companies or of certain manufacturers’ products does not imply that they are endorsed or recommended by the World Health Organization in preference to others of a similar...
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Báo cáo hóa học: "Safety evaluation of allogeneic umbilical cord blood mononuclear cell therapy for degenerative conditions" pot
... application of the technique and consent forms were obtained from each patient before initiation of treatment Cell processing Umbilical Cord Blood (100~ 150 mL) was collected from healthy unrelated donors ... information record including test results for sterility, mycoplasma and endotoxin Cell growth was regularly monitored and the inspection records updated accordingly Cells were harvested for clinical ... Development of CD4+CD25+FoxP3+ regulatory T cells from cord blood hematopoietic progenitor cells J Leukoc Biol 2009, 85:445-451 Gratwohl A, Baldomero H: Trends of hematopoietic stem cell transplantation...
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báo cáo hóa học: " Safety evaluation of topical applications of ethanol on the skin and inside the oral cavity" pdf
... capabilities of ethanol, which could lead to an increased absorption of other components of topically applied formulations (e.g nitrosamines from cosmetics) 16 Safety assessments of ethanol in any form of ... employing the best science for human safety evaluation part IV: Recommendation of a working group of the Gesellschaft fuer Umwelt-Mutationsforschung (GUM) for a simple and straightforward approach to ... general safety of alcohol-containing oral products It appears to be prudent precautionary public health policy to generally refrain from using ethanol in such products For example, the Centers for...
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Báo cáo sinh học: "Pitfalls in the phylogenomic evaluation of human disease-causing mutations" potx
... alignment of the more poorly conserved regions of the MSX proteins Having undertaken this alignment, sequence changes found in human MSX1 in samples from patients with either tooth agenesis or cleft ... around 1% of cases [8], prompting claims that MSX1 mutations are an important ‘cause’ of CL/P Importantly, none of the variants identified resides within the MH1N or homeodomain regions harboring ... depths of sequence conservation, human- amniote, human- tetrapod and human- cnidarian [1] Although MAPP is not the only method for undertaking this type of analysis, it is unlikely that choice of a...
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Bacteria are often maligned as the causes of human and animal disease (like this one, Leptospira, which causes serious disease in livestock)
... unilateral orchitis( inflammation of one or both of the testes) ** These conditions are usually relieved with the treatment of 1% atropine and steroids Epidemiology Ebola Hemorrhagic ... distribution of animals and plants This concept of can be used to explain the world’s shockingly small response to the Ebola Virus Because there was little travel to that region by people of more ... Outbreaks 1976- First Major Outbreak (ZEBOV) 1976- Sudan (SEBOV) Occur Sporadically www.cdc.gov for more information Where does Ebola hide? 2002- Fruit...
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Báo cáo y học: " Infections of respiratory or abdominal origin in ICU patients: what are the differences" docx
... worst value within 24 hours after hospital admission [16] Evaluation of organ function was made using the Sequential Organ Failure Assessment (SOFA) score, based on the most abnormal value for ... > for the organ in question [17] Early organ failure and late organ failure were defined as those occurring within and after 48 hours of a diagnosis of sepsis, respectively For the purposes of ... Use of the SOFA score to assess the incidence of organ dysfunction/failure in intensive care units: results of a multicenter, prospective study Working group on “sepsis-related problems” of the...
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Báo cáo y học: " Phylogenetic classification of Escherichia coli O157:H7 strains of human and bovine origin using a novel set of nucleotide polymorphisms" pps
... Figure of 42 polymorphism -derived genotypes in STEC O157 strains of human and cattle origin Frequencies Frequencies of 42 polymorphism -derived genotypes in STEC O157 strains of human and cattle origin ... correNeighbor-joining polymorphism -derived in corresponding polymorphisms outerorigin color with genotypes for strains polymorphisms fileused polymorphisms represent bootstrap of bovinepolymorphism ... isolated from clinically ill humans [26] A total of 1.306 Gb of genomic sequence was obtained from DNA pools of: 51 strains of bovine origin, tir 255 T>A A allele (346.2 Mb); 51 strains of bovine origin...
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PRINCIPLES FOR THE RISK ANALYSIS OF FOODS DERIVED FROM MODERN BIOTECHNOLOGY
... the Guideline for the Conduct of Food Safety Assessment of Foods Derived from Recombinant-DNA Plants (CAC/GL 45-2003), the Guideline for the Conduct of Food Safety Assessment of Foods Produced ... materials; and, the tracing of products for the purpose of facilitating withdrawal from the market when a risk to human health has been identified or to support post-market monitoring in circumstances ... other information relevant to risk analysis 30 Recognizing the rapid pace of development in the field of biotechnology, the approach to safety assessments of foods derived from modern biotechnology...
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Báo cáo y học: " Peptides derived from the HIV-1 integrase promote HIV-1 infection and multi-integration of viral cDNA in LEDGF/p75-knockdown cells" doc
... Quantitative analysis of the total amount of viral cDNA in cells infected with WT or ΔRev HIV-1, both at a MOI of 1.0, revealed the presence of about 30.0 to 35.0 copies (in average) per cell (Fig 2B) ... indicated concentration of INS and infected with wt or ΔRev HIV-1 at a MOI of 1.0 The average number of integration events per cell (A) and of total viral DNA copies per cell (B) was estimated ... Maxisorp Page of 11 Figure Schematic model of the process of viral cDNA integration in wt and LEDGF/p75-knockdown cells (A) In LEDGF/p75-knockdown cells, an early expressed Rev (green triangle), from...
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Báo cáo y học: "Impaired nuclear import and viral incorporation of Vpr derived from a HIV long-term non-progressor" docx
... requirement for virion incorporation With this in mind, we assessed the ability of nuclear import-inhibited cytosolic GFP-VprF72L to incorporate into forming virions Briefly, 293T cells were cotransfected ... Activation of afail to incorporate into formingcorrelating withshow decreased infectivity of non-dividing F72L-containing GFP-Vpr proteins Galactosidase Indicator) cells virions, which reduced importin-β3 ... fail to incorporate into forming virions, which show decreased infectivity of non-dividing MAGI (Multinuclear Activation of a Galactosidase Indicator) cells correlating with reduced importin-β3...
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EVALUATION OF THE REAL SITUATION OF IMPORT ACTIVITIES OF VIETNAM ENERGY DEVELOPMENT SUPPORT JOINT STOCK COMPANY FROM 2009 TO 2011. PROBLEMS AND SOLUTIONS.
... 2.1.3.4 Temporary import or re-export Temporary import or re-export means a company import products not for local consumption but for export to the third country for profit The imported goods ... Importers can enter goods for consumption, storage at the port of arrival, or transportation to another port of entry following the same procedures as for the port of arrival The entry of imports ... author will provide all information about import, including concept, characteristics, roles and forms of import Besides, some issues of import products and factors affecting energy- supported...
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Evaluation of Loading Rate of Nitrogen from Rice-Paddies by Small Watershed Method
... The observation of storm-runoff events is not so easy to carry out sufficient times of the observation Then, the samples of storm-runoff loads were supplemented with the storm-runoff loads calculated ... and 34% of TN Event was one of storm-runoffs after the second plowing in late-March, and showed the typical pattern distinguished clearly from those before the plowings The concentration of TN ... between the loads of TN and the drainage rates obtained from the storm-runoff observations ●: increasing period of drainage rate, ○: decreasing period of drainage rate, : regression line of increasing...
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Evaluation of Nutrient Loads from a Citrus Orchard in Japan
... forest had been changed to orchard, and the land use is simply composed of forest and orchard The study site downstream of the orchard receives the orchard discharge; the area of the watershed at the ... period of increasing of water discharge differed greatly from those in the period of their decreasing During a rainfall event, the SS concentrations increase by more than one or two orders of magnitude ... 0.15 Fig - Evaluation of phosphorus load in accordance with two L-Q equations Observed data of weekly research (from November 2006 to October 2007) are shown as dots Black line, for Case 3; gray...
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Tài liệu Báo cáo khoa học: Different modes of dipeptidyl peptidase IV (CD26) inhibition by oligopeptides derived from the N-terminus of HIV-1 Tat indicate at least two inhibitor binding sites doc
... structure of DP IV [43] provides a framework for future work and the basis for the investigation of the protein-bound, pharmacophore conformation of the ligands The stronger inhibitory potency of MWP-containing ... case of parabolic behavior of the Dixon plot the data were plotted according to Lineweaver–Burk (Eqn 3), yielding straight lines without a common point of intersection For the calculation of the ... in the parabolic behavior of the Dixon plot (Fig 2A), which therefore was not suitable for the determination of the Ki value From the Hill-plot, binding of the inhibitor to different binding...
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Tài liệu Báo cáo khoa học: Enhanced expression of Mcm proteins in cancer cells derived from uterine cervix docx
... BrdU-positive cells was approximately 32% for HeLa cells and 35% for WI-38 cells Measurements of growth curves suggested that the doubling time was approximately 21 h for HeLa cells and 25 h for WI-38 cells ... HeLa cells is maintained irrespective of cell cycle Next, we compared the concentration of Mcm proteins in cell lysate prepared from SV40-transformed human fibroblasts (GM00637) and normal human ... expressed more ubiquitously in cancer cells than in proliferative cells from normal uterine cervix or cells with dysplasia Their expression is probably more abundant in cancer cells than in normal...
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Tài liệu Báo cáo khoa học: The isolation and characterization of cytochrome c nitrite reductase subunits (NrfA and NrfH) from Desulfovibrio desulfuricans ATCC 27774 Re-evaluation of the spectroscopic data and redox properties ppt
... Gent, for the MALDI spectra We also thank to Prof B H Huynh from Department of Physics, Emory University, for his collaboration on the original Mossbauer ¨ studies This work was financially supported ... attempt of a soluble form of ccNiR Nitrite reductase activity was checked in the soluble cell fraction in order to investigate the existence of a soluble monomeric form of ccNiR, as reported on ... In order to fit these outer regions of the experimental spectra, we used three different components, two from the NrfA subunit and one from NrfH, according to the following considerations The original...
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Evaluation of the Patient Safety Improvement Corps pot
... hospital-based champions of patient safety Lack of full support for PSIC involvement from supervisor or CEO Supervisor or CEO complaining of PSIC time commitment (e.g., time out of office, team project) ... home organizations, lack of home organization resources, geographic distance between PSIC team members, and lack of full support for the project from the state or the corporate executive officer ... the RAND Corporation to serve as the Patient Safety Evaluation Center Under a four-year contract, the evaluation center is responsible for performing a longitudinal, formative evaluation of the...
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Báo cáo khoa học: Study of synthetic peptides derived from the PKI55 ppt
... level of PKC a, b1, b2 and f isoforms was also studied Results Synthesis of peptides derived from PKI55 and their inhibitory effect on rat brain PKC A series of peptides was synthesized in order ... selected for further study to identify their inhibitory profile versus specific PKC isoforms and to assess their potential anti-inflammatory action Inhibitory effect of peptides derived from PKI55 ... ability to inhibit the e isoform, whereas peptide was only effective on the b1, e and f isoforms Interestingly, the inhibitory action of peptides and on the b1 isoform was found to be significantly...
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Báo cáo khoa học: "FROM N-GRAMS TO COLLOCATIONS AN EVALUATION OF XTRACT" pot
... f deciding on a label for the b i g r a m from the set of label[i~'.s For this, we count the frequency of each label for the bigram and perform a statistical analysis of this distribution A collocation ... valid collocations from a set of candidates T h i s section describes an evaluation e x p e r i m e n t of the third stage of X t r a c t as a retrieval system Evaluation of retrieval systems ... distance of 3.1 OF THE ALGORITHM I n p u t : A bigram with some distance information indicating the most probable distance between the two words For example, takeover and thwart with a distance of...
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Báo cáo Y học: IgE reactivity of tandem repeats derived from cockroach allergen, Bla g 1 docx
... for allergenicity Possible reasons for the generation of multiple molecular forms of rBla g were investigated PCR analysis of Pichia genomic DNA showed that the origin of the multiple forms of ... methanol-induced Pichia Origin of expression of rBla g multiple forms The expression of rBla g in methanol-induced Pichia resulted in a mixture of proteins of 42.6, 31.9, 21.0 and kDa (as calculated from the ... expression times For scale-up, mL of the initial 10 mL culture was used to inoculate 500 mL of medium and grown for days Analysis of transformants for integration of Bla g DNA in P pastoris genome...
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