training independent validation modeling training and modeling testing sets for the inhibitors substrates of different cytochrome p450 isoenzymes
Machine learning approach in pharmacokinetics and toxicity prediction
... independent validation, modeling training and modeling testing sets for the inhibitors/ substrates of different cytochrome P450 isoenzymes 125 Table 6.2 Accuracies of the “best-trained” single ... inhibitors/ substrates of different P450 isoenzymes by using modeling testing sets and independent validation sets 136 Table 6.7 Important descriptor classes selected for the prediction of inhibitors/ substrates ... PMCSVM and PP-CSVM for the prediction of CYP3A4 and CYP2D6 inhibitors/ non -inhibitors by using the independent validation sets 130 Table 6.3 Accuracies of PP-CSVM for the prediction of CYP2C9 inhibitors/ noninhibitors...
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establish an anaerobic batch system by using guideline vdi 4630 and determine the biogas yield of different substrates in food processing villages
... oxygen demand) The biogas yield (per amount of substrate, per VS of inoculum, per COD of substrate) and the degradability of different substrates will be evaluated Objective The aim of this thesis ... from the interaction between the ingredients, the type of fermenter and the operation of the plant (KALTSCHMITT et al., 2009) The addition of substrates with high proportions of carbohydrates and ... Theoretical Basics Ratio of nutrient elements The C/N ratio and the C/N/P/S ratio can be used as an indicator of the optimal supply of carbon and nutrients If the C/N ratio is too high then the...
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Báo cáo y học: "Revision of late periprosthetic infections of total hip endoprostheses: pros and cons of different concepts"
... position for a certain period of time before the final prosthesis is implanted [17,20,30,33,34] The function of the spacer is on the one hand to release the antibiotic into the infected bed of the ... include the restoration of depleted bone stock, the correction of leg-length discrepancy and the ability to use conventional revision prostheses (and not megaprostheses) The preservation of the soft-tissue ... antibiotic-loaded cement of the spacer and used for the systemic treatment is chosen on the basis of the sensitivity of the bacterium causing the infection Since the use of several antibiotics...
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Consumer acceptance of cheese,influence of different testing conditions
... different For the central location test the overlap is the strongest, while for the in-home test the overlap is the weakest For the laboratory testing, the mid group overlaps with both the high and ... conclusion as for the full analysis, indicating no effect of the order of the testing situation Table shows data from the in-home testing The majority of the consumers (80%) tasted the cheese samples ... groups of samples Detailed information about average ratings of cheese samples and the standard deviations together with the total averages of the standard deviation per cheese sample and per testing...
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Evaluation of different weather files on energy analysis of buildings
... the effect the simulation domain size and the climate data have on the accuracy of the energy demands of a rather large complex of buildings To this aim, the energy demands of the buildings of ... obviously depends on both the quality of the data and on the sophistication of the simulation Of these data, those concerning the construction of the building and of the HVAC system are well defined ... certain The influence of the internal loads uncertainty on the final result depends on the time scale of the simulation and on the size of the simulation domain, since the increase of either or...
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Tài liệu Báo cáo khoa học: Identification of different isoforms of eEF1A in the nuclear fraction of human T-lymphoblastic cancer cell line specifically binding to aptameric cytotoxic GT oligomers ppt
... to quantify the amount of recovered protein owing to the presence of a high molar excess of BSA remaining in the buffer Therefore, a fixed aliquot of the protein was incubated with the indicated ... described in the Materials and methods The same samples were used for Western blotting analysis performed with the same amount of the cytoplasm and nuclear proteins used in the SouthWestern blot The specific ... 270) 3259 cells, the presence of two different clusters of eEF1A isoforms (cluster and cluster 2) The apparent pI of cluster ( pH 9.0), was calculated theoretically by considering the pH gradient...
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Improvement of different vaccine delivery systems for cancer therapy pptx
... through altering the interaction between the vaccine and different APCs at the site of injection Hence, the routes of administration and formulation of DNA clearly affect the therapeutic response ... two different arms of the immune system may be enhanced by using two different modalities (i.e., CD4+ and then CD8+ T cells); and 3) some of the most effective methods of immunization, like the ... the possibility of random integration of the vector DNA into the host genome and their high cost [48,49] Non-viral or synthetic vectors have many advantages over their viral counterparts as they...
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EVALUATION OF DIFFERENT TYPES OF CHEST SYMPTOMS FOR DIAGNOSING PULMONARY TUBERCULOSIS CASES IN COMMUNITY SURVEYS pot
... two surveys were 9.7 and 16.0%; and 14.4 and 17.3% respectively The yield of cases according to the interval between the onset of cough and the time of elicitation of cough is given in Table-3 It ... surveys The workload and the cost involved in collection of sputum from these symptomatics and processing the specimens in the laboratory can also be avoided The study emphasized the importance of ... Selvakumar and his staff of Bacteriology Department for reporting the results The authors thank the staff of Statistics and Electronic Data Processing (EDP) Divisions of the Epidemiology Unit for data...
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Báo cáo khoa học: Role of different moieties from the lipooligosaccharide molecule in biological activities of the Moraxella catarrhalis outer membrane pot
... lipid-A and two phosphate moieties The ions with m ⁄ z of 1519.6 and 1541.6 are mono- and di-sodiated forms of the de-O-acylated LOS and the ion with m ⁄ z of 1479.6 is the anhydrous form of the ... consists of two GlcNAc and two 3-OH C12:0 groups Among the other ions m ⁄ z of 2654.8, 2694.8 and 2717.4 indicates the presence of the anhydro form and mono- and di-sodiated form of the molecular ion ... shown in the inset The m ⁄ z 917.4 and 797.4 are due to sodiated and dehydrated forms, respectively, of the m ⁄ z 895.4 fragment ion The de-O-acylated LOSs from the wild-type O35E and the mutant...
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Báo cáo khoa học: Neuropeptide Y, B-type natriuretic peptide, substance P and peptide YY are novel substrates of fibroblast activation protein-a pdf
... This is the first identification of natural substrates of FAP dipeptidyl peptidase activity NPY, BNP, substance P and PYY were the most efficient FAP substrates, and the first hormone substrates of FAP ... consistent with the loss of the N-terminal dipeptide Tyr-Ala from GRF No further breakdown of either peptide was observed up to 72 h, and neither peptide showed breakdown at 37 °C in the absence of protease ... functions of proteases and their mechanisms of action in biology and disease DPP4 is the prototype member of this family, and over 30 different substrates have been identified The insulin-secreting...
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Báo cáo khoa học: The role of cytochrome P450 monooxygenases in microbial fatty acid metabolism pdf
... acid and the enzyme responsible for the conversion of myristic acid has been identified as a member of the P450 superfamily: P450SPa or CYP152B1 [33] However, the enzyme utilizes H2O2 instead of ... cluster and three of them are P450 enzymes The FUM6 protein (CYP505B1) intervenes in one of the first steps in fumonisin synthesis by hydroxylation of the polyketide-amino acid at C-14 and C-15 ... to the endoplasmatic reticulum and derived structures, and the body of the protein is located in the cytoplasmatic space [59] Cytochrome P450 reductase is a flavoprotein containing the flavin cofactors...
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Báo cáo khoa học: "Are These Documents Written from Different Perspectives? A Test of Different Perspectives Based On Statistical Distribution Divergence" ppt
... pairs of different perspectives and document collection pairs of the same perspective and others We thus evaluate the proposed test of different perspectives in the following four types of document ... definition of different perspectives We first develop statistical models for the two document collections, A and B, and then measure the degree of contrast by calculating the “distance” between A and ... is the sample variance of θ1 , θ2 , , θM , ˆ and Φ(·)−1 is the inverse of the standard normal cumulative density function The second kind of variance is due to the intrinsic uncertainties of...
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Báo cáo Y học: Interaction of plasminogen activator inhibitor type-1 (PAI-1) with vitronectin Characterization of different PAI-1 mutants pdf
... used in the SPR analysis, another as yet unknown part of active PAI-1 converts to the latent form and thus cannot bind to Vn anymore Therefore, the analysis of the interaction of PAI-1 and, especially, ... but for the PAI-1 mutants a different maximum for the speci®c activity may exist Furthermore, within the time frame of determination of the amount of active PAI-1 in a given preparation to the ... 37 °C for h Then, 10 lL of chromogenic substrate were added and the thrombin activity measured monitoring the change of optical density at 405 nm The activity of thrombin in the absence of inhibitor...
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shape-controllable synthesis of ultrafine zno powders of different
... regular crystal form and high purity The EDS pattern was performed on one of the ZnO flowerlike structures, and the composition analysis of the powder showed the existence of Zn and O (from the sample), ... h, and the micro-rods of the flower-like structures grew more regular In summary, the influences of the reaction temperature, the OHÀ/Zn2þ mol ratio and the reaction time on the morphologies of the ... ratio and reaction time 10 h 3.4 XRD patterns of ZnO powders and EDS pattern of flower-like structure The XRD patterns of ZnO of flower-like particles, rods and flake, and the EDS pattern of the ZnO...
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Báo cáo sinh học: " Comparisons of the M1 genome segments and encoded µ2 proteins of different reovirus isolates" pptx
... Sequences near the 5' (A) and 3' (B) ends of the M1 plus strands of 14 reovirus isolates Sequences near the 5' (A) and 3' (B) ends of the M1 plus strands of 14 reovirus isolates The start and stop ... as in the Nibert laboratory clone of T3D [23] For the previous study we had already examined the factories of T2J and some of the nine other isolates used for M1 sequencing above We nonetheless ... aliquots of each in 10% SDSPAGE gels and comparing dsRNA band mobilities [60] Oligonucleotide primers corresponding to either the 5' end of the plus strand or the 5' end of the minus strand were...
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Báo cáo sinh học: " Susceptibility of different leukocyte cell types to Vaccinia virus infection" potx
... recombinants and performed viral infections and participated in the drafting of the manuscript LS and GR performed the preparation of PBLs, carried out the flow cytometry and elaborated the data ... influence the infection rate of PBL cells Those might include a variety of such as the accessibility and amount of receptors, ability to internalize the virus, and the metabolic state of the cell ... receptors, the ability to internalize the virus, and the metabolic state of the cell In addition to cellular factors, genetic differences in the virus might influence the efficiency and fate of the...
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báo cáo hóa học:" Effect of different cuff widths on the motor nerve conduction of the median nerve: an experimental study" doc
... values of the percentage MNCV at different time durations before and following the application of the 14 cm and cm Mean Mean values of the percentage MNCV at different time durations before and ... before and following the application of the two cuffs was calculated by dividing the distance between the two stimulation sites by the difference in the onset latency proximal and distal to the ... both the axilla and the ante-cubital fossa The first recording was done at 5th minute of inflation, the second one at 10th minute and the third at 15th minute The cuff was then deflated and again...
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báo cáo hóa học:" Comparisons of the M1 genome segments and encoded µ2 proteins of different reovirus isolates" doc
... Sequences near the 5' (A) and 3' (B) ends of the M1 plus strands of 14 reovirus isolates Sequences near the 5' (A) and 3' (B) ends of the M1 plus strands of 14 reovirus isolates The start and stop ... as in the Nibert laboratory clone of T3D [23] For the previous study we had already examined the factories of T2J and some of the nine other isolates used for M1 sequencing above We nonetheless ... aliquots of each in 10% SDSPAGE gels and comparing dsRNA band mobilities [60] Oligonucleotide primers corresponding to either the 5' end of the plus strand or the 5' end of the minus strand were...
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Tìm thêm: xác định các mục tiêu của chương trình xác định các nguyên tắc biên soạn khảo sát các chuẩn giảng dạy tiếng nhật từ góc độ lí thuyết và thực tiễn khảo sát chương trình đào tạo của các đơn vị đào tạo tại nhật bản xác định thời lượng học về mặt lí thuyết và thực tế tiến hành xây dựng chương trình đào tạo dành cho đối tượng không chuyên ngữ tại việt nam điều tra đối với đối tượng giảng viên và đối tượng quản lí khảo sát thực tế giảng dạy tiếng nhật không chuyên ngữ tại việt nam xác định mức độ đáp ứng về văn hoá và chuyên môn trong ct mở máy động cơ lồng sóc các đặc tính của động cơ điện không đồng bộ hệ số công suất cosp fi p2 đặc tuyến hiệu suất h fi p2 đặc tuyến mômen quay m fi p2 đặc tuyến dòng điện stato i1 fi p2 động cơ điện không đồng bộ một pha sự cần thiết phải đầu tư xây dựng nhà máy phần 3 giới thiệu nguyên liệu chỉ tiêu chất lượng theo chất lượng phẩm chất sản phẩm khô từ gạo của bộ y tế năm 2008 chỉ tiêu chất lượng 9 tr 25