... that the O ε atom of Glu197 makes a hydrogen bond withthe ligand; the N ε atom of His438 is also caught up in hydrogen bonding to the same atom ofthe ligand, resulting in the cleavage ofthe ... deeper insight into the mechanism of their interactions and thus helping in the design of potent new ChE inhibitors The interaction mode ofthe selected pose within the active sites of ChEs is described ... potential of Compound A differs among ChEs In the Compound A-AChE complex, the extension ofthe cleft is vital for the entrance of Compound A The distance between the center of mass of Trp279...
... percentage of child deaths in the total the losses of life in the flood seasons in the MD Save the Children (2003) reported that the vast majority ofthe drowning deaths in recent years in the region ... those living in the urban areas, children in the rural area are familiar withthe water in rivers and canals Their daily lives are linked withthe rice fields and flood plains Some of them learn to ... rowed and fell down the water while sleeping In Vietnam, the first day ofthe new academic year is usually in early of September In the MD, this period coincides with a high risk of flood Many pupils...
... wavelength of 1.540600 Å The X-ray data was collected using an MBraun curved PSD with a chamber depth of cm The focal radius ofthe system was 57 mm, and the cm length ofthe PSD subtended ∼25° 2θ ofthe ... however, the assignment of component polymorphs to sample mixtures depended on the XRPD results Conclusions Interconversions ofthe Polymorphs of Disodium Salt The interconversions of polymorphs ofthe ... combined withthe onset of thermal degradation, or the melt of a minor quantity of crystalline material that recrystallized upon cooling from the melt Scheme Interconversions of polymorphs of dicarboxylate...
... model for the transport cycle ofthe active TAP variant 2–1C2 The initiation step and the progress ofthe transport cycle are similar to the hypothesized peptide translocation model ofthe wild-type ... homology of about 75% The most variable part ofthe core NBDs, in other ABC transporters as well as TAP, lies within the helical subdomains Ó FEBS 2003 Regulation ofthe nucleotide binding state of ... top) Thus, the chimeric NBD consisting ofthe core NBD2 withthe C-terminal segment of TAP1 confers the nucleotide binding behaviour of wild-type TAP1 whereas the chimeric NBD1 bearing the core...
... orientation, the catalytic site in the N-terminal domain of one subunit and the substrate recognition site in the C-terminal domain ofthe other face each other, thereby bringing together the substrate-binding ... illustrates the overall saddle shape ofthe dimeric structure and the key heparin-binding residues in the N-terminal domain held coordinately by the two subunits on the top ofthe hollow (Fig 1A) The ... peak of wild-type LPL The LPL in the eluate was detected by Western blot with LPL polyclonal antibody 7640 The fraction number ofthe high-affinity peak was the same for the wild type and the WW...
... one the officers stole out from the cabin with bare feet, and made their way up to the quarterdeck, until some thirty of them were gathered there, being all the officers ofthe regiment, the ... invasion of England He pushed his arguments with fiery zeal, urged the disaffection of all classes, the hatred ofthe Commons, the defection ofthe Lords, the alarm ofthe Church, and the wavering ... what they were, for when they got within a mile of us two black flags ran up to their mastheads "The captain he trained one ofthe stern chasers hisself, and the first mate took the other They...
... diffusion of silicon atoms from the surface to the catalyst/NW interface Here, h is the height ofthe NW and O is the atomic volume of a silicon atom in a silicon lattice, the factor is the ratio ofthe ... but by the direct adsorption of molecules to the vacant sites located in the very peripheral region of a catalyst particle The width ofthe region gradually decreases withthe increase in the input ... view of improving our understanding ofthe general features ofthe process The results obtained within the framework of a kinetic approach have been confirmed and amended by the MC simulation These...
... in the atmosphere, the influence of another gas is not studied The action of oxygen is first analyzed, then the ozone one The combined action ofthe two mixed gases is finally studied at the end of ... case, the interaction between the semiconductor material and the gases is approached by means ofthe adsorption theory of Wolkenstein in order to determine the equilibrium state ofthe grains The ... the first step, the bond between the adsorbate and the substrate is weak and does not involve electronic transfer, the electrons ofthe atom or the molecule remain located in the vicinity of the...
... transformation of Vis-TiO2 thin film into the inactive TiO2 nanowires having high surface areas Fig shows the effect ofthe hydrothermal treatment on the XRD patterns of Vis-TiO2/Ti The intensity ofthe ... was found that the hydrothermal treatment ofthe Vis-TiO2/Ti with NaOH aqueous solution led to the drastic increase in the surface area of Vis-TiO2/Ti as well as an enhancement ofthe anodic photocurrent ... can also be ascribed to the existence of small amounts of Na+ which enhances the recombination rate ofthe photoformed electrons and holes The photocatalytic activities of Vis-TiO2/Ti/Pt or NaOH(5)Vis-TiO2/Ti/Pt...
... Care in the Elderly 2012:4 Elderly patient with multiple sclerosis Pain Pain is one ofthe most common symptoms of MS and can be seen in more than half of all patients with MS Pain can either be ... presentation with findings on MRI that are characteristic ofthe disease The new criteria simplify the diagnostic work-up and allow a more rapid diagnosis of MS while maintaining the specificity ... resulting in the need for fewer MRI studies Based on the revised criteria, the presence of at least one T2 lesion in at least two ofthe four locations considered characteristic of MS including...
... model The adjective model assumes that the meaning ofthe composition is the same as the adjective: p=u The noun model assumes that the meaning ofthe composition is the same as the noun: p=v The ... is consistentwiththe assumption that people use adjectives to modify the meaning ofthe noun, rather than conjoining the meaning ofthe adjective and noun In this study, we represented the ... presented with 12 text labels of objects (e.g dog) and were instructed to think ofthe same properties ofthe stimulus object consistently during multiple presentations of each item The participants...
... forms ofthe receptor The decrease in the amount of TSHRs observed during the chase (Fig 2C) in the presence of MG132 could be explained by the fact that the TSHRs were retranslocated into the ... of TSHR (Fig 4) The association with CNX and/or CRT therefore seems contribute to the stability and/or the maturation ofthe TSHR To obtain further insights into the contribution of CNX and CRT ... with BiP To further investigate the folding and maturation of TSHR, we studied the possible involvement of BiP, one ofthe main molecular chaperones ofthe endoplasmic reticulum, in these events...
... [8] The correlations between the items and PCS and MCS components were then compared withthe hypothesised correlations The variance explained (the percent ofthe total measured variance in the ... age were collected The sample size was determined withthe aim of measuring the reliability coefficients for the PCS and MCS scores ofthe SF-8 This used the assumption that the reliability coefficients ... half ofthe SF-8 items [43] Questionnaires with or more incomplete SF-8 items were excluded from further analysis on the validity and reliability ofthe SF-8 The distribution of item responses of...
... nerve symptoms These resolved without any long-term sequelae, and were thought to be due to the rate of distraction Following docking ofthe proximal tibia withthe distal femur, the patient had ... rods (Figure 7) The soft tissues in the front ofthe knee were repaired in layers The patient was allowed to weight-bear in his fixator Figure CT scan demonstrating the lesion in the proximal tibia ... of cells (Figures and 6) En-bloc resection ofthe knee was performed including the proximal cm of tibia, tibial articular surface, the proximal fibula, the patella and quadriceps mechanism, the...
... select the CPs equidistantly along the MS ofthe specimen in the image acquired at the beginning ofthe missing interval The changes in their positions are estimated by elongating the branches of ... along the corresponding branches ofthe MS in the image acquired at the end ofthe interval so that the distance between the CPs on each branch remains uniform This simulates the growth ofthe ... 4(a)) The distance between the CPs is, for example, half the average width ofthe filament The segment withthe CPs is then gradually elongated along the whole branch in the second MS, so that the...
... (2.29) The theorem is proved Remark 2.5 If |rk | > 1, ≤ k ≤ p, in Theorem 2.3, then the sequence (yn )n≥0 is uniquely determined Proof The proof follows from Remark 2.2 Remark 2.6 If there exists ... (2.17) Proof We prove Theorem 2.3 by induction on p For p = 1, the conclusion of Theorem 2.3 is true in virtue of Lemma 2.1 Suppose now that Theorem 2.3 holds for a fixed p ≥ We have to prove the following ... |rs | = 1, then the conclusion of Theorem 2.3 is not generally true 106 Hyers-Ulam stability of a linear recurrence Proof Let ε > 0, and consider the sequence (xn )n≥0 , given by the recurrence...
... to the ends ofthe string, are reflected at the ends, and then return These pulses return while the hammer is still in contact withthe string, and since they are inverted by the reflection, they ... series of compression/decompression cy- Here, τ0 is a characteristic (memory) time scale associated withthe felt, is a measure ofthe magnitude ofthe hysteresis, and y f (t) is the variation ofthe ... proportional to the component ofthe string tension perpendicular to the plane ofthe board, and is calculated from the string portion ofthe model Finally, we include a loss term proportional to the parameter...
... receives, therefore, the coarser spatiotemporal resolution levels first and then, withthe help ofthe spatiotemporal neighbors, can predict the finest resolution ones The conditional law ofthe coefficients ... set to zero The higher improvement ofthe PSNR at the finest temporal resolution level is due to the fact that in this case, the loss ofthe packet influences only the reconstruction ofthe temporal ... can observe the increase ofthe variance ofthe model withthe conditioning value which leads to a double stochastic model, in which we consider the conditional probability law ofthe coefficients...
... to the domain of attraction ofthe normal law or it has slowly varying tails and one ofthe two tails completely dominates the other The interest of considering resampling sizes different to the ... ∗ (A) > 0), which completes the proof Proof of Theorem 2.1 If EX < ∞ then s2 → σ a.s Therefore, the theorem follows if we show that n ∗ the conditional distribution of YnNn converges weakly to ... belongs to the domain of attraction ofthe normal law Hall [10] completes the analysis in this setup showing that when there exists a bootstrap limit law (in probability) then either the parent...