the role of oxidative stress in the retinal lesion of ccl2 cx3cr1 deficiency mouse on rd8 background
báo cáo hóa học: " The microglial NADPH oxidase complex as a source of oxidative stress in Alzheimer''''s disease" ppt
... interact with the plasma membrane [116] Both of these interactions rely on the isoprenylation of Rac Therefore, reduction in ROS is likely a consequence of statin inhibition of Rac prenylation ... gp91phox and an increase in p47phox protein expression in monocytes primed with INFγ [59] Figure Activation of the Rac GTPase Activation of the Rac GTPase GTP-binding of the Rac protein confers an ... were increased in the Tg2576 mouse model of AD; however, no signs of ROS production were evident in a mouse model where the Tg2576 mouse lacked the gp91phox gene Surprisingly, the contribution of...
- 12
- 413
- 0
Báo cáo y học: "Nifedipine decreases sVCAM-1 concentrations and oxidative stress in systemic sclerosis but does not affect the concentrations of vascular endothelial growth factor or its soluble receptor" potx
... signalling We confirm herein the high concentration of VEGF in serum and its association with the early phase of the disease [9] Moreover, we report high concentrations of the sVEGFR-1 in patients ... 2) Ongoing angiotensin-converting enzyme inhibitors (no patients) Ongoing low-dose aspirin therapy (no patients) 25 Values are number (%) of patients unless otherwise indicated DLCO, carbon monoxide ... controls Several factors contribute to VEGF production, including hypoxic conditions and stimulation by transforming growth factor, CD40 ligand, interleukin 1, or interleukin [10] Oxidative stress...
- 6
- 518
- 0
Báo cáo khoa học: " The effect of methyl sulphonyl methane supplementation on biomarkers of oxidative stress in sport horses following jumping exercise" doc
... by increases in lipid peroxidation, glutathione oxidation, and oxidative protein damage [28] In our study exercise induced an increase in cellular oxidative stress (as shown by the increase in ... levels monoxide Effect of4 (CO) sulphonyl methane (MSM), alone or combined with vitamin C (Vit C), on training -induced changes on carbon Effect of methyl sulphonyl methane (MSM), alone or combined ... carbon monoxide; GSH: glutathione Competing interests The authors declare that they have no competing interests Authors' contributions GM: Participated in the design of the study and performed the...
- 9
- 296
- 0
Tài liệu Báo cáo khoa học: Oxidative stress in the hippocampus after pilocarpineinduced status epilepticus in Wistar rats doc
... Oxidative stress after status epilepticus in rats inefficiency of the electron-carrying components of the mitochondrial transport chain, monoamine degradation, xanthine oxidase reaction, and ... results show an increase in nitrite formation after SE, suggesting that there is a possible increase in concentrations of ROS, which are often involved in neuronal damage [7,15] Other studies have ... increased catalase activity in the hippocampus, indicating that this enzyme, in association with GSH, provides neuroprotection against the increase in lipid peroxidation and nitrite content These...
- 6
- 480
- 0
Báo cáo khoa học: Calcium, mitochondria and oxidative stress in neuronal pathology Novel aspects of an enduring theme pdf
... chain inducing overreduction of the complexes, favouring the generation of ROS [16,17,22]; (c) reduction in the matrix concentration of electron acceptors, i.e NAD+, results in ROS emission from ... activation of the one can lead to activation of the other, completing a vicious cycle Intriguingly, silencing the expression of TRPM7 with siRNA, led to an accompanying decrease in TRPM2 expression ... resulted in any clinically useful intervention to limit the neuronal damage following ischemia ⁄ reperfusion or other brain injury Inescapably, within a context of ischemia ⁄ reperfusion in which...
- 18
- 549
- 0
Role of an electrolyte and substrate on the stability of porous silicon
... cmÀ2) Decay of PL intensity is a good indication of the stability of porous silicon particularly of the surface bond configurations [3,16] In Fig 4(A), decay of the PL intensity at the peak wavelength ... nanocrystalline Si causes shrinkage of the Si-core due to the breaking of Si–Si bonds resulting in a blue-shift in PL spectra [11] However, apart from interpretation in terms of quantum confinement in ... the electrolyte (ethanol-based) in conjunction can have 271 a profound effect in improving the luminescent properties and stability of porous silicon films Conclusions The visual observation of...
- 9
- 537
- 0
Transformation of defects into fatigue cracks; the role of kt and defect scale on fatigue life of non pristine components
... fatigue initiation and propagation behaviour of cracks initiating from scratches in the surface of clad mm 2024-T351 sheet Tension tests were conducted on both clad and unclad material The influence ... striation spacing expressed in μm/cycle as function of function non dimensional crack length (a/t) for different tension coupons Non dimensional crack length was calculated adding notch depth to the ... section wide enough to accommodate a realistic long scratch without any other stress concentrations 669 A Cini, P.E Irving / Procedia Engineering (2010) 667–677 A Cini et al./ Procedia Engineering...
- 11
- 502
- 0
Báo cáo hóa học: " Oxidative stress in NSC-741909-induced apoptosis of cancer cells" potx
... efficacy of many antineoplastic agents [13,14] To investigate whether oxidative stress is involved in the cytotoxicity of oncrasin compounds, we examined the production of ROS and its effects on JNK ... generation is involved in epidermal growth factor receptor transactivation through the transient oxidization of Src homology 2-containing tyrosine phosphatase in endothelin-1 signaling pathway in ... (Figures 6A and 6B) These data further indicate that NSC-741909-induced generation of ROS may contribute to the sustained activation of JNK in oncrasinsensitive cells, which in turn, is critical...
- 10
- 576
- 0
báo cáo hóa học: " Brain inflammation and oxidative stress in a transgenic mouse model of Alzheimer-like brain amyloidosis" pptx
... levels in addition to the deposition of Aβ in brain [13,14] Despite this evidence, and the considerable theoretical and therapeutic interest, the relationship between brain inflammation responses ... brain inflammation when combined with indomethacin In summary, our findings support the hypothesis that oxidative stress and inflammation represent important but distinct therapeutic targets in ... further evidence that both oxidative stress and inflammation are indeed functionally relevant in the development of the phenotype of these animals However, we also provide new information on the...
- 9
- 490
- 0
Báo cáo hóa học: " The Role of Intrinsic and Surface States on the Emission Properties of Colloidal CdSe and CdSe/ZnS Quantum Dots Giovanni Morello Æ Marco Anni Æ Pantaleo Davide Cozzoli " potx
... (Fig 2B) By considering only thermal population effects in the range of 15–60 K, we have imposed and solved a set of rate equations The solutions gave us the expressions for the intensities I1, ... from the blue to the red side of the whole emission spectrum Moreover, the nonexponential decay can be neither due to Auger recombination, as the experiment is performed in a low excitation regime, ... obtained in continuous wave (CW) excitation (not shown here) show a symmetric line-shape, confirming that the relative weights of the two fastest components is too slight to feature the CW time integrated...
- 3
- 341
- 0
Báo cáo khoa học: "Comparative study of PM2.5 - and PM10 - induced oxidative stress in rat lung epithelial cells" pptx
... collected onto two separate filters: one filter containing PM10 and the other filter containing PM2.5 Preparation and extraction of filters Teflon filters were baked for h at 100oC and transferred into ... in 50 µl of TE buffer (pH 7.4) containing PM2.5 and PM10 stock, and then incubated at 37oC for day The exposed DNA samples were examined for the formation of SSBs Electrophoretic separation of ... epithelial cell was determined by Western Blotting The lower shows the ratio of Nrf2/actin using calculatging by densitometor In the cell treated with PM2.5, the level of Nrf2 was much highly increased...
- 8
- 442
- 1
Báo cáo lâm nghiệp: "Response to an ozone gradient of growth and enzymes implicated in tolerance to oxidative stress in Acer saccharum (Marsh.) seedlings" pot
... two-fold during the growing season in the absence of ozone During expansion and maturation of the leaves, N assimilation is mainly under the control of NR After maturation, N assimilation decreases ... grown in the absence of O3 decreased more than two-fold during the growing season In the truncated seedlings there was no change in the NR activity under O3 (Figs 6A6C) On day 85, the rst ush of the ... levels of ozone, regression is the most powerful way of analyzing the data [47] A series of linear regressions using the six dierent O3 concentrations as the independent variable and the pooled...
- 11
- 392
- 0
Báo cáo y học: "Potential involvement of oxidative stress in cartilage senescence and development of osteoarthritis: oxidative stress induces chondrocyte telomere instability and downregulation of chondrocyte function" pptx
... and the Japan Rheumatism Foundation References Conclusion This study provides insight into the involvement of oxidative stress in the pathogenesis of OA from the viewpoint of oxidative stress induced ... findings, demonstrating the oxidative stress (ROS) induced telomere erosion and replicative senescence in chondrocytes, suggest the involvement of oxidative stress in both the progression of cartilage ... After the end of the incubation period (48 hours of incubation), the cartilage sections were immunostained with anti-nitrotyrosine antibody Original magnifications are given in parentheses (b) The...
- 12
- 407
- 0
Báo cáo khoa hoc:" Lack of association between mutations of gene-encoding mitochondrial D310 (displacement loop) mononucleotide repeat and oxidative stress in chronic dialysis patients in Taiwan" ppsx
... normalized in each experiment against a serial dilution series of a control DNA sample Determination of D-loop sequence The mtDNA control region segment (corresponding to region 15911-602 in the Cambridge ... common D310 repeat alterations in both dialysis patients and control subjects, and 8-C was the most common in the control cohort In contrast, 7-C was the most common repeat alteration in the ... to oxidative damage, we intend to further investigate the possible link between oxidative stress and mtDNA mutations mtDNA deletions/insertions and base changes mainly involve purine transitions,...
- 7
- 352
- 0
Báo cáo y học: "Hepatic oxidative stress in an animal model of sleep apnoea: effects of different duration of exposure" potx
... nm The activity of GPx is based on the consumption of NADPH in the reduction of oxidised glutathione [33] The glutathione peroxidase activity was determined by the oxidation rate of NADPH in the ... ligation of the common bile duct [51,53] or by thymoquinone [59] The increased nitric oxide metabolites nitrite and nitrate in the livers of IH-35 mice confirms findings by other authors, who demonstrated ... mitochondrial level, confirmed by the presence in the histological examination of ballooning, steatosis, necrosis and the presence of neutrophils in the liver, similar to what is observed in NASH...
- 7
- 281
- 0
Báo cáo y học: "NITRIC OXIDE (NO), CITRULLINE – NO CYCLE ENZYMES, GLUTAMINE SYNTHETASE AND OXIDATIVE STRESS IN ANOXIA (HYPOBARIC HYPOXIA) AND REPERFUSION IN RAT BRAIN"
... Ca2+ influx (41) The increased activity of NOS and the increased formation of NO in brain in anoxia as observed by increase in NOx concentration in this study support the earlier findings of NO involvement ... brain regions significantly in anoxia suggesting an increased utilization of citrulline for the production of arginine in anoxia In reperfusion group the activities of these enzymes were increased ... argininosuccinate lyase (AL; EC 4.3.2.1) via the citrulline-NO cycle (18) Arginine in brain is also utilized by arginase (EC 3.5.3.1) for production of ornithine Co-induction of AS, cationic amino...
- 8
- 622
- 0
Báo cáo khoa học: Pyruvate:ferredoxin oxidoreductase and bifunctional aldehyde–alcohol dehydrogenase are essential for energy metabolism under oxidative stress in Entamoeba histolytica pdf
... domain, containing an iron-binding domain, which is involved in ADH activity The integrity of both domains and that of the iron-binding domain are required for ALDH activity [16] Moreover, the enzyme ... that in the PFOR reaction mechanism, the N4Â of the aminopyridine ring from TPP extracts a proton from C2 of the thiazole ring, promoting the formation of a carbanion radical that performs the ... (54%), overlapping of the model with the crystal structure was almost complete, with minimal nonmatching regions in the surfaces of the proteins (Fig 3) The extra C-terminal portion in the DaPFOR...
- 14
- 420
- 0
Báo cáo khoa học: Fasting-induced oxidative stress in very long chain acyl-CoA dehydrogenase-deficient mice pdf
... – 21.4 ± 1.6% of the dry weight in the WT mice and 26.4 ± 3.1% in the VLCAD KO mice – under nonfasting conditions, and these percentages increased further with fasting (Fig 1) In parallel with ... humans, clinical symptoms become mainly evident as a consequence of triggers such as fasting, resulting in the accumulation of long-chain acylcarnitines, hypoglycemia, and hepatopathy [1] The pathophysiology ... mice (Fig 3A) Interestingly, the MCT diet also induced AOX gene expression in WT mice After 24 h of fasting, both genotypes showed a significant increase in the expression of AOX with the MCT diet...
- 10
- 381
- 0
Báo cáo khoa học: A nonribosomal peptide synthetase (Pes1) confers protection against oxidative stress in Aspergillus fumigatus ppt
... responsible for the activation, thiolation and condensation of one specific amino acid substrate [11] In linear NRP synthetases, the three core domains are organized in the order condensation, ... shown by the death of 12 of 30 larvae (P < 0.001) Taken together, these data establish the critical role of pes1 in the success of A fumigatus infection in vivo Effect of pes1 disruption on conidial ... fumigatus revealed concomitant upregulation of pes1 and diminution of the latter, possibly implying a difference in functionality and bringing into question the classification of pes1 as a putative...
- 16
- 361
- 0
Báo cáo hóa học: " Role of protease-activated receptor-2 on cell death and DNA fragmentation in Helicobacter pylori-infected gastric epithelial cells" ppt
... fragmentation Inhibition of PAR-2 expression suppresses H pyloriinduced activation of MAPK in gastric epithelial cells To determine the role of PAR-2 on the activation of MAPK, the activation of three ... activation of MAPKs [20] We previously demonstrated that H pylori induces the activation and expression of PAR-2 in gastric epithelial cells [21,22] These results demonstrate the possible relations of ... under reducing conditions, and transferred onto Hybond-PVDF membranes (Amersham Inc., Arlington Heights, IL, USA) by electroblotting The transfer of protein and equality of loading in all lanes...
- 7
- 399
- 0
Tìm thêm: hệ việt nam nhật bản và sức hấp dẫn của tiếng nhật tại việt nam xác định các nguyên tắc biên soạn khảo sát chương trình đào tạo gắn với các giáo trình cụ thể xác định thời lượng học về mặt lí thuyết và thực tế điều tra đối với đối tượng giảng viên và đối tượng quản lí điều tra với đối tượng sinh viên học tiếng nhật không chuyên ngữ1 khảo sát thực tế giảng dạy tiếng nhật không chuyên ngữ tại việt nam nội dung cụ thể cho từng kĩ năng ở từng cấp độ xác định mức độ đáp ứng về văn hoá và chuyên môn trong ct phát huy những thành tựu công nghệ mới nhất được áp dụng vào công tác dạy và học ngoại ngữ mở máy động cơ lồng sóc mở máy động cơ rôto dây quấn hệ số công suất cosp fi p2 đặc tuyến hiệu suất h fi p2 đặc tuyến tốc độ rôto n fi p2 động cơ điện không đồng bộ một pha thông tin liên lạc và các dịch vụ từ bảng 3 1 ta thấy ngoài hai thành phần chủ yếu và chiếm tỷ lệ cao nhất là tinh bột và cacbonhydrat trong hạt gạo tẻ còn chứa đường cellulose hemicellulose chỉ tiêu chất lượng theo chất lượng phẩm chất sản phẩm khô từ gạo của bộ y tế năm 2008 chỉ tiêu chất lượng 9 tr 25