the role of caveolin 1 in skin cancer
Báo cáo y học: "The role of interleukin-1 in the pathogenesis of human Intervertebral disc degeneration" pdf
... reported in articular cartilage in osteoarthritis [11 ,12 ] In this disease, the body of evidence points towards these being part of a more profound change in chondrocyte biosynthesis [13 ] driven ... and reversing disc degeneration 10 11 12 Competing interests The author(s) declare that they have no competing interests 13 Authors' contributions CLM participated in the design of the study, ... beads: restoration of the differentiated phenotype and of the metabolic responses to interleukin-1beta J Cell Physiol 19 98, 17 6:303- 313 Mengshol JA, Vincenti MP, Brinckerhoff CE: IL -1 induces collagenase-3...
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Báo cáo y học: "α The role of HIF-1α in maintaining cartilage homeostasis and during the pathogenesis of osteoarthritis" pot
... the role of HIF -1 in chondrocytic energy generation, matrix synthesis and cell survival During hypoxic and normoxic conditions, functional inactivation of HIF -1 in the presence of interleukin -1 ... Forschungsgemeinschaft (PF383/4 -1) References 10 11 12 13 14 15 Yudoh K, Nakamura H, Masuko-Hongo K, Kato T, Nishioka K: Catabolic stress induces expression of hypoxia-inducible factor (HIF)-1a in articular ... death [15 ] Thus, the work by Yudoh and colleagues adds further experimental evidence for the suggested role of HIF -1 in protecting chondrocytes from cell death induced by pro-inflammatory cytokines...
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Báo cáo y học: " The role of endothelin-1 in hyperoxia-induced lung injury in mice" docx
... FR139 317 or PD 14 5065 Br J Pharmacol 19 94, 11 1(4) :10 09 -10 16 Henry PJ, Carr MJ, Goldie RG, Jeng AY: The role of endothelin in mediating virus-induced changes in endothelinB receptor density in ... in the regulation of the airway caliber [6,7 ,11 -14 ] Accordingly, the use of ET -1 receptor blockers may also be of promise for the prevention of the deleterious effects of ET -1 on the lungs; in ... in the other groups of mice Discussion The involvement of ET -1 in the hyperoxia-induced lung function deterioration was characterized in detail in the present study by assessing the changes in...
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Role of stathmin 1 in colorectal cancer metastasis and chemo resistance
... Stathmin -1 1. 2 .1 The Stathmin family 1. 2.2 STMN1 in microtubule regulation 10 1. 2.3 STMN1 in cell cycle regulation 12 1. 2.4 STMN1 in cancer 14 Chapter ... 11 3 6 .1. 4 Mutagenesis 11 3 6 .1. 5 6.2 HCT 116 and E1 cell lines 11 2 Transfection 11 4 Cell-based assays 11 5 6.2 .1 6.2.2 Wound healing 11 5 6.2.3 ... 10 7 Chapter Materials and methods 11 0 6 .1 Cell lines and constructs 11 2 6 .1. 1 6 .1. 2 Preparation of whole cell lysate 11 2 6 .1. 3 STMN1 KD and OE constructs 11 3...
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THE ROLE OF ANNEXIN 1 IN THE REGULATION OF INFLAMMATORY STRESS RESPONSE IN MACROPHAGES
... of ANXA1 29 1. 6 .1. 1 ANXA1 in inflammation 29 1. 6 .1. 2 ANXA1 in cellular proliferation, differentiation and apoptosis 31 1.6 .1. 3 ANXA1 in cancer 33 1. 6 .1. 4 ANXA1 in leukocyte migration 33 1. 6 .1. 5 ... 11 6 11 9 4 .1 The role of Annexin -1 in the regulation of inflammatory stress 11 9 response 4.2 Conclusion 14 4 4.3 Limitations of the study 14 5 4.4 Future work 14 6 Bibliography 14 8 Summary Annexin -1 ... (USA) 1: 1000 Cell Signaling (USA) 1: 1000 Cell Signaling (USA) 1: 1000 Cell Signaling (USA) 1: 1000 Cell Signaling (USA) 1: 1000 Cell Signaling (USA) 1: 1000 Cell Signaling (USA) 1: 1000 Cell Signaling...
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The role of prion protein in breast cancer cell metabolism
... Rabbit Rabbit Rabbit Rabbit Rabbit Rabbit Mouse 39 Dilution 1: 1,000 1: 5,000 1: 2,000 1: 1,000 1: 1,000 1: 1,000 1: 1,000 1: 5,000 1: 5,000 1: 10,000 1: 10,000 ... on cancer cell proliferation 11 1. 2.3 PI3K/AKT signalling pathway and altered metabolism in cancer cells 15 1. 2.4 p53 and its role in altered cancer cell metabolism 18 1. 3 The Role ... Summary Breast cancer is the major cause of cancer death in women in Singapore The incidence of breast cancer will continue to escalate, owing to multiple factors These include increased life...
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The role of caspase 1 in a murine model of influenza pneumonitis, and studies on cell death inhibitors in vitro
... 12 9 4.2 Expression of caspase -1 and growth of virus in influenza A/PR/8/34 (H1N1) infection of RAW264.7 macrophages 13 0 4.3 Insights into the role of caspase -1 using a murine ... Biochemistry of caspase -1 14 1. 8.2 Substrates of caspase -1 14 1. 8.3 Synthetic caspase inhibitors 15 1. 9 Animal models in influenza pneumonia 16 1. 10 Caspase -1 and ... caspase -1 Active caspase -1 processes the IL -1 precursor (step 7) in the cytosol results in the generation of the mature IL -1 An influx of calcium into the cell (step 8) with an increase in intracellular...
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Tài liệu Báo cáo khoa học: The role of N-glycosylation in the stability, trafficking and GABA-uptake of GABA-transporter 1 Terminal N-glycans facilitate efficient GABA-uptake activity of the GABA transporter pptx
... N-linked oligosaccharide side-chains are important for the GABA transport activity 1- Deoxymannojirimycin inhibits the GABA-uptake of GAT1 In order to gain further insight into the role of the ... misfolding of this protein, resulting in its partial retention in the ER and its rapid digestion thereafter [16 ,19 ] Accordingly, our results indicate that the intracellular trafficking of N-glycosylation ... from rat brain J Biol Chem 272, 12 03 12 10 11 Varki A (19 93) Biological roles of oligosaccharides: all of the theories are correct Glycobiology 3, 97 13 0 12 Lis H & Sharon N (19 93) Protein glycosylation...
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Báo cáo khoa học: Alternative initiation of transcription of the humanpresenilin 1gene in SH-SY5Y and SK-N-SH cells The role of Ets factors in the regulation ofpresenilin 1 pptx
... m wt )11 9/ +17 8 )11 9/ +14 3 )22/ +17 8 )22/+4 10 0 73 91 23 21 ± 10 ± 3.4 ± 2.6 10 0 13 3 10 0 15 0 ± ± ± ± 12 10 10 m ± ± ± ± 30 20 20 70 70 28 ± ± ± ± 20 not examined which sequences in the )11 8/)35 ... 2 71) 10 11 12 13 14 15 16 17 18 19 20 21 Deficiency of presenilin -1 inhibits the normal cleavage of amyloid precursor protein Nature 3 91, 387–390 Price, D.L & Sisodia, S.S (19 98) Mutant genes in ... mutations in Ets and Sp1 motifs on PS1 promoter activity The positions of Ets (d) and Sp1 (h) motifs in the )11 9/ +17 8 region of the PS1 promoter are indicated The positions relative to the +1 site of...
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Báo cáo khoa học: "Gamma-ray irradiation stimulates the expression of caveolin-1 and GFAP in rat spinal cord: a study of immunoblot and immunohistochemistry" pot
... tneicifed -1- niloevaC PM itnasiL ,GP knarF ,MT smailliW ,SG nassaH 711 1 -11 11 , 91 ,10 02 locnO nilC J 7059 lairT puorG ygolocnO 313 yparehT noitaidaR fo stluser :emrofitlum amotsalboilg rof noitaidar lainarc ... erew stolb ehT h rof ,)000,02 : 1( PAFG-itna dna )00 01 : 1( 1- niloevac-itna gnidulcni ,ydobitna yramirp hcae htiw detabucni neht dna h rof )lCaN Mm 0 51 dna ]4.7 Hp[ lCH-sirT Mm 01 ;SBT( enilas dereffub-sirT ... Co59 ta nim 01 rof )0.6 Hp( etartic muidos L/lomm 01 ni deliob erew gniniatsonummi 1- niloevac-itna rof snoitces niffarap emoS esadixorep suonegodne kcolb ot nim 02 rof retaw dezinoied ni edixorep...
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Báo cáo khoa học: "Increased phosphorylation of caveolin-1 in the spinal cord of irradiated rats" pdf
... demonstrating an increase in the level of caveolin- 1 phosphorylation in irradiated rats located primarily in the microglial and vascular endothelial cells of the spinal cord The findings suggest that the ... expression of CD86 on antigen-presenting cells by means of caveolin- 1 Proc Natl Acad Sci USA 2004, 10 1, 14 186 -14 1 91 11 Okamoto T, Schlegel A, Scherer PE, Lisanti MP Caveolins, a family of scaffolding ... up-regulation of IL -1 and TNFα mRNA synthesis at h and 24 h in vitro [7] IL -1 induces the phosphorylation of caveolin- 1 in HIT-T15 cells [12 ] Therefore, it is highly probable that IL -1 induces the phosphorylation...
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Báo cáo y học: " The role of vitamin D in pulmonary disease: COPD, asthma, infection, and cancer" ppsx
... Research 2 011 , 12 : 31 http://respiratory-research.com/content /12 /1/ 31 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 Steenbock H: The Induction of Growth Promoting and Calcifying Properties in a Ration ... retinoic acid in the A/J mouse model: evidence of retinoid mitigation of vitamin D toxicity Int J Cancer 2007, 12 0 :14 02 -14 09 doi :10 .11 86 /14 65-99 21- 12- 31 Cite this article as: Herr et al.: The role ... experimental demonstration of the existence of a vitamin which promotes calcium deposition 19 22 The effect of additions of fluorine to the diet of the rat on the quality of the teeth 19 25 J Biol Chem 2002,...
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The role of b cells in the pathogenesis of atherosclerosis 1
... 2 011 ) Taken together, prevailing studies indicate that the role of B2 cells is atherogenic while the role of B1a is atheroprotective through IgM antibodies secreted in atherosclerosis How the ... spleen of apoE-/mice 10 9 3.4.2 Increased oxysterol in the spleen of apoE-/- mice 11 0 3.4.3 Summary 11 2 3.5 Antibody production of B1a cells in apoE-/- mice 11 3 3.5 .1 ... Immunity in Atherosclerosis 12 1. 4 .1 Localization of B cells in Atherosclerosis 12 1. 4.2 Association of oxLDL-specific antibodies with Atherosclerosis 14 1. 4.3 Cloning of oxLDL-specific...
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The role of leadership theory in raising the profile of women in management
... women in management In fact, Schein’s ongoing studies (Schein, 19 73, 19 75, 19 92, 19 94, 19 96; Schein et al., 19 89) have highlighted the pervasive perceptions that the ‘‘think manager-think male’’ ... limited in raising the profile of women in management However, during this period of research, there was an emerging recognition of the importance of a concern for people in the behavioural theories ... way of leading could be achieved (Blake and Mouton, 19 64) All these behavioural theories were proposed in the 19 30s, but achieved prominence in the 19 60s at a time when the number of women in...
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Globalization: the Role of Institution Building in the Financial Sector _ The Case Study of China
... 10 19 99 19 98 19 97 19 96 19 95 19 94 19 93 19 92 19 91 1990 19 89 19 88 19 87 19 86 19 85 19 84 19 83 19 82 19 81 Graph Financing Sources of Enterprises C Monetarization of the economy sharply increased The ... and Others 19 81 28 .1 12.7 3.8 55.4 19 82 22.7 14 .3 4.9 58 .1 1983 23.8 12 .3 4.7 59.2 19 84 23 14 .1 3.9 59 19 85 16 20 .1 3.6 60.3 19 86 14 .6 21. 1 4.4 59.9 19 87 13 .1 23 4.8 59 .1 1988 9.3 21 5.9 63.8 19 89 ... 19 88 213 4 7425.8 10 5 51. 3 576.5 935.87 35 94.76 217 53.23 19 89 2344 10 786.2 14 360 .1 684.6 11 42. 81 41. 62 12 2. 91 29482.24 19 90 2644.4 14 012 .6 17 680.7 8 01 1343.4 45.9 15 5.76 36683.76 19 91 317 7.8 18 079...
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Tài liệu The Role of BCG Vaccine in the Prevention and Control of Tuberculosis in the United States: A Joint Statement by the Advisory Council for the Elimination of Tuberculosis and the Advisory Committee on Immunization Practices docx
... results The preferred method of skin testing is the Mantoux tuberculin skin test using 0 .1 mL of tuberculin units (TU) of purified protein derivative (PPD) (1 ) BCG vaccination contributes to the ... by only 1. 1%, and during 19 86, it increased by 1. 1% over the 19 85 rate (12 ) This upward trend continued through 19 92, when the incidence was 10 .5 cases per 10 0,000 population For 19 93, the reported ... explore the sources of the heterogeneity in the efficacy of the BCG vaccine reported in the individual studies Using a model that included the geographic latitude of the study site and the data...
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Tài liệu The Role of Community Banks in the U.S. Economy pdf
... 16 .5 28.6 10 .3 16 .8 13 .9 14 .1 13 .1 13.0 14 .7 34 .1 22.3 27.2 6.5 18 .4 20.6 7.4 5.3 12 .5 3.4 20.9 5.6 26 .1 29.5 27.9 24.2 9.8 13 .9 6.4 2 .1 63.7 28.5 58.7 14 .5 2.3 12 .5 15 .4 2.2 19 .8 1. 0 28.6 9.8 ... Urban < 1M 1M to 5M > 5M All U.S 11 ,787 11 ,778 5,222 3,887 2,669 23,565 57.8 24.2 30.9 23.2 17 .8 34 .1 325.9 412 .1 159.7 13 6.2 11 6 .1 737.9 49.3 13 .5 23.2 13 .9 8.4 19 .8 Source: Summary of Deposits ... < $10 0M 3,429 49.4 17 0.4 18 .5 $10 0M to $500M 2,946 42.5 5 21. 1 56.4 5 61 8 .1 2 31. 8 25 .1 6,936 10 0.0 923.3 10 0.0 $500M to $1B All Source: Reports of Condition and Income Applying the above definition...
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Tài liệu Báo cáo khoa học: The role of electrostatic interactions in the antitumor activity of dimeric RNases docx
... HHP-RNase RNase AA-GG RNase AA-G RNase AA 10 0 51 71 28 12 10 0 10 3 10 9 58 10 0 10 0 10 0 0 18 10 10 )63.8 )67.3 )44.3 )27.3 )14 .0 FEBS Journal 273 (2006) 3687–3697 ª 2006 The Authors Journal compilation ª ... were prepared using the crystallographic structures of these proteins (PDB codes 1BSR, 7RSA, 1A2W, 1F0V and 1Z7X, respectively) As in the 1Z7X structure of HP-RNase Lys1 is lacking, this residue ... through the exchange between subunits of either their N-terminal, or their C-terminal ends [33–35] We found that the behavior with the model membrane of the dimer in which the C-terminal ends...
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Tài liệu Báo cáo khoa học: "From HOPE en I''''ESPERANCE On the Role of Computational Neurolinguistics in Cross-Language Studies " pptx
... t is the in interaction of the results of these asynchronous processes that the process of comprehension is defined 4 .1 The processes are independent of the knowledge representations defined ... decided in the final stage of the production of the French sentences (Boitet and Nedobejkine, 19 81) The content words are s p e c i f i c a l l y marked as beginning with vowels or s i l e n t "h" The ... activation of a l l meanings of each recognized word in HOPE, the determination of the phonetic representation of a recognized word determines the breadth of active competition amon meanings for...
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Enterprise Adjustment and the Role of Bank Credit in Russia: Evidence from a 420 Firm''''s Qualitative Survey pdf
... 23.5% 33.5% 20% 10 % 15 % 10 .5% 11 % months + 1% - 2% - 10 % - 13 % month - 1% 0% - 18 % - 22% Enterprises of the top right quarter (group 1) correspond in principle to the better-off, as good real performances ... Khi(2) 1, 70 -0,0027 0, 011 61, 63 (6,602) ( -1, 844) (1, 949) à (1) =0,4994222 ; à(2) =1, 426 513 ; à(3) =1, 827084 C: Sub-groups & (lower half of Graph 1) No-debt Inventory Exp-prod Labour Khi(2) 1, 41 -0,00 017 05 ... In 19 96, the credit has overall been decreasing for 53% of the sample, it has been increasing for 36%, and has been stable for the remaining 11 % An increase in indebtedness (of 80% in average)...
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