the ranking exercise percentage of respondents ranking illness as most severe in uk and cr
Tài liệu Báo cáo khoa học: Critical roles of Asp40 at the haem proximal side of haem-regulated phosphodiesterase from Escherichia coli in redox potential, auto-oxidation and catalytic control doc
... alters the cyanide binding property only slightly, and may not significantly affect the exogenous ligand binding access channel at the haem distal side and/ or structure in terms of cyanide binding in ... activity was detected for the two Asp40 mutants analysed in this study This finding is in contrast with data on mutants of Met95 at The present study reveals an interesting aspect of the structural and ... only one phase The first-order rate constants for cyanide binding to Asp40 mutants were dependent on the cyanide concentration The rates of cyanide association to the Asp40Ala and Asp40Asn mutants...
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Báo cáo khoa học: Human telomeric G-quadruplex: The current status of telomeric G-quadruplexes as therapeutic targets in human cancer pdf
... catalytic subunit of telomerase (hTERT in humans) has reverse transcriptase enzymatic activity and synthesizes TTAGGG repeats on to the end of the 3¢ single-stranded overhang Inhibition of hTERT by ... consequence of the displacement of bound proteins from the singlestranded overhang, chiefly hPOT1, as well as possible uncapping of telomerase from the ends There are likely to be multiple mechanisms involved, ... structures as starting points [42–47], although these also indicate that the flexibility of the TTA loops is ligand dependent, and therefore structural information for a given class of ligand would be...
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Báo cáo Y học: Binding of Thermomyces (Humicola) lanuginosa lipase to the mixed micelles of cis-parinaric acid/NaTDC Fluorescence resonance energy transfer and crystallographic study ppt
... that the lid is involved in the binding of the mixed micelles of cis-PnA/NaTDC On the other hand, these shifts might result from the quenching of the tryptophan fluorescence in the presence of the ... A, the modeling of the ligand was restricted to its carboxylic group and the alkyl chain between C2 and C9 The remaining atoms of the OA in molecule A, C10–C18, were included in the final protein ... cis-PnA as a fluorescent reporter, indicate that the increase in the cis-PnA fluorescence intensity was due to its incorporation into the NaTDC micelles, resulting in a drastic change in the microenvironment...
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Báo cáo khoa học: Using directed evolution to improve the solubility of the C-terminal domain of Escherichia coli aminopeptidase P Implications for metal binding and protein stability pptx
... maintain the structure of the C-terminal domain in a conformation that allows the metals to bind Removing the N-terminal domain results in a C-terminal domain in which the acid residues of the ... repel one another, thus destabilizing the protein For the native protein, the presence of the N-terminal domain and the oligomeric structure of C-terminal domain of E coli aminopeptidase P A Glu383 ... further refinement of the domain size was carried out The locations of mutations that conferred increased solubility were noted Screening for the boundary of the C-terminal AMPP domain N-terminal...
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Báo cáo khoa học: Thermodynamic and kinetic analysis of the isolated FAD domain of rat neuronal nitric oxide synthase altered in the region of the FAD shielding residue Phe1395 docx
... studying the isolated FAD domain of nNOS has enabled us to analyse in detail the effects of these mutations in the absence of other in uences (most notably those induced by CaM binding and by interflavin ... differences in the environment of the FAD cofactor in the different proteins These differences might also be manifest in the semiquinone forms, as the relative intensities of the semiquinone signal in ... oxidation of NADPH The mechanistic origin of the second phase is uncertain, but one possibility is that the slow phase might represent further reduction of the flavin following release of NADP+, as the...
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Báo cáo khoa học: The inhibition of Ras farnesylation leads to an increase in p27Kip1 and G1 cell cycle arrest pdf
... processing and the accumulation of p27Kip1 ([6] and Fig 5) We observed an increase in p27Kip1 levels in the cyclin E/Cdk2 complex, and a corresponding reduction in the kinase activity of the complex ... their FTI led to an increase in p21CIP1 levels, in the same Rat1/ras model we used These authors, who did not report any effect on p27Kip1, attribute the increase in p21CIP1 to the increase in ... 2767 Fig HR12 treatment of Rat1/ras cells leads to an increase in the level of p27Kip1 in the Cyclin E/Cdk2 complex and inhibition of cyclin E/Cdk2 kinase activity (A) Rat1/ras cells were treated...
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Báo cáo Y học: Investigations into the mechanisms used by the C-terminal anchors of Escherichia coli penicillin-binding proteins 4, 5, 6 and 6b for membrane interaction ppt
... minor increases in gel phase fluidity, minor decreases in liquid crystalline phase fluidity with the gel to fluid phase transition occurring over the interval 20 to 30 °C rather than the 25 °C of ... whilst in the presence of P5 (.), phase transition occurred over the interval 20 to 30 °C accompanied by an increase in gel phase fluidity and a decrease in liquid crystalline phase fluidity (C) crystalline ... an increase in gel phase fluidity and a decrease in liquid crystalline phase fluidity (C) Here, we analyzed the C-terminal sequences of PBP4, PBP5, PBP6 and PBP6b to identify candidates with the...
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báo cáo hóa học: " Effects of betaine on lipopolysaccharide-induced memory impairment in mice and the involvement of GABA transporter 2" doc
... and both exogenous application of betaine and the introduction via transgenes of the betaine-biosynthetic pathway into plants that not naturally accumulate betaine increase the tolerance of these ... responses, and oxidative stress such as increases in mRNA levels of interleukin (IL)1ß and IL-6 [13], heme oxygenase-1, microglial activation [14], and iNOS activity in hippocampus [15] As neuroinflammation ... are increased in brain of rats with hyperosmotic serum induced by the injection and drinking of NaCl solution [31, 32] In addition, protein and mRNA expressions of GAT2/BGT-1 are upregulated in...
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Báo cáo khoa học: "Effects of needle clumping in shoots and crowns on the radiative regime of a Norway spruce canopy Alessandro Cescatti" ppsx
... support the photosynthesis On the other hand, leaf clumping in crowns increases the average canopy transmittance at the bottom of the canopy (LAI 7.84) up to 4.9 and 10.9 % for scenarios (OND) and ... distribution in dense canopies, maintaining most of the leaf area in the linear part of the photosynthetic light response curve [26] Considering that the photosynthetic performance of spruce canopies ... are crucial parameters in the description of tree canopies, as they determine radiation regimes and affect mass and energy exchange between vegetation and the atmosphere [17] The relevance of these...
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Báo cáo y học: "Therapeutic impact of the ethyl acetate extract of Tripterygium wilfordii Hook F on nephritis in NZB/W F1 mice" pot
... wrote the manuscript NL participated in pathological studies and was involved in drafting the manuscript PL participated in the design of the studies and was involved in drafting the manuscript and ... effects, including inhibition of the transcription of cytokine genes and genes encoding other molecules involved in the production of inflammatory mediators The effect of the active components of TwHF ... BUN was also determined and was increased and correlated with the severity of proteinuria in the three groups As shown in Figure 2, 10 out of 12 tested animals from the vehicle group had increased...
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Báo cáo khoa học: "The role of cardiac troponin I as a prognosticator in critically ill medical patients: a prospective observational cohort study" ppt
... disease was shown in this study The sample size was rather small (58 patients), however, and the majority of patients had sepsis (88%), which limits the interpretation of these results In contrast ... Even though the time course and kinetics of cTnI and its relation to outcome may be of interest, the main purpose of our study was to determine whether early cTnI elevation is of clinically relevant ... marker of severity of illness and is associated with high mortality rate is still clinically relevant, particularly in view of the fact that the Kaplan-Meier analysis indicates that the discriminative...
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Báo cáo y học: "Contribution of the C-terminal region within the catalytic core domain of HIV-1 integrase to yeast lethality, chromatin binding and viral replication" doc
... to the yeast SNF5 protein and was found to bind to HIV1 IN in a yeast two-hybrid system and was shown to increase the efficiency of integration in an in vitro assay [13] Also, inactivation of the ... Characterization of IN mutants binding to Ini1 and LEDGF/p75 Characterization of IN mutants binding to Ini1 and LEDGF/p75 A Interaction of the INwt and mutant with Ini1 Different IN- YFP plasmids, as indicated, ... the importance of the C-terminal region of the catalytic core domain of HIV-1 IN in its association with the chromatin of the host cell, viral replication and the INinduced lethal phenotype in...
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Báo cáo y học: " Effect of chloroquine on reducing HIV-1 replication in vitro and the DC-SIGN mediated transfer of virus to CD4+ T-lymphocytes" pdf
... clones of the CQ and control passages The sequence of the original virus 293.10 is shown A) the V1V2 region B) the V3 region including the PNG site at the base of the loop C) the V4 region The black ... of genotypic differences between the CQ and the control passaged virus, including an increased V1V2 charge, a lack of increase in the V3 overall charge, a shortened V4 region and modulation of ... neutralizing antibody responses and hence aide in the lowering of viral loads The significance of these findings to the in vivo setting will be identified through the study of HIV-1 infected individuals...
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Báo cáo y học: "In silico evidence for the species-specific conservation of mosquito retroposons: implications as a molecular biomarker" ppt
... quinquefasciatus quinquefasciatus quinquefasciatus quinquefasciatus quinquefasciatus quinquefasciatus quinquefasciatus quinquefasciatus quinquefasciatus quinquefasciatus Identity strain strain ... diverging – as shown by such examples of hits as integrin, alpha precursor and spermatogenic leucine zipper – from that of the six moieties of introns including reverse transcriptase or maturase ... contributions BW and WM conceived of the study, conducted the in silco analyses and contributed to drafting the final manuscript BW, WM and KH participated in data analysis and writing the final manuscript...
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Báo cáo y học: "Early down-regulation of the pro-inflammatory potential of monocytes is correlated to organ dysfunction in patients after severe multiple injury: a cohort study" pptx
... Data are plotted as boxes (interquartile range that contains the 50% of values) with a straight line at the median, a dashed line at the mean, and error bars defining the 5th and the 95th percentiles ... not as well delineated However, there is strong evidence suggesting that the overwhelming release of proinflammatory cytokines is one crucial initiating event in the posttraumatic acute phase ... understanding of the underlying mechanisms is still missing In particular, the importance of the major proinflammatory cytokines IL-1β, IL-6, IL-8, and TNFα in patients with multiple injuries were investigated...
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proceedings of the tax-payers' convention of south carolina, held at columbia, beginning february 17, and ending february 20, 1874
... are running the State into bankruptcy and ruin And, whereas, in the opinion of the members of this Convention, the only sure, practicable, and never-failing mode of reforming and purifying the Government, ... tliat the assets of the Bank of the State constitute " A Fund in Court," in the case of Bahney, Morgan S Co.^ vs the President and Directors of the Bank of This case was commenced in the the State ... appointed pointing C C Puifer, Esq., then, and still one, of the Joint Committee of the Legislature, to investigate the condition of the assets of the Bank, the Receiver of the said fund On the...
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lexical reiteration in the language of ict product advertisements a comparative study in english and vietnamese = lặp từ vựng trong ngôn ngữ quảng cáo sản phẩm công nghệ thông tin và truyền thông
... news as and when they occur In the 14th minute of the EURO 2012 Final, Andrés Iniesta got the ball and passed it to Cesc Fàbregas Cecs beat Giorgio Chiellini to the end line and then passed the ... PART I: INTRODUCTION This session carries the goal of providing the readers an overview of the study, consisting of the reason why the author chose this thesis, the aims of the study, the research ... parts of the world, with increasing possibilities of personal exchange, mutual understanding and friendship between “world citizens,” as well as creation of a global civilization Indeed, information...
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The administration place names of Tho Xuong district (Thang Long – Hanoi) in 19th century Địa danh hành chính huyện Thọ Xương (Thăng Long – Hà Nội) thế kỷ 19
... Objects of Thesis The object of the thesis is the administration place names of Tho Xuong district in the 19th century (mainly in the Nguyen Dynasty) We focus on structure, situation and transformation ... names from the point of language, culture and history Purposes of Thesis The first aim of the thesis is researching administration place names of Tho Xuong district in 19th century in terms of: identification ... changes in terms of every aspect Layout of the Thesis Beginning Chapter 1: BASIC THEORY OF TOPONYMY AND GENERAL INFORMATION OF THANG LONG-HANOI Chapter 2: ADMINISTRATION PLACE NAMES OF THO XUONG...
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Lexical reiteration in the language of ICT product advertisements A comparative study in English and Vietnamese
... used in Vietnamese and English advertisements of ICT products Part III: Conclusion sums up the study outcomes, points out the implications and limitations of the study as well as suggests ideas ... Analysis of Linguistic Features of Advertising Language Used in English Slogans for Food and Drink Products Luận văn thạc sĩ, Đại học Ngoại Ngữ, ĐHQG HN Cook, G (1992) The Discourse of Advertising, ... Advertising Laguage Used in Trade: A Comparison in English and Vietnamese Luận văn thạc sĩ, Đại học Ngoại Ngữ, ĐHQG HN Leech, G.N (1966) English in advertising: A Linguistic Study of Advertising in...
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Srichart 2016-The SEACEN Centre-Determinants of MP transmission via bank lending channel in Thailand-A Threshold Vector Autoregression approach
... Curve and the Equilibrium Output In addition to the size of shift in the AD curve, the slope of the AS curve is also vital in determining the output effect of monetary easing As shown in Figure ... delaying the recovery Putting together the factors affecting loan demand and supply would result in the equilibrium in the loan market This, in turn, determines the magnitude of the shift in the ... that the pass-through of monetary easing to credit could be limited during the low-growth phase In a period of economic downturn, banks tend to increase their credit standards, while firms have the...
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Tìm thêm: xác định các mục tiêu của chương trình xác định các nguyên tắc biên soạn khảo sát chương trình đào tạo của các đơn vị đào tạo tại nhật bản khảo sát chương trình đào tạo gắn với các giáo trình cụ thể tiến hành xây dựng chương trình đào tạo dành cho đối tượng không chuyên ngữ tại việt nam điều tra với đối tượng sinh viên học tiếng nhật không chuyên ngữ1 khảo sát thực tế giảng dạy tiếng nhật không chuyên ngữ tại việt nam nội dung cụ thể cho từng kĩ năng ở từng cấp độ xác định mức độ đáp ứng về văn hoá và chuyên môn trong ct phát huy những thành tựu công nghệ mới nhất được áp dụng vào công tác dạy và học ngoại ngữ mở máy động cơ lồng sóc các đặc tính của động cơ điện không đồng bộ hệ số công suất cosp fi p2 đặc tuyến hiệu suất h fi p2 đặc tuyến mômen quay m fi p2 đặc tuyến dòng điện stato i1 fi p2 sự cần thiết phải đầu tư xây dựng nhà máy từ bảng 3 1 ta thấy ngoài hai thành phần chủ yếu và chiếm tỷ lệ cao nhất là tinh bột và cacbonhydrat trong hạt gạo tẻ còn chứa đường cellulose hemicellulose chỉ tiêu chất lượng theo chất lượng phẩm chất sản phẩm khô từ gạo của bộ y tế năm 2008 chỉ tiêu chất lượng 9 tr 25