the pathophysiological link between obesity and erectile dysfunction remains poorly understood in this minireview
Tài liệu Báo cáo khoa học: Mechanisms of obesity and related pathologies: Androgen deficiency and endothelial dysfunction may be the link between obesity and erectile dysfunction pptx
... plasma androgen levels [14–19]. In this minireview, we discuss the link between obesity and ED by focusing on the potential pathophysiological links including obesity- related androgen deficiency and obesity- induced ... 2009)doi:10.1111/j.1742-4658.2009.07305.x Obesity is associated with a high prevalence of erectile dysfunction; how-ever, the pathophysiological link between obesity and erectile dysfunction remains poorly understood. In this minireview, ... 2009 The Authors Journal compilation ª 2009 FEBS MINIREVIEW Mechanisms of obesity and related pathologies: Androgendeficiency and endothelial dysfunction may be the link between obesity and erectile...
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Báo cáo khoa học: Interaction between Lim15/Dmc1 and the homologue of the large subunit of CAF-1 – a molecular link between recombination and chromatin assembly during meiosis pot
... diagram of the trunca-tion mutants of CcCac1L. (C) Interaction between CcCac1L and CcLim15 in a yeast two-hybrid assay. The inserts in the activation domain(AD) and DNA-binding domain (BK) are ... that they act in multiple ways at the site ofmeiotic recombination and contribute to the subse-quent assembly of chromatin. Therefore, there maybe coordination between meiotic recombination and CAF-1-dependent ... Moun-tain View, CA, USA). The cDNA encoding full-lengthCcLim15 was fused in- frame with the GAL4 DNA-bindingdomain in the pBKDT7 vector as bait. The cDNA librarywas subsequently cloned into the...
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Land-based marine pollution and the Arctic - polarities between principles and practice
... www.un.org/Depts/los.lead-zinc mines in Canada that discharge tailing effluents – the Polaris mine onLittle Cornwallis Island and the Nanisivik mine on the north coast of Baffin Island– and three former mines in Greenland ... practices relating to land-based pollution control in the Arctic, on the other. Following an introductorysummary of the sources of land-based marine pollution in and into the Arctic,further sections ... Working Group decidedupon a two-phased approach to reviewing international instruments, includingthose covering land-based activities. An initial updating of factual and legalinformation in the...
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Tài liệu "Promoting healthy diets and physical activity: a European dimension for the prevention of overweight, obesity and chronic diseases" doc
... aged 7-11. The rates of the increase in childhood overweight and obesity vary, with England and Poland showing the steepest increases49. 12. The factors underlying the onset of obesity are ... putting in place a comparable set of indicators for health status, including in the area of dietary intake, physical activity and obesity. IV.4.2. Under the health determinants strand, the Programme ... >25), and in parts of Europe45 the combination of reported overweight and obesity in men exceeds the 67% prevalence found in the USA’s most recent survey46. Despite efforts by individuals the...
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Health and Work of the Elderly: Subjective Health Measures, Reporting Errors and the Endogenous Relationship between Health and Work doc
... households in which the head of the household (i.e., the main incomeearner) was between 43 and 63 years of age at the date of the interview. In each household both head and partner, if present, were interviewed. ... ofhelp in validating the results obtained from separate analyses and that it therefore will add to ourunderstanding of the reproting mechanisms. In the empirical analyses we will take f1 and ... Modelling work related health measures, in X1 will gain in importance, we will return to this later. As documented in the introduction, the basic argument in the literature considering the peculiarrelationship...
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Báo cáo khoa học: Molecular dissection of the biosynthetic relationship between phthiocerol and phthiodiolone dimycocerosates and their critical role in the virulence and permeability of Mycobacterium tuberculosis doc
... postinfection, we observed amarked difference between the number of CFUs of the wild-type strain and that of the PMM56 mutantstrain in lungs and in the spleen (Fig. 7A). Indeed,both strains ... plates containing eitherkanamycin (Km) or hygromycin (Hyg). Mice werekilled 1 or 21 days postinfection, and the mutant and wild-type loads in lungs and spleens were determinedon the basis of ... mice, indicating that fewer than 50 bacteria of the PMM56 mutant strain were present in the spleen of these mice. For the determination of the number of PMM56 bacteria present in the spleen of these...
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Báo cáo khoa học: Biochemical evidence for conformational changes in the cross-talk between adenylation and peptidyl-carrier protein domains of nonribosomal peptide synthetases ppt
... of this change is coordinated through a commonmovement with the ACsubdomain during the closingof the subdomains. However, the flexible linker between the ACsubdomain and the PCP domain, and the ... [36]. Therefore,we also introduced a serine at this position. Finally,Cys473 is located in the subdomain ACof the A domain and is moderately conserved. Tyrosine and alanine are the other amino ... mutant) and shows the PCP on the acceptor site of the C-domain. The dis-tance of the S1003A residue to the active-site histidineof the C-domain is 16 A˚, making it within the reach of the missing...
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Tài liệu Báo cáo khoa học: Bioinformatics of the glycoside hydrolase family 57 and identification of catalytic residues in amylopullulanase from Thermococcus hydrothermalis doc
... Whencomparing the arrangement in the trees, subtle modifica-tions and rearrangements can be found, i.e. those concern-ing either the relationships within a subfamily or the relatedness between the ... (W120, W221 and W357, highlighted), as well as the residues in the corresponding positions in other GH-57 members, could be of interest. The glucose molecule (in the middle) is also shown. The PDB ... Importantly, the overall integrity of all subfamilies was save d in all trees,including the Pfam-tree, based on simplified alignment of 300 N-terminal amino acid residues. Therefore, togetherwith the...
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Báo cáo khoa học: The Rab5 effector Rabaptin-5 and its isoform Rabaptin-5d differ in their ability to interact with the small GTPase Rab4 doc
... Rabaptin-5 in the pPC86 vector and the Fig. 9. Mapping of the Rab4 binding site in Rabaptin-5 using the yeast two-hybrid protein–protein interaction assay. Indicated frag-ments of Rabaptin-5 ... chain and the Rab4 binding site of Rabaptin-5 arelocated in the N-terminal portion of protein. However,some discrepancy exists in the literature concerning the position of the Rab4-binding site. ... containing KpnI and BglII sites, and subcloned between the KpnI and HindIII sites of pBluescriptSK II(+) vector using the internal HindIII site (plasmidp5Rn5). The 3¢-end of the Rabaptin-5 coding...
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- obesity is associated with a high prevalence of erectile dysfunction; however
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