... at the last base, G to A, abolished the interaction of HIPPI, so the last motif would notinteract with HIPPI. The other two motifs might be the target of HIPPI. In the upstream sequence of the Table ... positions ofthe motifs are indicatedby distance from the transcription start site (TSS). The position upstream ofthe TSS of any gene is denotedby ‘–’ followed by the distance from the TSS. In the caspase-8 ... confirmed the in vitro resultthat mutation ofthe motif abolished the binding of HIPPI to the specific sequence ofthe caspase-1 geneupstream sequence, and the increased expression of caspase-1...
... in the presence of KCl.Considering also the 3D structure of CDase I-5, the analysis ofthe quaternary state of CDase I-5 revealedFig. 8. Fluorescence spectra of CDase I-5. (A) - - - -, the ... the adjacentmonomer, of which G538 forms a hydrogen bond to the carbonyl oxygen of M51. Two residues at the N-terminus (H49 and H89) of a subunit were locatedclose to the C-domain ofthe other ... either in the secondarystructure ofthe protein according to far-UV CDdata or in the size ofthe protein determined by size-exclusion HPLC. They suggested that the changemight occur either...
... than the wild-type both in the absence a nd in the p resence of Fig. 3. Normalized zinc-dependent ATPase activity ofthe wild-type andmutated enzymes. TheATPaseactivity(percentageoftheactivityofthewild-type) ... The effect of 30 lMZn2+on the Pi-phosphorylation ofthe wild-type and the P401Lenzymes (gray columns). Note that the maximal phosphorylation of the P401L mutant is only 8% ofthe wild-type ... possible that the tolerance for the s ubstitutions at this siteis related to the size and hydrophobicity ofthe substitutingside chain. Inspection of a theoretical model of the Ca-ATPase in the E2state...
... with the Substance P receptor [25]. Detachment of the cells from the surface ofthe culture dish could r eflectdisassembly ofthe actin cytoskeleton in the me mbraneregions as a consequence of ... both the cAMP and the PLC pathway [22], the second messengerproduct of either or both of these pathways couldbe invo lved in agonist-stimulated internalization of thisreceptor. The effect of ... f125I-labelled sauvagine could be observedin the presence of any of these inhibitors. These findingsindicate that neither the activation of PKA nor the activation of PKC is necessary for agonist-induced...
... osteoar-thritis of 1 grade in 52% ofthe patients, 35% of the patients had an increase of 2 grades and 3% ofthe patientshad an increase of 3 grades. (Table 4, 5 and 6) 10 % of the patients had ... per-formance, the score may appear too high, and will reflect the actual function ofthe knee as well as the satisfaction of the patient. The Lysholm score has never been validatedfor the purpose of following ... test). Thesepatients were considered at high risk of further knee injurydue to the degree of laxity and the desired level of activity[27]. In order to minimise the development of arthrofi-brosis,...
... major motivat ional theme as it demon-strates yet another dimension ofthe QOL AppraisalProfile and further helps e lucidate the nuances o f the profile. The major theme of reaching an event/milestone ... needed. Other patients c om-pleted the Quality of Life Appraisal Profile and othermeasures during the time that they were receiving neo-adjuvant chemotherapy. In order to see whether theseconfounders ... College of Medicine of Yeshiva University, Bronx, New York, USA.Authors’ contributionsBAM assisted in the organization/administration ofthe study, gathering of the data, analysis of data,...
... between Theorems 2 and 8;thatis,in Theorem 2,thedifferentiability of a function φ is not emphasized which is used in the proof. Also, the proof of Theorem 2 is completely analogous to the proof of ... 6,page37. Therefore, w e willlook back only on case i of Theorem 1.By applying Theorem 3 to the function Fx, yx/y, we obtain the following result.Theorem 7. Suppo se that all the conditions of ... a discrete version of Theorem 8. It is obvious that the main results presented in 2 are special cases of results given in 3, Theorem 1, Corollary 1, Remark 2.Note that there is a difference...
... and Mathematical Theory, vol. 1748 of Lecture Notes inMathematics, Springer, Berlin, Germany, 2000.13 V. V. Zhikov, “Averaging of functionals ofthe calculus of variations and elasticity theory,” ... they apply the mountainpass theorem to get the nontrivial solutions ofthethe system.In 30, the author obtains the existence and multiplicity of solutions for the followingproblem:− div|∇u|px−2∇u∂F∂ux, ... υzdx.3.26Since the restriction operator is continuous, then un,n u, in W1,px0Br ì W1,qx0Br.Because ofthe compactness of Fr, the first expression on the right-hand side ofthe equationtends...
... 2,700 acres, from the preponderance of arable, the chief source of income to thelord was from the grain crops; other sources may be seen from the following table ofthe lord& apos;s receipts ... 3d. The rector ofthe parish had part of a furrow, i.e. one of the divisions ofthe common arable field, and paid 2d. a year for it. Another tenant held a cottage in the demesne under the obligation ... of keeping two lamps lighted in the church. Another person was tenant-at-will ofthe parish mill, at a rent of 40s. a year. The rest ofthe tenants were villeins or cottagers, thirteen of the...
... accepted the cutoff SUVmax value as 2.5 in their study at which the role of PET/CT was investigated, and they found out the sensitivity ofthe technique 40% [12]. In our study,because there was ... [17]. The guidelinealso recommends PET for evaluation of therapyresponse and to make the decision of continuing the ongoing therapy or stopping and redirecting the patientto other salvage therapies. ... important limitation th at the number of patients issmall especially in the first group, the number of studiesintheliteratureinvestigatingtheroleofPETinthediagnosis of distant metastasis preoperatively...
... boiling time and the degree of starch swelling (Crosbie 1992). Accurate measurement ofthe color of boiled noodles necessitates the use of a method that minimizes the effect of variation on ... independent of noodle thickness. These were considerations in the development of methods in the present study. The aims ofthe study were to develop new and improved methods for measuring color, ... Tests in Experiment 1 The distance along the visual analogue scales (VAS) for each of the six samples was measured, the results ofthe 32 panelists were combined, and the mean scores were compared...
... after excision of giant cell tumour of distal radius. J Hand Surg Br 1990, 15(4):496-500.33. Gold AM: Use of a prosthesis for the distal portion ofthe radiusfollowing resection of a recurrent ... maintained all the records of the patients and followed them. All the authors read and approved the finalmanuscriptConflict of Interests The authors declare that they have no competing interests.Received: ... Santavirta S, Kiviluoto O, Koskinen EV: Application of freeautogenous fibular graft in the treatment of aggressive bone tumours of the distal end ofthe radius. Arch Orthop Trauma Surg 1981, 98(4):285-7.13....