... partners and their roleinthe developing cytoskeleton The work in this thesis focuses on the developing fly eye, the targeting of axons from the eye to the brain andthe anchoring of posterior ... critical roles in regulating the guidance of both crossing and non-crossing axons at the ventral midline ofthe developing vertebrate spinal cord andthe Drosophila ventral nerve cord For example, these ... This thesis looks at thefunctionof bif andits interacting partners, Protein phosphatase and Homer, in several different developmental contexts and focuses on Bif functioninthe eye, the larval...
... SUMMARY AND CONCLUSIONS The banking industry is undergoing three major changes the consolidation ofthe industry, the spread of Internet banking, andthe increased freedom to combine banking with other ... obstacle in continuing to fill this rolethe increased difficulty of obtaining funds I MAJOR CHANGES INTHE BANKING SYSTEM While always in a state of flux, the nation’s banking system is now undergoing ... Economics of Small Business Finance: The Roles of Private Equity and Debt Markets inthe Financial Growth Cycle,” Journal of Banking and Finance, August, pp 657-59 Board of Governors 1997 “Report to the...
... aluminium and steel which in uence the welding behaviour: • The difference in melting points ofthe two metals and their oxides The oxides of iron all melt close to or below the melting point of ... Increasing the arc current increases the temperature ofthe weld pool and thereby increases the rate of absorption of hydrogen inthe molten metal Conversely, inthe flat welding position increasing the ... between the grains there is a mismatch, a loss of order, inthe orientation of these arrays Both the grain boundaries andthe size ofthe grains can have a marked effect on the properties of the...
... experiment, the collection, analysis and interpretation of data, the drafting the manuscript and acquisition of funding RWC contributes to the analysis and interpretation of data, drafting the manuscript ... manuscript and acquisition of funding AO contributes to the analysis and interpretation of data, drafting the manuscript and acquisition of funding All authors have read and approved the final manuscript ... pressure ofthe compartments needed to stop further water transmission across the membrane At the beginning of each experiment, the fluid heights indicating the pressure in both compartments, i.e either...
... doi:10.1038/cddis.2011.12 Theroleof protein kinase C inthe synergistic interaction of safingol and irinotecan in colon cancer cells Leong-Uung Ling, Hui-Min Lin, Kuan-Boone Tan and Gigi N.C Chiu International ... presenting author) Podium Presentation Theroleof protein kinase C inthe synergistic interaction of safingol and irinotecan in colon cancer cells Leong-Uung Ling*, Hui-Min Lin, Kuan-Boone Tan and ... a protein kinase C (PKC) and sphingosine kinase (SK) inhibitor, and is currently evaluated in Phase I clinical trials Yet, the underlying mechanisms ofits action remain largely unknown The research...
... depicting various motifs ofthe CK2 proteins Within the α subunit of human CK2, the domain in grey includes the invariant Lys-68 which is involved in ATP binding, followed by a cluster of basic ... proximal to the N-terminal boundary ofthe Cdk5-binding and activating domain in p35, and contains an amphipathic α-helix (Chin et al., 1999) Further evidence from the interaction studies indicates ... advantage of this method is the ability to isolate protein complexes and interacting proteins in their native states It is particularly useful in identifying indirectly interacting proteins, 38 since...
... domain and ∆BAR domain in vitro In addition, the random coil domain does not affect the bridging of SH3 domain to PRD in vitro Therefore, the random coil domain or Ca2+ is not involved in interactions ... detail study on theroleof this domain to the functions ofthe SH3 & BAR domains The praline-rich random coil domain exists in all the members ofthe Endophilin family but its amino acid sequence ... An interesting hypothesis was proposed suggesting that the SH3 domain of endophilin might bind to its own proline rich domain located between the SH3 domain and BAR domain inthe presence of...
... broaden the scientific underpinnings ofthe PBT analysis, the difficulty of prescribing a meaningful way to quantitatively weight the various PBT parameters and to integrate them into a single numerical ... distribution This book reports the findings of a workshop organized around the constructs of PBT for purposes of examining strengths and weakness in each of these criteria and identifying alternatives or ... reviewing the scientific underpinnings ofthe use of persistence in hazard evaluation andof persistence measures as applied to metals, including the potential to use bioavailability measures in...
... deceleration during the second half ofthe move, with concomitant high jerk at the beginning, middle and end ofthe perturbation [13,14] While standing barefoot and blindfolded on the SLIPFALLS ... aided in data analysis and drafting Page of 10 and revising the manuscript SM performed data analysis and aided in drafting and revising the manuscript CMS performed data acquisition, aided in data ... threshold over the course ofthe 30 trials in two ofthe three distances (1 mm, mm, and 16 mm) and were not used inthe analysis There are a few possible explanations for this A small number of these...
... of C with Î U, F(U)bounded and F : U → C a condensing mapping Then, either F has a fixed point in U or there is a point u Î ∂U and l Î (0,1) with u = lF(u); here U and ∂U denote the closure of ... contributions The work presented here was carried out in collaboration between all authors SP and AA defined the research theme SP designed theorems and methods of proof and interpreted the results ... as: Arunchai and Plubtieng: On the Krasnoselskii-type fixed point theorems for the sum of continuous and asymptotically nonexpansive mappings in Banach spaces Journal of Inequalities and Applications...
... in PC3 and LNCaP prostatecancer cells Moreover, we compared the effects of ErPC3 to the effects ofthe PI3K inhibitor LY294002 LY294002 inhibits the upstream kinase PI3K thereby preventing the ... based on their ability to induce apoptosis in tumor cells and their ability to increase cytotoxic efficacy of chemotherapy and radiotherapy in preclinical investigations [10-12] Induction of apoptosis ... differences inthe basal levels or treatmentinduced changes inthe expression of several proteins ofthe Bcl-2 family known to function as key regulators ofthe mitochondrial homeostasis and intrinsic...
... reviewing the scientific underpinnings ofthe use of persistence in hazard evaluation andof persistence measures as applied to metals, including the potential to use bioavailability measures in ... explanation without intent to infringe Library of Congress Cataloging -in- Publication Data Adams, William J., 1946Assessing the hazard of metals and inorganic metal substances in aquatic and terrestrial ... and regulation of natural resources, education, research and development, and manufacturing and distribution Specific goals ofthe society are: • Promote research, education, and training in the...
... membranes ofthe epithelial cells by endocytosis and further metabolic processing The intestine is also the site of small organic molecule uptake Metals may bind to these molecules and inadvertently ... considering the organism as consisting of different kinetic compartments These compartments may or may not reflect physiological units depending on the degree of detail inthe model Inits most ... andthe United States The biodynamic model requires concentrations of metals within the food of M edulis, and these were estimated using the distribution coefficient, KD (l/kg) andthe following...
... providing input to the UWM, and (3) providing an interim solution to the use of aquatic toxicity data in metal categorization, independent ofandin advance ofthe UWM 5.2 DATA ACCEPTABILITY The ... species, and (2) the toxicity of these species, rather than (3) the toxicity ofthe original metal substance There is no doubt that characteristics such as solubility and transformation (and their kinetics), ... the speciation component ofthe BLM The current use of WHAM (Tipping 1994) inthe BLM construct, however, does not preclude the future use of other types of speciation models, such as WHAM (introduced...
... affecting the mass balance of metals in soils are the anthropogenic and natural inputs andthe outputs via leaching to groundwater and removal through surface erosion and crop harvesting The elimination ... changes in climate and land use 6.3.3 AGING OF METALS IN SOIL Persistence of total metals in soil and persistence of metal bioavailability and solubility are not the same Inthe latter case, the ... determined by averaging the ranks of birds and mammals Rank determined by reassigning the wildlife ranks to and then averaging ranks of wildlife, plants, and invertebrates b (Section 6.4.2) or using...
... parallels the more potent NRTIs being administrated and possibly the protective roleofthe other drugs inthe regimen (e.g., boosted protease inhibitors) The rising prescriptions of NNRTIs during the ... assistance ofthe virologist through the interpretation ofthe genotypic resistance information In particular, the decline in resistance can be partially explained by the fact that inthe early years of ... discussed inthe introduction, most publications state that the prevalence of resistance is increasing over time, resulting inthe continued focus of drug designers on the activity of drugs against...
... results proved the change of brain resistance andthe improvement of brain compliance (by the increasing of velocity) The PI decreased collerately with the change of intracranial pressure The result ... hematoma: The formation andthe size ofthe hematoma will define the severity of increasing ICP The clinical manifestation includes: subarachnoid hemorrhage, intracranial hemorrhage, intra-ventricular ... surrounding the lesion, or the whole brain, cause diffuses brain edema Brain edema and brain vessel vasodilation can worsening the primary lesion Brain edema: Brain edema is defined as increase of...
... documents ofthe remote sensing image analysis saw that inthe mountainous areas in research had 420 points ofthe moving rock and soil on slope and sloping roof In particular, sloping roof on the ... according to the moving type (mechanisms) The laws of distribution moving points of rock and soil by type (mechanisms) of moving on slope and sloping roof in research area as following: Dominant landslide ... inthe entire of research space 4.4 Mapping the zoning risk of lanslide on slope in research area Zoning and prediction map ofthe risk of landslide was built on the principle of overlapping integrated...