... VOLUME 225 The titles published in this series are listed at the end of this volume Surgical OptionsfortheTreatmentof Heart Failure edited by ROY G MASTERS, MD FRCSC Division of Cardiac ... preventive measures and earlier surgical interventions This book outlines the major surgicaloptionsforthetreatmentof heart failure and brings together a very broad base of opinions with contributions ... "eternity" for these patients, in the context of their expected medical longevity The survival for our low EF CABG patients at years is 80% At five years, the survival is 60% These figures include the...
... are the potential triggers of apoptosis in the failing heart '"' However, the rt)ie of apoptosis IS usually questioned on the basis ofthe fact that the number of mvocytes so Pathophysiology of ... receptors in the myocardium may depend both on the etiology of congestive heart failure and the stage ofthe heart failure Tlie activation ofthe sympathetic nervous system is accompanied by the activation ... marked loss of myofibrillar protein was observed in electron micrographs ofthe failing human heart and this reduction of contiactile units seems to form the basis forthe depression of both systolic...
... of sutures farther apart on the tissue than on the Teflon to plicate the length ofthe ventriculotomy and partially restore the shape ofthe ventricle.^'* Endoventricidar Repair ofJatene (Figure!) ... process The influence of these tliree factors is fijrther illustrated in Figure 4, which represents a continuum based on the severit}' of symptoms, the degree of left ventncular function and the ... performed with complete excision ofthe subvalvular apparatus.''" " * •fhe issues of depression of ejection fraction from elimination ofthe low-pressure decompression into the left atrium and of...
... with the cost of immediate disappointment preventing the tragedy of protracted postoperative misery prior to death, and the tragedy ofthe premature end of a donor heart, fransplantation for otherwise ... ineligible for transplantation At the other end ofthe spectrum of heart failure, there is now increasing evidence that early intervention can reduce the development of heart failure ^*'" Even after the ... on the other hand, generally indicate the potential for improvement from further adjustment of medical therapy) More subtle frends of declimng cardiac index and renal function on maximal therapy...
... growtli through 1993, on the basis of tlie past years' data, this growth has clearly ceased, again m spite ofthe use of increasingly older donors (Figure 26) The age distribution for lung transplantation ... failure accounts forthe largest proportion of deaths In the mtennediate penod, there is an approximately equal representation by aeute rejection and infection Late after transplantation the most common ... is 2.6 years because ofthe high first-year mortality rate The conditional Yi life for those sun-iving the first year is more than 8.4 years Tables V and VI demonstrate the multivariate logistic...
... with the use of these devices so that current results have improved The weanability and discharge rates appear to be related to a) the promptness of implantation ofthe device, b) the age ofthe ... (for support needed for < hrs) or via a graft sutured to the femoral arterv' or the ascending aorta (for support needed for days) The catheter is then advanced through the aortic valve into the ... an offshoot from the development of cardiopulmonary bypass Early efforts in the design and development of devices were focused on providing support forthe body and the heart during periods of...
... avoid tension ofthe intact neurovascular pedicle The ligamentous insertion ofthe LDM is then affixed to the periosteum ofthe second or third rib with a non-absorbable heavy suture The skin is ... two sutures to the posterior pericardium; one just to the left ofthe pulmonic valve, and the other at the inferior vena cava-right atrial junction.''' The LDM is then folded around the heart from ... as necessary The LDM is left unstimulated for 10 to 14 days while the patient recuperates from the operation.''"" ^ lliis is to allow forthe reaivery ofthe distal jjortion ofthe mascle graft...
... xenografts.^" The first recipients of a xenograft will clearly be pioneers in the field The key issues here are that the recipient is fully informed ofthe likely outcome ofthe pr(x;edure, the need for ... Lives in the Balance The Ethics of using animals in biomedical research The Report of a Working Party ofthe Institute of Medical Ethics OUP 1991 Report on The Ethics of Xenotransplantation The Nuffield ... subject of in-depth research To date, there is no single, effective, widely practiced therapy for heart failure patients While Roy Masters (editor) SurgicalOptionsfortheTreatmentof Heart...
... were the external devices or console driven versions ofthe implantable devices."' Unfortunately these are the devices least suited to the permanent application since, as with the TAH, the patients ... (i.e the rib cage) to prevent device migration and 3) eliminating the need for diaphragmatic perforation and extension ofthe incision into the abdominal area However, to achieve the goal of intrathoracic ... considered the gold standard fortreatmentof end-stage heart failure the chronic shortage of donor organs and the need for chronic immunosuppression with its attendant complications severely limits the...
... guidelines forthe screening and selection of patients for Page of 10 APBI [22,23], and these guidelines formed the basis for patient selection in the EBT multicenter study [20] Ofthe 65 patients ... of 1.8 was tabulated The mean score was 1.5 forthe 20 patients who received local anesthesia, forthe patient administered sedation, and 2.1 forthe 18 patients who received both local anesthesia ... maintain the distance from the balloon to the skin surface The greater the volume ofthe balloon, with the attendant compression of adjacent breast tissue, the more fully the target breast tissue...
... observed in the past [13] One main risk associated with surgery is the often inevitable dissection ofthe vascular supply ofthe nerve, which leads to severe visual impairment in about 95% ofthe patients ... returned in 32 out ofthe 40 patients (80%) The median age at the time of radiotherapy was 44 years (range 17-83 years) The tumor manifestation was on the right eye in 16 patients and on the left eye ... as the gross tumor volume (GTV), adding 1-2 mm safety margin forthe planning target volume (PTV) The median PTV was 9.2 ml Radiotherapy planning for FSRT was performed using the Voxelplan ® software...
... 100% relief of their pain in 86% ofthe patients with a median relief period of months The range of relief varied from zero days to up to 13 months forthe facet injection group None ofthe lumbar ... median period of pain relief being months The range of relief forthe radiofrequency group was from zero days to 16 months for all 26 patients who underwent the radiofrequency procedure Ofthe 14 patients ... that the direct visualization ofthe joint allows better de-innervation ofthe joint and removal ofthe entire end-plate receptors that adhere to the bone and capsular tissue Limitations of the...
... and neural structures increases the risk of adverse events with invasive approaches Open surgical correction is the current standard of care for foraminal stenosis of cervical and lumbar vertebrae ... laminoforaminoplasty, should decrease the risk of major adverse events, allow for same day hospital discharge, and decrease the need for postoperative analgesia and immobility [5] [6] In the current ... and all patients were discharged the day of surgery Additionally, there was no need for thoracotomy, unlike other surgical approaches At the same time, reports in the literature suggest similar...
... ethanol at a final concentration of 10%, then transported to the laboratory of UT at 4oCstored Then, each ofthe samples were divided into two One of them was for DNA extraction and was washed ... general, the higher concentration of primers can lead to the formation of primer dimers Also, the cost ofthe chemicals should be minimized if the same quantitativeness can be achieved The results ... Another was for FISH analysis and was stored at -80oC The extraction of DNA was performed with Fast DNA SPIN Kit for Soil (Qbuiogene, USA) according to the instruction by the manufacturer In the...
... with the increased HRT ofthe adsorption tank From an engineering application point of view, the appropriate operational parameters ofthe recycle ratio, HRT ofthe regeneration tank, HRT ofthe ... in the PO43 P removal These results revealed that the selection ofthe operational parameters ofthe CARS process had a great influence on the overall system performance Adsorptive capability of ... technical feasibility of this process was demonstrated The effects of recycle ratio, HRT ofthe regeneration tank, HRT ofthe adsorption tank and SRT ofthe system were evaluated The removal efficiency...
... from data in the RCT The survival of patients receiving ASC/BSC was calculated from the survival ofthe patients in the cetuximab monotherapy arm ofthe RCT The data from the monotherapy arm NICE ... negligible if further active treatment was not available Therefore the results seen in the single-arm cetuximab studies for these outcomes could be interpreted as an effect ofthe drug It also ... from the perspective ofthe NHS Unlike the manufacturer’s models the outcome data were based on published overall survival curves from the two studies The utility value for pre-progression was the...
... reported on the efficacy and/or effectiveness of hydroxyurea treatmentof hematologic diseases, the toxicity of hydroxyurea in thetreatmentof any disease, and the barriers to thetreatmentof sickle ... reviewer reconciled the results ofthe first two reviewers in the case ofthe randomized trials 29 Forthe other study designs, the results ofthe two reviewers were averaged The quality assessment ... reliability ofthe instruments used A pair of reviewers each performed the quality assessment independently In the case ofthe RCTs, a third reviewer reconciled the results ofthe first two reviewers; for...
... (COX) In these enzymes, the redox potential ofthe metals is harnessed to provide the enzymes with their electron transfer capabilities Paradoxically, it is the same redox potential ofthe metals ... that the interaction between Ab and these metals can promote the formation of Ab oligomers, aggregates and fibrils [48,52–55] Metal mediated oligomerization of Ab may therefore contribute to the ... within the physiological ranges that could be expected within the brain The capacity for metals to facilitate this process may therefore be a critical factor in the Ab mediated pathology of the...
... the inclusion of lysine residues in the protein sequence ofthe A fragment but not the B fragment of PE Because only the A fragment must traffic to the cytosol for activity, the lack of lysine residues ... altering the rate of internalization ofthe receptor or influencing the intracellular trafficking The proteome ofthe target cell also influences the pathway We have observed large differences in the ... 14) of patients showed a partial response to treatment 4692 J E Weldon and I Pastan The future of PE-based RITs Many obstacles have been overcome in the development of RITs forthetreatment of...