... around inflammatory foci inthe spinal cord of rats with EAE, thus identifying potential determinants for trafficking of these cells to the CNS These findings are discussed in relation to therapeutic ... areas ofthe spinal cord displaying focal inflammation and demyelination (Fig 2E) Quantification of CCR1, CCR2 and CCR5 mRNAexpressing cells in relation to the stage of demyelinating activity The ... immunization) of EAE show extensive inflammation involving the white and grey matter (D), with marked demyelination inthe inflammatory areas (F) The majority ofthe infiltrating inflammatory...
... treatment, there was a 2.5-fold increase in apoptosis inthe subventricular zone (SVZ) and a 4-fold increase inthe dentate gyrus ofthe hippocampus (DG) The increased cell death persisted inthe SVZ and ... demyelinated axons, including partial or complete loss of myelin sheaths and increases in inter-laminar splitting ofthe myelin sheaths Analysis of transverse sections (Figure 9) provided further ... decreased levels of MBP inthe CC andinthe white-matter tracts ofthe striatum of treated animals (Figure 10) In agreement with the majority ofthe cell bodies inthe mature CC belonging to oligodendrocytes...
... nNOS and iNOS in neurons increased when bacterial encephalitis occurred This is the first study of NOS expression inthe goat brain with listeriosis The involvement of iNOS in bovine and caprine ... brainstem andthe staining pattern was similar to those of control brains with nonneurological diseases Inthe microabscesses, iNOS was recognized in inflammatory cells (mainly macrophages) inthe ... hematoxylin Magnification A and B, ×66 C and D, ×132 Immunohistochmical study of nitric oxide synthase inthecentralnervoussystemof goat Enhanced expression of nNOS and iNOS in L monocytogenes-infected...
... inthe study ofthe role of EphrinB2 in vivo EphrinB2 expression has been detected inthe visual systemin other organisms The aim of this project was to study the expression pattern of EphrinB2 ... guidance at the midline, Eph-Ephrins are also involved in creating patterned neuronal connections inthe CNS andthe peripheral nervoussystem Similar to the topographic mapping inthe visual system, ... target neurons inthe tectum The Recombination activating gene-1 (RAG1) is expressed inthe vertebrate immune systemandinthenervous system, including the zebrafish visual system (Chun et...
... nAuNPs inthe cockroach’s brain and to study the interactions between nAuNPs andthe brain tissue: hyperspectral Page of imaging, XPS, confocal microscopy, and TEM imaging The Hyperspectral imaging ... identify the organs affected by the nAuNPs The XPS was used to verify the presence of nAuNPs embedded inthe brain tissue The confocal microscope and TEM were used to gain insights into the interaction ... eliminated by using only young males in this study The effects of temperature, humidity, and wind were diminished by maintaining them in a controlled environment However, the fluctuations in Rocha...
... neurotransmitter inthe brain The interaction of glutamate with the N-methyl-D-aspartate (NMDA) receptor is important inthe workings of memory and learning In AD an increase in glutamate activity results in ... targeting cerebral amyloid generation in AD They either inhibit the production of Aβ or escalate its clearance inthe brain The most common mechanisms of action of these drugs are the inhibition of ... like tau is involved in microtubule assembly It serves as a binding for the tubulin Mutations in α-synuclein lead to loss of this binding ability, resulting in tubulin and α-synuclein aggregation...
... be studied using FCS These intensity fluctuations contain information which can be extracted by analysing the rates andthe amplitudes ofthe intensity fluctuations and subjecting them to an autocorrelation ... catalyzes the hydrolysis of ceramide to sphingosine Ceramide is the simplest form of sphingolipid and was shown to promote clustering of nanoscale domains in supported lipid bilayers [46] andin cells ... also given Chapter introduces the concepts and theory of FCS as well as the experimental setup of this instrument The calibration ofthe FCS system is also discussed The last part of this chapter...
... discovery of a brain-specific MT isoform, GIF, in 1991, sparked considerable interest in understanding the role of all MTs inthe brain, and particularly within the injured or diseased brain Inthe ... studies examining the role of GIF in AD, linked to its initial discovery as a factor deficient inthe AD brain There remains no clear consensus on the role of GIF inthe pathogenesis of AD, and therefore ... whether GIF acts in a neuroinhibitory manner when administered directly into the brain following traumatic brain injury In one such study, the injection of GIF into the site of a stab wound promoted...
... Highlands, 8.9% for theCentral Coast, and 2.1-3% for the Southeastern andthe Southwestern) Goats inthe Northern moutainous areas make up 48% ofthe country, and 67% ofthe North Most of them ... another, unlike the destructive gobbling nature ofthe cows Inthe other hand, goat helps to prevent the weeds and fertilize the plants with its excrement • Lack of experience is one ofthe main ... contamination and plague spreading still lingers around 3) Help the goats regain their strength by sufficient feeding and mineral and vitamine supplement 4) In case of diarrhoea, drinking water and salt...
... described the MRI features GL provided the pathological diagnosis TJ was the surgeon and gave the final approval ofthe version to be published Competing interests The authors declare that they have ... angiitis ofthecentralnervous system: initial and follow-up MR features Neuroradiology 2009, 51:651-659 12 Ay H, Sahin G, Saatci I, Söylemezoğlu F, Saribaş O: Primary Angiitis oftheCentralNervous ... centralnervous system: serial MRI of brain and spinal cord Neuroradiology 2001, 43:599-607 14 Moore PM: Diagnosis and management of isolated angiitis ofthecentralnervoussystem Neurology...
... NH and OB conceived ofthe study, participated in its design, andin drafting the manuscript HT and JB participated inthe study design and coordination andin discussing manuscript NH, NBF and ... using the Neighbor-Joining method The evolutionary distances were computed using the Maximum Composite Likelihood method and are inthe units ofthe number of base substitutions per site There ... resulted in an additional fragment of 160 pb The presence ofthe same site of restriction in this region of genotype D strains was also observed in sequences available in GenBank under the following...
... refutes the idea of mixing SVC and IVC blood as the mechanism for development of Δ[Lac] The finding of greater SO2 and [Lac] in IVC and SVC than in pulmonary artery indicates that further dilution of ... position ofthe catheter at each sampling site andthe blood sampling procedure was performed within a span of min, with no changes noted in heart rate or blood pressure in any ofthe patients Finally, ... answered by further clinical studies Conclusion The development of ΔSO2 and Δ[Lac] inthe patient population studied cannot be explained by the mixing of SVC and IVC blood The development of these gradients...
... SFPD intheCentral Highlands; - Perfecting organisation and operation of state management of SFPD intheCentral Highlands; - Enhancing inspection, monitoring, and supervision of SFPD intheCentral ... Conducting close inspection and control of converting forestry land into other purposes; - Enhancing measures of inspection, monitoring, and supervision; - Directing and implementing inspection and ... protection and development intheCentral Highlands Objects and Scopes ofthe Study The objects ofthe dissertation include both theoretical and practical issues of state management of socialization of...
... within the cell is reverse transcribed into double-stranded DNA which can then integrate randomly into the host cell genome The use of retrovirus vectors for gene delivery to thenervoussystem ... to achieve the optimized infection condition and enhance the virus replicating efficiency, we investigated the relationship between the amount of input virus andthe yield of resulting replicated ... human body, in which case they are more controllable and have reduced risk inthe gene therapy applications Inthe following section, one type of viral vectors derived from the insect origin, namely...
... major functional cells inthenervous system, carrying out the fundamental tasks of receiving, conducting and transmitting signals Therapeutic protection of these cells is one ofthe main goals of ... one ofthe key issues of gene therapy The expression level and specificity ofthe therapeutic gene is primarily determined by the activity ofthe promoter at the transcriptional level, andthe ... between the sites of Not I and Xba I Luciferase was used as the reporter gene for all the constructions and was inserted into the downstream ofthe promoters, between the sites of Xho I and Hind...
... inequality of income and income inequality has been seen as important cause ofthe problem of social inequality in general Income inequality is both the cause and a result of other forms of inequality ... Status of income inequality inthe region andthe provinces here have increased continuously from 2001 to 2013, andthe gap of income inequality tend to widening according to the growth process Income ... observations inthe data space, in order to avoid violating the assumptions ofthe model Methods of analysis and evaluation ofthe impact of income inequality to economic growth: The thesis has select the...
... (basic meanings) the meaning ofthe rules (rule m e a n i n g s ) In Montague Grammar these meanings are expressed in intensional logic Inthe Rosetta systemthe meanings of rules and basic expressions ... on the one hand and by the notion projection from X-theory on the other hand The second problem was that there is no way of explicitly controlling the application of rules in free Mgrammars and ... XPPROP and C L A U S E ) The fact that in X-theory the phrase markers ofthe resulting constituents are Inthe example ofthe smart girl / the girl that is 8mart the subgrammars for the projection...
... Schematicin cancer ofthe time ofthecentralnervoussystem Figure (CNS) via portals exposing some part course of radiation-induced Schematic concept ofthe time course of radiation-induced reactions ... phase where chemokines, cytokines and growth factors play important roles in intra- and intercellular communication CNS radiotherapy induces the production of inflammatory cytokines and mediators ... neurons), stem and progenitor cells andthe vascular system, also resulting in important alterations ofthe local microenvironment [9] The latent time preceding the clinical manifestation of damage...
... and towns intheCentral Highlands provinces - Analyze, assess the status of implementation ofthe law of democracy in communes, wards and towns inthe provinces oftheCentral Highlands inthe ... wards and towns inthe provinces oftheCentral Highlands 3.2.1 The specific factors affecting the implementation ofthe law of democracy in communes, wards and towns inthe provinces oftheCentral ... and towns inthe provinces oftheCentral Highlands From the analysis of theoretical basis and practical implementation ofthe law of democracy in communes, wards and towns inthe provinces of...
... with certain brain tumors, especially for the very young Because ofthe rapid myelinization that occurs in infants, the finding by Noble and colleagues [1] ofthe adverse effects of chemotherapy ... radiation The response of investigators has been to reduce the dose and/ or volume of radiation and, in some cases, to eliminate radiation entirely, adding combination chemotherapy to the treatment ... Abnormal CT scans ofthe brain in asymptomatic children with acute lymphocytic leukemia after prophylactic treatment ofthecentralnervoussystem with radiation and intrathecal chemotherapy N Engl...