... written informed consent HADS Patients completed the self-administered and validated German version of the HADS[19] The HADS measures depression and generalised anxiety in in- and outpatients andin ... linear regression analysis where the instrument of interest is the dependent andthe anchors the independent variable Using the equation one can estimate the minimal important difference of the ... 0.5.[23] Using the regression equation andthe minimal important difference of the anchors (0.5 points for the CRQ[15] and points for the FT[23]) we estimated the minimal important difference of the...
... ActiTest The aim of this study was to assess the inter-laboratory variability of FibroTest and ActiTest, including their six serum liver components, inpatientswithchronic liver disease, and to ... of the ULN (ULN units), variations inthe definition of normal may have important practical consequences Results The main characteristics of the included patients are outlined in Table According ... between laboratories andthe reference center are summarized in Table The intercept and slope between the reference center and other laboratories were excellent for the three proteins with only one...
... of the diagnostic value of FibroTest for the staging of hepatic fibrosis and comparisons with hyaluronic acid, the Forns Index andthe APRI Index inpatientswithchronic hepatitis C, from the ... VR, and YB participated inthe coordination of the study, and drafted the manuscript AM participated inthe design and coordination of assays inthe control group All authors read and approved the ... large number of patientswithchronic hepatitis C, andthe results were reproducible in different populations, including patients coinfected with HIV There was a small variability inthe AUROCs,...
... IL-9 and IFN-g plasma levels withthepatients echocardiographic parameters, such as LVEF and LVIDd, andwith disease duration Interestingly, in ICM patients, IL-9 levels inversely correlated with ... increased inpatientswith ICM as well as in NIDCM with respect to controls (p < 0.05) Further, the IL-6 cytokine (panel F) was significantly increased in ICM patients vs healthy controls (p < 0.05) The ... ovals), are linked to each other in terms of expression and/ or function (black thick lines), and to a number of molecules, namely Norepinephrine, Endothelin-1, IL-1A, Galectin-3, TNFa, IL-6 and IL-18...
... drawing illustrating pendulum test motion sensors Line supine and leg swinging freely with performed with subLine drawing illustrating pendulum test performed with subject supine and leg swinging ... weight and by employing other tests meant to reflect spasticity, we were able to examine the reliability and validity of the test as well Measurements obtained withthe magnetic tracking system, ... those of the measures tested As expected, adding weight to the ankle during the pendulum test altered pendular kinematics Presumably it contributed to the inertia of the leg against which the quadriceps...
... IL-9 and IFN-g plasma levels withthepatients echocardiographic parameters, such as LVEF and LVIDd, andwith disease duration Interestingly, in ICM patients, IL-9 levels inversely correlated with ... increased inpatientswith ICM as well as in NIDCM with respect to controls (p < 0.05) Further, the IL-6 cytokine (panel F) was significantly increased in ICM patients vs healthy controls (p < 0.05) The ... ovals), are linked to each other in terms of expression and/ or function (black thick lines), and to a number of molecules, namely Norepinephrine, Endothelin-1, IL-1A, Galectin-3, TNFa, IL-6 and IL-18...
... included inthe questionnaire withthe aim of comparing their performance in evaluating pain exacerbations in terms of reproducibility and of discriminatory capability to distinguish pain exacerbations ... the design of the study, collected data and revised the drafted manuscript MB, LL participated inthe design of the study and revised the drafted the manuscript AC conceived and coordinated the ... background pain as "very severe" with VRS and as "10" with NRS, being it difficult for them to effectively discriminate between background and peak pain intensities (data not shown in table) 19 patients...
... the importance of allowing ‘local’ input or control into the intervention design, andthe need to provide feedback regarding the impact of the intervention andthe possibility to change the intervention ... as providing further evidence that the clinical settings are CASs For interventions to be effective in improving patient outcomes, they must take this into account The difference inthe individual ... understanding them [15-22] This framework suggests that clinical settings are environments in which individuals learn, inter-relate, self-organize, and co-evolve in response to changes in their internal...
... disability in a wide range of physical and mental disorders The goodness of fit indices obtained withthe CFA models together withthe high factor loadings confirmed the domain structure of WHODAS-2 and ... 15 andthe clinical specialist responsible of thepatients' management Criteria used for classifying patients as being mild, moderate or severe are defined in Table The sample sizes of the final ... baseline andthe third evaluation of these patients were conducted In this case, the magnitude of the difference was also assessed with ES coefficients, but computed dividing the difference in the...
... respectively Seven patients had mixed infections: 1a andin cases, 1a and 1bin cases and 1a andin one case The viremia levels for HBV and HCV inthe studied patientsand controls, according to their status ... OB and HT participated inthe study design, inthe data analysis andin drafting and discussing the manuscript SBH and AS carried out the molecular tests and participated in data NM, IC, MA and ... identification of thepatients included into study, providing clinical and epidemiological data and drafting the manuscript All authors read and approved the final manuscript Competing interests The authors...
... participated inthe design and coordination of the study and helped to draft the manuscript PKP participated in drafting the script MP participated in its design and coordination and helped to draft the ... is chronic rhinosinusitis, in which the expression of thechronic inflammatory changes in computed tomography of the sinuses is not correlated withthe subjectively evaluated symptoms [18] The ... disease of the middle ear and/ or mastoid with irreversible mucosal damage or infection lasting more than months This definition covers adequately the clinical course and findings in our patients...
... measurements split into quartiles depending on thepatients baseline FEV1 values The LOESS curves in each panel, again intended to highlight the main trends, are also displayed inthe right-hand plot, ... study) and treatment arm of each study, for both indacaterol (lefthand panel) and comparators (right-hand panel) Visual inspection of the indacaterol data points indicated that with increasing dose ... 6), the similar outcomes from the two analyses reinforce the overall conclusions while providing further insights into the impact of patient characteristics on dose response The key finding of the...
... algorithm The shaded bar contains the cough event Cough is indicated by a single solid line at the end of the breath that contains the cough Note the change inthe posture from supine to upright ... time stamp inthe LS software data stream which was referenced to the video data time display to determine the beginning of the recording period Patients were allowed free range of the research ... well tolerated during the recording period Figure and Figure depict a representative recording of a single cough during quiet breathing and during a series of coughs close together, respectively...
... categories infected and 2323 (37%) as having cleared the infection Compared to patientsinthe cleared group, patientswithchronic HCV-infection were more likely to be male, and they also were older and ... chronic vs cleared HCV-infection, corresponding to an 8-year risk of 1.4% inpatientswithchronic HCVinfection and of 0.0% inpatientswith cleared HCV-infection) (Fig 3) There were no deaths ... 95% CI: 23.5–27.5) with 448 deaths inthechronic group and 153 deaths inthe cleared group Five-year survival was 86% (95% CI: 84–87%) among patientsinthechronic HCV group and 92% (95% CI:...
... malnutrition and atherosclerosis inpatientswith kidney failure (38, 40) In some studies the relation between hypoalbuminemia and CVD is the reflection of inflammation induced malnutrition The underlying ... morbidity and mortality in CKD 3-5 patientsin Spain (31) Our study extends this finding to patientswith more preserved renal function in American population Our hypothesis that serum albumin is ... malnutrion and inflammation in ESRD patients (25, 26) Hypoalbuminemia, a marker of malnutrition and underlying inflammation has come up as a powerful predictor of mortality inpatientswith ESRD...
... that the prevalence of diagnosed COPD, the number of deaths, andthe associated health costs will increase during the next decade In addition to the social strain, COPD also influences thepatients' ... written information about the study, an informed consent form giving their permission to take part inthe study, and a questionnaire with a hand-signed cover letter and a pre-stamped envelope when they ... design, and included 136 patientswith COPD recruited from the outpatient clinic at a medium-sized hospital between August 2005 and August 2007 Thepatients were referred to the out-patient clinic...
... Competing interests The author(s) declare that they have no competing interests KK participated in acquisition and interpretation of data, and drafting of the manuscript KWW was involved in conceptualizing ... our study, these preliminary findings suggest physicians andpatients may weight different aspects of disease severity and incorporating both perspectives in clinical decision making and outcomes ... of the patient actually having an infarction [37] Other investigators found that in predicting return to work inpatientswith coronary disease, both physicians' andpatients' estimates had independent...
... others) The variables included inthe Cox models for discontinuation of the second treatment were the same plus the main reason of discontinuation of the first treatment The bivariate models included ... at the time of the last reliable information The registry was approved by the Spanish Medicines Agency (Ministerio de Sanidad y Consumo), andthe information regarding patients was gathered in ... dramatically, especially if taking into account that, in this case, the initiation and discontinuation date are the same, something very unusual with other preparations Furthermore, the intravenous route...
... from the study after experiencing syncopal episodes during treatment and no further assessments of these patients were made Of the five patients who remained inthe study, all were treated for the ... infarct, cerebrovascular accident or other vascular event In both cases thepatients recovered fully within minutes of the event and had no subsequent events that were reported to us Inthe interest ... and editing the manuscript JBM contributed to data analysis and editing the manuscript KAC oversaw the administration of radiation therapy to the patients, conducted follow-up examinations, and...
... http://www.virologyj.com/content/7/1/311 examination of the biological and clinical effects of IFN inpatientswith CHC, the prediction of treatment responses in individual patients still remains difficult [5,6] Inthe framework ... andthe wide variability in miRNA expression observed in them As expected, the same trend was also observed for MxA We then examined the expression of IFN-induced miRNAs and MxA inpatientswith ... drawn with regard to the relationship between baseline or IFNinduced miRNA expression andthe clinical outcome of IFN alpha therapy inpatientswith CHC The limitations of this study included the...