... action of CY in the stomach in this study was due to the activation of p53 and therefore leading to the suppression ofthe c-Myc/ODC pathway All these findings could explain the mechanism of CY ... conducted with the consent ofthe Committee on the Use of Live Animals in Teaching and Research ofthe University of Hong Kong Male ICR mice (weighing 25–30 g) were reared on a standard laboratory ... studied CY significantly down-regulated the protein levels of VEGF, cMyc and ODC in the gastric mucosa (Fig 4A, 4B and 4C respectively) There was a 73% decrease in the VEGF protein level and a 22%...
... move against the war and restricted the global trade in oil export This is still known as the Arab oil embargo.8, 9) The idea of saving energy spread throughout in the world as a result of this ... by the “Act for Maintenance of Sanitation in Buildings”; however, small buildings and individual residences are not included, andthe substances in indoor air and their concentrations fromthe ... habitation The cause ofthe disease onset relates to a house, symptoms occur within the house, symptoms are less serious or disappear when the patient is away fromthe house, and when the patient...
... hemolymph of several crustaceans hasbeen well known since the beginning ofthe 20th century [34] An evaluation ofthe literature revealed that purification of lectin fromthe hemolymph of crustaceans ... with LSB at °C until the A280 ofthe effluent was < 0.002, and it was then transferred from °C to 32 °C and was washed again with warm (32 °C) LSB until the A280 ofthe effluent was < 0.002 This ... the fractions The fractions that contained significant amount of lectin were pooled and dialysed against mM CaCl2, at °C for 18 h, andthen for h with fresh mM CaCl2 The dialysate was then aliquoted,...
... XTC.UC1 and RO 82 W-1, the expression of PRC and ERRa was correlated with the mitochondrial mass, the expression of mitochondrial genes andthe activity ofthe COX and CS enzymes ERRa has already been ... PRC and ERRa in the transition fromthe G1 to the S phase ofthe cell cycle [29,33] When the cells are mostly involved in an oxidative process, as in the case ofthe FTC-133 thyroid cell line, the ... with the apparent independence ofthe mtDNA copy number and expression ofthe respiratory chain subunits reported by Vercauteren et al [29] They modulated the expression of PRC and found the regulation...
... giving the best fit to the scattering intensity The resulting dummy atom model represents the shape ofthe scattering particle To increase the reliability ofthe results, the final model for the dummy ... structure The high stability of ovorubin oligomers might be due to a shift ofthe pK ofthe amino acid residues beyond 12, owing to their involvement in salt bridges At acidic pH, the stability of ovorubin ... w [32] The crude homogenates were then sonicated for 15 s and centrifuged at 10 000 g for 30 min, andthen at 100 000 g for 60 The pellet was discarded, andthe supernatant was stored at )70...
... the crystal and/ or NMR structures of other members ofthe family The molecule is depicted in strand representation, and a helices are numbered from I to IV (B) Residues Leu7, Arg8 and Phe11 from ... fractions obtained fromthe Superose column were incubated for 12 h and applied again to the gel-filtration column In both cases, the two forms were obtained againandthe ratio of monomer to dimer ... acetyl group, the molecular mass was calculated to be 8670 Da The alignment ofthe amino-acid sequence of lungfish calhepatin with other members ofthe S100 family indicates that the number of amino-acid...
... millilitres of Hb was transferred to the tonometer and equilibrated for h in the shaking tonometer to ensure full equilibration ofthe Hb to the gas atmosphere ofthe system The tonometer was then transferred ... evaluated from plots ofthe concentrations ofthe four Hb derivatives as function of time The reaction rates for the nitrite reaction with deoxyHb and oxyHb were obtained by differentiation ofthe ... max (àM) The addition of ATP to stabilize the T state and to impede the T to R transition caused the disappearance ofthe well-dened peak for the deoxyHb reaction rate and decreased the absolute...
... United States In the United States, the Clean Air Act mandates the protection of human health and welfare fromthe effects of exposure to tropospheric O3 through the setting of primary and secondary ... date, the primary and secondary standards for O3 have been set equal to each other In 1997, a new EPA regulation that increased the stringency of both the primary and secondary O3 standards from ... uptake and response (32) Currently, the AOT40 parameter exceeds 3000 ppbh in most ofthe European Union with the exception of northern Scandinavia andthe UK (32a) This implies that most of Europe...
... close friend will differ from that ofthe letter to his lecturer In other words, the stylistic variation in communication largely depends on the contexts (The concept of stylistic variation was ... variation ofthe English language, and that Vietnamese English belongs to them as they are the owners of English in the Expanding Circle (Brown, [13]) More importantly, their awareness of social ... seriously judged if they not affect the transformation of meaning in the writing In case grammatical correction must be provided, the teacher should specify what the error is, and explain why there is...
... also reduce the expression of these genes We therefore tested the effect of rapamycin on the LPS-induced expression of iNOS and G-CSF Fig 3A shows that detectable levels of iNOS and G-CSF mRNAs ... ⁄ +35)-Luc and phRLTK, then, 24 h later, were pretreated with rapamycin and with LPS for h andthe Photinus and Renilla luciferase activities were measured The levels of Photinus luciferase activity ... Mutation ofthe octamer in the iNOS and G-CSF promoters results in a reduction of more than 90% in the LPS-induced promoter activities of these genes [13,30], suggesting the essential role of the...
... awareness ofthe extent of human individuality is seen in the diversity ofthe genomics ofthe human race that has evolved over many thousands of years, and that is responsible for the uniqueness of ... dysphasia Moreover these occur differently in various parts of Finland, the first to the northwest, the second to the south with a slight prevalence to the southwest, andthe third to southeast The ... molecules, and these in turn pass on the information about the interaction to other proteins, and other molecules, ofthe body How would we therefore simulate the whole body at the level of every...
... isoforms can be found in seeds and leaves ofthe soapwort Saponaria of cinalis and some have been expressed in Escherichia coli and characterized biochemically [18,19] The catalytic subunits of ... 5A), the newly synthesized polypeptides all showed the expected electrophoretic mobility, those ofthe mutants being decreased compared with the wild-type chimera At the end ofthe 24 h chase ... retained within the oocyte (compare lanes and 4) Fewer than 20% ofthe newly synthesized ATFSAPKDEL polypeptides were found in the oocyte medium after 24 h of chase Western blot analysis ofthe 72 h...
... antiserum, which suggest the presence of two populations of antibodies directed against different parts ofthe OPS or against the OPS andthe core region ofthe LPS In the passive haemagglutination ... was obtained from LPS-I and LPS-II at a yield of 44% and 21% ofthe total material eluted fromthe column of Sephadex G-50, respectively A preferable distribution to the water phase of LPS-I with ... [13] The absolute L configuration of Rha and D configuration of Fuc and ara4dHex were determined by GLC-MS ofthe acetylated (S)-2-octyl glycosides [19] The content of O-acetyl groups [17] and 6-deoxyhexoses...
... not in most ofthe others at the corresponding positions It is likely that some of them are the residues responsible for stability, and in fact Ala7, Met13, and Tyr43 in HT c-552 have been shown, ... in the wild-type PA c-551 and its quintuple mutant The mutated residues in the quintuple mutant, andthe corresponding ones ofthe wild-type PA c-551 and HT c-552 are colored purple, green, and ... subtle changes in them can affect the overall stability Thus, it is usually difficult to identify the exact factors that contribute to the enhanced stability ofthe proteins from thermophilic bacteria...
... sir, as a peace offering." And then, to the porter's surprise, he dropped a coin into his hand The porter looked hard at the coin in his hand, andthen at the cripple He was a man of no sentiment, ... spoke, he had already torn fromthe hands ofthe man Matteo a pair of trunks of blue cloth slashed with amber silk, and quick as an eye could wink, he was into them Andthen he fastened on a similarly ... strength But the foolish old man was hurled to the ground, andthen one ofthe brigands fell upon him, brandishing a huge knife Hunston here interfered, and gave a command which made the men laugh...
... appreciation of aesthetic art Or, alternatively, the appreciation of non-aesthetic art could depend on nothing corresponding to the perception of aesthetic properties in the appreciation of aesthetic ... that the appreciation of non-aesthetic art is very unlike the appreciation of aesthetic art is that it would strengthen arguments for aesthetic theories’ rival theories of art This is because ... reacts against (S) and proposes the third solution’ as a way to incorporate avant-garde artworks into the aesthetic theory of art The third solution invokes the idea of non-perceptual aesthetic...
... consumption As the plane crested the top ofthe building, I knew the images were getting good, and by the time the plane reached the top ofthe frame and thus also the top ofthe Capitol dome—I ... spread in the magazine where several of my images documented the patriotic celebration marking the end ofthe Gulf War The cover of Cigar Lifestyles magazine was one of many ofthe reuses ofthe Harrier ... myself in the middle of a throng of photographers, out ofthe reach of credential checkers who might miss me in the crush of movement andthe flurry of activity as the photographers rushed the field...
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... Aquinas’ theology I consider them two ofthe most outstanding philosophical theologians who have been at work during my lifetime, very different in their approaches; and it hasbeen a privilege and ... because they presented only theories of obligation, or of right and wrong, and I was not ready to offer a theory ofthe good I had some thought that a theistic metaethical theory ofthe good ... that the form ofthe Good (or of Beauty) occupies in Plato’s ‘middle dialogues’, and more and more convinced ofthe centrality ofthe idea of intrinsic excellence, both for ethical theory and...