roles of oxidative stress in signaling and inflammation induced by particulate matter
báo cáo hóa học: " The microglial NADPH oxidase complex as a source of oxidative stress in Alzheimer''''s disease" ppt
... complex leads to theinitiation of complex signaling events leading to proteintyrosine phosphorylation and activation of the src-familykinases Lyn and Fyn as well as the tyrosine kinase Syk[30,32,52]. ... [86,91-94]. Levels of both dityrosine and nitrotyrosine are elevated in brain regions specificallyaffected in AD [91]. Protein nitration is also increased in the hippocampus of AD patients compared ... the inducible nitric oxide synthase(iNOS) [75-77]. Fibrillar Aβ peptides stimulate the induc-tion of iNOS and NO production through an NADPH-dependent oxidative deamination of L-arginine[56,75,78,79]....
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Báo cáo hóa học: " Research Article Recognition of Nonprototypical Emotions in Reverberated and Noisy Speech by Nonnegative Matrix Factorization" potx
... Batliner, and D. Seppi, “The hinterland of emotions: facing the open-microphone challenge,” in Pro-ceedings of the 3rd International C onference on Affective Com-puting and Intelligent Interaction ... development set. Thispartitioning ensures that the original challenge conditionscan be r estored by jointly using the instances in the training and development sets for training.Note that—as it is ... esting condition,while the−5 dB level was excluded from training. Thus, themulticondition training, as well as training with BA or STnoise, involves the union of training data corresponding...
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báo cáo hóa học: " Brain inflammation and oxidative stress in a transgenic mouse model of Alzheimer-like brain amyloidosis" pptx
... a subset of NSAIDs(e.g. ibuprofen, flurbiprofen, indomethacin) reducedbrain inflammation and Aβ levels in addition to the dep-osition of Aβ in brain [13,14]. Despite this evidence, and the ... that a full dose of indomethacin alone despite a significant reduction in brain inflammation had only a marginal effect on brain oxidative stress in the Tg2576 mice [16]. This finding sug-gests ... implicating both oxidative stress and inflammatory mechanisms in AD pathogenesis.Effect of indomethacin plus vitamin E supplementation on sol-uble Aβ levelsFigure 3Effect of indomethacin plus...
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Báo cáo khoa học: Calcium, mitochondria and oxidative stress in neuronal pathology Novel aspects of an enduring theme pdf
... activated by mitochondrial Ca2+overloading and other factors including oxidative stress [88,89]. In neurons the presence of PTP in situ has notgained wide acceptance among investigators and results ... imposing a continuous load of calcium to the neuron. The turning point upon whichthe cell looses the ability to buffer the incoming calciumresulting in an abrupt, sustained and irreversibleincrease ... depolarization of in situ mitochondria by oxidative stress parallels a decrease in NAD(P)H level in nerve terminals. Neurochem Int 36, 483–488.61 Chinopoulos C & Adam-Vizi V (1999) Depolarization of in...
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Báo cáo khoa học: Effect of oxidative stress and involvement of poly(ADP-ribose) polymerase (PARP) in Dictyostelium discoideum development doc
... PARP inhibitor, on oxidative stress- induced changes in D. discoideum development. Interestingly, oxidative stress resulted in PARPactivation within 5 min that was inhibited by benzamide. Oxidative ... significantly inhibited by 1 mm ben-zamide (Fig. 4A,B), confirming PARP activation in D. discoideum under oxidative stress. PARP inhibition during oxidative stress- induced growth changes in D. discoideumPARP ... studied the effect of PARP inhibition under oxidative stress on two genera-tions by reviving the spores and monitoring growth and doubling time. It was found that in normal cells,PARP inhibition (1...
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báo cáo hóa học: " Biomarkers of oxidative stress and its association with the urinary reducing capacity in bus maintenance workers" pptx
... oxida-tive stress. The observed increase of reducing species in urine would mirror an increased level in blood originat-ing from a response to oxidative stress in the body mon-itored by the urinary ... only 10% of urate is excreted in the urine (theremaining 90% being recirculated by the renal system[3]), an increase of this antioxidant in blood will alsolead to an increase in urine. The ... concentration in the creatinine-corrected spoturine and the 24 hour urine [24]. Thus, the creatininecorrection may be applied in the present case.Measurement of the reducing capacity in urineWe...
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Báo cáo khoa học: "Comparative study of PM2.5 - and PM10 - induced oxidative stress in rat lung epithelial cells" pptx
... of PM2.5 - and PM10 - induced oxidative stress in rat lung epithelial cells 15three concentration of PM2.5 and PM10 (5, 1, 0.2àg/cm2)for 1day. The level of catalase mRNA induced by PM2.5was ... Expression of Nrf2 protein in the PM2.5 - and PM10 -treated rat lung epithelial cell was determined by WesternBlotting. The lower shows the ratio of Nrf2/actin usingcalculatging by densitometor. ... 11–18Comparative study of PM2.5 - and PM10 - induced oxidative stress in rat lung epithelial cellsJin-Hyuk Choi, Jun-Sung Kim, Young-Chul Kim1, Yoon-Shin Kim2, Nam-Hyun Chung3 and Myung-Haing Cho*Laboratory...
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Báo cáo y học: "NITRIC OXIDE (NO), CITRULLINE – NO CYCLE ENZYMES, GLUTAMINE SYNTHETASE AND OXIDATIVE STRESS IN ANOXIA (HYPOBARIC HYPOXIA) AND REPERFUSION IN RAT BRAIN"
... synthase. The increased activities of argininosuccinate synthetase and argininosuccinate lyase suggest the increased and effective recycling of citrulline to arginine in anoxia, making nitric ... findings of NO involvement in pathophysiol-ogy of hypobaric hypoxia in brain (42-43). In this study the increased activity of NOS in anoxia may represent predominantly the nNOS form. In inflam-matory ... continuous supply of arginine at the site of synthesis. Arginine is a semi essential amino acid and in CNS, its availability depends upon: (a) uptake from the circu-lating arginine and (b)...
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Tài liệu Báo cáo khoa học: Roles of the human Rad51 L1 and L2 loops in DNA binding doc
... within the L1loop with alanine, a short side chain amino acid, significantly decreased theDNA-binding ability of human Rad51, without affecting the protein fold-ing or the salt -induced, DNA-independent ... Thisnucleotide -induced allosteric effect on the L1 loop mayexplain the mechanism of DNA-binding regulation by nucleotide binding.The L2 loop is close to the DNA-binding siteThe L2 loop of HsRad51 contains ... tech-nique and by measurements of the DNA-dependentATPase activity. To ensure that the defect in DNAbinding is not due to incorrect folding of the Rad51mutants or a loss of binding cooperativity by...
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Tài liệu Báo cáo khoa học: Enhancement of oxidative stress-induced apoptosis by Hsp105a in mouse embryonal F9 cells pptx
... determine theeffects of Hsp105a on JNK and p38 signalling pathways, weexamined the activation of JNK and p38 in F9 cells by oxidative stress. As shown in Fig. 6A, JNK was notactivated in control ... mitogen-activated protein kinase(p38). Furthermore, oxidative stress- induced apoptosis wassuppressed by SB202190, a potent inhibitor of p38, in F9cells. These findings indicated that the activation of p38 ... to enhance the oxidative stress- induced activation of p38 but not JNK in F9 cells.As Hsp105a enhances the activation of p38 induced by oxidative stress, we further examined whether its activationis...
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Báo cáo khoa học: Roles of matrix metalloproteinases in cancer progression and their pharmacological targeting pdf
... theirmain roles focus on ectodomain shedding and nonpro-teolytic functions, such as binding to adhesion mole-cules, integrins and interacting with phosphorylationsites for serine ⁄ threonine and ... tetracyclines, lacking antibiotic activities, mayinhibit MMPs by binding to metal ions such as zinc and calcium. This family of inhibitors, including metastat(COL-3), minocycline and doxycycline, cause ... effect by activating indirectly theserine ⁄ threonine kinase Akt ⁄ protein kinase B throughthe signaling cascades of EGFR and IGFR [20,32].MMPs also promote apoptosis, most likely indirectlyby...
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