... higher in normal breast cell line (MCF10A) than breastcancer cell lines (MCF7, SK-BR-3, and MDA-MB-231) Proliferation rate inbreastcancer cell lines Up-regulation of p53 inbreastcancer cell lines ... overview of the roleof PrP inbreastcancer metabolism in the study model Picture showing different lactate production in normal and cancer situation Schematic overview of the roleof PrP incancer ... the finding of early markers for therapeutic intervention that has disease modifying effect, in hope of bringing down death due to breastcancerIn addition, the contribution of PrP to breast cancer...
... to this kind ofstressin referring, proclaiming, and reporting utterances Tonic stress is almost always found in a content word in utterance final position Consider the following, in which the ... clear to you The roleof sentence stressin enhancing English speaking competence Sentence stress is the governing stressin connected speech All words have their individual stressin isolation When ... 34 8.1 Final intonation 36 8.1.1 Rising-falling intonation 36 8.1.2 Rising intonation 37 8.2 Non-final intonation 39 8.2.1 Rising-falling intonation...
... use of vitamin E and vitamin C in combination reduced the prevalence and incidence of AD in an elderly population; however, the use of either of these vitamins alone had no effect [110] Finally, ... gp91phox and an increase in p47phox protein expression in monocytes primed with INFγ [59] Figure Activation of the Rac GTPase Activation of the Rac GTPase GTP-binding of the Rac protein confers an ... src-family tyrosine kinases or inhibition of phosphatidylinositol-3 kinase (PI3K) attenuates ROS production These findings suggest that these kinases are involved in upstream signaling cascades responsible...
... Conclusion This study provides insight into the involvement ofoxidativestressin the pathogenesis of OA from the viewpoint ofoxidativestress induced genomic instability, especially telomere ... Our findings clearly show the presence ofoxidativestressin degenerating cartilage, and the resultant telomere erosion and dysfunction of chondrocytes in vitro and in vivo, suggesting a role ... and maintenance of GAG content in articular cartilage in tissue culture Interestingly, treatment of cultured cartilage with an antioxidative agent not only inhibited GAG loss but also maintained...
... measurements of each of the nine points of irradiated skin were compared with corresponding points of non-irradiated skin by using a t-test This test determined the significance of differences ... measurement points taken in patients with Grade Figure Erythema and dry desquamation seen in Grade grade 4) showed a convincing trend of an increased probability of thinning in the skin thickness ... variation in skin thickness in the conservatively managed breast This finding suggests a need to use the same examination point when performing serial and comparative examinations The results of this...
... fusions Inbreast cancer, recurrent gene fusions have only been identified in rare subtypes, such as ETV6-NTRK3 in secretory breast carcinoma [12] and MYB-NFIB in adenoid cystic carcinoma of the breast ... the inhibition of apoptosis [29,30] IKZF3 is located at the most common telomeric breakpoint of the ERBB2amplicon [31] Interestingly, our preliminary analysis of clinical breast cancers shows ... splicing at the fusion junction, suggesting fusion junction diversity (Figure 2) VAPB-IKZF3 fusion is required for the cancer cell phenotype In order to gain insight into the functional role of...
... verification Haematoxylin and eosin (H&E) staining and immunohistochemical staining are shown on pathology sections of tumors implanted in NOD/SCID mice In a, b and c, the staining showed a single cell type ... be one of the causes of high expression of the drug-metabolising enzyme CYP1B1 in cancerous tissues [14] Finally, as a tumor suppressor inbreastcancer cells, miR-17-5p regulates breastcancer ... Ras-GAP binding proteins (G3BP) Oncogene 2007, 26(29):4209-4215 27 French J, Stirling R, Walsh M, Kennedy HD: The expression of Ras-GTPase activating protein SH3 domain-binding proteins, G3BPs, in...
... combined with vitamin C (Vit C), on training -induced decrease of reduced Effect of methyl sulphonyl methane (MSM), alone or combined with vitamin C (Vit C), on training -induced decrease of reduced ... combined with vitamin C (Vit C), on training -induced increase of lipid Effect of methyl (LPO) levels Effect of methyl sulphonyl methane (MSM), alone or combined with vitamin C (Vit C), on training ... by increases in lipid peroxidation, glutathione oxidation, and oxidative protein damage [28] In our study exercise induced an increase in cellular oxidativestress (as shown by the increase in...
... about 10% of all cancer incidence and mortality in 20132 Consistent with trends in developed countries, CRC is the most frequent cancerin Singapore, accounting for 14% to 18% of all cancer incidence ... 2005-20093 Colorectal cancers usually begin as non-cancerous polyps in the inner lining of the colon or rectum4 Over many years, adenomatous polyps in the dysplasic colon may develop into pre-neoplastic ... of kDa These cell line models are used in subsequent investigations to elucidate the functional roleof STMN1 in colorectal cancer metastasis Expression of endogenous STMN1 and/or STMN1-DDK in...
... points out the potential of ANXA1 playing a non-trivial roleinbreastcancer However, its specific roleinbreastcancer initiation and progression remains unclear 1.3: Models for breastcancer ... expression inbreast carcinomas, its roleinbreastcancer initiation and progression remains unclear The study presented here seeks to characterize ANXA1 in initiation and tumorigenesis ofbreastcancer ... effect of ANXA1 on the proliferation of tumor-derived cell lines The status of ANXA1 in certain clinical cancer tissues has been tabulated in Table Table 1: The status of ANXA1 in clinical cancer...
... apoptosis In fact, ROS-induced oxidativestress and cell death play important roles in the efficacy of many antineoplastic agents [13,14] To investigate whether oxidativestress is involved in the ... decreased protein levels of MKP1, one of MAP kinase phosphatases that inactivate JNK and p38 MAP kinases [2] Interestingly, NSC-741909 induced an increase of MKP1 mRNA expression in both time- ... several LOX inhibitors, including aesculetin (a nonselective LOX inhibitor), MK886 (an inhibitor of the 5-LOX-activating protein), zileuton (a 5-LOX inhibitor), baicalein (a 12/15-LOX inhibitor),...
... 1.1.3 Breastcancer Incidence ofbreastcancer Classification ofbreastcancer Aetiology ofbreastcancer 1 1.2 1.2.1 1.2.2 1.2.3 1.2.4 1.2.5 1.2.6 HER-2/neu-positive breastcancer Definition Clinical ... XVI Chapter Introduction CHAPTER INTRODUCTION 1.1 Breastcancer 1.1.1 Incidence ofbreastcancerBreastcancer is the second leading cause ofcancer deaths in women today after lung cancer and ... frequent cancers affecting Singapore women, 2003-2007 Breastcancer is the top cancer type affecting the women in Singapore Data extracted from Singapore Cancer Registry, Interim Report: Trends in Cancer...
... activation of p38 induced by oxidative stress, we further examined whether its activation is responsible for the induction of apoptosis in F9 cells using SB202190, a potent inhibitor of p38 As shown in ... determine the effects of Hsp105a on JNK and p38 signalling pathways, we examined the activation of JNK and p38 in F9 cells by oxidativestress As shown in Fig 6A, JNK was not activated in control ... hydrogen peroxide In contrast, hydrogen peroxide-treatment induced marked activation of JNK within 30 in S23 cells, but not in S3 cells Therefore, the enhancement of the oxidative stress- induced JNK-activation...
... increase in the amount of ROS [21]; (b) loss of cytochrome c impairs the flow of electrons in the respiratory chain inducing overreduction of the complexes, favouring the generation of ROS [16,17,22]; ... element binding protein, isocitrate dehydrogenase is an RNA-binding protein, while kgd2p is a mitochondrial DNA binding protein [81–84] Mitochondria from different brain regions contain different ... buffer the incoming calcium resulting in an abrupt, sustained and irreversible increase in [Ca2+]c, probably coincides with the cleavage of the exchanger (but see [164]) Therefore, inhibition of the,...
... with larger fruits PARP involvement during oxidative stress- induced developmental changes in D discoideum To determine the roleof PARP inoxidative stressinduced developmental changes, D discoideum ... important role under oxidativestress [21]; however, there is no report on the roleof PARP in D discoideum development We have investigated the roleof PARP in D discoideum development by inhibiting ... to investigate the long-term effects of PARP inhibitors for two successive generations n=3 Fig Effect of PARP inhibition during oxidative stress- induced growth changes in D discoideum Under oxidative...
... p-value less than 0.05 Injection of free DiD resulted in no increase in fluorescent intensity within the tumor at any time point post-infusion Figure labeling (a) Optical imaging of DiD-labeled cells ... intravenous injection of DiD-labeled monocytes (a) In vivo optical imaging of a control FVB/n mouse after (a) In vivo optical imaging of a control FVB/n mouse after intravenous injection of DiD-labeled ... innate immune cells during breastcancer progression BreastCancer Res 2007, 9:212 Balkwill F, Charles KA, Mantovani A: Smoldering and polarized inflammation in the initiation and promotion of...
... reacting with the murine receptor resulted in a faint stain of the cytoplasm and rarely in staining of the membrane of the tumor cells (Figure 3B) In the more advanced 30 weeks tumors the staining ... characterized by positive staining ranging from moderate to intense staining In the context of the potential association of htid expression with the biology of human breast cancers of different subtype ... analysis Page of 13 revealed elevated htid expression in 81% of the luminal A type tumors (Figure 1A), in 20% of the cases of the luminal B type over expressing ErbB-2 and in 18% of tumors diagnosed...
... quality -of- life measurement in randomized clinical trials inbreastcancer – taking stock Journal of the National Cancer Institute 2003, 95(4):263-281 Montazeri A: Health-related quality of life inbreast ... and Treatment ofCancer QLQC30: a quality -of- life instrument for use in international clinical trials in oncology J Natl Cancer Inst 1993, 85(5):365-376 Bottomley A, Aaronson NK: International ... clinical trial investigating several follow-up strategies for curatively treated breastcancer patients [10] to address whether the EQ-5D is responsive to changes in HRQoL in a population of breast...
... that a full dose of indomethacin alone despite a significant reduction in brain inflammation had only a marginal effect on brain oxidativestressin the Tg2576 mice [16] This finding suggests that ... indomethacin plus vitamin Effect of1 brain oxidativestress E supplementation on Effect of indomethacin plus vitamin E supplementation on markers of brain oxidativestress Total cerebral cortex homogenates ... presence of vitamin E significantly reduced two independent markers ofoxidativestress injury in both brain regions Thus, neocortex and hippocampus levels of iPF2α-VI (a reliable biomarker of lipid...