... imaging of the brain was also performed in a subset of patients in this study.36 It was found that use ofcorticosteroids possibly reduced the risk of developing hydrocephalus and vasculitic infarcts; ... bronchoscopic healing rate, radiological findings, and pulmonary functions Corticosteroidsin HIV-related TB Evidence from clinical trials on the use ofcorticosteroidsin specific forms of HIV-related ... play an important rolein the disruption of the bloodbrain barrier in TBM Corticosteroids significantly reduce the CSF levels of MMP-9 in patients with TBM 38 Corticosteroids also inhibit Mycobacterium...
... trochlear notch Additional interfragmentary screw fixation of single fragments may in single cases be necessary [Figure 10] Insertion of the remaining shaft screws into the ulna completed the ... disability in activities of daily living and was calculated for 45 out of 80 patients at a minimum of months postoperatively (range 8-84 months) Criteria of the PREE score include pain, function in specific ... Primary principles oftreatment are restoration of joint congruity and stability while permitting early range of motion [21] Earlier studies point out the importance of anatomic reduction of the...
... trochlear notch Additional interfragmentary screw fixation of single fragments may in single cases be necessary [Figure 10] Insertion of the remaining shaft screws into the ulna completed the ... disability in activities of daily living and was calculated for 45 out of 80 patients at a minimum of months postoperatively (range 8-84 months) Criteria of the PREE score include pain, function in specific ... Primary principles oftreatment are restoration of joint congruity and stability while permitting early range of motion [21] Earlier studies point out the importance of anatomic reduction of the...
... glucose-stimulated insulin secretion and its inhibition resulted in enhanced insulin secretion Myotrophin, a protein that has a rolein exocytosis, was identified as one of the targets of miR-375 Inhibition of ... deletion or loss -of- function mutations in the survival of motor neuron (SMN) protein results in SMA [12] Gemin and Gemin are shared components of SMN and miRNAcontaining ribonucleoprotein particles ... mutations can result in inherited forms of Parkinson's disease [7] Kim et al [8] suggest that miRNAs are essential for maintaining the dopaminergic neurons in the brain Given that Parkinson's disease...
... block international trade in generic medicines when they are suspected of infringing patents in the countries through which they transit These types of Page of border measures blocked medicines ... understanding of the role that Indian generic medicines producers play in HIV/AIDS treatmentin developing countries will shed light on the potential consequences of recently proposed intellectual ... are being negotiated between industrialized and developing countries contain measures that restrict access to medicines [7] Agreements involving India are of particular concern because of the...
... interaction is defined by various symptoms including impairment in the use of nonverbal behaviours (e.g eye contact, use of gestures and facial expressions); lack of showing, bringing or pointing out objects; ... research findings make it clear, however, that the pathophysiology of autism involves genes that code for proteins from the family of neurexins and neuroligins that play, in turn, a rolein the ... functioning of synaptic and in particular glutamatergic and GABA-ergic networks (Lisé & El-Husseini, 2006; Buchsbaum, 2009) The first X-linked mutations in genes involved in the coding of neuroligin...
... routine use of these types of pharmacologic intervention is not recommended as primary treatmentof EIB.12 Other therapies are still being investigated.12 Inhaled Corticosteroids Regular use of inhaled ... protective effect of CysLT1 receptor antagonists against EIB, providing strong evidence of an important roleof cysteinyl leukotrienes in regard to EIB.10 Treatmentof Exercise-Induced Bronchoconstriction ... action of a single mediator (An in- depth discussion of the mediators involved in EIB and their cellular sources are beyond the scope of this review.) 61 activity in individuals with underlying airway...
... survival rate of patients undergoing resection with involvement of the portal and superior mesenteric veins is very low[7] Infiltration of the superior mesenteric vein often prevents a margin negative ... nihilistic beliefs of clinicians It should be remembered that CRT confers a secondary resectability rate of 10 - 20% offering these patients the prospect of curative treatment Conflict of interests The ... PW, Lee JE, Lenzi R, et al.: Combining gemcitabine with radiation in pancreatic cancer: understanding important variables influencing the therapeutic index SeminOncol 2001, 28(3 Suppl 10):25-33...
... a-LA in the treatmentof peripheral nerve injuries, but further studies are needed to explain the mechanisms of its neuroprotective effects and before the use of a-LA in low back pain can be instituted, ... with our recent findings in which the combined employment of a-LA and g-linolenic acid with a rehabilitation program for six weeks reduced sensory symptoms and neuropathic pain in patients with ... Stasi M, Megna M: The use of alpha-lipoic acid (ALA), gamma linolenic acid (GLA) and rehabilitation in the treatmentof back pain: effect on health-related quality of life Int J Immunopathol Pharmacol...
... Journal of Negative Results in BioMedicine 2006, 5:14 Median (interquartile range) are shown A decrease in HOMA-S and ISI is indicative of a reduction in insulin sensitivity * Changes in insulin sensitivity ... Cavallo-Perin P, Cassader M, et al.: An in vivo and in vitro study of the mechanism of prednisone-induced insulin resistance in healthy subjects J Clin Invest 1983, 72:1814-1820 Asensio C, Muzzin P, ... the insulin receptor in obesity-diabetes Central roleof tumor necrosis factor-alpha J Clin Invest 1994, 94:1543-1549 Zhang S, Kim KH: Tnf-alpha inhibits glucose-induced insulin secretion in a...
... mcg/kg/min Arginine-vasopressin (Pitressin; Monarch Pharmaceuticals, Bristol, United Kingdom) infusion was started at a rate of 0.0003 U.I./Kg/min Within minutes, a pump flow at 100 ml/kg/min generated ... pump flow initially set to 150 ml/kg/min (corresponding to a cardiac index of 3.3 L/min/m2) generating a perfusion pressure of 20 mmHg with systemic vascular resistances index (SVRI) of 470 dyne*s/cm5/m2 ... clinical finding of bilateral pulmonary wheezing In order to reestablish hemodynamic stability, volume resuscitation was started (30 ml/Kg) and two intravenous (iv) boluses of 500 mcg of epinephrine...
... He was examined weekly for the first month Followup visits were made by phone interview monthly and by clinical examination at intervals of three months By the end of the sixth week of the surgery ... the main reason for medial patellar subluxation following lateral release was vastus lateralis insufficiency In contrast to this common opinion about the etiopathology of medial instability of patients ... lateral release, Quervain et al [12] claimed that medial patellofemoral instability is mostly caused by the insufficiency of the lateral retinaculum following the release of the patellotibial and...
... gain during antipsychotic drug therapy [15] An understanding of the roleof appetite changes in weight gain during antipsychotic treatment would be helpful to clinicians and patients, some of ... eating; EB = Eating Behavior Assessment; EI = Eating Inventory; FCI = Food Craving Inventory; kg = kilograms; N = number of patients in study included in the current analyses; n = number of patients ... 2009, 113:41-48 Poole Hoffman V, Case M, Jacobson JG: Algorithms Including Amantadine, Metformin and Zonisamide for Mitigation of Weight Gain During Olanzapine Treatmentin Outpatients with Schizophrenia...
... curve in patients in relation to use of inhaled corticosteroids (ICS) and long-acting beta-2-agonists Figure (LABA) Kaplan-Meier survival curve in patients in relation to use of inhaled corticosteroids ... records information was collected on treatment at discharge, including long-term oxygen therapy The patients were categorized in four treatment categories based on the utilization of inhaled corticosteroids ... thus indicating that, in addition to COPD, cardiovascular co-morbidity adds to lower health status In the present study the use of inhaled corticosteroids and long-acting beta-adrenergic inhalers...
... Recombinant activated factor VIIa in an unselected series of cases with upper gastrointestinal bleeding Thromb Res 2005, Epub ahead of print 18 Rizoli SB, Chughtai T: The emerging roleof recombinant ... JP: The roleof recombinant factor VIIa in the treatmentof life-threatening haemorrhage in blunt trauma Injury 2005, 36:495-500 Boffard KD, Riou B, Warren B, Choong PI, Rizoli S, Rossaint R, ... multicenter survey of off-label use of rFVIIa in American academic hospitals [16], which reported that only 52% of the patients stopped bleeding within hours of rFVIIa administration and 9% suffered...
... Society of Intensive Care Medicine; Society of Critical Care Medicine; Society of Hospital Medicine; Surgical Infection Society; World Federation of Societies of Intensive and Critical Care Medicine: ... Clin Endocrinol Metab 2006, 91:3725-3745 63 Minneci P, Deans K, Natanson C, Eichacker PQ: Increasing the efficacy of anti-inflammatory agents used in the treatmentof sepsis European Journal of ... Double- Yes blind Double- No blind Double- NA blind Double- Yes blind Double- Yes blind Double- Yes blind Double- Yes blind Openlabel Double- NA blind Double- Yes blind Double- Yes blind Yes No...
... like tau is involved in microtubule assembly It serves as a binding for the tubulin Mutations in α-synuclein lead to loss of this binding ability, resulting in tubulin and α-synuclein aggregation ... neurotransmitter in the brain The interaction of glutamate with the N-methyl-D-aspartate (NMDA) receptor is important in the workings of memory and learning In AD an increase in glutamate activity results in ... levels of Aβ can trigger the changes in tau protein culminating into formation of NFTs It has been shown that protein α-synuclein (core components of lewy body based pathologies, known as synucleinopathies),...
... view, in this thesis, we are trying to find the roleof GIT transit using bran scan in IBS patients with bloating (See later chapter) 1.3 The roleof Serotonin in IBS Serotonin (5-hydroxytryptamine, ... effect oftreatment with an intestinal prokinetic agent, tegaserod, on bloating and intestinal transit The aims of this study are to determine: 1) To investigate the baseline gastrointestinal & ... objective of this study is to investigate the symptomatology of bloating, the roleof gastrointestinal transit and effect of tegaserod in non-diarrhea IBS patients with bloating In the first part of...
... effects of H2S on cardiac myopathy Specifically, we will Investigate effect of H2S in lowering renin in renin-dependent renal hypertension 47 Liu Yi Tong Determine underlying mechanisms of H2S inhibition ... effects involve inhibition of the renin-angiotensin system (RAS) 151, attenuation of vascular remodeling 152 and activation of KATP channels 18 1.4 Clinical Significance of H2S Unveiling the ... renin inhibitor, aliskiren, was approved by the Food and Drug Administration for use in the United States in March 2007 Aliskiren binds to the active site of renin and prevents the binding of...