reactive oxygen species and nitric oxide in plants under cadmium stress from toxicity to signaling
báo cáo khoa học: " Reactive oxygen species and transcript analysis upon excess light treatment in wild-type Arabidopsis thaliana vs a photosensitive mutant lacking zeaxanthin and lutein" pps
... npq1lut2 plants under chilling stress accumulated tocopherols to higher levels than wild-type plants when exposed to excess light for d (Figure 4D) and contained ~70% more a-tocopherol Tocopherol ... membrane Taken together, these data suggest that 1O2 plays a key role in fulfilling the increased demand for protein import into the chloroplast during photo-oxidative stress, reflecting the higher ... I, Vanderauwera S, Gechev TS, Laloi C, Minkov IN, Shulaev V, Apel K, Inze D, Mittler R, Van Breusegem F: Transcriptomic footprints disclose specificity of reactive oxygen species signaling in...
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báo cáo khoa học: " Differential patterns of reactive oxygen species and antioxidative mechanisms during atrazine injury and sucrose-induced tolerance in Arabidopsis thaliana plantlets" ppsx
... damages in plants The herbicide atrazine, of the triazine family, binds to the D1 protein, which results in inhibition of photosystem II (PSII) by blocking electron transfer to the plastoquinone ... reduction of oxygen at the PSI site [52] Atrazine binding to D1 protein of PSII and inhibition of electron feeding to PSI were indeed likely to decrease superoxide radical production by blocking the ... involved in supplying reducing power to reductases detoxifying lipid hydroperoxides or repairing oxidized proteins [37] Thioredoxins could also act as regulators of scavenging mechanisms [38-40] and...
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Sphingosine kinase 1 regulates the expression of proinflammatory cytokines and nitric oxide in activated microglia
... A Ling and S T Dheen*, "Sphingosine kinase signaling mediates the activation of microglia by inducing proinflammatory cytokines " 2008 Neuroscience Meeting Planner (2008): 356.13/BB28 Online: ... inflammatory mediators including proinflammatory cytokines, chemokines and reactive oxygen species Microglial activation has been implicated as one of the causative factors for neuroinflammation in various ... erythro-sphingosine (Sphingosine), dihydrosphingosine and phytosphingosine, which are key sphingolipids (Melendez, 2008) In adult mouse, SphK1 is present abundantly in the spleen, heart, lung and brain,...
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Báo cáo y học: " Helicobacter pylori induces mitochondrial DNA mutation and reactive oxygen species level in AGS cells"
... grown in the F12 culture medium containing 10% FBS, 100 U/ml penicillin and 100 µg/ml streptomycin in a humidified atmosphere of 5% CO2 and 95% air at 37°C Hp was grown in the brain heart infusion ... with continuous shaking E coli were maintained in the LB liquid medium (containing 100 µg/ml ampicillin) at 37°C for 12 h with continuous shaking Preparation of Hp and E.coli extract The Hp and E ... Jiaotong University School of Medicine 57 Reagents F12 culture medium (Hangzhou Jino Biology Co., Ltd China), fetal bovine serum (FBS), ampicillin, penicillin and streptomycin (Shanghai Bio-engineering...
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Báo cáo khoa học: Antioxidant defences and homeostasis of reactive oxygen species in different human mitochondrial DNA-depleted cell lines pot
... provided insights into oxygen metabolism [13,17,19–21] and the role of mitochondria in redox signalling during apoptosis [22,23] Redox-sensitive signalling and sensitivity to oxidative stress depend ... I and III, or a rise in oxygen tension (state respiration) Defects in respiratory complexes [9] and normal aging [10] also lead to increased mitochondrial ROS production A recent study [11] indicates ... assayed in total cells and in cytosolic and mitochondria-enriched fractions, respectively In mitochondria-enriched fractions CS activity was twice the value found in the whole cells, whereas cytosolic...
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Báo cáo khoa học: Neuroglobin and cytoglobin expression in mice Evidence for a correlation with reactive oxygen species scavenging doc
... Betts DM & Grozdanic S (2006) Neuroglobin and cytoglobin: oxygen- binding proteins in retinal neurons Invest Ophthalmol Vis Sci 47, 1016–1023 Stein I, Itin A, Einat P, Skaliter R, Grossman Z & Keshet ... tolerant to hypoxia [15] and thus more tolerant to higher H2O2 levels For brain and eyes, there was a gradual increase in the amount of H2O2 after hypoxia and reoxygenation In heart, muscle and liver, ... hypoxia-inducible factor (HIF)-1a and upregulation of Cygb mRNA, and hypothesized that Cygb (and Ngb) may have a vital role in retinal oxygen homeostasis, enabling the retina to sustain longer...
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Báo cáo y học: "Reactive oxygen species induce expression of vascular endothelial growth factor in chondrocytes and human articular cartilage explants" pps
... complex and involves multiple pathways [14] ROS can induce changes in biosynthetic activity [15], in addition to apoptosis [16] In addition, ROS can influence transcription factors in chondrocytes and ... cartilage explants There were bold signals corresponding to VEGF-121 and fine bands corresponding to VEGF-165 In general, more intense signals were present in the chondrocytes compared with those in cartilage ... Poltorak Z: Vascular endothelial growth factor (VEGF) and its receptors FASEB J 1999, 13:9-22 Firestein GS: Starving the synovium: angiogenesis and inflammation in rheumatoid arthritis J Clin Invest...
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Báo cáo y học: " Reduced levels of reactive oxygen species correlate with inhibition of apoptosis, rise in thioredoxin expression and increased bovine leukemia virus proviral loads" potx
... Spearman test doxin system leading to ROS generation and induction of apoptosis in cancer cells (for review, see [38]) HDAC inhibitors are known to be proapoptotic for cells infected by HTLV-1 ... thioredoxin system Our results thus provide evidence linking inhibition of apoptosis and reduced ROS levels resulting in a Experimental animals A total of 13 BLV-infected sheep and controls used in ... François Debande and André Théwis for support in animal housing facilities, Michèle Nuttings and Daniel Portetelle for providing monoclonal antibodies and Vincenzo Ciminale for helpful comments and critiques...
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Báo cáo y học: "Endogenous TGF-β activation by reactive oxygen species is key to Foxp3 induction in TCR-stimulated and HIV-1-infected human CD4+CD25- T cells" docx
... molecular mechanism underlying TCRinduction of Foxp3 in human T cells is not understood Since TGF-β has been implicated in the induction of Tregs in murine cells, we set out to investigate whether ... Ploquin MJY, Desoutter JF, Santos PR, Pandrea I, Diop OM, Hosmalin A, Butor C, Sinoussi FB, Muller-Trutwin MC: Distinct expression profiles of TGF-b1 signaling mediators in pathogenic SIVmac and ... with increased mitochondrial membrane hyperpolarization, which may lead to ROS re-distribution into the cytosol to initiate cell death The late apoptotic and/ or dead cells may release ROS into...
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Tài liệu Báo cáo khoa học: Autophagy inhibits reactive oxygen species-mediated apoptosis via activating p38-nuclear factor-kappa B survival pathways in oridonin-treated murine fibrosarcoma L929 cells doc
... oridonin-induced apoptosis and autophagy were demonstrated in that they inhibited 1292 apoptosis but promoted autophagy Oridonin-induced p38 mitogen-activated protein kinase activation was shown to ... induced autophagy in L929 cells Inhibition of autophagy up-regulates apoptosis in oridonin-induced L929 cells To investigate the role of autophagy in oridonininduced apoptosis in L929 cells, we ... reducing cytotoxic oxygen radicals Nat Med 13, 688–694 Nathan C (2003) Specificity of a third kind: reactive oxygen and nitrogen intermediates in cell signaling J Clin Invest 111, 769–778 Finkel...
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Báo cáo khoa học: Transport of L-arginine and nitric oxide formation in human platelets pdf
... of the total arginine in ux Thus its contribution to arginine in ux seems to be minor To clarify the actual contributions of system y+ and y+L to the overall rate of L-arginine transport under ... in which the L-leucine effect was tested (B), L-leucine and L-arginine were added simultaneously After min, incubation was stopped and L-arginine uptake measured as described in Experimental procedures ... y+L from total in ux Each point represents the mean ± SD of seven experiments carried out in duplicate In (B) data have been plotted according to Lineweaver–Burk Fig Effect of valinomycin and...
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Báo cáo khoa học: Structure, regulation and evolution of Nox-family NADPH oxidases that produce reactive oxygen species pptx
... binding of Ca2+ to the EF-hands [65] In plants, the EF-hands of Rboh localize within the Rac-binding region at the N-terminus, and binding of Ca2+ to the EF-hands prevents Rac from binding to ... proteins containing TPR motifs and a PB1 domain [94,180], they not retain conserved Rac-binding residues and are therefore not expected to function by interacting with Rac Instead, Rac directly binds ... distributed in protostomes and deuterostomes (Fig 3), suggesting that Nox5 and Duox, containing four and two EF-hands, respectively, diverged after the emergence of a p22phox-binding Nox2-like oxidase in...
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Báo cáo khoa học: Is there more to aging than mitochondrial DNA and reactive oxygen species? pot
... are inadequate Lack of histones in mitochondria and susceptibility of mtDNA to oxidative stress Histone proteins are reported to protect DNA from a variety of potentially dangerous reactive species, ... as histones, under conditions in which histones protect against oxidative stress [82] This is in agreement with a report that mitochondrial transcription factor A (a DNA-binding protein and a ... mtDNA damage, leading to aging However, aging can occur in the absence of detectable exposure to environmental toxins, which suggests that a role of these toxins in natural aging is limited At...
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báo cáo hóa học:" Airborne particulate matter PM2.5 from Mexico City affects the generation of reactive oxygen species by blood neutrophils from asthmatics: an in vitro approach" docx
... Medicine and Toxicology 2009, 4:17 Figure by neutrophils in contact with PM2.5 In vitro generation of reactive oxygen and nitrogen species In vitro generation of reactive oxygen and nitrogen species ... and black carbon components found mainly in ultra-fine particles confer greater in vivo and in vitro toxicity than fine particles, and this effect is said to be independent of the soluble metal ... Grenfell AM, Hicks JJ: Reactive Oxygen Species (ROS) induce chemical and structural changes on human insulin in vitro, including alterations in its immunoreactivity Frontiers in bioscience 2005,...
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Báo cáo y học: "Serum, urinary, and salivary nitric oxide in rheumatoid arthritis: complexities of interpreting nitric oxide measures" doc
... of NOx/creatinine ratios acts as a control for individual differences in creatinine clearances The finding of increased NOx and NOx/creatinine ratios in serum (but not in urine) in patients with ... remaining amounts being eliminated in unknown proportions by the exocrine glands and by the respiratory and gastrointestinal tracts [11,12] The total amount of NOx measured in the urine and serum ... hours, the urine NOx excretion during the period from 48 to 72 hours, the serum and urine NOx/creatinine ratios during the period from 48 to 72 hours, and NOx urinary clearance and fractional...
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báo cáo khoa học: "Reactive oxygen species-mediated apoptosis contributes to chemosensitization effect of saikosaponins on cisplatin-induced cytotoxicity in cancer cells" pdf
... as indicated in (A), and then stained with annexin V and PI followed by flow cytometry analysis Early apoptosis is defined by Annexin V+/PIstaining (Q4) and late apoptosis is defined by Annexin ... roles in intracellular redox modulation have never been addressed To investigate the mechanism of the saikosaponins and cisplatin-induced cytotoxicity, we examined the effect of saikosaponin and ... iodide (PI) following manufacturer’s instruction Early apoptosis is defined by Annexin V+/PI- staining (Q4) and late apoptosis is defined by Annexin V + /PI + staining (Q2) as determined by FACScan...
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Báo cáo y học: "Ex vivo effects of flavonoids extracted from Artemisia herba alba on cytokines and nitric oxide production in Algerian patients with Adamantiades-Behcet''''s disease" pptx
... baicalin inhibits superantigen-induced inflammatory cytokines and chemokines FEBS Letters 2001, 500:52-55 39 Trinchieri, G: Interleukin 12 and its role in the generation of TH1 cells Immunol Today ... of Th2-type cytokines, including IL-4, IL-10, and IL-13 in ABD patients [8], suggesting disturbed cytokines production in ABD Such dysregulation in cytokine release contributes to the regulation ... overexpression of either inducible NO and proinflammatory cytokines might be intimately involved in the pathogenesis and the evolution of ABD [12, 42] An increase in the concentration of NO during the ABD...
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Báo cáo y học: " The anti-inflammatory effects of the tellurium redox modulating compound, AS101, are associated with regulation of NFB signaling pathway and nitric oxide induction in macrophages" doc
... the NFB pathway by modifying specific cysteine residues in IKKa and in the p50-subunit resulting in the inhibition of nuclear translocation and DNA-binding to the iNOS promoter Nevertheless ... Bahar I, et al: Inflammatory modulation of hepatocyte apoptosis by nitric oxide: in vivo, in vitro, and in silico studies Curr Mol Med 2004, 4:753-62 Moncada S, Higgs EA: Nitric oxide and the vascular ... reduce pro-inflammatory cytokines and inhibit iNOS expression and NO release in LPS-stimulated RAW264.7 macrophages by targeting the NFB activation pathway Materials And Methods Cell Culture and Sample...
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Báo cáo y học: " Central role of nitric oxide in the pathogenesis of rheumatoid arthritis and systemic lupus erythematosus" potx
... lymphocytes leads to an increase in mitochondrial and cytoplasmic Ca2+ levels In contrast, the NO chelator C-PTIO (carboxy-2-phenyl-4,4,5,5-tetramethyl-imidazoline-1-oxyl-3 -oxide) powerfully inhibits ... reticulum and because mitochondria may also serve as Ca2+ stores, this increased mitochondrial mass may alter Ca2+ signaling in SLE [10,26] Although NO production was found to be increased in both ... mammalian target of rapamycin activity and TCRζ expression in SLE The mammalian target of rapamycin (mTOR) is a serine/ threonine protein kinase and a sensor of the Page of mitochondrial transmembrane...
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