... K, Hoffmann S, Bauer F, Friedrich U, Kardinal C, Feller SM, Biesinger B & Sticht H (2002) Structural investigation ofthe binding of a herpesviral protein to the SH3 domain of tyrosine kinase ... undetectable inthepresenceof Mn2+ The solvent-exposed C-terminus of VpUcyt probably pointed away from the surface ofthe micelle The three amide cross-peaks originating from the hydrophobic ... ofthe observed VpUcyt structure One ofthe most studied activities of VpU is the induction of CD4 degradation inthe endoplasmatic reticulum of infected CD4+ cells Only the cytoplasmic domain...
... activity ofthe reaction intermediate, FVaint This facilitated the determination of loss of FVa cofactor activity during the initial stage of inactivation and minimized thein uence ofthe k306 ... part ofthe heparin-binding site in these three crystallized protein heparin complexes were given as starting point for the docking search [30] At least one conformation ofthe simulated protein peptide ... time the loss of FVa activity inthe absence of heparin (open circles) did not differ from that obtained inthepresenceof heparin (closed circles) This indicates that thepresenceof heparin...
... hydration oftheprotein domain is the driving force ofprotein stabilization or folding [3,4] Furthermore, the effect of osmolytes on the functional activity of an enzyme has also been investigated ... and DGD° values inthepresenceof these osmolytes are given in Table However, DGD° values of RNase-A inthepresenceof alanine, serine, lysine, b-alanine, taurine and dimethylglycine have not ... efficiency inthepresenceof this group of osmolytes Interestingly, there is a linear relationship between DDGD° and Dlog(kcat ⁄ Km) inthepresenceof methylamines and sugar However, the slopes of the...
... softening depends on the melting of these crystallites, but can be changed by a chemical crosslinked network [5] The crosslinking influences on the softening point (Ts) ofthe PVC samples in comparing ... inthepresenceof phr of TMPTMA ofthe PVC crosslinked samples decreases with increasing concentration of TMPTMA up to 15 phr Therefore, in order to obtain PVC having the highest , 0.4 phr of ... improves the molecular mobility, melting and softening of PVC and a result, Ts decreases with increasing Table 1: Softening point ofthe PVC samples containing different concentrations of DAPC...
... alignment in linear space, using a sliding window, while also identifying the intersections ofthe corresponding path with the established cut-points; inthe second step, we recompute separately the ... reverse translation of a protein usually refers to obtaining one ofthe DNA sequences that encodes the given protein Several methods for achieving this exist [10,11], aiming at finding the DNA sequence ... (w) are the probabilities ofthe word w inthe reading frame imposed by the position ofthe first and second codon, respectively This is computed as the products ofthe probabilities ofthe codons...
... self-financing portfolio if and only if certain integral equations ofthe first kind (the “hedging equations”) have solutions Furthermore, the integral operators appearing in these equations (the “hedging ... apply part ofthe present theorem We now turn to the issue of so called “martingale modelling”, and remark that one ofthe main morals ofthe martingale approach to arbitragefree pricing of derivative ... turn out to be adjoint ofthe martingale operators • We show that uniqueness ofthe martingale measure is equivalent to the denseness ofthe image space ofthe hedging operators In particular, it...
... identify the site of action ofthe fatty acids inthe plasmin molecule, the amidolytic activity of two truncated plasmin variants was examined (Fig 8) Miniplasmin (des-kringle 1-4 plasmin) contains the ... resulted in a decrease, of up to two-fold, inthe kp of plasmin Considering the recently described reversible nature ofthe plasmin inhibition by oleic acid [3] and the changes ofthe kinetic parameters ... catalytic action of plasmin inthepresenceof stearate The p-nitroaniline (P) released inthe course of hydrolysis of 40 lM Spectrozyme-PL by 20 nM plasmin inthepresenceof 115 lM stearate is...
... consistent with titration ofthe catalytic histidine, H438(440) The persistence of activity inthepresenceofthe protonated form ofthe catalytic histidine is inconsistent with the generally accepted ... form of BuChE, as indicated In each panel, the solid circles indicate the measured kcat values, the solid squares indicate the measured bkcat values, and the lines are the result of fitting the ... excess-substrate binding appears to involve the intricate interplay of a variety of residues inthe active site pH dependence of A328W Fig pH dependence for the turnover number (kcat) inthe absence of excess...
... the complexity of these drug interactions, the key role ofthe rifamycins inthe success of tuberculosis treatment mandates that the drug-drug interactions between the rifamycins and antiretroviral ... least the first months of treatment among patients with advanced HIV disease 8, Predicting Drug Interactions Involving Rifamycins Knowledge ofthe mechanisms of drug interactions can help predict the ... isozymes The rifamycins vary in their potential as CYP450 inducers, with rifampin being most potent, rifapentine intermediate, and rifabutin being much less active Rifampin also upregulates the synthesis...
... of KNO3 With an increase inthe content of KNO3, the dimension of nanoparticles only became smaller Similarly, the nanorods and nanoparticles were obtained inthe products with the addition of ... need the anisotropy during the growth process for the nanoparticles In our experiments, thepresenceofthe salts is also an important factor influencing the crystallization process and the growth ... growth ofthe WO3 nanowires With the addition of different inorganic salts, the compositions and the corresponding properties ofthe solution are different inthe hydrothermal conditions The changes...
... These results are largely robust to including the proportion of Group pupils inthe surrounding area as the explanatory variable, rather than the total number of Group pupils inthe surrounding ... treatment in 1998 This was partly because of confusion inthe field about pupil age, and partly because inthe early stages ofthe program several ofthe Kenya Ministry of Health nurses administered ... correlated among these individuals at the margin of receiving treatment 34 We have also calculated Manski bounds on within-school externalities inthepresenceof selection into treatment, but these are...
... of p-amindinobenzamidine Figure 2B shows time courses for trypsinogen autoactivation inthepresenceof 100 lM p-amindinobenzamidine As seen in this figure, thepresenceof p-amindinobenzamidine ... analyze the effects of acetamidine, p-amidinobenzamidine and benzamidine on the autoactivation of trypsinogen by trypsin Figure shows time courses of trypsinogen autoactivation inthepresenceof ... Effect of p-amindinobenzamidine concentration on Km for autoactivation of trypsinogen by trypsin gives a straight line, indicating that p-amindinobenzamidine is a competitive inhibitor for the trypsinogen...
... above, we examined the performance ofthe models using hand-processed evaluations ofthe PUZZLE CORPUS data The following presents the results ofthe three different models on 10 trials ofthe PUZZLE ... balance of linguistic and visual salience is needed in order to account for patterns of referring behavior Inthe remainder of this paper, we begin by presenting a brief discussion ofthe motivation ... human-agent interactionsin a wide variety of contexts that include visual objects of interest Such systems may benefit from a datadriven model of how collaborative pairs adapt their language inthe presence...
... are involved inthe transmission of mechanical signals to signaling pathways Inthe M line, mechanical stimulation activates the interaction of a protein complex with the kinase domain of titin, ... expression [18] The MARP family is composed of three proteins, ankyrin repeat domain-containing protein (Ankrd2), cardiac ankyrin repeat protein (CARP) and diabetes-related ankyrin repeat protein (DARP), ... Considering the location ofthe N-terminal extremity of DNter2 on the structure of CARP and thepresenceofthe potential cleavage sites, we identified the localization ofthe cleavage site within...
... the parameter estimates obtained inthe absence ofthe inhibitors (see above) Inthe case of gallamine investigated inthepresenceof MeCN, the calculation ofthe kinetic parameters was based ... for the inhibition of AChE by gallamine inthe absence of MeCN (B) Plot of int0 (int0)1) and int1 (int1)1) versus the reciprocal concentrations of gallamine Inhibition kinetics of acetylcholinesterase ... AChEgallamine to hydrolyse ATCh is 1.7 25% of that of free AChE Inuence of MeCN on the inhibition of AChE The inhibition of AChE by tacrine, gallamine and compound was investigated inthepresence of...
... (broken lines), either inthe form of aggregates formed inthepresenceof Cu2+ [(i) and (iii)] or Zn2+ [(ii) and (iv)], or as fibrils formed inthepresenceof EDTA [(v) and (vi)] The amount of amyloid ... Error bars indicate the experimental uncertainty ofthe measurements observed between the Cu2+-induced and Zn2+-induced aggregates, reflecting the differences in metal-binding properties of Ab [26,30,33–35] ... formed inthepresenceof a molar excess of divalent metal ions failed to attain the classic morphology of amyloid fibrils [37,46] The aggregates of Ab(1–40) and Ab(1–42) formed inthepresenceof a...
... variant and that the lower fitness ofthe recombinant virus can not be increased by pre-passaging in cell culture The observed survival time ofthe recTULV inthepresenceofthe Page of (page number ... conserved inverted repeat inthe 3'-noncoding region ofthe S segment seems to be involved in recombi- nation events, leading, however, to the deletion ofthe hairpin-forming sequences (A Plyusnin, ... Figure recombinant S RNA segments Checking of specificity of RT-PCRs for the wt and the Checking of specificity of RT-PCRs for the wt and the recombinant S RNA segments Lines 1–3: products of RT-PCR...
... variant and that the lower fitness ofthe recombinant virus can not be increased by pre-passaging in cell culture The observed survival time ofthe recTULV inthepresenceofthe Page of (page number ... conserved inverted repeat inthe 3'-noncoding region ofthe S segment seems to be involved in recombi- nation events, leading, however, to the deletion ofthe hairpin-forming sequences (A Plyusnin, ... Figure recombinant S RNA segments Checking of specificity of RT-PCRs for the wt and the Checking of specificity of RT-PCRs for the wt and the recombinant S RNA segments Lines 1–3: products of RT-PCR...
... less intensive than their fully coordinated counterpart since they only require the local processing ofthe beamforming weights Besides the difficult exchange ofthe data and CSI between the transmit ... impacts of CFO in coordinated schemes are hence worse than for point-to-point communications Because the frequency offset translates into the possibly destructive combination ofthe incoming streams, ... the energy toward the receiver P1 obtained by averaging the instantaneous SNR over the channel realizations and indicates the SNR gain over the single-user (SU) single-input-single-output (SISO)...