... mechan-ism is rather delicate (it encompasses all types of bonds250- 15 0- 10 0-75-50-37-25-20- 15 - 10 -Mr(kDa)Mr(kDa)3 pI 10 A250- 15 0- 10 0-75-50-37-25-20- 15 - 10 -3 pI 10 BFig. 5. ... synthesis ofthe beads and some of theirfundamental properties has recently been published[20], together with reviews describing the basic con-cepts [9, 21, 22]. The mechanism of action ofthe Equal-izer ... whichmight baffle even the most famous investigator, Sher-lock Holmes [1] . The reason is that, in any proteome,a few proteins dominate the landscape and often oblit-erate the signal ofthe rare ones,...
... though the air was crisp and cold. In London, with the moisture ofthe Thames close-by, I would have thought it raw, but not so in the dry and clear air ofthe countryside. Leaving the buildings of ... Brent. Considering the speed ofthe freight andthe position ofthe riflemen guarding it, there was no way the thieves could have gotten on the train save from above." Holmes& apos;s careful ... target and they had to land at just the right spot to shove the smoke bombs into the armored cubicle before the guards recovered their wits and started shooting. They couldn't just jump at the...
... variants [9 ,13 ], the lowlevels of HIV detected in many ofthe samples onlyallowed the analysis ofthe predominant genotypes ingenital secretions. Despite this, andthe inherent limita-tions of PCR ... drafted the manuscript. PK participated in the study design and con-ducted the statistical analyses. RC participated in the design and coordination ofthe study and facilitated the collection of ... gel,mobility ratios ofthe heteroduplexes formed betweensample and probe V3 sequences were analyzed and usedto determine the predominant genotype ofthe patientsample, as described [9 ,12 ,13 ]. R5-like...
... and Lim15/Dmc1 [8]. The heterodimeric complex of Hop2 and Mnd1 stimulates strand exchange of Lim15/Dmc1[9 11 ]. The meiosis-specific proteins Mei5 and Sae3form a complex with Lim15/Dmc1 and are ... recruits the DNA polymeraseto the site of Lim15/Dmc1. The broken line represents newly syn-thesized DNA. (C) CAF -1 forms a complex with Lim15/Dmc1 and PCNA. CAF -1 deposits histones H3 and H4 or other ... homolog Dmc1. Cell 11 9, 927–940. 13 Tsubouchi H & Roeder GS (2004) The budding yeastmei5 and sae3 proteins act together with dmc1 duringmeiotic recombination. Genetics 16 8, 12 19 12 30. 14 Neyton...