oncolytic herpes simplex virus g207 therapy from basic to clinical
Báo cáo " Isomeranzin against Herpes simplex virus in vitro from Clausena heptaphylla (Roxb.) W. & ARN.: Isolation, structure and biological assay " potx
... growth/cytotoxicity ( 0%) +/- = very little viral growth/cytotoxicity (< 5%) + = definite viral growth/cytotoxicity (< 25%) ++ = major viral growth/cytotoxicity (< 60%) +++ =extreme viral growth/cytotoxicity ... against HSV-2 with minor cytotoxic effects First symbol refers to viral toxicity, second symbol to cytotoxicity Thus +++/- would show extreme viral growth, but no cytotoxic effects and +/+++ shows ... cytotoxicity of the compound in different solvents is summarized in Table As can be observed from the table, this compound is cytotoxic to Vero cells Although some of the solvents used were cytotoxic...
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Báo cáo hóa học: " Herpes simplex virus type-1(HSV-1) oncolytic and highly fusogenic mutants carrying the NV1020 genomic deletion effectively inhibit primary and metastatic tumors in mice" pptx
... virology have enabled investigators to construct viruses that selectively destroy cancer cells (oncolytic virotherapy) Genetically engineered viruses belonging to different viral families have ... OncdSyn virus, which in addition to the gBsyn3 mutation also carried the gKsyn1 mutation known to enable the virus to fuse even difficult to fuse cells [38] Intra-tumor injections of either virus ... xenograft model [37] To further increase the ability of the OncSyn virus to cause virusinduced cell fusion, the syncytial mutation gKsyn1 (Alato-Val at position 40) known to cause virus- induced cell...
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Báo cáo khoa học: "Herpes simplex virus infection in pregnancy and in neonate: status of art of epidemiology, diagnosis, therapy and preventio" potx
... delivery on transmission rates of herpes simplex virus from mother to infant JAMA 2003, 289:203-209 25 26 27 28 29 30 31 32 33 Desselberger U: Herpes simplex virus infection in pregnancy: diagnosis ... of herpes simplex virus by foetal scalp electrode Obstet Gynecol 1982, 59:263-265 Guill MA, Aton JK, Rogers RB: Neonatal herpes simplex associated with foetal scalp monitor J Am Acad Dermatol ... Epidemiology of herpes simplex virus type infection in the developing world Herpes 2004, 11:24A-35A Fleming DT, McQuillan GM, Johnson RE, Nahmias AJ, Aral SO, Lee FK, St Louis ME: Herpes simplex virus...
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Báo cáo y học: " Identity of zinc finger nucleases with specificity to herpes simplex virus type II genomic DNA: novel HSV-2 vaccine/therapy precursors" pps
... Herpes simplex virus type II as a cause of human genital ulcerative disease Herpes simplex virus types I and II (HSV-1 and 2, respectively), together with the varicella-zoster (chicken-pox) virus, ... Contemporary approaches to vaccination against herpes simplex virus Curr Top Microbiol Immunol 1992, 179:137-158 19 Whitley RJ: Prospects for vaccination against herpes simplex virus Pediatr Ann 1993, ... of herpes simplex virus type J Virol 1998, 72(3):2010-2021 28 Roizman B: The structure and isomerization of herpes simplex virus genomes Cell 1979, 16:481-494 29 Chou J, Roizman B: Herpes simplex...
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Báo cáo sinh học: "A dual function fusion protein of Herpes simplex virus type 1 thymidine kinase and firefly luciferase for noninvasive in vivo imaging of gene therapy in malignant glioma" ppsx
... an important step towards optimization of gene therapy protocols Methods Vector construction The HSV-TK cDNA from the retroviral vector G1Tk1SvNa ([16], kind gift from E Otto, GTI Inc., Gaithersburg, ... clinical evaluation of herpes simplex virus type thymidine kinase and ganciclovir gene therapy as an adjuvant to surgical resection and radiation in adults with previously untreated glioblastoma ... measure for cytotoxic efficacy than tumor size, as has also been suggested by others [34,35] Herpes simplex virus type I thymidine kinase has also been used as a reporter gene for monitoring therapeutic...
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COMPARISON OF CYTOSINE DEAMINASE 5 FLUOROCYTOSINE VERSUS HERPES SIMPLEX VIRUS THYMIDINE KINASE GANCICLOVIR ENZYME PRODRUG SYSTEMS IN GLIOBLASTOMA GENE THERAPY
... delivery of adenoviruses Baculoviruses (Autographa californica multiple nucleopolyhedrovirus) are emerging as vectors for gene therapy Compared with conventional viral vectors, the baculovirus has several ... Fluorescence-Activated Cell Sorting FBS Fetal bovine serum GBM Glioblastoma Multiforme GCV Ganciclovir HSV Herpes Simplex Virus HSVtk Herpes Simplex Virus Thymidine Kinase Luc Luciferase MOI Multiplicity of ... propagated from P1 virus according to the manual Budded viruses in the Sf-900 II serum-free medium were centrifuged at 500 g for to remove cell debris The supernatant was stored at 4°C and kept from...
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Tài liệu Báo cáo khoa học: Role for nectin-1 in herpes simplex virus 1 entry and spread in human retinal pigment epithelial cells docx
... phagocytosislike uptake in herpes simplex virus entry J Cell Biol 174, 1009–1021 Nicola AV, McEvoy AM & Straus SE (2003) Roles for endocytosis and low pH in herpes simplex virus entry into HeLa ... that are known to express herpes simplex virus entry receptors were used a positive control Flow cytometry analysis For cell surface expression of HVEM and nectin-1 receptor, flow cytometery analysis ... Campadelli-Fumi G (1998) The ectodomain of a novel member of the immunoglobulin subfamily related to the poliovirus receptor has the attributes of a bona fide receptor for herpes simplex virus types and in...
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Báo cáo khoa học: Viral entry mechanisms: cellular and viral mediators of herpes simplex virus entry potx
... with other viruses, such as retroviruses and human papillomavirus type-16 [13,14] Surfing is also shared by many additional herpesviruses, including cytomegalovirus and human herpesvirus-8 (V ... RJ & Wiley DC (2001) Herpes simplex virus glycoprotein D bound to the human receptor HveA Mol Cell 8, 169–179 Gianni T, Amasio M & Campadelli-Fiume G (2009) Herpes simplex virus gD forms distinct ... for endocytosis and low pH in herpes simplex virus entry into HeLa and Chinese hamster ovary cells J Virol 77, 5324–5332 Nicola AV, Hou J, Major EO & Straus SE (2005) Herpes simplex virus type...
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herpes simplex virus protocols
... less-well-known herpesvirus One such less-well-characterized herpesvirus is the porcine alpha-herpesvirus pseudorabies virus (PRV, synonyms: suid herpesvirus type 1, Auleszky’s disease vu-us) To explore ... Radiolabeled Virions to Cells This assay measures the proportton of total virus particles that bmd to cells with time Purified radrolabeled virus particles are allowed to bmd to cells for given ... and spraymg virus mto the face Mycoplasma contammatton of vnus stocks is hard to detect, although mycoplasma usually cause blood agar plates to dtscolor If the cells used to grow virus test posmve...
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Báo cáo sinh học: " The herpes simplex virus UL20 protein functions in glycoprotein K (gK) intracellular transport and virus-induced cell fusion are independent of UL20 functions in cytoplasmic virion envelopment" docx
... been shown to function in endocytosis of alphaherpesvirus envelope proteins from plasma membranes to the TGN [32-36] The acidic cluster motifs appear to direct TGN localization by binding to a cellular ... UL11 functions of herpes simplex virus type cytoplasmic virion envelopment Journal of virology 2007, 81(7):3097-3108 McMillan TN, Johnson DC: Cytoplasmic domain of herpes simplex virus gE causes ... Membrane fusion induced by herpes simplex virus In Viral fusion mechanisms Edited by: Bentz J Boca Raton, Fla , CRC Press.; 1993:201-232 Spear PG: Entry of alphaherpesviruses into cells Seminars in...
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Báo cáo sinh học: " Persistent expression of chemokine and chemokine receptor RNAs at primary and latent sites of herpes simplex virus 1 infection" pptx
... Neonatal herpes simplex infection: Herpes simplex virus interaction with TLR2 contributes to lethal encephalitis PNAS 2004, 101:1315-1320 Lund J, Sato A, Akira S, Medzhitov R, Iwasaki A: Toll-like ... infection by herpes simplex virus type J Virol 1995, 69:4898-4905 Halford WP, Gebhardt BM, Carr DJJ: Persistent cytokine expression in trigeminal ganglion latently infected with herpes simplex virus ... gamma herpesvirus 68 It will be of interest to determine how widespread this effect is among different virus infections or whether it is unique to viruses that persist in the host, such as the herpesviruses...
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Báo cáo sinh học: " Re-evaluating the role of natural killer cells in innate resistance to herpes simplex virus type 1" pot
... resistance to HSV-1 is not dependent on NK cell cytotoxicity Innate resistance to HSV-1 is not dependent on NK cell cytotoxicity A Cytotoxic activity of WBCs from BALB/c, BALB/c scid, or NOD scid mice, ... Johnson D: Herpes simplex virus turns off the TAP to evade host immunity Nature 1995, 375:411-415 Tomazin R, van Schoot NE, Goldsmith K, Jugovic P, Sempe P, Fruh K, Johnson DC: Herpes simplex virus ... activators of Stat 1-induced resistance to HSV-1 in vivo However, further studies are necessary to determine if chemokines and pro-inflammatory cytokines are also important contributors to Stat...
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Báo cáo sinh học: " Macrophages and cytokines in the early defence against herpes simplex virus" potx
... belong to the subfamily of Alphaherpes- Structure of herpes simplex virus As all other herpesviruses the herpes simplex viruses are enveloped, icosahedral DNA viruses with a capsid of approximately ... surface protein with herpesvirus entry activity (HveB) confers susceptibility to infection by mutants of herpes simplex virus type 1, herpes simplex virus type 2, and pseudorabies virus Virol 1998, ... receptors that mediate the entry of herpes simplex viruses and animal alphaherpesviruses into cells Rev Med Virol 2000, 10:305-319 Nicola AV, Hou J, Major EO, Straus SE: Herpes simplex virus...
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Báo cáo sinh học: " Detection, quantification and genotyping of Herpes Simplex Virus in cervicovaginal secretions by real-time PCR: a cross sectional survey" potx
... PCR assays for detection of herpes simplex virus J Clin Microbiol 2005, 43:2391-2398 Ashley RL: Laboratory techniques in the diagnosis of herpes simplex infection Genitourin Med 1993, 69:174-183 ... immunodeficiency virus and herpes simplex virus type seropositivity among male factory workers in Zimbabwe J Infect Dis 1998, 177:481-484 Obasi A, Mosha F, Quigley M, Sekirassa Z, Gibbs T, Munguti K, Todd ... Corey L: Frequency of acquisition of first-episode genital infection with herpes simplex virus from symptomatic and asymptomatic source contacts Sex Transm Dis 1985, 12:33-39 Koutsky LA, Stevens...
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Báo cáo sinh học: " Functional inaccessibility of quiescent herpes simplex virus genomes" doc
... Alphaherpesvirus proteins related to herpes simplex virus type ICP0 affect cellular structures and proteins J Virol 2000, 74(21):10006-10017 Russel J, Stow ND, Stow EC, Preston CM: Herpes simplex ... transcription during herpes simplex virus latency J Gen Virol 2000, 81:1-19 Stow EC, Stow ND: Complementation of a herpes simplex virus type Vmw110 deletion mutant by human cytomegalovirus J Gen Virol ... recombination of the alphaherpesvirus bovine herpesvirus J Virol 2004, 78(8):3872-3879 Johnson RM, Spear PG: Herpes simplex virus glycoprotein D mediates interference with herpes simplex virus infection...
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báo cáo hóa học: " Toll-like receptor 2 signaling is a mediator of apoptosis in herpes simplex virus-infected microglia" pdf
... JR: Cutting Edge: TLR2-mediated production of proinflammatory cytokines and chemokines by microglial cells in response to herpes simplex virus J Immunol 2005, 175:4189-4193 Kurt-Jones EA Chan M, ... Wang J, Reed G, Bronson R, Arnold MM, Knipe D M, Finberg RW: Herpes simplex virus interaction with Toll-like receptor contributes to lethal encephalitis Proc Natl Acad Sci USA 2004, 101(5):1315-1320 ... BCL2/adenovirus E1B-interacting protein Baculoviral IAP repeat-containing BCL2/adenovirus E1B-interacting protein Apoptosis inhibitor TSC22 domain family Cell-death inducing DNA fragmentation factor...
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báo cáo hóa học: " A role for DNA-dependent activator of interferon regulatory factor in the recognition of herpes simplex virus type 1 by glial cells" pot
... with herpes simplex virus J Neurovirol 2001, 7:208-219 13 Lund J, Sato A, Akira S, Medzhitov R, Iwasaki A: Toll-like receptor 9mediated recognition of herpes simplex virus- 2 by plasmacytoid dendritic ... apoptotic signaling in primary glial cells infected with herpes simplex virus J Neurovirol 2006, 12:501-510 Konat GW, Kielian T, Marriott I: The role of Toll-like receptors in CNS response to ... RW: Neonatal herpes simplex infection: Herpes simplex virus I interaction with TLR2 contributes to lethal encephalitis Proc Natl Acad Sci 2004, 101:1315-1320 15 Fu Y, Comella N, Tognazzi K, Brown...
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báo cáo hóa học: " Reactive oxygen species drive herpes simplex virus (HSV)-1-induced proinflammatory cytokine production by murine microglia" ppt
... electrons across membranes from NADPH in the cytosol to an electron acceptor (i.e., oxygen) in the extracellular space or phagosome [8] This results in toxicity being directed towards the invading ... in the cytokine response of microglial cells to inflammatory stimuli p38 MAPK has recently been shown to be critical for the neurotoxic phenotype of monocytic cells following exposure to HIV gp120 ... 120-induced neurotoxicity J Immunol 2010, 185:4883-4895 Schachtele SJ, Hu S, Little MR, Lokensgard JR: Herpes simplex virus induces neural oxidative damage via microglial cell Toll-like receptor-2 J Neuroinflammation...
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Báo cáo hóa học: " The product of the Herpes simplex virus 1 UL7 gene interacts with a mitochondrial protein, adenine nucleotide translocator 2" pot
... (f)ANT cyto mito cyto mito cyto mito cyto mito UL7 (f)ANT actin COX IV Figure UL7 Both of and ANT2 were exist in the mitochondrial fractions Both of UL7 and ANT2 were exist in the mitochondrial ... Smiley JR: Herpes simplex virus eliminates host mitochondrial DNA EMBO Rep 2007, 8:188-193 Zhou G, Roizman B: Wild-type herpes simplex virus blocks programmed cell death and release of cytochrome ... release of cytochrome C, which is known to be a stress-responsive mitochondrial protein, into the cytoplasm [31,32]; it thus confirms the influence of HSV infection on mitochondrial condition From these...
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