... the status of being the received view ever since The present book, on the other hand, is the first major-length study of Darwin on the nature of species, and one of its themes is that the received ... transcend not only their social milieu but also the science of their time There is no finer example of this than Darwin This is the grand theme of Michael Ghiselin’s The Triumph ofthe Darwinian Method ... from other things, and always be found the same” (443).5 14 DARWIN ANDTHE NATURE OF SPECIES What we have to keep in mind in all of this is that in Darwin’s time, so unlike today, the equation of...
... local and systemic feedback can shape the decision tracking of individual actors in a system by increasing of knowledge about the intentions of others andthe likely payoff for cooperating Feedback: ... understand the socialvalue orientation ofthe individual—whether innate or conditioned—as a way of understanding the problem of free riders Others focus on the group-level antidote: monitoring and ... Cooperation in Business: Managing Dilemmas inthe 21st Century, we take the first steps in exploring this emerging field of knowledge and practice, looking for ways to think about two key business...
... is in agreement with the domain organization inthe first line The third line shows a summary ofthe identified linear motifs (after filtering processing taking in account the accessibility ofthe ... flavin ring ofthe FAD cofactor and extends along the substrate-binding domain Despite the similar overall folding topology inthe AOD enzymes, there is significant variability inthe size and ... substrate such as the histone tail inthe eukaryotic cell nucleus, and because it is one ofthe first examples ofthe insertion of a protein–protein interaction module (the Tower domain) into a highly...
... set, there is an overlap between the training sets; however, for a training set size of 50 out of a pool of 295 or 203, the amount of overlap between the training sets is small The average size of ... First, should the sample be split into training and test data? Since our interest is in small samples, we only consider the case where the same data is used for training and testing The second issue ... are separated into training and test sets with 50 examples for the training set andthe remaining for the test set; (2) a feature-selection method is applied on the training set to find a feature...
... the case of CsrA this is binding to Shine-Dalgarno-like sequences [9] All these regulatory pathways taken together allow for fine-tuning ofthe cellular transcriptional mechanisms, giving the bacterium ... temperature) and from different in vivo conditions (intestinal lumen and blood), at least two ofthe sRNAs were found to be involved in virulence One of these was rli38, which was upregulated 25-fold in ... myth inthe distinction between eukaryotes and prokaryotes The development of ‘next generation’ DNA sequencing and direct RNA sequencing will no doubt throw even more light on the role of RNA in...
... during the period when Michael Jordan andthe Bulls made all Chicagoans proud of their city at the intersection ofthe highway andthe railroad tracks about 4.5 kilometers northwest of Tingüindín—a ... within this network of families, I gathered data both in Chicago andin their village of origin in Michoacán, Mexico, including extensive field notes and 150 audiotapes of daily conversation and ... {Laughter} And a drunk says, about what they were making fun of /?/ with the drunk, with the, with the drunk’s sister, they were making and then the drunk gets up from over there where he was sitting and...
... Barringer and Peter Lacy CEOs around the world are starting to see the shape of a new era of sustainability coming into view Inthe face of rising global competition, technological change andthe ... beginning to recognise the scale ofthe challenge that they face in aligning sustainability with core business, andin creating the environment necessary for sustainable business to prosper They ... challenges Accelerating the tipping point: Business action is needed In order to overcome these challenges and accelerate a tipping point inthe integration of sustainability into core business, CEOs...
... this level Giving the WFTC to the main earner (in our simulation always the father) results in an increase ofthe bargaining power of men in 1741 couples In 205 cases the man’s bar gaining power ... (difference in gross investment/savings income be tween the man andthe woman), relative unearned income and on the earning potential implied by the tax and benefit system From the point of view ofthe ... the mother Since the WFTC2 reform gives the payment to the main earner (and inthe 40 combination of hours it will be the father), and WFTC1 always gives it to the mother, the value of YfUN will...
... nuclear–cytoplasmic shuttling of FADD and results inthe recycling of CD95 To further investigate whether inhibition of apoptotic signaling affects the subcellular localization of CD95 and ⁄ or FADD, BJAB ... formation and apoptosis Mutation ofthe nuclear export signal within FADD, such that FADD FADD trafficking and CD95 signaling is retained within the nucleus, reduces the deathinducing efficacy of FADD ... against CD3 (1 lgÆmL)1, UCHT1; BD Pharmingen, Franklin Lakes, NJ, USA) and CD28 (5 lgÆmL)1, CD28.2; BD Pharmingen), and maintained in RPMI-1640 standard medium containing recombinant human interleukin-2...
... xylene ring ofthe flavin isoalloxazine moiety Furthermore, theory shows that the size of this coupling responds sensitively to polarity changes inthe protein surroundings [52] (c) Flanking the H(8a) ... upon altering the pH Thus, replacement of His354 by alanine leads to significant modification ofthe cofactorbinding site at the 8a-methyl group and at the linkage ofthe ribityl side chain Hence, ... structural information regarding the distance and location ofthe two histidines with respect to the flavin observer was obtained: the strong shift inthe isotropic hyperfine coupling of H(1¢) in His354Ala,...
... on the recognition of transcription factors and perhaps other intrinsically unstable proteins such as ODC by the QR The active site ofthe enzyme with its flavin cofactor – FAD inthe case ofthe ... Not surprisingly, the enzymatic activity ofthe QR is also compromised inthe presence of proteasome, supporting the direct or indirect involvement ofthe flavin cofactor in protein complex formation ... reduction ofthe flavin (B) Close-up ofthe flavin cofactor andthe loop close to the flavin N(5) for both the oxidized (PDB code 5nll) and reduced (PDB code 5ull) form of flavodoxin Amino acid residues...
... strain was chosen in which the donor element is integrated into the 3’ untranslated region of an actin gene [8], resulting in expression of EGFP in muscle tissue as well as inthe eyes; in individuals ... present inthe same individual The resulting new transposon insertions were then stabilized inthe next generation by segregating away the helper element (that is, the piggyBac transposase) Dominant ... should increase with improvements to the mutating potential of donor elements (for example, via the use of insulator sequences or splice acceptor sites) and/ or the introduction of dominant marking...
... criteria included: being between the age of 14 and 26, self-reported use of illicit drugs other than or in addition to marijuana inthe past 30 days, andtheprovisionof informed consent The study ... studies, syringe sharing included lending or borrowing used syringes, and inconsistent condom use was defined as not always using a condom during vaginal and anal intercourse with all regular and casual ... all ofthe data and takes responsibility for the integrity ofthe results andthe accuracy ofthe statistical analysis BM conceived the study concept and design and was responsible for the composition...
... reduction inthe mass inthe left upper lobe andinthe size ofthe hilar and mediastinal lymphadenopathy There was no change inthe nodules inthe right lower lobe, or inthe appearance ofthe abdominal ... picture, the patient's history of lung cancer, the MRI findings andthe results ofthe brain biopsy, we concluded that our patient had a 'definite' diagnosis of PLE The patient continued the anti-epileptic ... proteins, intrathecal synthesis of immunoglobulin G, oligoclonal bands) supporting the diagnosis of an inflammatory or immune-mediated neurological disorder and by confirming the absence of malignant...
... support be, and is it the task ofthe investigation to determine the details of such support?’31 The accompanying memo also presented ongoing co-operation and other initiatives inthe area The Information ... i.e writing and paddling, the aim is to come out the other side unscathed despite the feeling of being trapped in deep water The arduous struggle against invisible undercurrents andthe constant ... 91-7295-019-6 Working with the Fogbow Design and Reconfiguration of Services and Participation in eGovernment Annelie Ekelin Abstract This thesis is about the metaphors ofthe rainbow andthe fogbow, investigations...
... taken by companies and their boards, including examining the expensing issue, weighing the pros and cons of stock options, exploring alternative forms of incentives, and improving board governance ... Chapter Three The Accounting Story 43 Behind the Scenes ofthe Accounting Debate 45 FASB’s Renewed Campaign 48 Measuring the Value of Options 51 Determining Fair Value 54 A New Chapter inthe Story ... sufficient in determining the size and scope of executive compensation Rather the issue of standing out should apply in a very positive way to the amount of quality oversight and study given to the...
... reappear inthe valley ofthe St Lawrence; while many northern plants pushing southward maintain a more or less precarious existence upon the mountain summits or inthe cold swamps ofNew England, and ... trunk is reinforced at the base, the measurements are made above the swell ofthe roots; when reinforced at the ground and also at the branching point, as often inthe American elm, the measurements ... inthe Adirondacks and to 4300 in North Carolina; west to Minnesota and Iowa Habit. The tallest tree andthe stateliest conifer oftheNew England forest, ordinarily from 50 to 80 feet high and...
... concentration of palytoxin and ostreocin-D provided interesting insights into how these toxins modify the cytoskeleton of neuroblastoma cells: (a) the distortion ofthe actin cytoskeleton begins at ... a new role for this cation in palytoxin action against the actin cytoskeleton (Fig 3) At present, in spite ofthe importance ofthe unpolymerized actin pool for the maintenance ofthe F-actin ... analysis [28] There were two reasons for starting this type of study with an intestinal model: (a) the great complexity ofthe actin cytoskeleton in these cells; and (b) the severe gastrointestinal toxicity...
... CA protein sequences Identical and similar amino acids shared by at least 50% ofthe isoforms are shown in black and grey, respectively Histidine residues involved in zinc binding inthe catalytic ... side of each filament (Fig 2D), a homogenous fluorescence was observed inthe cytoplasm ofthe cells The staining appears to be specific ofthe probe sequence because the staining is clear with the ... exhibit a proline The three histidine residues (named H94, H96 and H119 in reference to positions 94, 96 and 119 in CAII from Homo sapiens) which are directly involved in binding the zinc cofactor,...