issues interpretation of the mod agez1 shoulder and predicted frequency of distant branch points
Báo cáo y học: "Challenging the spliceosome machine" pot
... polymorphism and go to Step 3; otherwise, go to Step If the first base upstream of the region and the last base in the region not match, record their positions as the locations of the donor and acceptor ... at the ends of the region, record the boundary positions as the locations of the donor and acceptor splice sites and go to step 8; otherwise, move the start and finish positions of the region ... sites The enhancement of A content in the vicinity of D-1 to D6 may reduce the likelihood of RNA secondary structure and thereby facilitate spliceosome function by increasing the availability of the...
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Báo cáo y học: " A suboptimal 5'''' splice site downstream of HIV-1 splice site A1 is required for unspliced viral mRNA accumulation and efficient virus replication" pptx
... including the absence of the ψ RNA packaging signal and a deletion preventing Env expression [16] HPNd is transcribed from the CMV promoter but because of the presence of the HIV-1 TAR and RRE, ... transfection of the indicated plasmids and treatment with actinomycin D for the indicated times Quantitation of the changes in accumulation of the spliced (B) viral mRNA species after the addition of actinomycin ... within exons and would increase inclusion of these exons and act to prevent accumulation of excessive levels of vif and vpr mRNAs A second possibility to explain the presence of exons and is that...
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Báo cáo y học: " The strength of the HIV-1 3'''' splice sites affects Rev function" doc
... overview of HIV-1 splice sites and their strength Schematic overview of HIV-1 splice sites and their strength (A) Schematic drawing of the HIV-1 pre-mRNA and the distribution of the splice sites The ... AG-dinucleotide) and the cis-acting elements contribute to the overall strength of the different HIV-1 3'ss and their response to Rev To evaluate the impact on the intrinsic strength of the 3'ss, i.e., the ... of this ESE may be sufficient to influence the strength of at least one of the 3'ss A4c, A4a and A4b (A4cabex) The result showed that in the absence of the bidirectional ESE in exon none of these...
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Báo cáo y học: "Impairment of alternative splice sites defining a novel gammaretroviral exon within gag modifies the oncogenic properties of Akv murine leukemia virus" pdf
... by the box The boldfaced A in the sequence indicates the presumed branch point capsid gene, the mutations affect the branch point site, the pyrimidine region, the conserved splice junction AG and ... positions and orientations of the PCR primers (see Materials and Methods) from the four primer sets depicted below The predicted origins and sizes of the amplified fragments are given at the right ... signify the PCR primers used to verify the stability of the introduced mutations Lower panel shows the positions and types of the introduced mutations, marked by asterisks and underlined The SA'/SD'-delineated...
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Báo cáo y học: " Characterization of a new 5'''' splice site within the caprine arthritis encephalitis virus genome: evidence for a novel auxiliary protein" pot
... within the Env coding region Characterization of the rtm ORF The splice junction between the SD6140 and SA8514 sites predicted the existence of a novel ORF in which the Nand C-terminal parts of the ... [13,23,24] The ratio between the 18- and 17-kDa isoforms depends on the context and/ or the level of the Rtm expression, the 18-kDa being the major product in transfected 293T cells whereas the 17kDa ... junction confirmed the existence of the rtm ORF Like Rev, the Rtm expression was initiated at the env ORF start codons and led to the production of two major protein isoforms of 1 8and 17-kDa Previous...
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Báo cáo y học: " Violating the splicing rules: TG dinucleotides function as alternative 3'''' splice sites in U2-dependent introns" docx
... length of the affected as well as the downstream introns, and length of the upstream and downstream exons (data not shown) TG 3' splice sites are significantly often found in the first intron of the ... whether undiscovered SNPs, or even inaccuracies in the available human genome sequence, may explain some of the remaining candidates The genomic sequence of the splice site regions of GNAS and ... summary, of the 39 RefSeqs showed robust support for unusual TG acceptor sites (Table 1, entries in bold), and of these overlap with cases obtained from the EST screening approach while the others...
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The Position of Marketing Within High-Tech Companies
... reviews the opportunities and threats of outside factors that can affect the future of the business The results of the SWOT analysis define the main issues to be addressed in the plan The marketing ... authority on other departments They have all the accountability and none of the power They must convince these departments because they can never “force” their ideas Therefore, they must have ... objectives they want to achieve, their strategies to achieve them, the resources required, and the expected results The operational marketing plan is the detailed scheduling and budgeting of the actions...
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Tài liệu Module 3: Building Sample Sites pptx
... Creating the Home Page for Institute of Art ! Create a home page ! Create the home page for the Institute of Art The home page for the site will display the following text as the profile of the institute: ... institute: The Institute of Art assures the highest standard of presentation and content We are continually developing a range of courses to meet the professional and creative needs of the community ... institute The Web site should be designed such that the home page consists of the institute’s profile, and below the profile, there are two links: • List of Courses • Registration Clicking the first...
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Tài liệu E-business Part 1 of 3 ppt
... Classification of EC by the Nature of the Transaction • Business-to-business (B2B) : EC model in which all of the participants are businesses or other organizations • Business-to-consumer (B2C): EC model ... The market and the customers • Risk analysis • The industry and competition • Technology analysis • The specifics of the products and/ or services 31 Storefront Model • Storefront model enables ... 15 The Content of a Business Plan • Marketing and sales plan • Mission statement and company description • Operations plan • The management team • Financial projections and plans • The market and...
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Tài liệu E-Business Part 2 of 3:Internet Marketing ppt
... description of page, keywords and title of page • Most search engines rank your site by sending out a spider to inspect the site • The spider reads the META tags, determines the relevance of the Web ... locations and demographic profiles • Determine the level of personalization • Personalized direct e-mail targets consumers with specific information and offers by using customer names, offering the ... at the right time and sending promotions • Response rate • Shows campaign success or failure by measuring the percentage of responses generated from the target market Promotions • Online and offline...
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Tài liệu E-business Part 3 of 3: Online industries pptx
... Other Web retailers integrate other models such as the auction model or price-comparison model Retailing on the Web (cont.) • E-tailers often offer lower prices to generate brand awareness and ... up the price and then offers the products to consumers • Online retailers can communicate easily with suppliers, shipping companies and customers • Most Web retailers use the shopping-cart model ... questions • Health Insurance Portability and Accountability Act (HIPAA) • Requires medical offices and other healthcare related agencies to perform many of their administrative tasks online • Examples:...
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Tài liệu Build Your Own ASP.NET 3.5 Web Site Using C# & VB, 3rd Edition docx
... walk in the park The birds were singing and the kids were all back at school. If the code may be found in the book’s code archive, the name of the file will appear at the top of the program ... 978-0-9804552-1-2 Printed and bound in the United States of America v About the Authors Cristian Darie is a software engineer with experience in a wide range of modern technologies, and the author of numerous ... the name of your computer), choosing Properties, and selecting Security from the panel, as shown in Figure 1.6 Here we’ve modified the Server authentication mode to SQL Server and Windows Authentication...
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Tài liệu Critical Miscellanies (Vol. 3 of 3) Essay 10: Auguste Comte ppt
... (Vol of 3), by John Morley 13 This arrangement of the sciences and the Law of the Three States are together explanatory of the course of human thought and knowledge They are thus the double key of ... considerations of utility and a balance of expediencies Many of these proposals are of the highest interest, and many of them are actually available; but there does not seem to be one of them of an available ... as the other phenomena of the universe, and with the hope of exploring these laws by the same instruments of observation and verification as had done such triumphant work in the case of the latter...
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Tài liệu Báo cáo Y học: Thermostability of manganese- and iron-superoxide dismutases from Escherichia coli is determined by the characteristic position of a glutamine residue pdf
... metal at the active site The presence of iron is therefore a prerequisite for its effect and suggests that the absence of reactivity with the MnSOD mutants is due to the lack of activity in these ... involving other residues and solvent molecules An unexpected result was the extremely high thermostability of Mn[G77Q] and the very low thermostability of Fe[A141Q] (Fig 5) Each of these mutants ... and E coli SODs with the intention of altering their metal specificities In the former cambialistic enzyme, mutations Q70G/A142Q reduced the iron-supported activity of the enzyme and altered the...
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Tài liệu Báo cáo Y học: Prediction of protein–protein interaction sites in heterocomplexes with neural networks ppt
... in the interaction with DnaK [41], and one of the residues of the motif is also predicted by neural networks As a whole, the predicted residues indicate the expected and probable regions of interaction, ... distribution of the residues predicted to be in the contact surface (black bars in Fig 2) The pattern is similar to that of the residue distribution both in the contact and in the whole surface The dependence ... dependence of the accuracy values and of the fraction of total residues with a given accuracy on the reliability index [34] of the prediction are shown in Fig It appears that 70% of the exposed...
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Tài liệu Báo cáo Y học: Study of substrate specificity of human aromatase by site directed mutagenesis pdf
... ring of the androstenedione led to a modification of the conformation of this ring We optimized the position of the ligand and the orientation of the hydrophobic group of V370 (modification of dihedral ... complex to the C(19) methyl of testosterone; and (d) the role of D309 and of E302 in aromatization of androgens and nor-androgens, respectively Thus, N130, located at the opposite face of D476, ... [11] the existence of a coordination bond between the pyridine group and iron (Soret band) Because of this, we have suggested the following position of the ligand inside the active site (Figs and...
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Hinduism And Buddhism, Volume II. (of 3) An Historical Sketch docx
... features of the Mahayana are the worship of Bodhisattvas and idealist philosophy These are obviously parallel to the worship of Siva and Vishnu, and to the rise of the Vedanta Now the worship of these ... after 450 On the other hand portions of the sutra about Amợda's Paradise, of the Prajủõ-põramitõ, and of the Avatamsaka were translated about 150 A.D and translations of the Lotus and Lalita-vistara ... East[118] and was the fundamental thesis of Bodhidharma, the founder of the Zen school But the practical character of the Chinese and Japanese has led them to attach more importance to the moral and...
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Hinduism and Buddhism, Vol I. (of 3) An Historical Sketch doc
... world, the soul and God (the three terms being practically the same) have two modes of existence: one of repose and bliss, the other of struggle and trouble Of these the first mode is the better and ... the world, He is the Lord of the world and He is myself." Here the last words destroy the apparent determinism of the first part of the sentence And similarly the Chandogya Upanishad says, "They ... whereas the pantheism of the Smartas grew out of the feeling that the many gods of tradition must all be one, the pantheism of the Vishnuites was not evolved out of pre-buddhist Brahmanism and is...
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Báo cáo khoa học: Characterization of HbpR binding by site-directed mutagenesis of its DNA-binding site and by deletion of the effector domain pot
... as described in the main text Relevant restriction sites and the direction of transcription for the hbpR and the luxAB genes are indicated (A) (B) Detail of the region of the calmodulin-binding ... of the hbpC promoter in Escherichia coli Results Mutagenesis of the HbpR-binding sites Sequence alignment of the UASs found in the HbpR operators in the hbpC and hbpD promoters defined a set of ... (in which the mutations had been placed), was impaired both at the 3¢ end of the central regions R22 and R23, whereas the region R21 and the 5¢ part of R22 were again protected, as for the wild-type...
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Tìm thêm: xác định các mục tiêu của chương trình xác định các nguyên tắc biên soạn khảo sát các chuẩn giảng dạy tiếng nhật từ góc độ lí thuyết và thực tiễn khảo sát chương trình đào tạo của các đơn vị đào tạo tại nhật bản khảo sát chương trình đào tạo gắn với các giáo trình cụ thể xác định thời lượng học về mặt lí thuyết và thực tế tiến hành xây dựng chương trình đào tạo dành cho đối tượng không chuyên ngữ tại việt nam điều tra đối với đối tượng giảng viên và đối tượng quản lí điều tra với đối tượng sinh viên học tiếng nhật không chuyên ngữ1 nội dung cụ thể cho từng kĩ năng ở từng cấp độ xác định mức độ đáp ứng về văn hoá và chuyên môn trong ct các đặc tính của động cơ điện không đồng bộ đặc tuyến hiệu suất h fi p2 đặc tuyến mômen quay m fi p2 đặc tuyến tốc độ rôto n fi p2 đặc tuyến dòng điện stato i1 fi p2 động cơ điện không đồng bộ một pha sự cần thiết phải đầu tư xây dựng nhà máy chỉ tiêu chất lượng theo chất lượng phẩm chất sản phẩm khô từ gạo của bộ y tế năm 2008 chỉ tiêu chất lượng 9 tr 25