instis for the catalytic cavity of integrase in complex with 5citep correlates with the in vitro inhibitory potencies
Báo cáo y học: "Sequential emergence and clinical implications of viral mutants with K70E and K65R mutation in reverse transcriptase during prolonged tenofovir monotherapy in rhesus macaques with chronic RT-SHIV infection" pptx
... Selection of K70E followed by K65R mutation in RT during prolonged tenofovir monotherapy For of the 10 animals for which viremia decreased following the onset of tenofovir therapy, the nadir of plasma ... The early effect of tenofovir therapy on the percentage of CD4+ T lymphocytes in peripheral blood was variable, as only half of the animals showed a relative increase of 3% within weeks of therapy ... during continued tenofovir monotherapy are reminiscent of observations in people who are infected with M184V mutant HIV-1, and for whom continuation of lamivudine monotherapy is associated with...
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Báo cáo khoa học: "METONYMY: REASSESSMENT, SURVEY OF ACCEPTABILITY, AND ITS TREATMENT IN A MACHINE TRANSLATION SYSTEM S" ppt
... obtained from the intuition of the analysts However, we think that the patterns which are based on the analysts' intuition to begin with should be supported and determined more precisely by the ... the original form, then the system should use the result of the metonymic inference and come up with an acceptable translation REFERENCES Fass, Dan (1991) met*:A Method for Discriminating Metonymy ... in the group to which the expression belongs to in the result of the survey, the system should accept it for analysis, and come up with some metonymic reading using its inference mechanism (Iverson...
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Báo cáo sinh học: " Complement component C5a Promotes Expression of IL-22 and IL-17 from Human T cells and its Implication in Age-related Macular Degeneratio" potx
... expression in the serum of AMD patients [15,16], we found significantly increased levels of IL-22 and IL-17 in the sera of AMD patients, suggesting possible roles of IL-22 and IL-17 in the inflammation ... from human T cells in vitro, which correlates with the increased levels of Th17 cytokines in AMD blood IL-22 has been shown to induce apoptosis of fetal retinal pigment epithelium (RPE) cells ... (Roche, Indianapolis, IN) according to the Liu et al Journal of Translational Medicine 2011, 9:111 http://www.translational-medicine.com/content/9/1/111 Page of 12 Table Clinical information of AMD...
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báo cáo hóa học: " Formation of multinucleated giant cells and microglial degeneration in rats expressing a mutant Cu/Zn superoxide dismutase gene" ppt
... microglia in the brainstem (level of cranial nerve VII) in wildtype animals (A) and in late symptomatic/end Lectin staining of microglia in the brainstem (level of cranial nerve VII) in wildtype ... symptomatic of microglia in midbrain with GSA-I-B4 lectin (A-F) and in motor cortex with OX-42 (G) and OX-6 (H) during Visualization disease Visualization of microglia in midbrain with GSA-I-B4 lectin ... regardless of disease stage, with any of the microglial markers employed (Figs 5G,H) Histopathology in the brain stem Sections from the brainstem at the level of cranial nerve VII during disease...
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Báo cáo y học: "The VH gene repertoire of splenic B cells and somatic hypermutation in systemic lupus erythematosus" potx
... mutations within the CDRs, of which the most prevalent was from serine to asparagine; other mutations included serine to threonine, tyrosine, aspartate, methionine and proline Discussion The immunohistology ... is therefore increased likelihood of random mutations occurring In order to correct for this, the number of mutations in each segment is expressed as a percentage of the total number of bases in ... competition for binding to antigen on the surface of FDCs This process is generally believed to result in an increase in the ratio of replacement to silent mutations, especially within CDRs, and often in...
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báo cáo khoa học: " Efficacy of Mesenchymal Stem Cells in Suppression of Hepatocarcinorigenesis in Rats: Possible Role of Wnt Signaling" doc
... mimicking the one of resident cells in the host tissue Insults trigger the release of chemokines from the endothelium inducing adhesion and migration of circulation BMDC into the liver parenchyma The ... development of HCC seems to be the abnormal regulation of the transcription factor b-catenin, a key component of the Wnt signaling pathway [58] In the normal state, the binding of members of a family of ... that CCl4-induced liver injury (which was the case in the present study)resulted in increased activity of the enzyme MMP-2 and emergence of MMP9 in the liver of NOD/SCID mice As for the mechanisms...
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Báo cáo y học: "The role of mast cells and fibre type in ischaemia reperfusion injury of murine skeletal muscles" pot
... restores the susceptibility of skeletal muscles to IR injury irrespective of the other abnormalities in these mice The role of mast cells has not been considered when investigating the susceptibility ... variation in the period of ischaemia, the muscle temperature during ischaemia and the period of reperfusion allowed for manifestation of the reperfusion injury Idstrom [12] utilised a period of 2, ... obtained by counting a minimum of 100 mast cell profiles in tongue, skin and heart as well as skeletal muscle Using 100 X magnification all mast cell profiles that fell within a grid area of 1.35...
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Báo cáo y học: " Kinetics of hepatitis C virus RNA load during pegylated interferon alpha-2a and ribavirin treatment in naïve genotype 1 patients" potx
... conception, the design of the study, and the drafting of the paper HJ has been involved in drafting and revising the paper HK has been responsible for testing the serums GP has been responsible for the ... dynamics, the mechanisms of action of interferon as well as the consequences of varying dosages of interferon [14] The high turnover rates of HCV explain the rapid generation of viral diversity and the ... the median reduction of the viral load (in log10) from baseline to week 2, 4, 8, and 12 of treatment, week point time tend to be better than other time points for predicting SVR, with a PPV of...
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Tài liệu Báo cáo khoa học: The role of the SEA (sea urchin sperm protein, enterokinase and agrin) module in cleavage of membrane-tethered mucins pdf
... domain in the processing of membrane-tethered mucins The mechanism by which the heavily glycosylated portion of these molecules is released at epithelial surfaces within the airway, the intestine ... fragments were then cloned into the SpeI ⁄ XhoI sites of the polylinker in MUC1FDTR The remaining portions of the polylinker introduced leucine and valine residues N-terminal to the MUC3 and MUC12 ... containing the transmembrane region and the cytoplasmic tail These two parts of the protein remain associated by noncovalent interaction, probably involving sequences within the SEA domain The...
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Child-friendly health care: the views and experiences of children and young people in Council of Europe member States doc
... consistency in this question with the same proportions – roughly four out of five children saying that they were given the information they wanted at their appointment with their health care professional, ... waiting to see the health care professional For the highest proportion of children (37.5%), they felt bored waiting for their appointment Broadly similar numbers of respondents said that they ... hospital setting, explained below In addition, the children consulted by the Ombudsman for Children in Ireland expressed views about the importance of the physical environment for children in the health...
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Báo cáo Y học: Group IID heparin-binding secretory phospholipase A2 is expressed in human colon carcinoma cells and human mast cells and up-regulated in mouse inflammatory tissues doc
... measurement of in vitro sPLA2 activity were performed as described in our previous reports [8–12] RESULTS Determination of the heparin-binding site of mouse sPLA2-IID The amino-acid sequences of mouse ... and for cPLA2a (right) After staining of the gel with ethidium bromide, samples were taken for Southern blotting using cDNA probes for the mixture of these sPLA2s RT-PCR (Fig 6A) After administration ... degradation, thereby leading to inactivation of the HSPG-binding sPLA2s [34,35] Thus, in addition to their enzymatic characteristics, the HSPG-binding properties of sPLA2s also dictate their cellular...
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Báo cáo khoa học: Mechanism for transcriptional synergy between interferon regulatory factor (IRF)-3 and IRF-7 in activation of the interferon-b gene promoter docx
... to the specific arrangement of the cis-acting elements in the promoter and to the nature of the factors they bind To investigate the effect of promoter context on the transcriptional activity of ... p300–C(1571–2370) The intensity of binding, expressed as percentage of input bound, is indicated by different shades of gray and only interactions resulting in binding to more than 1.5% of input are shown ... also for the coactivators Nevertheless, the observation of a strong threshold effect, even with the IRF-3E7/IRF-7Di-containing set (Fig 5B), further suggests that the binding of the set of virus-activated...
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Báo cáo khoa học: Subcellular localization of yeast Sec14 homologues and their involvement in regulation of phospholipid turnover pptx
... compare the sites of action of these polypeptides, C-terminal fusions of Sfh-proteins with yEGFP were constructed and the localization of the proteins in the yeast cell was determined The enzyme ... upstream of the STOP codon of the ORF of interest and on the 3¢ end, 65–70 nucleotides of the genomic region downstream of the ORF of interest Transformants were recovered based on their geneticine ... integrative versions of C-terminal yEGFP fusions in frame with the ORF of interest Thus, yEGFP fusions were present in single copy in the genome and driven by the native promoter of the ORF of...
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Tế bào gốc và ứng dụng trong y sinh học (Stem cells and the application in biomedicine) potx
... differentiation from a human pancreatic cell line in vitro and in vivo Mol Endocrinol 15, 476 - 483 Dzierzak, E et al (1998); Embryonic beginnings of definitive hematopoietic stem cells Ann N Y Acad ... sinh tự tái tạo nhng không biệt hoá thời gian dài nuôi cấy in vitro Tế bào gốc bào thai ngời tăng sinh năm qua 300 - 450 lần phân chia tế bào mầm bào thai có khả tăng sinh hơn, hầu hết tăng sinh ... et al (2000); Clonally derived human embryonic stem cell lines maintain pluripotency and proliferative potential for prolonged periods of culture Dev Biol 227, 271 - 278 Beltrami, A P., et al...
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báo cáo hóa học:" Sigma-2 receptor ligands potentiate conventional chemotherapies and improve survival in models of pancreatic adenocarcinoma" ppt
... cells in vitro The murine pancreatic adenocarcinoma cell, Panc02, was treated with SV119 alone or in combination with gemcitabine or paclitaxel After 24 hours of treatment, samples were stained for ... (pentazocine, Panel B) The apoptotic effect of the sigma-2 ligand, SV119, is enhanced by conventional chemotherapy in vitro In order to evaluate the potential therapeutic effect of the sigma-2 ... SV119, in combination with conventional chemotherapy, we treated pancreatic cancer cell lines with SV119 and the chemotherapeutic agents gemcitabine and paclitaxel After 24 hours of treatment in the...
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báo cáo hóa học: " Proinflammatory and proapoptotic markers in relation to mono and di-cations in plasma of autistic patients from Saudi Arabia" docx
... prostaglandin synthesis, resulting in increased permeability of the blood-brain barrier [46]; thus the administration of LPS to fetal sheep results in the extravasation of plasma proteins and macrophages ... consent A written consent was obtained from the parents of each individual case, according to the guidelines of the ethical committee of King Khalid Hospital, King Saud University Blood samples ... with the exception of Mg2+ and Na+ which show low specificity values Discussion Protection of the brain from injury during the fetal, neonatal and postnatal periods is of major importance owing...
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báo cáo hóa học:" The role of FGF-2 and BMP-2 in regulation of gene induction, cell proliferation and mineralization" pptx
... rinsed five times in room temperature phosphate buffered saline (PBS) and fixed We then visualized the mineralizing cells with 2% Alizarin Red After rinsing in distilled water and air drying the ... BMP-2, the yin and yang of mineralization: Contrast of effect of 24 hours of treatment with FGF-2 or BMP2 on fold increase in abundance of mineralization-related gene expression Mineralizing MC3T3-E1 ... heal the defect The increase in cell replication in a mineralizing cell likely represents a de-differentiation from the mineralizing phase to the growing phase, and increases expression of GFs...
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báo cáo hóa học:" The role of FGF-2 and BMP-2 in regulation of gene induction, cell proliferation and mineralization" pdf
... rinsed five times in room temperature phosphate buffered saline (PBS) and fixed We then visualized the mineralizing cells with 2% Alizarin Red After rinsing in distilled water and air drying the ... BMP-2, the yin and yang of mineralization: Contrast of effect of 24 hours of treatment with FGF-2 or BMP2 on fold increase in abundance of mineralization-related gene expression Mineralizing MC3T3-E1 ... heal the defect The increase in cell replication in a mineralizing cell likely represents a de-differentiation from the mineralizing phase to the growing phase, and increases expression of GFs...
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Tìm thêm: khảo sát các chuẩn giảng dạy tiếng nhật từ góc độ lí thuyết và thực tiễn khảo sát chương trình đào tạo của các đơn vị đào tạo tại nhật bản khảo sát chương trình đào tạo gắn với các giáo trình cụ thể xác định thời lượng học về mặt lí thuyết và thực tế tiến hành xây dựng chương trình đào tạo dành cho đối tượng không chuyên ngữ tại việt nam khảo sát các chương trình đào tạo theo những bộ giáo trình tiêu biểu nội dung cụ thể cho từng kĩ năng ở từng cấp độ phát huy những thành tựu công nghệ mới nhất được áp dụng vào công tác dạy và học ngoại ngữ mở máy động cơ rôto dây quấn hệ số công suất cosp fi p2 đặc tuyến hiệu suất h fi p2 đặc tuyến mômen quay m fi p2 đặc tuyến dòng điện stato i1 fi p2 động cơ điện không đồng bộ một pha sự cần thiết phải đầu tư xây dựng nhà máy thông tin liên lạc và các dịch vụ phần 3 giới thiệu nguyên liệu từ bảng 3 1 ta thấy ngoài hai thành phần chủ yếu và chiếm tỷ lệ cao nhất là tinh bột và cacbonhydrat trong hạt gạo tẻ còn chứa đường cellulose hemicellulose chỉ tiêu chất lượng theo chất lượng phẩm chất sản phẩm khô từ gạo của bộ y tế năm 2008 chỉ tiêu chất lượng 9 tr 25