following up linkage analysis of complex phenotypes with population based association studies
Báo cáo khoa học: "A Computational Analysis of Complex Noun Phrase in Messages" docx
... symptomatic of two major mechanisms text compression in Navy messages: of complex noun sequences and nominalizations Complex noun sequences A major feature of noun phrases in this set of messages ... Acknowledgments This research was supported by the Oflace of Naval Research and the Ofllce of Naval Technology PE-62721N The author gratefully acknowledges the efforts of Joan Bachenko, Judy Froseher, ... diode is a component of a circuit In antenna coupler, coupler is a component part of an antenna Part names may also describe the function of the piece of equipment For example, in the phrase high...
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Báo cáo khoa học: "Historical Analysis of Legal Opinions with a Sparse Mixed-Effects Latent Variable Model" potx
... property of latent variables The weight update of λ(R) and λ(Q) is bound by the averaged accuracy of the two classification tasks in the training data, which is similar to the notion of minimizing ... and number of topics, we have achieved better system accuracy than state -of- the-art generative and discriminative models of text Our quantitative analysis shows that early US state supreme court ... different periods of time In addition, our model has been shown to be effective for qualitative analysis of historical data, revealing patterns that are consistent with the history of the period...
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BUSINESS AND Financial analysis OF BRITISH PETROLEUM WITH COMPARISON TO SHELL PLC
... 3.6.4 Collection of Secondary Data 43 3.7 43 3.7.1 Reliability of Data Collected 43 3.7.2 Method of Data Analysis Validity of the data 43 2011 Business and Financial Analysis of BP with comparison ... Layer Financial Analysis: The above figure depicts the following scorecards analysis of ratios breakeven analysis and various trends 24 Business and Financial Analysis of BP with comparison to ... ratio analysis is done for the purpose of the income statement analysis and balance sheet analysis and with the supporting element of the financial scorecard tool to provide the unique picture of...
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Báo cáo sinh học: " Determination of suitable housekeeping genes for normalisation of quantitative real time PCR analysis of cells infected with human immunodeficiency virus and herpes viruses" pdf
... of cell types infected with a variety of strains of HIV-1, HSV-1, VZV and cytomegalovirus (CMV) compared to mock infected cells Results A range of cell lines and primary cells were infected with ... measures analysis of variance was then used to test for the presence of interaction between the effects of Page of (page number not for citation purposes) Virology Journal 2007, 4:130 the within ... for use in QPCR studies of viral infections Nevertheless it is of benefit for researchers to be able to determine a shortlist of potential candidates To date the variability of housekeeping gene...
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Báo cáo hóa học: " Determination of suitable housekeeping genes for normalisation of quantitative real time PCR analysis of cells infected with human immunodeficiency virus and herpes viruses" pot
... of cell types infected with a variety of strains of HIV-1, HSV-1, VZV and cytomegalovirus (CMV) compared to mock infected cells Results A range of cell lines and primary cells were infected with ... measures analysis of variance was then used to test for the presence of interaction between the effects of Page of (page number not for citation purposes) Virology Journal 2007, 4:130 the within ... for use in QPCR studies of viral infections Nevertheless it is of benefit for researchers to be able to determine a shortlist of potential candidates To date the variability of housekeeping gene...
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Báo cáo hóa học: "Multicriteria Gene Screening for Analysis of Differential Expression with DNA Microarrays" potx
... (wild type) of subjects and a treated population (knockout) of subjects whose DNA has been altered in some way Each population is comprised of T different age groups arranged in T subpopulations ... fall into the category of a two-way layout [21], where each cell in the layout corresponds to a set of replicates of samples from one of the two populations (row) and one of T-time points (column) ... eigenvalue spread in a principal components analysis (PCA) of all pairs of gene expression profiles, the ratio of betweenpopulation-variation to within -population- variation, or the cross correlation between...
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Báo cáo hóa học: " Spectral Analysis of Polynomial Nonlinearity with Applications to RF Power Amplifiers" pdf
... autocovariance function of x(t) as c2x (τ) We point out that (wide-sense) stationarity of x(t) is assumed in [1, 2, 3, 4, 6], often without justification The PSD of x(t) is defined as the FT of c2x (τ): c2x ... correlation function in terms of cyclic correlation with cycles −2πm/T The bandwidth of H( f ) affects the number of cycles present in c2x (t; τ) [15, 16] Since the bandwidth of H( f ) is limited to ... the (complex- valued) coefficients for the PA We see from (11) that the complex gain is G(x(t)) = y(t)/x(t) = K=0 a2k+1 |x(t)|2k , which is a function of r = k |x(t)| only Spectral Analysis of Polynomial...
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Báo cáo y học: "Analysis of alternative splicing with microarrays: successes and challenges" docx
... expression-data analysis to be ‘noise’ are actually reproducible signals, indicative of different patterns of regulation of multiple splice forms Recently, two large-scale microarray studies of alternative ... performed a quantitative analysis of distinct splice forms of two human genes (CD44 and TPM2) using an Affymetrix microarray platform Castle et al [24] reported studies of two human genes (RB1 ... show experimental evidence of alternative splicing It should be emphasized that this estimate is not an independent validation of EST -based estimates of the extent of alternative splicing, because...
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Báo cáo y học: "Reducing the exome search space for Mendelian diseases using genetic linkage analysis of exome genotypes" ppsx
... use of erroneous genotypes in linkage analyses may reduce power to detect linkage peaks or result in false positive linkage peaks [37] We compared the results of linkage analysis using array -based ... integrated the relatively new field of MPS in families with classical linkage analysis Where feasible, we strongly advocate the use of linkage mapping in combination with MPS studies that aim to discover ... variant of interest Conclusions Linkage analysis is of great potential benefit to WES studies that aim to discover genetic variants resulting in Mendelian disorders As variants outside of linkage...
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Báo cáo y học: " Allele-specific copy number analysis of tumor samples with aneuploidy and tumor heterogeneity" ppt
... Identification of heterogeneity within the tumor cell population Plotting a chromosome highlighted against the whole sample allows discovery of genomic regions with heterogeneity within the tumor cell population, ... aberrations with high sensitivity even when the proportion of tumor cells is as low as 30% Analysis of cancer samples indicates that TAPS is well suited to investigate samples with aneuploidy and ... Department of Medical Sciences, Uppsala University, Akademiska sjukhuset, SE-751 85 Uppsala, Sweden Department of Immunology, Genetics and Pathology, Uppsala University, Rudbeck Laboratory, SE-751 85 Uppsala,...
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báo cáo khoa học: " A histomorphometric meta-analysis of sinus elevation with various grafting materials" ppt
... number of obserTable 2: Distribution of articles and material observations Σ Case reports Retrospective studies Prospective studies Studies 30 26 Examined grafting materials (in these studies) ... point of view, the use of autogenous bone is advantageous if a prosthetic rehabilitation (with functional loading) is expected within months In other cases the use of Bio Oss® in combination with ... complications of bone grafting of the floor of the maxillary sinus for the placement of endosseous implants Mund Kiefer Gesichtschirurgie Mund Kiefer Gesichtschir 1999 May;3 Suppl 1:S65-9 1999, Suppl...
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Báo cáo y học: "Cis-regulation of IRF5 expression is unable to fully account for systemic lupus erythematosus association: analysis of multiple experiments with lymphoblastoid cell lines" doc
... we not know which of the results with the two LCL collections is more representative of the population at large We found a consistent association of the SLE risk haplotype with higher IRF5 expression ... Hashimoto H, Behrens TW, Tsuchiya N: Association of IRF5 polymorphisms with systemic lupus erythematosus in a Japanese population: support for a crucial role of intron polymorphisms Arthritis Rheum ... CEU population of HapMap Two different groups of results were identified (Figure 2) The first group included eight probes that were highly correlated (mean pairwise r2 = 0.79) They hybridised with...
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Báo cáo sinh học: " Longitudinal random effects models for genetic analysis of binary data with application to mastitis in dairy cattle" pdf
... algorithms, with a burn-in period of 20 000 samples Analysis was based on 50 000 additional samples, drawn without thinning RESULTS AND DISCUSSION The posterior mean for heritability of liability ... feasibility and advantage of a longitudinal analysis of sequential binary responses A random regression model proved to be superior than a model with constant genetic value over time based on the Bayes ... effect of year-month of test m (m = 1, 2, , 89); br = [b0r , b1r , b2r , b3r , b4r ] = × vector of regressions of liability by agedays in milk j for cow i ; ui = additive season (five classes) of...
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Báo cáo y học: "Systematic profiling of cellular phenotypes with spotted cell microarrays reveals mating-pheromone response genes" pot
... extent of growth arrest in this assay correlates well with the penetrance of shmooing across the populations of cells as measured with the cell-chip assay 12 B To validate the involvement of these ... (TIR3) Loss of any of these genes disrupts pheromone response, possibly indicating membrane properties feeding back into control of mating response, consistent with the important role of plasma-membrane ... MRPL16 MRPL28 TAP-MS complex Figure Comparison of results with the known response pathway Comparison of results with the known response pathway This comparison reveals that of the 18 known genes...
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Báo cáo sinh học: "A marginal quasi-likelihood approach to the analysis of Poisson variables with generalized linear mixed models" pot
... advantage of [15] is to provide estimates ofp which can be computed in a similar way as with mixed model equations of Henderson (1984) These equations also imply as a by-product an estimate of u which, ... hand A simple example of that is the classical animal model In (a2! ) x! p + +pi, for the jth performance of the ith female (eg ovulation rate of an ewe) as a function of = a From as now on GAR ... specification of the marginal mean vector and of the variance requires 11 covariance matrix V of the vector Y of observations Given the moment generating function of the multivariate normal distribution...
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PHÂN TÍCH ỨNG xử TĨNH tấm SANDWICH có lõi tổ ONG STATIC ANALYSIS OF SANDWICH PLATES WITH HONEYCOMB CORES
... Theoretical Approach to the Deformation of Honeycomb -Based Composite Materials, Composite, 209-214 (1979) [4] Becker, W., Closed Form Analysis of the Thickness Effect of Regular Honeycomb Core Material, ... 67-70 [5] Liu, Q., Zhao, Y., Effect of Soft Honeycomb Core on Flexural Vibration of Sandwich Panel using Low Order and High Order Shear Deformation Models, Journal of Sandwich Structures and Materials, ... computations of the effective properties of thin plates, International Journal of Solids and Structures, 45 (2008), 6518–6534 [17] Nguyen T K., Sab K., Bonnet G., Bounds for the effective properties of...
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Báo cáo y học: " A comparative analysis of HIV drug resistance interpretation based on short reverse transcriptase sequences versus full sequences" pps
... analyzed per drug in two groups: group 1: sequences that were attributed a ‘susceptible’ profile (MA or S), based on virco®TYPE analysis of the full RT sequence; and group 2: sequences that were ... biological cut-offs (BCOs) are used A biological cut-off is based on laboratory observations of viruses derived from treatment naïve patients, and gives an indication of the normal range of in vitro ... performance of virco®TYPE versus Stanford Materials and methods Amplification of a short RT sequence useful in HIVDR testing As of today, HIV resistance testing is based on amplifying and sequencing of...
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Analysis of dose response data from developmental toxicity studies
... ANALYSIS OF DOSE-RESPONSE DATA FROM DEVELOPMENTAL TOXICITY STUDIES PANG ZHEN (Master of Science, Beijing University of Technology) A THESIS SUBMITTED FOR THE DEGREE OF DOCTOR OF PHILOSOPHY ... PHILOSOPHY DEPARTMENT OF STATISTICS AND APPLIED PROBABILITY NATIONAL UNIVERSITY OF SINGAPORE 2005 i Acknowledgements This thesis would not have been possible without the support and help of many people ... developmental toxicity studies Depending on the application, a cluster could mean a litter of animals, a household of individuals, or measurements of the same type taken from different locations of the same...
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Thesic_suitability analysis of urban green space system based on GIS”
... SUITABILITY ANALYSIS OF URBAN GREEN SPACE SYSTEM BASED ON GIS Methodology 3.1 Definition of suitability analysis Land suitability analysis is the process of determining the fitness of a given tract of ... suitability analysis of urban green space system based on GIS, and sensitivity analysis that is to test the validity of scores, weights used and the ranking of alternatives by using DSS (decision support ... 68 SUITABILITY ANALYSIS OF URBAN GREEN SPACE SYSTEM BASED ON GIS Introduction 1.1 Background Land suitability analysis is the process of determining the fitness of a given tract of land for a...
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